microphthalmia-associated transcription factor (MITF) - coding DNA reference sequence

(used for variant description)

(last modified February 10, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_198159.2 in the MITF gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011631.1, covering MITF transcript NM_198159.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  gtaaactccccgcgctggggcgggcggccgcgagccggcgagc       c.-121

 .         .         .         .         .         .                g.5103
 gggcagagctcggcactgcgccggggcgcacggctcgggggacccaggcccagctacctt       c.-61

 .         .         .         .         .         .                g.5163
 ccctccgcccccgggctctgttctcactttccagcagtggaaggacgggaagcgggagcc       c.-1

          .         .         .         .         .         .       g.5223
 ATGCAGTCCGAATCGGGGATCGTGCCGGATTTCGAAGTCGGGGAGGAGTTTCATGAAGAG       c.60
 M  Q  S  E  S  G  I  V  P  D  F  E  V  G  E  E  F  H  E  E         p.20

          .         .         .         .     | 02   .         .    g.144715
 CCCAAAACCTATTACGAACTCAAAAGTCAACCGCTGAAGAGCAG | CAGTTCCGCCGAGCAT    c.120
 P  K  T  Y  Y  E  L  K  S  Q  P  L  K  S  S  |  S  S  A  E  H      p.40

          .         .         .         .         .         .       g.144775
 CCTGGGGCCTCCAAGCCTCCGATAAGCTCCTCCAGTATGACATCACGCATCTTGCTACGC       c.180
 P  G  A  S  K  P  P  I  S  S  S  S  M  T  S  R  I  L  L  R         p.60

          .         .         .         .         .         .       g.144835
 CAGCAACTCATGCGTGAGCAGATGCAGGAGCAGGAGCGCAGGGAGCAGCAGCAGAAGCTG       c.240
 Q  Q  L  M  R  E  Q  M  Q  E  Q  E  R  R  E  Q  Q  Q  K  L         p.80

          .         .         .         .         .         .       g.144895
 CAGGCGGCCCAGTTCATGCAACAGAGAGTGCCCGTGAGTCAGACACCAGCCATAAACGTC       c.300
 Q  A  A  Q  F  M  Q  Q  R  V  P  V  S  Q  T  P  A  I  N  V         p.100

          .         .         .         .         .     | 03   .    g.203393
 AGTGTGCCCACCACCCTTCCCTCTGCCACGCAGGTGCCGATGGAAGTCCTTAAG | GTGCAG    c.360
 S  V  P  T  T  L  P  S  A  T  Q  V  P  M  E  V  L  K   | V  Q      p.120

          .         .         .         .         .         .       g.203453
 ACCCACCTCGAAAACCCCACCAAGTACCACATACAGCAAGCCCAACGGCAGCAGGTAAAG       c.420
 T  H  L  E  N  P  T  K  Y  H  I  Q  Q  A  Q  R  Q  Q  V  K         p.140

          .         .         .         .         .         .       g.203513
 CAGTACCTTTCTACCACTTTAGCAAATAAACATGCCAACCAAGTCCTGAGCTTGCCATGT       c.480
 Q  Y  L  S  T  T  L  A  N  K  H  A  N  Q  V  L  S  L  P  C         p.160

          .         .         .         .         .         .       g.203573
 CCAAACCAGCCTGGCGATCATGTCATGCCACCGGTGCCGGGGAGCAGCGCACCCAACAGC       c.540
 P  N  Q  P  G  D  H  V  M  P  P  V  P  G  S  S  A  P  N  S         p.180

          .         .         .         .   | 04     .         .    g.204681
 CCCATGGCTATGCTTACGCTTAACTCCAACTGTGAAAAAGAG | GGATTTTATAAGTTTGAA    c.600
 P  M  A  M  L  T  L  N  S  N  C  E  K  E   | G  F  Y  K  F  E      p.200

          .         .         .         .         .         .       g.204741
 GAGCAAAACAGGGCAGAGAGCGAGTGCCCAGGCATGAACACACATTCACGAGCGTCCTGT       c.660
 E  Q  N  R  A  E  S  E  C  P  G  M  N  T  H  S  R  A  S  C         p.220

        | 05 .         .         .         .         .         .    g.206855
 ATGCAG | ATGGATGATGTAATCGATGACATCATTAGCCTAGAATCAAGTTATAATGAGGAA    c.720
 M  Q   | M  D  D  V  I  D  D  I  I  S  L  E  S  S  Y  N  E  E      p.240

