malonyl-CoA decarboxylase (MLYCD) - coding DNA reference sequence

(used for variant description)

(last modified April 23, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_012213.2 in the MLYCD gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering MLYCD transcript NM_012213.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         ggcagctgttgtggggcacc       c.-1

          .         .         .         .         .         .       g.5080
 ATGCGAGGCTTCGGGCCAGGCTTGACGGCCAGGCGTCTCCTCCCGCTGCGGTTGCCCCCG       c.60
 M  R  G  F  G  P  G  L  T  A  R  R  L  L  P  L  R  L  P  P         p.20

          .         .         .         .         .         .       g.5140
 CGGCCGCCCGGGCCCCGGCTGGCGAGCGGGCAGGCGGCCGGCGCCCTGGAGCGGGCCATG       c.120
 R  P  P  G  P  R  L  A  S  G  Q  A  A  G  A  L  E  R  A  M         p.40

          .         .         .         .         .         .       g.5200
 GACGAGCTGCTGCGCCGCGCGGTGCCGCCGACGCCGGCCTACGAGCTGCGCGAGAAGACA       c.180
 D  E  L  L  R  R  A  V  P  P  T  P  A  Y  E  L  R  E  K  T         p.60

          .         .         .         .         .         .       g.5260
 CCGGCGCCCGCCGAGGGTCAGTGCGCGGACTTCGTGAGCTTCTACGGTGGGCTGGCCGAG       c.240
 P  A  P  A  E  G  Q  C  A  D  F  V  S  F  Y  G  G  L  A  E         p.80

          .         .         .         .         .         .       g.5320
 ACGGCCCAGCGGGCCGAACTGCTGGGCCGCCTGGCGCGGGGCTTCGGCGTGGACCACGGC       c.300
 T  A  Q  R  A  E  L  L  G  R  L  A  R  G  F  G  V  D  H  G         p.100

          .         .         .         .         .         .       g.5380
 CAGGTGGCGGAGCAGAGCGCCGGCGTGCTCCATCTGCGCCAGCAGCAGCGGGAGGCGGCG       c.360
 Q  V  A  E  Q  S  A  G  V  L  H  L  R  Q  Q  Q  R  E  A  A         p.120

          .         .         .         .         .         .       g.5440
 GTGCTGCTGCAGGCCGAGGACCGGCTGCGCTACGCGCTGGTGCCGCGCTATCGCGGCCTC       c.420
 V  L  L  Q  A  E  D  R  L  R  Y  A  L  V  P  R  Y  R  G  L         p.140

          .         .         .         .         .         .       g.5500
 TTCCACCACATCAGCAAGCTGGACGGCGGCGTGCGCTTCCTGGTGCAGCTGCGGGCCGAC       c.480
 F  H  H  I  S  K  L  D  G  G  V  R  F  L  V  Q  L  R  A  D         p.160

          .         .         .         .         | 02         .    g.12874
 CTGCTGGAGGCGCAGGCCCTCAAGCTGGTGGAGGGGCCGGACGTCCGG | GAAATGAATGGG    c.540
 L  L  E  A  Q  A  L  K  L  V  E  G  P  D  V  R   | E  M  N  G      p.180

          .         .         .         .         .         .       g.12934
 GTGCTGAAAGGAATGCTCTCAGAATGGTTTTCCTCCGGGTTCCTGAACCTAGAACGGGTT       c.600
 V  L  K  G  M  L  S  E  W  F  S  S  G  F  L  N  L  E  R  V         p.200

          .         .         .         .  | 03      .         .    g.14020
 ACCTGGCATTCACCGTGTGAAGTGCTTCAGAAAATCAGTGA | GGCTGAGGCTGTGCATCCT    c.660
 T  W  H  S  P  C  E  V  L  Q  K  I  S  E  |  A  E  A  V  H  P      p.220

          .         .         .         .         .         .       g.14080
 GTAAAAAACTGGATGGACATGAAGCGCCGCGTTGGGCCCTACAGAAGGTGTTACTTCTTT       c.720
 V  K  N  W  M  D  M  K  R  R  V  G  P  Y  R  R  C  Y  F  F         p.240

          .         .         .         .         .         .       g.14140
 TCTCACTGTTCGACCCCTGGGGAGCCCCTGGTCGTTTTGCACGTGGCACTGACTGGTGAC       c.780
 S  H  C  S  T  P  G  E  P  L  V  V  L  H  V  A  L  T  G  D         p.260

          .         | 04         .         .         .         .    g.18135
 ATCTCCAGCAACATCCAG | GCAATCGTGAAGGAACATCCTCCATCAGAAACAGAAGAGAAG    c.840
 I  S  S  N  I  Q   | A  I  V  K  E  H  P  P  S  E  T  E  E  K      p.280

          .         .         .         .         .         .       g.18195
 AACAAAATCACTGCTGCGATCTTTTATTCCATCAGCTTGACCCAGCAGGGACTCCAAGGG       c.900
 N  K  I  T  A  A  I  F  Y  S  I  S  L  T  Q  Q  G  L  Q  G         p.300

