membrane metallo-endopeptidase (MME) - coding DNA reference sequence

(used for variant description)

(last modified September 29, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_000902.3 in the MME gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering MME transcript NM_000902.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 gagagcgccgagacgcgcggggcgcggagatgtgcaagtggcgaagcttgaccgagagca       c.-61

 .         .         .         .         .          | 02            g.9521
 ggctggagcagccgcccaactcctggcgcgggatctgctgaggggtcacg | attttaggtg    c.-1

          .         .         .         .         .         .       g.9581
 ATGGGCAAGTCAGAAAGTCAGATGGATATAACTGATATCAACACTCCAAAGCCAAAGAAG       c.60
 M  G  K  S  E  S  Q  M  D  I  T  D  I  N  T  P  K  P  K  K         p.20

          .         .         .         .         .         .       g.9641
 AAACAGCGATGGACTCCACTGGAGATCAGCCTCTCGGTCCTTGTCCTGCTCCTCACCATC       c.120
 K  Q  R  W  T  P  L  E  I  S  L  S  V  L  V  L  L  L  T  I         p.40

          .         .         .         . | 03       .         .    g.10432
 ATAGCTGTGACAATGATCGCACTCTATGCAACCTACGATG | ATGGTATTTGCAAGTCATCA    c.180
 I  A  V  T  M  I  A  L  Y  A  T  Y  D  D |   G  I  C  K  S  S      p.60

          .       | 04 .         .         .         .         .    g.40391
 GACTGCATAAAATCAG | CTGCTCGACTGATCCAAAACATGGATGCCACCACTGAGCCTTGT    c.240
 D  C  I  K  S  A |   A  R  L  I  Q  N  M  D  A  T  T  E  P  C      p.80

          .         .         .         .         .         .       g.40451
 ACAGACTTTTTCAAATATGCTTGCGGAGGCTGGTTGAAACGTAATGTCATTCCCGAGACC       c.300
 T  D  F  F  K  Y  A  C  G  G  W  L  K  R  N  V  I  P  E  T         p.100

          .         .         .         .         .         | 05    g.41834
 AGCTCCCGTTACGGCAACTTTGACATTTTAAGAGATGAACTAGAAGTCGTTTTGAAAG | AT    c.360
 S  S  R  Y  G  N  F  D  I  L  R  D  E  L  E  V  V  L  K  D |       p.120

          .         .         .         .         .         .       g.41894
 GTCCTTCAAGAACCCAAAACTGAAGATATAGTAGCAGTGCAGAAAGCAAAAGCATTGTAC       c.420
 V  L  Q  E  P  K  T  E  D  I  V  A  V  Q  K  A  K  A  L  Y         p.140

          .          | 06        .         .         .         .    g.42058
 AGGTCTTGTATAAATGAAT | CTGCTATTGATAGCAGAGGTGGAGAACCTCTACTCAAACTG    c.480
 R  S  C  I  N  E  S |   A  I  D  S  R  G  G  E  P  L  L  K  L      p.160

          .         .         .         .         .      | 07  .    g.42226
 TTACCAGACATATATGGGTGGCCAGTAGCAACAGAAAACTGGGAGCAAAAATATG | GTGCT    c.540
 L  P  D  I  Y  G  W  P  V  A  T  E  N  W  E  Q  K  Y  G |   A      p.180

          .         .         .         .         .         .       g.42286
 TCTTGGACAGCTGAAAAAGCTATTGCACAACTGAATTCTAAATATGGGAAAAAAGTCCTT       c.600
 S  W  T  A  E  K  A  I  A  Q  L  N  S  K  Y  G  K  K  V  L         p.200

          .         .         .         .         .     | 08   .    g.44105
 ATTAATTTGTTTGTTGGCACTGATGATAAGAATTCTGTGAATCATGTAATTCAT | ATTGAC    c.660
 I  N  L  F  V  G  T  D  D  K  N  S  V  N  H  V  I  H   | I  D      p.220