          .         .         .         .   | 06     .         .    g.214634
 ATCTTGGGCTTGATGGATCCTGCTTTGCAAATGGCAAATACG | TTGCCTGTCTCGGGAAAC    c.780
 I  L  G  L  M  D  P  A  L  Q  M  A  N  T   | L  P  V  S  G  N      p.260

          .         .         .         .         .         .       g.214694
 TTGATTGATCTTTATGGAAACCAAGGTCTGCCCCCACCAGGCCTCACCATCAGCAACTCC       c.840
 L  I  D  L  Y  G  N  Q  G  L  P  P  P  G  L  T  I  S  N  S         p.280

          .         .         .         . | 07       .         .    g.217415
 TGTCCAGCCAACCTTCCCAACATAAAAAGGGAGCTCACAG | AGTCTGAAGCAAGAGCACTG    c.900
 C  P  A  N  L  P  N  I  K  R  E  L  T  E |   S  E  A  R  A  L      p.300

          .         .         .        | 08.         .         .    g.222043
 GCCAAAGAGAGGCAGAAAAAGGACAATCACAACCTGA | TTGAACGAAGAAGAAGATTTAAC    c.960
 A  K  E  R  Q  K  K  D  N  H  N  L  I |   E  R  R  R  R  F  N      p.320

          .         .         .         .         .    | 09    .    g.224845
 ATAAATGACCGCATTAAAGAACTAGGTACTTTGATTCCCAAGTCAAATGATCC | AGACATG    c.1020
 I  N  D  R  I  K  E  L  G  T  L  I  P  K  S  N  D  P  |  D  M      p.340

          .         .         .         .         .         .       g.224905
 CGCTGGAACAAGGGAACCATCTTAAAAGCATCCGTGGACTATATCCGAAAGTTGCAACGA       c.1080
 R  W  N  K  G  T  I  L  K  A  S  V  D  Y  I  R  K  L  Q  R         p.360

          .         .         .         .         .         .       g.224965
 GAACAGCAACGCGCAAAAGAACTTGAAAACCGACAGAAGAAACTGGAGCACGCCAACCGG       c.1140
 E  Q  Q  R  A  K  E  L  E  N  R  Q  K  K  L  E  H  A  N  R         p.380

          .         .  | 10      .         .         .         .    g.230451
 CATTTGTTGCTCAGAATACAG | GAACTTGAAATGCAGGCTCGAGCTCATGGACTTTCCCTT    c.1200
 H  L  L  L  R  I  Q   | E  L  E  M  Q  A  R  A  H  G  L  S  L      p.400

          .         .         .         .         .         .       g.230511
 ATTCCATCCACGGGTCTCTGCTCTCCAGATTTGGTGAATCGGATCATCAAGCAAGAACCC       c.1260
 I  P  S  T  G  L  C  S  P  D  L  V  N  R  I  I  K  Q  E  P         p.420

          .         .         .         .         .         .       g.230571
 GTTCTTGAGAACTGCAGCCAAGACCTCCTTCAGCATCATGCAGACCTAACCTGTACAACA       c.1320
 V  L  E  N  C  S  Q  D  L  L  Q  H  H  A  D  L  T  C  T  T         p.440

          .         .         .         .         .         .       g.230631
 ACTCTCGATCTCACGGATGGCACCATCACCTTCAACAACAACCTCGGAACTGGGACTGAG       c.1380
 T  L  D  L  T  D  G  T  I  T  F  N  N  N  L  G  T  G  T  E         p.460

          .         .         .         .         .         .       g.230691
 GCCAACCAAGCCTATAGTGTCCCCACAAAAATGGGATCCAAACTGGAAGACATCCTGATG       c.1440
 A  N  Q  A  Y  S  V  P  T  K  M  G  S  K  L  E  D  I  L  M         p.480

          .         .         .         .         .         .       g.230751
 GACGACACCCTTTCTCCCGTCGGTGTCACTGATCCACTCCTTTCCTCAGTGTCCCCCGGA       c.1500
 D  D  T  L  S  P  V  G  V  T  D  P  L  L  S  S  V  S  P  G         p.500