          .         .         .         .         | 05         .    g.20843
 GTGGAGCTGGGAACATTCCTCATAAAGCGAGTCGTCAAGGAGTTGCAG | AGAGAGTTTCCT    c.960
 V  E  L  G  T  F  L  I  K  R  V  V  K  E  L  Q   | R  E  F  P      p.320

          .         .         .         .         .         .       g.20903
 CACCTTGGGGTGTTTTCAAGTCTGTCACCTATACCTGGTTTCACCAAATGGCTTCTGGGG       c.1020
 H  L  G  V  F  S  S  L  S  P  I  P  G  F  T  K  W  L  L  G         p.340

          .         .         .         .         .         .       g.20963
 CTTCTGAACTCGCAAACGAAGGAGCATGGGAGGAATGAACTCTTTACAGATTCGGAATGT       c.1080
 L  L  N  S  Q  T  K  E  H  G  R  N  E  L  F  T  D  S  E  C         p.360

          .         .         .         .         .         .       g.21023
 AAGGAAATCTCGGAGATCACAGGTGGCCCCATTAACGAGACCCTCAAGCTCCTCCTCAGC       c.1140
 K  E  I  S  E  I  T  G  G  P  I  N  E  T  L  K  L  L  L  S         p.380

          .         .         .         .         .         .       g.21083
 AGCAGCGAGTGGGTGCAGTCGGAGAAGCTGGTGCGGGCGCTGCAGACTCCGCTGATGAGG       c.1200
 S  S  E  W  V  Q  S  E  K  L  V  R  A  L  Q  T  P  L  M  R         p.400

          .         .         .         .         .         .       g.21143
 CTGTGCGCCTGGTACCTGTATGGAGAGAAGCACCGCGGCTACGCGCTGAACCCCGTGGCC       c.1260
 L  C  A  W  Y  L  Y  G  E  K  H  R  G  Y  A  L  N  P  V  A         p.420

          .         .         .         .         .         .       g.21203
 AACTTCCACCTGCAGAACGGGGCGGTGCTGTGGCGCATCAACTGGATGGCGGATGTGAGC       c.1320
 N  F  H  L  Q  N  G  A  V  L  W  R  I  N  W  M  A  D  V  S         p.440

          .         .         .         .         .         .       g.21263
 CTCAGAGGCATCACCGGCTCCTGCGGCCTGATGGCCAACTACCGCTACTTCCTGGAGGAG       c.1380
 L  R  G  I  T  G  S  C  G  L  M  A  N  Y  R  Y  F  L  E  E         p.460

          .         .         .         .         .         .       g.21323
 ACGGGCCCCAACAGCACCTCCTACCTCGGCTCCAAGATCATCAAAGCCTCTGAGCAGGTC       c.1440
 T  G  P  N  S  T  S  Y  L  G  S  K  I  I  K  A  S  E  Q  V         p.480

          .         .         .         .                           g.21365
 CTCAGCCTAGTGGCCCAGTTTCAAAAGAACAGCAAGCTCTGA                         c.1482
 L  S  L  V  A  Q  F  Q  K  N  S  K  L  X                           p.493

          .         .         .         .         .         .       g.21425
 cagtaaacctctcctaaagcacagggccccggctaagaaaacgatcattttcaggagggg       c.*60

          .         .         .         .         .         .       g.21485
 ccgggagttatgtatctgaagcagctttccaagcaaagccaaagttgactgtgttcttgt       c.*120

          .         .         .         .         .         .       g.21545
 cccgcagccggtccacactgtgaggccaggcctcaacttccctcaccctgggcgtgacat       c.*180

          .         .         .         .         .         .       g.21605
 gcacccagtgcaagacggttgtgggtgcgggtgcacacaaatgagtgggttgctgtgctg       c.*240

          .         .         .         .         .         .       g.21665
 tctccggaagattctgtcgttgcccttggcctggctccctgcccggggctggtgctgtgg       c.*300

          .         .         .         .         .         .       g.21725
 tacctacatcttcaggaagctgtgcagcctctgccattgccatcccagggggatctggca       c.*360

          .         .         .         .         .         .       g.21785
 tcctcctaaggaccggggcgcgtggcccagataagaataggtgttcctttgtgctcataa       c.*420

          .         .         .         .         .         .       g.21845
 aacagaatgcggcgatggttgctttagccgtttctcaccatgcaatgcagagggacaaag       c.*480

          .         .         .         .         .         .       g.21905
 ggctgtgctacacttcccagttacattctgaagctcataaatgtatgagaaggtttgtga       c.*540

          .         .         .         .         .         .       g.21965
 ttttgcacaaggtgtgtgtagtaagttaaattgttgaacacaaaaatgttgctgcttgag       c.*600

          .         .         .         .         .         .       g.22025
 gcataagttggataataggctttaaatgatcagggattcaggttcataatgaacttcaca       c.*660

          .         .         .                                     g.22058
 gtaaagaacacgtttgttctgtaaagcattgaa                                  c.*693

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Malonyl-CoA decarboxylase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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