makorin ring finger protein 3 (MKRN3) - coding DNA reference sequence

(used for variant description)

(last modified October 11, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_005664.3 in the MKRN3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012875.1, covering MKRN3 transcript NM_005664.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5056
     tgtttcagaatctataggattatattttttttaaggcagacagatacgaaaataca       c.-421

 .         .         .         .         .         .                g.5116
 acgaagcgtgcatgaccgaaaccagaagagattaaagtaaaacctcattctcctgaggaa       c.-361

 .         .         .         .         .         .                g.5176
 atcgtgtgagaagggacttagggactgccggaacacagcgaagcagaggcagaaggcaga       c.-301

 .         .         .         .         .         .                g.5236
 caaaaggggctgggttggtccccgcctgtgtgaacgaaaaaatatgtcagattggaaaat       c.-241

 .         .         .         .         .         .                g.5296
 tgcggtaaaaaccaggcagagcacgtacgttgcccccacaggaagtgtccgccatgctgc       c.-181

 .         .         .         .         .         .                g.5356
 ctgtgcccggaagtaggtaggaacacacagtcagagggacccaaaagcaggggggaagga       c.-121

 .         .         .         .         .         .                g.5416
 aaaagagatgcacacttcccccagagaagcctccgagcgcggccgccattccgggcctca       c.-61

 .         .         .         .         .         .                g.5476
 agcccataaagaaaaaataccggagaggttctggcaccatttcggggtgccaaagcagcc       c.-1

          .         .         .         .         .         .       g.5536
 ATGGAAGAGCCTGCAGCTCCCTCAGAAGCCCACGAGGCAGCCGGGGCCCAGGCAGGTGCT       c.60
 M  E  E  P  A  A  P  S  E  A  H  E  A  A  G  A  Q  A  G  A         p.20

          .         .         .         .         .         .       g.5596
 GAGGCAGCAAGGGAGGGTGTGTCTGGGCCGGACCTTCCCGTCTGTGAGCCCTCCGGGGAA       c.120
 E  A  A  R  E  G  V  S  G  P  D  L  P  V  C  E  P  S  G  E         p.40

          .         .         .         .         .         .       g.5656
 TCTGCTGCTCCAGATTCAGCCCTGCCACATGCGGCAAGGGGCTGGGCCCCCTTCCCTGTA       c.180
 S  A  A  P  D  S  A  L  P  H  A  A  R  G  W  A  P  F  P  V         p.60

          .         .         .         .         .         .       g.5716
 GCTCCAGTCCCTGCCCACCTCCGCAGAGGAGGCCTGAGGCCTGCCCCAGCCTCAGGAGGA       c.240
 A  P  V  P  A  H  L  R  R  G  G  L  R  P  A  P  A  S  G  G         p.80

          .         .         .         .         .         .       g.5776
 GGAGCCTGGCCCAGTCCGTTGCCAAGCCGAAGCAGCGGCATTTGGACAAAGCAGATCATC       c.300
 G  A  W  P  S  P  L  P  S  R  S  S  G  I  W  T  K  Q  I  I         p.100

          .         .         .         .         .         .       g.5836
 TGCAGGTATTATATACATGGGCAGTGCAAGGAGGGGGAGAACTGTCGCTATTCGCACGAC       c.360
 C  R  Y  Y  I  H  G  Q  C  K  E  G  E  N  C  R  Y  S  H  D         p.120

          .         .         .         .         .         .       g.5896
 CTTTCTGGTCGGAAGATGGCCACTGAGGGTGGCGTTTCGCCGCCTGGGGCCTCTGCAGGT       c.420
 L  S  G  R  K  M  A  T  E  G  G  V  S  P  P  G  A  S  A  G         p.140

          .         .         .         .         .         .       g.5956
 GGAGGCCCTAGCACGGCTGCGCACATCGAGCCCCCGACTCAGGAAGTGGCGGAAGCCCCC       c.480
 G  G  P  S  T  A  A  H  I  E  P  P  T  Q  E  V  A  E  A  P         p.160

          .         .         .         .         .         .       g.6016
 CCGGCTGCATCCTCCCTTTCCTTGCCTGTGATTGGCTCGGCTGCTGAAAGGGGTTTCTTT       c.540
 P  A  A  S  S  L  S  L  P  V  I  G  S  A  A  E  R  G  F  F         p.180

          .         .         .         .         .         .       g.6076
 GAAGCCGAGAGAGACAATGCAGACCGTGGAGCTGCTGGAGGAGCAGGTGTAGAAAGCTGG       c.600
 E  A  E  R  D  N  A  D  R  G  A  A  G  G  A  G  V  E  S  W         p.200

          .         .         .         .         .         .       g.6136
 GCGGATGCCATTGAGTTTGTTCCAGGGCAGCCCTACCGGGGCCGCTGGGTTGCATCTGCC       c.660
 A  D  A  I  E  F  V  P  G  Q  P  Y  R  G  R  W  V  A  S  A         p.220

          .         .         .         .         .         .       g.6196
 CCCGAGGCTCCTCTACAGAGCTCAGAGACTGAGAGGAAGCAGATGGCTGTGGGCAGTGGG       c.720
 P  E  A  P  L  Q  S  S  E  T  E  R  K  Q  M  A  V  G  S  G         p.240

          .         .         .         .         .         .       g.6256
 TTGCGGTTTTGCTATTATGCTTCCAGGGGAGTTTGCTTTCGTGGGGAGAGCTGTATGTAC       c.780
 L  R  F  C  Y  Y  A  S  R  G  V  C  F  R  G  E  S  C  M  Y         p.260