          .         .         .         .         .         .       g.230811
 GCTTCCAAAACAAGCAGCCGGAGGAGCAGTATGAGCATGGAAGAGACGGAGCACACTTGT       c.1560
 A  S  K  T  S  S  R  R  S  S  M  S  M  E  E  T  E  H  T  C         p.520

                                                                    g.230814
 TAG                                                                c.1563
 X                                                                  p.520

          .         .         .         .         .         .       g.230874
 cgaatcctccctgcactgcattcgcacaaactgcttcctttcttgattcgtagatttaat       c.*60

          .         .         .         .         .         .       g.230934
 aacttacctgaaggggttttcttgataattttcctttaatatgaaattttttttcatgct       c.*120

          .         .         .         .         .         .       g.230994
 ttatcaatagcccaggatatattttatttttagaattttgtgaaacagacttgtatattc       c.*180

          .         .         .         .         .         .       g.231054
 tattttacaactacaaatgcctccaaagtattgtacaaataagtgtgcagtatctgtgaa       c.*240

          .         .         .         .         .         .       g.231114
 ctgaattcaccacagactttagctttctgagcaagaggattttgcgtcagagaaatgtct       c.*300

          .         .         .         .         .         .       g.231174
 gtccatttttattcaggggaaacttgatttgagatttttatgcctgtgacttccttggaa       c.*360

          .         .         .         .         .         .       g.231234
 atcaaatgtaaagtttaattgaaagaatgtaaagcaaccaaaaagaaaaaaaaaaagaaa       c.*420

          .         .         .         .         .         .       g.231294
 gaaagaggaaaagaaatccatactaacccttttccattttataaatgtattgattcattg       c.*480

          .         .         .         .         .         .       g.231354
 gtactgccttaaagatacagtacccctctagctttgtttagtctttatactgcaaactat       c.*540

          .         .         .         .         .         .       g.231414
 ttaaagaaatatgtattctgtaaaagaaaaaaaaaatgcggccttttcatgaggatcgtc       c.*600

          .         .         .         .         .         .       g.231474
 tggttagaaaacataactgataccaaccgaaactgaagggagttagaccaaggctctgaa       c.*660

          .         .         .         .         .         .       g.231534
 atataaagtctaatcttgctctcttttattctgtgctgttacagttttcttcatcaatga       c.*720

          .         .         .         .         .         .       g.231594
 gtgtgatccagtttttcataagatattttattttgaaatggaaattaatgtcctctcaaa       c.*780

          .         .         .         .         .         .       g.231654
 gtaaaatattgaggagcactgaaagtatgttttactttttttttattttatttttgcttt       c.*840

          .         .         .         .         .         .       g.231714
 tgataagaaaaccgaactgggcatatttctaattggctttactatttttatttttaaatt       c.*900

          .         .         .         .         .         .       g.231774
 atgttttactgttcatttgatttgtacagattctttattatcattgttcttttcaatata       c.*960

          .         .         .         .         .         .       g.231834
 tttgtattaatttgtaagaatatgcatcttaaaatggcaagttttccatatttttacaac       c.*1020

          .         .         .         .         .         .       g.231894
 tcactggtggttttccgcattctttgtacacccatgaaagaaaacttttatgcaaggtct       c.*1080

          .         .         .         .         .         .       g.231954
 tgcatttaaaagacagctttgcgaatattttgtaaattacagtctcactcagaactgttt       c.*1140

          .         .         .         .         .         .       g.232014
 ttggacacatttaaggtgtagtattaataggttaaaaccaggctttctagaaagaataaa       c.*1200

          .         .         .         .         .         .       g.232074
 cttacatatttatttttaggacatgaaaatagcaatattcttggagattgataaccatag       c.*1260

          .         .         .         .         .         .       g.232134
 cattaatacgcccattatggtcatttaaattggggtttatttcagcaaacttgttgaatt       c.*1320

          .         .         .         .         .         .       g.232194
 tatttttaagaaagaaatactgtattgggaagttactgttacttgataacaatgttttaa       c.*1380

          .         .         .         .         .         .       g.232254
 caagaagcaatgttataaagttagtttcagtgcattatctacttgtgtagtcctatgcaa       c.*1440

          .         .         .         .         .         .       g.232314
 taacagtagtgttacatgtatcaagcctagatgttttatacagatgccatatagtgttat       c.*1500

