matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (MMP2) - coding DNA reference sequence

(used for variant description)

(last modified March 20, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_004530.4 in the MMP2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering MMP2 transcript NM_004530.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5011
                                                  acatctggcgg       c.-301

 .         .         .         .         .         .                g.5071
 ctgccctcccttgtttccgctgcatccagacttcctcaggcggtggctggaggctgcgca       c.-241

 .         .         .         .         .         .                g.5131
 tctggggctttaaacatacaaagggattgccaggacctgcggcggcggcggcggcggcgg       c.-181

 .         .         .         .         .         .                g.5191
 gggctggggcgcgggggccggaccatgagccgctgagccgggcaaaccccaggccaccga       c.-121

 .         .         .         .         .         .                g.5251
 gccagcggaccctcggagcgcagccctgcgccgcggagcaggctccaaccaggcggcgag       c.-61

 .         .         .         .         .         .                g.5311
 gcggccacacgcaccgagccagcgacccccgggcgacgcgcggggccagggagcgctacg       c.-1

          .         .         .         .         .         .       g.5371
 ATGGAGGCGCTAATGGCCCGGGGCGCGCTCACGGGTCCCCTGAGGGCGCTCTGTCTCCTG       c.60
 M  E  A  L  M  A  R  G  A  L  T  G  P  L  R  A  L  C  L  L         p.20

          .         .         .         .         .         .       g.5431
 GGCTGCCTGCTGAGCCACGCCGCCGCCGCGCCGTCGCCCATCATCAAGTTCCCCGGCGAT       c.120
 G  C  L  L  S  H  A  A  A  A  P  S  P  I  I  K  F  P  G  D         p.40

          .         .         .    | 02    .         .         .    g.8767
 GTCGCCCCCAAAACGGACAAAGAGTTGGCAGTG | CAATACCTGAACACCTTCTATGGCTGC    c.180
 V  A  P  K  T  D  K  E  L  A  V   | Q  Y  L  N  T  F  Y  G  C      p.60

          .         .         .         .         .         .       g.8827
 CCCAAGGAGAGCTGCAACCTGTTTGTGCTGAAGGACACACTAAAGAAGATGCAGAAGTTC       c.240
 P  K  E  S  C  N  L  F  V  L  K  D  T  L  K  K  M  Q  K  F         p.80

          .         .         .         .         .         .       g.8887
 TTTGGACTGCCCCAGACAGGTGATCTTGACCAGAATACCATCGAGACCATGCGGAAGCCA       c.300
 F  G  L  P  Q  T  G  D  L  D  Q  N  T  I  E  T  M  R  K  P         p.100

          .         .         .         .         .         .       g.8947
 CGCTGCGGCAACCCAGATGTGGCCAACTACAACTTCTTCCCTCGCAAGCCCAAGTGGGAC       c.360
 R  C  G  N  P  D  V  A  N  Y  N  F  F  P  R  K  P  K  W  D         p.120

          .         . | 03       .         .         .         .    g.9887
 AAGAACCAGATCACATACAG | GATCATTGGCTACACACCTGATCTGGACCCAGAGACAGTG    c.420
 K  N  Q  I  T  Y  R  |  I  I  G  Y  T  P  D  L  D  P  E  T  V      p.140

          .         .         .         .         .         .       g.9947
 GATGATGCCTTTGCTCGTGCCTTCCAAGTCTGGAGCGATGTGACCCCACTGCGGTTTTCT       c.480
 D  D  A  F  A  R  A  F  Q  V  W  S  D  V  T  P  L  R  F  S         p.160

          .         .         .         .          | 04        .    g.11141
 CGAATCCATGATGGAGAGGCAGACATCATGATCAACTTTGGCCGCTGGG | AGCATGGCGAT    c.540
 R  I  H  D  G  E  A  D  I  M  I  N  F  G  R  W  E |   H  G  D      p.180

          .         .         .         .         .         .       g.11201
 GGATACCCCTTTGACGGTAAGGACGGACTCCTGGCTCATGCCTTCGCCCCAGGCACTGGT       c.600
 G  Y  P  F  D  G  K  D  G  L  L  A  H  A  F  A  P  G  T  G         p.200

          .         .         .         .         .         | 05    g.11437
 GTTGGGGGAGACTCCCATTTTGATGACGATGAGCTATGGACCTTGGGAGAAGGCCAAG | TG    c.660
 V  G  G  D  S  H  F  D  D  D  E  L  W  T  L  G  E  G  Q  V |       p.220

          .         .         .         .         .         .       g.11497
 GTCCGTGTGAAGTATGGGAACGCCGATGGGGAGTACTGCAAGTTCCCCTTCTTGTTCAAT       c.720
 V  R  V  K  Y  G  N  A  D  G  E  Y  C  K  F  P  F  L  F  N         p.240