          .         .         .         .         .         .       g.44165
 CAACCTCGACTTGGCCTCCCTTCTAGAGATTACTATGAATGCACTGGAATCTATAAAGAG       c.720
 Q  P  R  L  G  L  P  S  R  D  Y  Y  E  C  T  G  I  Y  K  E         p.240

  | 09       .         .         .         .         .         .    g.63515
  | GCTTGTACAGCATATGTGGATTTTATGATTTCTGTGGCCAGATTGATTCGTCAGGAAGAA    c.780
  | A  C  T  A  Y  V  D  F  M  I  S  V  A  R  L  I  R  Q  E  E      p.260

          .         .         .         .         .         .       g.63575
 AGATTGCCCATCGATGAAAACCAGCTTGCTTTGGAAATGAATAAAGTTATGGAATTGGAA       c.840
 R  L  P  I  D  E  N  Q  L  A  L  E  M  N  K  V  M  E  L  E         p.280

          .      | 10  .         .         .         .         .    g.65589
 AAAGAAATTGCCAAT | GCTACGGCTAAACCTGAAGATCGAAATGATCCAATGCTTCTGTAT    c.900
 K  E  I  A  N   | A  T  A  K  P  E  D  R  N  D  P  M  L  L  Y      p.300

          .         .         .         .         .        | 11.    g.67347
 AACAAGATGACATTGGCCCAGATCCAAAATAACTTTTCACTAGAGATCAATGGGAAG | CCA    c.960
 N  K  M  T  L  A  Q  I  Q  N  N  F  S  L  E  I  N  G  K   | P      p.320

          .         .         .         .         .         .       g.67407
 TTCAGCTGGTTGAATTTCACAAATGAAATCATGTCAACTGTGAATATTAGTATTACAAAT       c.1020
 F  S  W  L  N  F  T  N  E  I  M  S  T  V  N  I  S  I  T  N         p.340

          .         .         .         .         .         .       g.67467
 GAGGAAGATGTGGTTGTTTATGCTCCAGAATATTTAACCAAACTTAAGCCCATTCTTACC       c.1080
 E  E  D  V  V  V  Y  A  P  E  Y  L  T  K  L  K  P  I  L  T         p.360

          .     | 12   .         .         .         .         .    g.67636
 AAATATTCTGCCAG | AGATCTTCAAAATTTAATGTCCTGGAGATTCATAATGGATCTTGTA    c.1140
 K  Y  S  A  R  |  D  L  Q  N  L  M  S  W  R  F  I  M  D  L  V      p.380

          .         .         .         .         | 13         .    g.68808
 AGCAGCCTCAGCCGAACCTACAAGGAGTCCAGAAATGCTTTCCGCAAG | GCCCTTTATGGT    c.1200
 S  S  L  S  R  T  Y  K  E  S  R  N  A  F  R  K   | A  L  Y  G      p.400

          .         .         .         .         .         .       g.68868
 ACAACCTCAGAAACAGCAACTTGGAGACGTTGTGCAAACTATGTCAATGGGAATATGGAA       c.1260
 T  T  S  E  T  A  T  W  R  R  C  A  N  Y  V  N  G  N  M  E         p.420

          .         .         .         .         .        | 14.    g.69715
 AATGCTGTGGGGAGGCTTTATGTGGAAGCAGCATTTGCTGGAGAGAGTAAACATGTG | GTC    c.1320
 N  A  V  G  R  L  Y  V  E  A  A  F  A  G  E  S  K  H  V   | V      p.440

          .         .         .         .         .         .       g.69775
 GAGGATTTGATTGCACAGATCCGAGAAGTTTTTATTCAGACTTTAGATGACCTCACTTGG       c.1380
 E  D  L  I  A  Q  I  R  E  V  F  I  Q  T  L  D  D  L  T  W         p.460

          .         .         .       | 15 .         .         .    g.72521
 ATGGATGCCGAGACAAAAAAGAGAGCTGAAGAAAAG | GCCTTAGCAATTAAAGAAAGGATC    c.1440
 M  D  A  E  T  K  K  R  A  E  E  K   | A  L  A  I  K  E  R  I      p.480

          .         .         .         .         .        | 16.    g.73906
 GGCTATCCTGATGACATTGTTTCAAATGATAACAAACTGAATAATGAGTACCTCGAG | TTG    c.1500
 G  Y  P  D  D  I  V  S  N  D  N  K  L  N  N  E  Y  L  E   | L      p.500

