major facilitator superfamily domain containing 2A (MFSD2A) - coding DNA reference sequence

(used for variant description)

(last modified January 24, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001136493.1 in the MFSD2A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_053084.1136493.1, covering MFSD2A transcript NM_001136493.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            a       c.-181

 .         .         .         .         .         .                g.5061
 gaactataagaggcgcggagggggcgtgcagcagagtgcgttcctcgtctgccagccggc       c.-121

 .         .         .         .         .         .                g.5121
 ttggctagcgcgcggcggccgtggctaaggctgctacgaagcgagcttgggaggagcagc       c.-61

 .         .         .         .         .         .                g.5181
 ggcctgcggggcagaggagcatcccgtctaccaggtcccaagcggcgtggcccgcgggtc       c.-1

          .         .         .         .         .         .       g.5241
 ATGGCCAAAGGAGAAGGCGCCGAGAGCGGCTCCGCGGCGGGGCTGCTACCCACCAGCATC       c.60
 M  A  K  G  E  G  A  E  S  G  S  A  A  G  L  L  P  T  S  I         p.20

          .         .         .    | 02    .         .         .    g.7002
 CTCCAAAGCACTGAACGCCCGGCCCAGGTGAAG | AAAGAACCGAAAAAGAAGAAACAACAG    c.120
 L  Q  S  T  E  R  P  A  Q  V  K   | K  E  P  K  K  K  K  Q  Q      p.40

          .         .         .         .         .         .       g.7062
 TTGTCTGTTTGCAACAAGCTTTGCTATGCACTTGGGGGAGCCCCCTACCAGGTGACGGGC       c.180
 L  S  V  C  N  K  L  C  Y  A  L  G  G  A  P  Y  Q  V  T  G         p.60

          .         .         .         .         | 03         .    g.8562
 TGTGCCCTGGGTTTCTTCCTTCAGATCTACCTATTGGATGTGGCTCAG | AAGGATGAGGAA    c.240
 C  A  L  G  F  F  L  Q  I  Y  L  L  D  V  A  Q   | K  D  E  E      p.80

          .         .         .         .         .         .       g.8622
 GTTGTCTTTTGCTTCTCCTCATTCCAGGTGGGCCCTTTCTCTGCCTCCATCATCCTGTTT       c.300
 V  V  F  C  F  S  S  F  Q  V  G  P  F  S  A  S  I  I  L  F         p.100

          .         .         .         .         .         .       g.8682
 GTGGGCCGAGCCTGGGATGCCATCACAGACCCCCTGGTGGGCCTCTGCATCAGCAAATCC       c.360
 V  G  R  A  W  D  A  I  T  D  P  L  V  G  L  C  I  S  K  S         p.120

          .         .         .   | 04     .         .         .    g.15127
 CCCTGGACCTGCCTGGGTCGCCTTATGCCCTG | GATCATCTTCTCCACGCCCCTGGCCGTC    c.420
 P  W  T  C  L  G  R  L  M  P  W  |  I  I  F  S  T  P  L  A  V      p.140

          .         .         .         .         .         .       g.15187
 ATTGCCTACTTCCTCATCTGGTTCGTGCCCGACTTCCCACACGGCCAGACCTATTGGTAC       c.480
 I  A  Y  F  L  I  W  F  V  P  D  F  P  H  G  Q  T  Y  W  Y         p.160

          .         .         .       | 05 .         .         .    g.15383
 CTGCTTTTCTATTGCCTCTTTGAAACAATGGTCACG | TGTTTCCATGTTCCCTACTCGGCT    c.540
 L  L  F  Y  C  L  F  E  T  M  V  T   | C  F  H  V  P  Y  S  A      p.180

          .         .         .         .         .      | 06  .    g.15750
 CTCACCATGTTCATCAGCACCGAGCAGACTGAGCGGGATTCTGCCACCGCCTATC | GGATG    c.600
 L  T  M  F  I  S  T  E  Q  T  E  R  D  S  A  T  A  Y  R |   M      p.200

          .         .         .         .         .         .       g.15810
 ACTGTGGAAGTGCTGGGCACAGTGCTGGGCACGGCGATCCAGGGACAAATCGTGGGCCAA       c.660
 T  V  E  V  L  G  T  V  L  G  T  A  I  Q  G  Q  I  V  G  Q         p.220

          .         .         .         .         .         .       g.15870
 GCAGACACGCCTTGTTTCCAGGACCTCAATAGCTCTACAGTAGCTTCACAAAGTGCCAAC       c.720
 A  D  T  P  C  F  Q  D  L  N  S  S  T  V  A  S  Q  S  A  N         p.240

          .         .         .    | 07    .         .         .    g.16516
 CATACACATGGCACCACCTCACACAGGGAAACG | CAAAAGGCATACCTGCTGGCAGCGGGG    c.780
 H  T  H  G  T  T  S  H  R  E  T   | Q  K  A  Y  L  L  A  A  G      p.260

          .         .         .         .         .         .       g.16576
 GTCATTGTCTGTATCTATATAATCTGTGCTGTCATCCTGATCCTGGGCGTGCGGGAGCAG       c.840
 V  I  V  C  I  Y  I  I  C  A  V  I  L  I  L  G  V  R  E  Q         p.280

      | 08   .         .         .         .         .         .    g.16755
 AGAG | AACCCTATGAAGCCCAGCAGTCTGAGCCAATCGCCTACTTCCGGGGCCTACGGCTG    c.900
 R  E |   P  Y  E  A  Q  Q  S  E  P  I  A  Y  F  R  G  L  R  L      p.300

