McKusick-Kaufman syndrome (MKKS) - coding DNA reference sequence

(used for variant description)

(last modified July 3, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_170784.2 in the MKKS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009109.1, covering MKKS transcript NM_170784.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5039
 agagctgcgcgtgctccgtgccctcgcgcgacgcgaaggttgtcgggatccgcggcagca       c.-721

 .         .         .         .         .         .                g.5099
 gcggctgcttgagatctgtttctggggcctctggcggtggcggcctggggcggcgcgacg       c.-661

 .         .  | 02      .         .         .         .             g.18508
 gctggtgcgcag | gtacactgatgctgaagtactatgagccttcggaacttgtggagagac    c.-601

 .         .         .         .         .         .                g.18568
 tacaaagttttggttgttatggtccctttagttgggctcatacatttggggtggtacaga       c.-541

 .         .         .         .         .         .                g.18628
 atcaaaagcagccctgttttccaaatacctaaaaacgacgacattcctgagcaagatagt       c.-481

 .         .         .         .         .         .                g.18688
 ctgggactttcaaatcttcagaagagccaaatccaggggaagtagcaggcttgcaatctt       c.-421

 .   | 03     .         .         .         .         .             g.25344
 cag | gtaaagaagcagctttgaatctgagcttcatatcgaaagaagagatgaaaaatacca    c.-361

 .         .         .         .         .         .                g.25404
 gttggattagaaagaactggcttcttgtagctgggatatctttcataggtgtccatcttg       c.-301

 .         .         .         .         .         .                g.25464
 gaacatactttttgcagaggtctgcaaagcagtctgtaaaatttcagtctcaaagcaaac       c.-241

 .         .         .         .         .         .                g.25524
 aaaagagtattgaagagtgaagtaaaataaatatttggaattactaatttgtcattaaat       c.-181

 .         .         .         .         .         .                g.25584
 cattctatgctgattagcttcataaacattgaactttttgattttatagccacaatgctg       c.-121

 .         .         .         .         .         .                g.25644
 catattcatactttaattcctaaagaataatttttaatgttaaaacgtgataatgcaata       c.-61

 .         .         .         .         .         .                g.25704
 aatagaaaaatgtggtttacaaaataaaaacggtcttcactagttaccacctgaagtaag       c.-1

          .         .         .         .         .         .       g.25764
 ATGTCTCGTTTGGAAGCTAAGAAGCCATCATTGTGTAAGAGTGAACCACTGACAACTGAG       c.60
 M  S  R  L  E  A  K  K  P  S  L  C  K  S  E  P  L  T  T  E         p.20

          .         .         .         .         .         .       g.25824
 AGAGTCAGGACCACACTTTCTGTCTTGAAAAGAATTGTAACATCATGCTATGGCCCCTCA       c.120
 R  V  R  T  T  L  S  V  L  K  R  I  V  T  S  C  Y  G  P  S         p.40

          .         .         .         .         .         .       g.25884
 GGTAGGCTGAAGCAGCTGCACAATGGCTTTGGAGGTTACGTGTGTACAACCTCACAGTCC       c.180
 G  R  L  K  Q  L  H  N  G  F  G  G  Y  V  C  T  T  S  Q  S         p.60

          .         .         .         .         .         .       g.25944
 TCAGCTCTGCTCAGTCACCTTTTGGTCACACATCCCATTTTAAAGATCCTGACAGCCTCC       c.240
 S  A  L  L  S  H  L  L  V  T  H  P  I  L  K  I  L  T  A  S         p.80

          .         .         .         .         .         .       g.26004
 ATACAGAATCATGTGTCAAGCTTCAGTGATTGTGGCTTATTCACAGCTATTCTTTGCTGC       c.300
 I  Q  N  H  V  S  S  F  S  D  C  G  L  F  T  A  I  L  C  C         p.100

          .         .         .         .         .         .       g.26064
 AACCTGATTGAAAATGTTCAGAGATTAGGCTTGACACCCACCACTGTCATTAGATTAAAT       c.360
 N  L  I  E  N  V  Q  R  L  G  L  T  P  T  T  V  I  R  L  N         p.120