          .         .         .         .         .         .       g.11557
 GGCAAGGAGTACAACAGCTGCACTGATACCGGCCGCAGCGATGGCTTCCTCTGGTGCTCC       c.780
 G  K  E  Y  N  S  C  T  D  T  G  R  S  D  G  F  L  W  C  S         p.260

          .         .         .         .         .   | 06     .    g.14382
 ACCACCTACAACTTTGAGAAGGATGGCAAGTACGGCTTCTGTCCCCATGAAG | CCCTGTTC    c.840
 T  T  Y  N  F  E  K  D  G  K  Y  G  F  C  P  H  E  A |   L  F      p.280

          .         .         .         .         .         .       g.14442
 ACCATGGGCGGCAACGCTGAAGGACAGCCCTGCAAGTTTCCATTCCGCTTCCAGGGCACA       c.900
 T  M  G  G  N  A  E  G  Q  P  C  K  F  P  F  R  F  Q  G  T         p.300

          .         .         .         .         .         .       g.14502
 TCCTATGACAGCTGCACCACTGAGGGCCGCACGGATGGCTACCGCTGGTGCGGCACCACT       c.960
 S  Y  D  S  C  T  T  E  G  R  T  D  G  Y  R  W  C  G  T  T         p.320

          .         .         .         .       | 07 .         .    g.15496
 GAGGACTACGACCGCGACAAGAAGTATGGCTTCTGCCCTGAGACCG | CCATGTCCACTGTT    c.1020
 E  D  Y  D  R  D  K  K  Y  G  F  C  P  E  T  A |   M  S  T  V      p.340

          .         .         .         .         .         .       g.15556
 GGTGGGAACTCAGAAGGTGCCCCCTGTGTCTTCCCCTTCACTTTCCTGGGCAACAAATAT       c.1080
 G  G  N  S  E  G  A  P  C  V  F  P  F  T  F  L  G  N  K  Y         p.360

          .         .         .         .         .         .       g.15616
 GAGAGCTGCACCAGCGCCGGCCGCAGTGACGGAAAGATGTGGTGTGCGACCACAGCCAAC       c.1140
 E  S  C  T  S  A  G  R  S  D  G  K  M  W  C  A  T  T  A  N         p.380

          .         .         .         . | 08       .         .    g.17652
 TACGATGATGACCGCAAGTGGGGCTTCTGCCCTGACCAAG | GGTACAGCCTGTTCCTCGTG    c.1200
 Y  D  D  D  R  K  W  G  F  C  P  D  Q  G |   Y  S  L  F  L  V      p.400

          .         .         .         .         .         .       g.17712
 GCAGCCCACGAGTTTGGCCACGCCATGGGGCTGGAGCACTCCCAAGACCCTGGGGCCCTG       c.1260
 A  A  H  E  F  G  H  A  M  G  L  E  H  S  Q  D  P  G  A  L         p.420

          .         .         .         .         .         .       g.17772
 ATGGCACCCATTTACACCTACACCAAGAACTTCCGTCTGTCCCAGGATGACATCAAGGGC       c.1320
 M  A  P  I  Y  T  Y  T  K  N  F  R  L  S  Q  D  D  I  K  G         p.440

          .       | 09 .         .         .         .         .    g.19033
 ATTCAGGAGCTCTATG | GGGCCTCTCCTGACATTGACCTTGGCACCGGCCCCACCCCCACG    c.1380
 I  Q  E  L  Y  G |   A  S  P  D  I  D  L  G  T  G  P  T  P  T      p.460

          .         .         .         .         .         .       g.19093
 CTGGGCCCTGTCACTCCTGAGATCTGCAAACAGGACATTGTATTTGATGGCATCGCTCAG       c.1440
 L  G  P  V  T  P  E  I  C  K  Q  D  I  V  F  D  G  I  A  Q         p.480

          .         .         .   | 10     .         .         .    g.22785
 ATCCGTGGTGAGATCTTCTTCTTCAAGGACCG | GTTCATTTGGCGGACTGTGACGCCACGT    c.1500
 I  R  G  E  I  F  F  F  K  D  R  |  F  I  W  R  T  V  T  P  R      p.500

          .         .         .         .         .         .       g.22845
 GACAAGCCCATGGGGCCCCTGCTGGTGGCCACATTCTGGCCTGAGCTCCCGGAAAAGATT       c.1560
 D  K  P  M  G  P  L  L  V  A  T  F  W  P  E  L  P  E  K  I         p.520

          .         .         .         .          | 11        .    g.24131
 GATGCGGTATACGAGGCCCCACAGGAGGAGAAGGCTGTGTTCTTTGCAG | GGAATGAATAC    c.1620
 D  A  V  Y  E  A  P  Q  E  E  K  A  V  F  F  A  G |   N  E  Y      p.540

          .         .         .         .         .         .       g.24191
 TGGATCTACTCAGCCAGCACCCTGGAGCGAGGGTACCCCAAGCCACTGACCAGCCTGGGA       c.1680
 W  I  Y  S  A  S  T  L  E  R  G  Y  P  K  P  L  T  S  L  G         p.560

