meiosis-specific nuclear structural 1 (MNS1) - coding DNA reference sequence

(used for variant description)

(last modified June 16, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_018365.2 in the MNS1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering MNS1 transcript NM_018365.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5045
                acttttggtcgagcggagggcgcgcagctccaccgttgccaagac       c.-121

 .         .         .         .         .         .                g.5105
 gccgcgtaaacacccgagcgcgcgcagccaggtgcgctccttggggctgctggctgctgc       c.-61

 .         .         .         .         .         .                g.5165
 gtttgcggcgggaggtggtggccgcggtcccacgagagggggtatttttcgtcagccaag       c.-1

     | 02    .         .         .         .         .         .    g.5947
 ATG | GGTTCCAAAAGGAGAAATTTGAGCTGTAGTGAAAGGCATCAGAAATTAGTAGATGAA    c.60
 M   | G  S  K  R  R  N  L  S  C  S  E  R  H  Q  K  L  V  D  E      p.20

          .         .         .         .         .         .       g.6007
 AACTACTGCAAAAAATTACATGTCCAAGCTCTAAAAAACGTCAACAGTCAAATCAGGAAT       c.120
 N  Y  C  K  K  L  H  V  Q  A  L  K  N  V  N  S  Q  I  R  N         p.40

          .         .         .         .         .         .       g.6067
 CAAATGGTGCAGAATGAAAATGATAACCGTGTTCAGCGCAAGCAATTTCTCAGATTATTA       c.180
 Q  M  V  Q  N  E  N  D  N  R  V  Q  R  K  Q  F  L  R  L  L         p.60

          .         .         .         .      | 03  .         .    g.13631
 CAAAATGAACAATTTGAGTTGGATATGGAAGAGGCCATTCAAAAG | GCAGAAGAAAACAAG    c.240
 Q  N  E  Q  F  E  L  D  M  E  E  A  I  Q  K   | A  E  E  N  K      p.80

          .         .         .         .         .         .       g.13691
 AGATTGAAAGAACTCCAGCTCAAACAAGAAGAAAAACTGGCTATGGAATTGGCAAAACTG       c.300
 R  L  K  E  L  Q  L  K  Q  E  E  K  L  A  M  E  L  A  K  L         p.100

          .         .         .         .         .    | 04    .    g.23201
 AAACATGAAAGTCTAAAGGACGAAAAGATGAGGCAACAAGTAAGAGAAAACAG | CATTGAG    c.360
 K  H  E  S  L  K  D  E  K  M  R  Q  Q  V  R  E  N  S  |  I  E      p.120

          .         .         .         .         .         .       g.23261
 CTTAGAGAATTGGAGAAGAAATTAAAAGCAGCTTACATGAATAAAGAAAGGGCAGCTCAG       c.420
 L  R  E  L  E  K  K  L  K  A  A  Y  M  N  K  E  R  A  A  Q         p.140

          .         .         .       | 05 .         .         .    g.25488
 ATTGCTGAAAAGGATGCCATTAAATATGAACAAATG | AAACGTGATGCTGAAATAGCCAAA    c.480
 I  A  E  K  D  A  I  K  Y  E  Q  M   | K  R  D  A  E  I  A  K      p.160

          .         .         .         .         .         .       g.25548
 ACCATGATGGAAGAACACAAGAGAATAATAAAGGAAGAGAATGCTGCAGAAGACAAACGA       c.540
 T  M  M  E  E  H  K  R  I  I  K  E  E  N  A  A  E  D  K  R         p.180

          .         .         .         .         .         .       g.25608
 AACAAAGCGAAAGCACAGTACTATCTTGACTTAGAGAAACAACTTGAAGAACAAGAAAAA       c.600
 N  K  A  K  A  Q  Y  Y  L  D  L  E  K  Q  L  E  E  Q  E  K         p.200