          .         .         .         .         .         .       g.73966
 AACTACAAAGAAGATGAATACTTCGAGAACATAATTCAAAATTTGAAATTCAGCCAAAGT       c.1560
 N  Y  K  E  D  E  Y  F  E  N  I  I  Q  N  L  K  F  S  Q  S         p.520

          .         .         .         .  | 17      .         .    g.85762
 AAACAACTGAAGAAGCTCCGAGAAAAGGTGGACAAAGATGA | GTGGATAAGTGGAGCAGCT    c.1620
 K  Q  L  K  K  L  R  E  K  V  D  K  D  E  |  W  I  S  G  A  A      p.540

          .         .         .         . | 18       .         .    g.92275
 GTAGTCAATGCATTTTACTCTTCAGGAAGAAATCAGATAG | TCTTCCCAGCCGGCATTCTG    c.1680
 V  V  N  A  F  Y  S  S  G  R  N  Q  I  V |   F  P  A  G  I  L      p.560

          .         .         .         .         .         .       g.92335
 CAGCCCCCCTTCTTTAGTGCCCAGCAGTCCAACTCATTGAACTATGGGGGCATCGGCATG       c.1740
 Q  P  P  F  F  S  A  Q  Q  S  N  S  L  N  Y  G  G  I  G  M         p.580

          .         .         .         . | 19       .         .    g.93865
 GTCATAGGACACGAAATCACCCATGGCTTCGATGACAATG | GCAGAAACTTTAACAAAGAT    c.1800
 V  I  G  H  E  I  T  H  G  F  D  D  N  G |   R  N  F  N  K  D      p.600

          .         .         .         .         .         .       g.93925
 GGAGACCTCGTTGACTGGTGGACTCAACAGTCTGCAAGTAACTTTAAGGAGCAATCCCAG       c.1860
 G  D  L  V  D  W  W  T  Q  Q  S  A  S  N  F  K  E  Q  S  Q         p.620

          .         .         .         .         .     | 20   .    g.94091
 TGCATGGTGTATCAGTATGGAAACTTTTCCTGGGACCTGGCAGGTGGACAGCAC | CTTAAT    c.1920
 C  M  V  Y  Q  Y  G  N  F  S  W  D  L  A  G  G  Q  H   | L  N      p.640

          .         .         .         .         .         .       g.94151
 GGAATTAATACACTGGGAGAAAACATTGCTGATAATGGAGGTCTTGGTCAAGCATACAGA       c.1980
 G  I  N  T  L  G  E  N  I  A  D  N  G  G  L  G  Q  A  Y  R         p.660

  | 21       .         .         .         .         .         .    g.97530
  | GCCTATCAGAATTATATTAAAAAGAATGGCGAAGAAAAATTACTTCCTGGACTTGACCTA    c.2040
  | A  Y  Q  N  Y  I  K  K  N  G  E  E  K  L  L  P  G  L  D  L      p.680

          .         .         .       | 22 .         .         .    g.97913
 AATCACAAACAACTATTTTTCTTGAACTTTGCACAG | GTGTGGTGTGGAACCTATAGGCCA    c.2100
 N  H  K  Q  L  F  F  L  N  F  A  Q   | V  W  C  G  T  Y  R  P      p.700

          .         .         .         .         .    | 23    .    g.105720
 GAGTATGCGGTTAACTCCATTAAAACAGATGTGCACAGTCCAGGCAATTTCAG | GATTATT    c.2160
 E  Y  A  V  N  S  I  K  T  D  V  H  S  P  G  N  F  R  |  I  I      p.720

          .         .         .         .         .         .       g.105780
 GGGACTTTGCAGAACTCTGCAGAGTTTTCAGAAGCCTTTCACTGCCGCAAGAATTCATAC       c.2220
 G  T  L  Q  N  S  A  E  F  S  E  A  F  H  C  R  K  N  S  Y         p.740

          .         .         .                                     g.105813
 ATGAATCCAGAAAAGAAGTGCCGGGTTTGGTGA                                  c.2253
 M  N  P  E  K  K  C  R  V  W  X                                    p.750

          .         .         .         .         .         .       g.105873
 tcttcaaaagaagcattgcagcccttggctagacttgccaacaccacagaaatggggaat       c.*60