          .         .         .         .         .         .       g.16815
 GTCATGAGCCACGGCCCATACATCAAACTTATTACTGGCTTCCTCTTCACCTCCTTGGCT       c.960
 V  M  S  H  G  P  Y  I  K  L  I  T  G  F  L  F  T  S  L  A         p.320

        | 09 .         .         .         .         .         .    g.17028
 TTCATG | CTGGTGGAGGGGAACTTTGTCTTGTTTTGCACCTACACCTTGGGCTTCCGCAAT    c.1020
 F  M   | L  V  E  G  N  F  V  L  F  C  T  Y  T  L  G  F  R  N      p.340

          .         .         . | 10       .         .         .    g.17546
 GAATTCCAGAATCTACTCCTGGCCATCATG | CTCTCGGCCACTTTAACCATTCCCATCTGG    c.1080
 E  F  Q  N  L  L  L  A  I  M   | L  S  A  T  L  T  I  P  I  W      p.360

          .         .         .         .         .     | 11   .    g.17698
 CAGTGGTTCTTGACCCGGTTTGGCAAGAAGACAGCTGTATATGTTGGGATCTCA | TCAGCA    c.1140
 Q  W  F  L  T  R  F  G  K  K  T  A  V  Y  V  G  I  S   | S  A      p.380

          .         .         .         .         .         .       g.17758
 GTGCCATTTCTCATCTTGGTGGCCCTCATGGAGAGTAACCTCATCATTACATATGCGGTA       c.1200
 V  P  F  L  I  L  V  A  L  M  E  S  N  L  I  I  T  Y  A  V         p.400

          .         .         .         .        | 12.         .    g.18235
 GCTGTGGCAGCTGGCATCAGTGTGGCAGCTGCCTTCTTACTACCCTG | GTCCATGCTGCCT    c.1260
 A  V  A  A  G  I  S  V  A  A  A  F  L  L  P  W  |  S  M  L  P      p.420

          .         .         .         .         .         .       g.18295
 GATGTCATTGACGACTTCCATCTGAAGCAGCCCCACTTCCATGGAACCGAGCCCATCTTC       c.1320
 D  V  I  D  D  F  H  L  K  Q  P  H  F  H  G  T  E  P  I  F         p.440

          .         .         .         .         .         .       g.18355
 TTCTCCTTCTATGTCTTCTTCACCAAGTTTGCCTCTGGAGTGTCACTGGGCATTTCTACC       c.1380
 F  S  F  Y  V  F  F  T  K  F  A  S  G  V  S  L  G  I  S  T         p.460

          .  | 13      .         .         .         .         .    g.18506
 CTCAGTCTGGA | CTTTGCAGGGTACCAGACCCGTGGCTGCTCGCAGCCGGAACGTGTCAAG    c.1440
 L  S  L  D  |  F  A  G  Y  Q  T  R  G  C  S  Q  P  E  R  V  K      p.480

          .         .         .         .         .         .       g.18566
 TTTACACTGAACATGCTCGTGACCATGGCTCCCATAGTTCTCATCCTGCTGGGCCTGCTG       c.1500
 F  T  L  N  M  L  V  T  M  A  P  I  V  L  I  L  L  G  L  L         p.500

          .         .         .         .         .         .       g.18626
 CTCTTCAAAATGTACCCCATTGATGAGGAGAGGCGGCGGCAGAATAAGAAGGCCCTGCAG       c.1560
 L  F  K  M  Y  P  I  D  E  E  R  R  R  Q  N  K  K  A  L  Q         p.520

          | 14         .         .         .         .         .    g.19445
 GCACTGAG | GGACGAGGCCAGCAGCTCTGGCTGCTCAGAAACAGACTCCACAGAGCTGGCT    c.1620
 A  L  R  |  D  E  A  S  S  S  G  C  S  E  T  D  S  T  E  L  A      p.540

          .                                                         g.19457
 AGCATCCTCTAG                                                       c.1632
 S  I  L  X                                                         p.543

          .         .         .         .         .         .       g.19517
 ggcccgccacgttgcccgaagccaccatgcagaaggccacagaagggatcaggacctgtc       c.*60

          .         .         .         .         .         .       g.19577
 tgccggcttgctgagcagctggactgcaggtgctaggaagggaactgaagactcaaggag       c.*120

          .         .         .         .         .         .       g.19637
 gtggcccaggacacttgctgtgctcactgtggggccggctgctctgtggcctcctgcctc       c.*180

          .         .         .         .         .         .       g.19697
 ccctctgcctgcctgtggggccaagccctggggctgccactgtgaatatgccaaggactg       c.*240

          .         .         .         .         .         .       g.19757
 atcgggcctagcccggaacactaatgtagaaacctttttttttacagagcctaattaata       c.*300

          .         .         .         .         .         .       g.19817
 acttaatgactgtgtacatagcaatgtgtgtgtatgtatatgtctgtgagctattaatgt       c.*360

          .         .                                               g.19845
 tattaattttcataaaagctggaaagca                                       c.*388

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Major facilitator superfamily domain containing 2A protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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