          .         .         .         .         .         .       g.6316
 CTCCATGGAGACATATGCGACATGTGTGGGCTGCAGACCTTGCACCCCATGGATGCTGCC       c.840
 L  H  G  D  I  C  D  M  C  G  L  Q  T  L  H  P  M  D  A  A         p.280

          .         .         .         .         .         .       g.6376
 CAGAGGGAAGAACATATGAGGGCCTGCATTGAAGCACACGAGAAAGATATGGAACTCTCG       c.900
 Q  R  E  E  H  M  R  A  C  I  E  A  H  E  K  D  M  E  L  S         p.300

          .         .         .         .         .         .       g.6436
 TTTGCTGTGCAGCGTGGTATGGACAAGGTGTGTGGCATCTGCATGGAGGTTGTCTATGAG       c.960
 F  A  V  Q  R  G  M  D  K  V  C  G  I  C  M  E  V  V  Y  E         p.320

          .         .         .         .         .         .       g.6496
 AAGGCCAACCCCAATGACCGCCGCTTTGGCATTCTTTCCAATTGCAACCATTCCTTCTGT       c.1020
 K  A  N  P  N  D  R  R  F  G  I  L  S  N  C  N  H  S  F  C         p.340

          .         .         .         .         .         .       g.6556
 ATTAGGTGTATCCGCAGGTGGAGAAGTGCCAGACAGTTTGAGAACAGGATCGTCAAGTCT       c.1080
 I  R  C  I  R  R  W  R  S  A  R  Q  F  E  N  R  I  V  K  S         p.360

          .         .         .         .         .         .       g.6616
 TGCCCACAGTGCAGGGTCACCTCTGAATTGGTCATTCCCAGTGAGTTCTGGGTGGAGGAG       c.1140
 C  P  Q  C  R  V  T  S  E  L  V  I  P  S  E  F  W  V  E  E         p.380

          .         .         .         .         .         .       g.6676
 GAGGAAGAGAAGCAGAAACTTATTCAGCAATACAAGGAGGCAATGAGCAACAAGGCCTGC       c.1200
 E  E  E  K  Q  K  L  I  Q  Q  Y  K  E  A  M  S  N  K  A  C         p.400

          .         .         .         .         .         .       g.6736
 AGGTATTTTGCGGAAGGCAGGGGTAACTGCCCATTTGGAGACACATGCTTTTACAAGCAT       c.1260
 R  Y  F  A  E  G  R  G  N  C  P  F  G  D  T  C  F  Y  K  H         p.420

          .         .         .         .         .         .       g.6796
 GAATACCCTGAGGGCTGGGGAGATGAGCCTCCTGGGCCAGGTGGTGGGTCATTCAGCGCA       c.1320
 E  Y  P  E  G  W  G  D  E  P  P  G  P  G  G  G  S  F  S  A         p.440

          .         .         .         .         .         .       g.6856
 TACTGGCATCAACTTGTGGAGCCTGTGCGAATGGGAGAGGGCAACATGCTCTATAAAAGC       c.1380
 Y  W  H  Q  L  V  E  P  V  R  M  G  E  G  N  M  L  Y  K  S         p.460

          .         .         .         .         .         .       g.6916
 ATTAAGAAGGAGCTTGTCGTGCTTCGGCTGGCCAGTCTGTTGTTTAAGCGGTTTCTTTCA       c.1440
 I  K  K  E  L  V  V  L  R  L  A  S  L  L  F  K  R  F  L  S         p.480

          .         .         .         .         .         .       g.6976
 CTGAGAGATGAGTTACCCTTCTCTGAGGACCAGTGGGACTTGCTTCATTATGAGCTGGAA       c.1500
 L  R  D  E  L  P  F  S  E  D  Q  W  D  L  L  H  Y  E  L  E         p.500

          .         .                                               g.7000
 GAATATTTCAATTTGATTCTGTAG                                           c.1524
 E  Y  F  N  L  I  L  X                                             p.507

          .         .         .         .         .         .       g.7060
 catcgtgctgtggcatgtggtctagtctgctgaggttctgtcgtctgctattgcctgttt       c.*60

          .         .         .         .         .         .       g.7120
 tccctgtgttgacactcttactgctttcaggggctgttgaggcagtgcttctgttttctt       c.*120

          .         .         .         .         .         .       g.7180
 gtctattctgcatatctttccccctaggattatggtgattatctgtgttaaaaaataagt       c.*180

          .         .         .         .         .         .       g.7240
 ccttaaagttactgttttggtgaaattaatattaatgtcagcttatggcttttttttgtc       c.*240

          .         .         .         .         .         .       g.7300
 atctctgttgtcaacaggattaactcagttctagtgtagtgtttactgaatttccacact       c.*300

          .         .         .         .         .         .       g.7360
 tattttgaagaccctcaagagtaaatgtggcagagtgaaaggagaagttttaattgaact       c.*360

          .         .         .         .         .         .       g.7420
 agtagctttgtgctataatagccttaacaaatggacccttgcagggctttgcagctgctc       c.*420

          .         .         .         .         .         .       g.7480
 atctgtttgtttacagtttgttctttccctccttccccttcaagtgcacttgttaaactg       c.*480

          .         .         .         .         .         .       g.7540
 tgatgaacttgtgattttgtgttttacttgaccaaaaccaagtgtatatgtttacatgtt       c.*540

          .         .         .         .         .         .       g.7600
 tttatcctgtttagcttgacatgaaataatttatatttggaaatatatatttaagaatta       c.*600

          .         .         .         .         .         .       g.7660
 tatatataaaaatatatatgtataagagttatgtatttgaaaaaaatatataaaagaata       c.*660

          .         .         .         .         .                 g.7714
 tacatcacaatataatatttatgtttatgtaataaagtaaatacagagctgaaa             c.*714

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Makorin ring finger protein 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 17
©2004-2016 Leiden University Medical Center