          .         .         .         .         .         .       g.105933
 tctctaatcgaaagaaaatgggccctaggggtcactgtactgacttgagggtgattaaca       c.*120

          .         .         .         .         .         .       g.105993
 gagagggcaccatcacaatacagataacattaggttgtcctagaaagggtgtggagggag       c.*180

          .         .         .         .         .         .       g.106053
 gaagggggtctaaggtctatcaagtcaatcatttctcactgtgtacataatgcttaattt       c.*240

          .         .         .         .         .         .       g.106113
 ctaaagataatattactgtttatttctgtttctcatatggtctaccagtttgctgatgtc       c.*300

          .         .         .         .         .         .       g.106173
 cctagaaaacaatgcaaaacctttgaggtagaccaggatttctaatcaaaagggaaaaga       c.*360

          .         .         .         .         .         .       g.106233
 agatgttgaagaatacagttaggcaccagaagaacagtaggtgacactatagtttaaaac       c.*420

          .         .         .         .         .         .       g.106293
 acattgcctaactactagtttttacttttatttgcaacatttacagtccttcaaaatcct       c.*480

          .         .         .         .         .         .       g.106353
 tccaaagaattcttatacacattggggccttggagcttacatagttttaaactcattttt       c.*540

          .         .         .         .         .         .       g.106413
 gccatacatcagttattcattctgtgatcatttattttaagcactcttaaagcaaaaaat       c.*600

          .         .         .         .         .         .       g.106473
 gaatgtctaaaattgttttttgttgtacctgctttgactgatgctgagattcttcaggct       c.*660

          .         .         .         .         .         .       g.106533
 tcctgcaattttctaagcaatttcttgctctatctctcaaaacttggtatttttcagaga       c.*720

          .         .         .         .         .         .       g.106593
 tttatataaatgtaaaaataataatttttatatttaattattaactacatttatgagtaa       c.*780

          .         .         .         .         .         .       g.106653
 ctattattataggtaatcaatgaatattgaagtttcagcttaaaataaacagttgtgaac       c.*840

          .         .         .         .         .         .       g.106713
 caagatctataaagcgatatacagatgaaaatttgagactatttaaacttataaatcata       c.*900

          .         .         .         .         .         .       g.106773
 ttgatgaaaagatttaagcacaaactttagggtaaaaattgccattggacagttgtctag       c.*960

          .         .         .         .         .         .       g.106833
 agatatatatacttgtggttttcaaattggactttcaaaattaaatctgtccctgagagt       c.*1020

          .         .         .         .         .         .       g.106893
 gtctctgataaaagggcaaatctgcacctatgtagctctgcatctcctgtcttttcaggt       c.*1080

          .         .         .         .         .         .       g.106953
 ttgtcatcagatggaaatattttgataataaattgaaattgtgaactcattgctccctaa       c.*1140

          .         .         .         .         .         .       g.107013
 gactgtgacaactgtctaactttagaagtgcatttctgaatagaaatgggaggcctctga       c.*1200

          .         .         .         .         .         .       g.107073
 tggaccttctagaattataagtcacaaagagttctggaaaagaactgtttactgcttgat       c.*1260

          .         .         .         .         .         .       g.107133
 aggaattcatcttttgaggcttctgttcctctcttttcctgttgtattgactattttcgt       c.*1320

          .         .         .         .         .         .       g.107193
 tcattacttgattaagattttacaaaagaggagcacttccaaaattcttatttttcctaa       c.*1380

          .         .         .         .         .         .       g.107253
 caaaagatgaaagcagggaatttctatctaaatgatgagtattagttccctgtctcttga       c.*1440

          .         .         .         .         .         .       g.107313
 aaaatgcccatttgcctttaaaaaaaaaagttacagaaatactataacatatgtacataa       c.*1500

          .         .         .         .         .         .       g.107373
 attgcataaagcataagtatacagttcaataaacttaactttaactgaacaatggccctg       c.*1560

          .         .         .         .         .         .       g.107433
 tagccagcacctgtaagaaacagagcagtaccagcgctctaaaagcacctccttgtcact       c.*1620

          .         .         .         .         .         .       g.107493
 ttattactcccagaacaacaactatcctgacttctaatatcattcactagctttgcctgg       c.*1680