          .         .         .         .         .         .       g.232374
 gagccaggctgttgaatggaatttctcagtagcagcctacaactgaatagcaagtggcat       c.*1560

          .         .         .         .         .         .       g.232434
 aaagcatatccattcagaatgaagtgccttaaatatagcagtagtcttttttggactagc       c.*1620

          .         .         .         .         .         .       g.232494
 actgactgaactgtaatgtaggggaaagtttcatgatggtatctatagtcaagacgaaca       c.*1680

          .         .         .         .         .         .       g.232554
 tgtagcatggtgcctatgtagacaatataagagcttccaattttccttcagatattttta       c.*1740

          .         .         .         .         .         .       g.232614
 atattaaatatattttagtgacagagtgccaacttctttcatcaggaaaccttattcagg       c.*1800

          .         .         .         .         .         .       g.232674
 agggtttttaaaaagtgtttaaatgtcaaatgtgaattggtgatgggtgatggagggttc       c.*1860

          .         .         .         .         .         .       g.232734
 agagaggagtgatcgtcagatgtgtgaatggacggtttaggtgaaaataatcaactgcat       c.*1920

          .         .         .         .         .         .       g.232794
 agttcccatgcacgctgggcaatgagaatccttggaaacattggtgatgctatcagtttt       c.*1980

          .         .         .         .         .         .       g.232854
 atagctttatttcttaagggggtagggaaaattagttcccattctttcaacccccttaac       c.*2040

          .         .         .         .         .         .       g.232914
 tgtatagctcttttcctagaatagtgacgcaaatctgcatgaacagctaattgtaccata       c.*2100

          .         .         .         .         .         .       g.232974
 gtgttcattgatacaatcatagcattgtctatttttctcttcatatttatatggggggga       c.*2160

          .         .         .         .         .         .       g.233034
 gggcgctggatgcaaaagttgaagatcgtgatgctatgatgttagttttccttagctgat       c.*2220

          .         .         .         .         .         .       g.233094
 tttgagggtttttaaaaataaagcaaggttgactaacctacggccacgggaacaggacca       c.*2280

          .         .         .         .         .         .       g.233154
 tggttaagcaaccatatagaaagctttgttgaaagaaagtatggcatcttgtaccactgc       c.*2340

          .         .         .         .         .         .       g.233214
 cctgactgtcacaactcctaaccttgccattgcctgcctccccctccccttctccttaag       c.*2400

          .         .         .         .         .         .       g.233274
 agacaatttctgcaggtggcaggtgagcaagcccaggagaatgctgcaatcttgggggtg       c.*2460

          .         .         .         .         .         .       g.233334
 gttttatttatttcttttttgccaaatagagtgtggattcatttcaggggctagctaagc       c.*2520

          .         .         .         .         .         .       g.233394
 caagaggcagtggtttgggcttgttgtttgtaacaagaaaatgatccacaccactccccc       c.*2580

          .         .         .         .         .         .       g.233454
 gattcccgggtgcagaattgtaactcggggttgggcctctatatggagtgaccaaaatgc       c.*2640

          .         .         .         .         .         .       g.233514
 caaaattgtccatctgcctctgagtagggcaatggaaataccaaaccttctgactttgcc       c.*2700

          .         .         .         .         .         .       g.233574
 aaaaagcatacaagcaacctggtcatacataggatgacaaaattctttctggttgttttt       c.*2760

          .         .         .         .         .         .       g.233634
 aaacaataaagcaataagaacaaatacaatacataggaagttaaaagcacaaaggaatga       c.*2820

          .         .         .         .         .         .       g.233694
 acttattaatatttttgaaaaatgcactgggaaaaagttgatgtcaataacagtataaaa       c.*2880

          .         .         .         .         .         .       g.233754
 cagccctatttcttgataaaaaatgacaaatgactgtctcttgcggatgcttggtactgt       c.*2940

          .         .         .         .         .         .       g.233814
 aatgttaataatagtcacctgctgttggatgcagcaataatttctgtatggtccatagca       c.*3000

          .         .         .         .         .         .       g.233874
 ctgtatattatggatcgatattaatgtatccaatgaaataatcgacttgttcttgatagc       c.*3060

          .         .                                               g.233903
 ctcattaaagcatttggtttttcacatag                                      c.*3089

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Microphthalmia-associated transcription factor protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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