          .         .         .         .         .         .       g.26124
 AAACATCTTTTGAGTCTTTGCATCAGTTATCTCAAGTCTGAGACCTGTGGTTGTCGAATC       c.420
 K  H  L  L  S  L  C  I  S  Y  L  K  S  E  T  C  G  C  R  I         p.140

          .         .         .         .         .         .       g.26184
 CCAGTGGACTTTAGTAGTACTCAGATCCTCCTTTGTTTGGTGCGTAGTATATTAACAAGT       c.480
 P  V  D  F  S  S  T  Q  I  L  L  C  L  V  R  S  I  L  T  S         p.160

          .         .         .         .         .         .       g.26244
 AAACCTGCCTGTATGCTCACCAGAAAGGAAACAGAGCATGTCAGTGCTTTGATCCTGAGA       c.540
 K  P  A  C  M  L  T  R  K  E  T  E  H  V  S  A  L  I  L  R         p.180

          .         .         .         .         .         .       g.26304
 GCCTTTTTGCTTACAATTCCAGAAAATGCTGAAGGCCACATCATTTTAGGAAAGAGTTTA       c.600
 A  F  L  L  T  I  P  E  N  A  E  G  H  I  I  L  G  K  S  L         p.200

          .         .         .         .         .         .       g.26364
 ATTGTACCTTTAAAAGGTCAAAGAGTTATAGATTCCACTGTATTACCTGGGATACTCATT       c.660
 I  V  P  L  K  G  Q  R  V  I  D  S  T  V  L  P  G  I  L  I         p.220

          .         .         .         .         .         .       g.26424
 GAAATGTCAGAAGTTCAATTAATGAGGCTATTACCTATCAAAAAATCAACTGCCCTCAAG       c.720
 E  M  S  E  V  Q  L  M  R  L  L  P  I  K  K  S  T  A  L  K         p.240

          .         .         .         .         .         .       g.26484
 GTGGCACTCTTTTGTACAACTTTATCCGGAGACACTTCTGACACTGGAGAAGGAACTGTG       c.780
 V  A  L  F  C  T  T  L  S  G  D  T  S  D  T  G  E  G  T  V         p.260

          .         .         .         .         .         .       g.26544
 GTGGTCAGTTATGGGGTTTCTCTTGAAAATGCAGTCTTGGACCAGCTGCTTAACCTAGGA       c.840
 V  V  S  Y  G  V  S  L  E  N  A  V  L  D  Q  L  L  N  L  G         p.280

          .         .         .         .         .         .       g.26604
 AGGCAGCTAATCAGTGACCACGTAGATCTTGTCCTGTGCCAAAAAGTTATACATCCATCT       c.900
 R  Q  L  I  S  D  H  V  D  L  V  L  C  Q  K  V  I  H  P  S         p.300

          .         .         .         .         .         .       g.26664
 TTGAAGCAGTTTCTCAATATGCATCGTATTATTGCCATAGACAGAATTGGAGTGACTCTG       c.960
 L  K  Q  F  L  N  M  H  R  I  I  A  I  D  R  I  G  V  T  L         p.320

          .         .      | 04  .         .         .         .    g.30450
 ATGGAACCCCTGACTAAAATGACAG | GAACACAGCCTATTGGATCCCTAGGCTCAATATGT    c.1020
 M  E  P  L  T  K  M  T  G |   T  Q  P  I  G  S  L  G  S  I  C      p.340

          .         .         .         .         .         .       g.30510
 CCTAATAGTTATGGAAGTGTGAAAGATGTGTGCACTGCAAAATTTGGCTCCAAACATTTT       c.1080
 P  N  S  Y  G  S  V  K  D  V  C  T  A  K  F  G  S  K  H  F         p.360

          .         .         .         .         .         .       g.30570
 TTTCATCTTATTCCTAATGAAGCAACAATCTGCAGCTTGCTTCTCTGCAACAGAAATGAC       c.1140
 F  H  L  I  P  N  E  A  T  I  C  S  L  L  L  C  N  R  N  D         p.380

          .         .  | 05      .         .         .         .    g.31531
 ACTGCCTGGGATGAGCTGAAG | CTCACGTGTCAGACGGCACTGCATGTCCTGCAGTTAACA    c.1200
 T  A  W  D  E  L  K   | L  T  C  Q  T  A  L  H  V  L  Q  L  T      p.400