          .         .         .         .         .         .       g.107553
 ttttgtcttttatgcagatagaatcaatcagtatgtattcttttgtgcctggcttctttc       c.*1740

          .         .         .         .         .         .       g.107613
 tctcagccttacatttgtgagattcctctgtattgtgctgattgtggatcttttcattct       c.*1800

          .         .         .         .         .         .       g.107673
 cattgcagaataatgttctattgtgggacttattacaatttgttcatcctattgttgatg       c.*1860

          .         .         .         .         .         .       g.107733
 ggcacttgagaactttccattttggcgctattacaaatagtgcaactatgaatgtactgc       c.*1920

          .         .         .         .         .         .       g.107793
 atgttaccatcttacttgagcctttaatggacttatttcttcaaatccttccaaaaatta       c.*1980

          .         .         .         .         .         .       g.107853
 ttataagcattgaaattatagtttcaagccaactgtggatacccttaccctttcctcctt       c.*2040

          .         .         .         .         .         .       g.107913
 tatcacaaccaccgttacaagtatacttatatttccctaaaatacatttaaaacttacct       c.*2100

          .         .         .         .         .         .       g.107973
 aagtgacatttgtagttggagtaataggagcttccagctctaataaaacagctgtctcta       c.*2160

          .         .         .         .         .         .       g.108033
 acttattttatttccatcatgtcagagcaggtgaagagccagaagtgaagagtgactagt       c.*2220

          .         .         .         .         .         .       g.108093
 acaaattataaaaagccactagactcttcactgttagctttttaaaacattaggctccca       c.*2280

          .         .         .         .         .         .       g.108153
 tccctatggaggaacaactctccagtgcctggatcccctctgtctacaaatataagattt       c.*2340

          .         .         .         .         .         .       g.108213
 tctgggcctaaaggatagatcaaagtcaaaaatagcaatgcctccctatccctcacacat       c.*2400

          .         .         .         .         .         .       g.108273
 ccagacatcatgaattttacatggtactcttgttgagttctgtagagccttctgatgtct       c.*2460

          .         .         .         .         .         .       g.108333
 ctaaagcactaccgattctttggagttgtcacatcagataagacatatctctaattccat       c.*2520

          .         .         .         .         .         .       g.108393
 ccataaatccagttctactatggctgagttctggtcaaagaaagaaagtttagaagctga       c.*2580

          .         .         .         .         .         .       g.108453
 gacacaaagggttgggagctgatgaaactcacaaatgatggtaggaagaagctctcgaca       c.*2640

          .         .         .         .         .         .       g.108513
 atacccgttggcaaggagtctgcctccatgctgcagtgttcgagtggattgtaggtgcaa       c.*2700

          .         .         .         .         .         .       g.108573
 gatggaaaggattgtaggtgcaagctgtccagagaaaagagtccttgttccagccctatt       c.*2760

          .         .         .         .         .         .       g.108633
 ctgccactcctgacagggtgaccttgggtatttgcaatattcctttgggcctctgcttct       c.*2820

          .         .         .         .         .         .       g.108693
 ctcacctaaaaaaagagaattagattatattggtggttctcagcaagagaaggagtatgt       c.*2880

          .         .         .         .         .         .       g.108753
 gtccaatgctgccttcccatgaatctgtctcccagttatgaatcagtgggcaggataaac       c.*2940

          .         .         .         .         .         .       g.108813
 tgaaaactcccatttacgtgtctgaatcgagtgagacaaaattttagtccaaataacaag       c.*3000

          .         .         .         .         .         .       g.108873
 taccaaagttttatcaagtttgggtctgtgctgctgttactgttaaccatttaagtgggg       c.*3060

          .         .         .         .         .         .       g.108933
 caaaaccttgctaattttctcaaaagcatttatcattcttgttgccacagctggagctct       c.*3120

          .         .         .         .         .         .       g.108993
 caaactaaaagacatttgttattttggaaagaagaaagactctattctcaaagtttccta       c.*3180

          .         .         .         .         .         .       g.109053
 atcagaaatttttatcagtttccagtctcaaaaatacaaaataaaaacaaacgtttttaa       c.*3240

          .         .         .                                     g.109083
 tactattgcttttatgcctagtcaactctg                                     c.*3270

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Membrane metallo-endopeptidase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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