          .         .         .         .         .         .       g.24251
 CTGCCCCCTGATGTCCAGCGAGTGGATGCCGCCTTTAACTGGAGCAAAAACAAGAAGACA       c.1740
 L  P  P  D  V  Q  R  V  D  A  A  F  N  W  S  K  N  K  K  T         p.580

          .         .          | 12        .         .         .    g.28641
 TACATCTTTGCTGGAGACAAATTCTGGAG | ATACAATGAGGTGAAGAAGAAAATGGATCCT    c.1800
 Y  I  F  A  G  D  K  F  W  R  |  Y  N  E  V  K  K  K  M  D  P      p.600

          .         .         .         .         .         .       g.28701
 GGCTTCCCCAAGCTCATCGCAGATGCCTGGAATGCCATCCCCGATAACCTGGATGCCGTC       c.1860
 G  F  P  K  L  I  A  D  A  W  N  A  I  P  D  N  L  D  A  V         p.620

          .          | 13        .         .         .         .    g.31211
 GTGGACCTGCAGGGCGGCG | GTCACAGCTACTTCTTCAAGGGTGCCTATTACCTGAAGCTG    c.1920
 V  D  L  Q  G  G  G |   H  S  Y  F  F  K  G  A  Y  Y  L  K  L      p.640

          .         .         .         .         .         .       g.31271
 GAGAACCAAAGTCTGAAGAGCGTGAAGTTTGGAAGCATCAAATCCGACTGGCTAGGCTGC       c.1980
 E  N  Q  S  L  K  S  V  K  F  G  S  I  K  S  D  W  L  G  C         p.660

                                                                    g.31274
 TGA                                                                c.1983
 X                                                                  p.660

          .         .         .         .         .         .       g.31334
 gctggccctggctcccacaggcccttcctctccactgccttcgatacaccgggcctggag       c.*60

          .         .         .         .         .         .       g.31394
 aactagagaaggacccggaggggcctggcagccgtgccttcagctctacagctaatcagc       c.*120

          .         .         .         .         .         .       g.31454
 attctcactcctacctggtaatttaagattccagagagtggctcctcccggtgcccaaga       c.*180

          .         .         .         .         .         .       g.31514
 atagatgctgactgtactcctcccaggcgccccttccccctccaatcccaccaaccctca       c.*240

          .         .         .         .         .         .       g.31574
 gagccacccctaaagagatactttgatattttcaacgcagccctgctttgggctgccctg       c.*300

          .         .         .         .         .         .       g.31634
 gtgctgccacacttcaggctcttctcctttcacaaccttctgtggctcacagaacccttg       c.*360

          .         .         .         .         .         .       g.31694
 gagccaatggagactgtctcaagagggcactggtggcccgacagcctggcacagggcagt       c.*420

          .         .         .         .         .         .       g.31754
 gggacagggcatggccaggtggccactccagacccctggcttttcactgctggctgcctt       c.*480

          .         .         .         .         .         .       g.31814
 agaacctttcttacattagcagtttgctttgtatgcactttgtttttttctttgggtctt       c.*540

          .         .         .         .         .         .       g.31874
 gttttttttttccacttagaaattgcatttcctgacagaaggactcaggttgtctgaagt       c.*600

          .         .         .         .         .         .       g.31934
 cactgcacagtgcatctcagcccacatagtgatggttcccctgttcactctacttagcat       c.*660

          .         .         .         .         .         .       g.31994
 gtccctaccgagtctcttctccactggatggaggaaaaccaagccgtggcttcccgctca       c.*720

          .         .         .         .         .         .       g.32054
 gccctccctgcccctcccttcaaccattccccatgggaaatgtcaacaagtatgaataaa       c.*780

          .         .         .         .         .         .       g.32114
 gacacctactgagtggccgtgtttgccatctgttttagcagagcctagacaagggccaca       c.*840

          .         .         .         .         .         .       g.32174
 gacccagccagaagcggaaacttaaaaagtccgaatctctgctccctgcagggcacaggt       c.*900

          .         .         .         .         .         .       g.32234
 gatggtgtctgctggaaaggtcagagcttccaaagtaaacagcaagagaacctcagggag       c.*960

          .         .         .         .         .         .       g.32294
 agtaagctctagtccctctgtcctgtagaaagagccctgaagaatcagcaattttgttgc       c.*1020

          .         .         .         .         .         .       g.32354
 tttattgtggcatctgttcgaggtttgcttcctctttaagtctgtttcttcattagcaat       c.*1080

          .         .         .         .         .         .       g.32414
 catatcagttttaatgctactactaacaatgaacagtaacaataatatccccctcaatta       c.*1140

          .         .         .         .         .         .       g.32474
 atagagtgctttctatgtgcaaggcacttttcacgtgtcacctattttaacctttccaac       c.*1200

          .         .         .                                     g.32506
 cacataaataaaaaaggccattattagttgaa                                   c.*1232

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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