          .         .         .         .         .         .       g.31591
 CTCAAGGAACCATGGGCTTTGTTGGGAGGTGGCTGTACTGAAACTCATTTGGCTGCATAT       c.1260
 L  K  E  P  W  A  L  L  G  G  G  C  T  E  T  H  L  A  A  Y         p.420

          .   | 06     .         .         .         .         .    g.33579
 ATCAGACACAAG | ACTCACAACGACCCAGAAAGCATTCTCAAAGATGATGAATGTACTCAA    c.1320
 I  R  H  K   | T  H  N  D  P  E  S  I  L  K  D  D  E  C  T  Q      p.440

          .         .         .         .         .         .       g.33639
 ACAGAACTTCAATTAATTGCTGAAGCATTTTGCAGTGCCCTAGAATCTGTTGTTGGCTCT       c.1380
 T  E  L  Q  L  I  A  E  A  F  C  S  A  L  E  S  V  V  G  S         p.460

          .         .         .         .         .         .       g.33699
 TTAGAACATGATGGAGGTGAAATTCTCACTGACATGAAGTATGGACACCTTTGGTCAGTT       c.1440
 L  E  H  D  G  G  E  I  L  T  D  M  K  Y  G  H  L  W  S  V         p.480

          .         .         .         .         .         .       g.33759
 CAGGCAGATTCTCCCTGTGTTGCTAACTGGCCAGATTTGCTTTCACAGTGTGGCTGTGGA       c.1500
 Q  A  D  S  P  C  V  A  N  W  P  D  L  L  S  Q  C  G  C  G         p.500

          .         .         .         .         .         .       g.33819
 TTATACAATAGCCAGGAAGAACTCAACTGGTCTTTCTTAAGAAGCACACGTCGTCCATTT       c.1560
 L  Y  N  S  Q  E  E  L  N  W  S  F  L  R  S  T  R  R  P  F         p.520

          .         .         .         .         .         .       g.33879
 GTGCCACAAAGCTGCCTTCCACATGAAGCTGTGGGCTCAGCCAGCAACCTGACCTTGGAC       c.1620
 V  P  Q  S  C  L  P  H  E  A  V  G  S  A  S  N  L  T  L  D         p.540

          .         .         .         .         .         .       g.33939
 TGTTTGACTGCAAAGCTTAGTGGCCTACAGGTGGCTGTAGAGACAGCCAATTTGATTTTG       c.1680
 C  L  T  A  K  L  S  G  L  Q  V  A  V  E  T  A  N  L  I  L         p.560

          .         .         .                                     g.33972
 GATCTTTCATATGTTATTGAAGATAAAAACTAA                                  c.1713
 D  L  S  Y  V  I  E  D  K  N  X                                    p.570

          .         .         .         .         .         .       g.34032
 gagaatagcatgttcgtattacaagagaaacaaataaactagtctgttggcaattgagaa       c.*60

          .         .         .         .         .         .       g.34092
 aaattgtgagtgtatttgttttctcccaaagccctgttctacatatttggacaaatgact       c.*120

          .         .         .         .         .         .       g.34152
 cataaaattatagatacacttatttaggaaaaaaggtgattcgtgaatggaaatgccatg       c.*180

          .         .         .         .         .         .       g.34212
 aaacaataaaaatatgaagcattatttatttaaaaatattatagttatcttagggattct       c.*240

          .         .         .         .         .         .       g.34272
 atactggctgctgtacattgttctaaatttttgttatgttggcatcattttgagagcaaa       c.*300

          .         .         .         .         .         .       g.34332
 caaataaaaaagactcctaatccatgctctagtttggatatacatattttagatattttc       c.*360

          .         .         .         .         .         .       g.34392
 cagttagcagtaattacatatgcttaaagtataaaactagatctcaaagtgtcacaaaac       c.*420

          .         .         .         .                           g.34439
 attcagtatatattgctcaatcaaaagaagtattcaaactgcacatt                    c.*467

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The McKusick-Kaufman syndrome protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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