          .         .         .         .         .         .       g.25668
 AAAAAGCAGGAAGCTTATGAGCAGCTGCTAAAAGAGAAACTCATGATTGATGAAATTGTT       c.660
 K  K  Q  E  A  Y  E  Q  L  L  K  E  K  L  M  I  D  E  I  V         p.220

          .         .       | 06 .         .         .         .    g.26317
 AGGAAGATCTATGAAGAAGATCAGTT | GGAAAAACAACAAAAGTTAGAAAAAATGAATGCA    c.720
 R  K  I  Y  E  E  D  Q  L  |  E  K  Q  Q  K  L  E  K  M  N  A      p.240

          .         .         .         .         .         .       g.26377
 ATGCGAAGGTATATAGAAGAGTTTCAGAAAGAGCAGGCTCTCTGGAGAAAAAAGAAACGT       c.780
 M  R  R  Y  I  E  E  F  Q  K  E  Q  A  L  W  R  K  K  K  R         p.260

          .         .         .         .         .         .       g.26437
 GAGGAGATGGAAGAAGAAAACAGAAAAATCATAGAGTTTGCTAACATGCAGCAGCAAAGA       c.840
 E  E  M  E  E  E  N  R  K  I  I  E  F  A  N  M  Q  Q  Q  R         p.280

          .         .         .         .         .         .       g.26497
 GAAGAAGATCGGATGGCAAAAGTTCAAGAAAATGAGGAGAAAAGGCTACAGCTTCAGAAT       c.900
 E  E  D  R  M  A  K  V  Q  E  N  E  E  K  R  L  Q  L  Q  N         p.300

     | 07    .         .         .         .         .         .    g.26657
 GCG | TTGACACAGAAATTAGAAGAAATGCTGCGGCAACGTGAAGATTTGGAACAAGTGCGA    c.960
 A   | L  T  Q  K  L  E  E  M  L  R  Q  R  E  D  L  E  Q  V  R      p.320

          .         .         .         .         .  | 08      .    g.35751
 CAAGAATTATACCAGGAAGAACAAGCTGAAATATATAAGAGCAAGCTAAAA | GAAGAAGCA    c.1020
 Q  E  L  Y  Q  E  E  Q  A  E  I  Y  K  S  K  L  K   | E  E  A      p.340

          .         .         .         .         .         .       g.35811
 GAAAAGAAATTGAGAAAGCAAAAAGAGATGAAGCAAGATTTTGAAGAACAAATGGCCTTG       c.1080
 E  K  K  L  R  K  Q  K  E  M  K  Q  D  F  E  E  Q  M  A  L         p.360

          .         .         .         .         .         .       g.35871
 AAGGAATTAGTGCTACAGGCTGCAAAAGAGGAAGAGGAGAACTTTAGAAAAACTATGCTA       c.1140
 K  E  L  V  L  Q  A  A  K  E  E  E  E  N  F  R  K  T  M  L         p.380

          .         .         .         .         .         .       g.35931
 GCTAAATTTGCTGAGGATGATCGAATAGAATTAATGAATGCTCAGAAACAAAGAATGAAG       c.1200
 A  K  F  A  E  D  D  R  I  E  L  M  N  A  Q  K  Q  R  M  K         p.400

          .         .         .         .         .         .       g.35991
 CAGCTGGAACACAGGAGGGCTGTGGAAAAACTTATTGAAGAGCGTCGCCAACAATTCCTT       c.1260
 Q  L  E  H  R  R  A  V  E  K  L  I  E  E  R  R  Q  Q  F  L         p.420

           | 09        .         .         .         .         .    g.38690
 GCAGACAAA | CAACGTGAACTAGAAGAGTGGCAGTTGCAGCAAAGGCGGCAAGGATTTATT    c.1320
 A  D  K   | Q  R  E  L  E  E  W  Q  L  Q  Q  R  R  Q  G  F  I      p.440

          .         .         .         .         .         .       g.38750
 AATGCAATTATTGAAGAAGAAAGGCTAAAACTTCTTAAAGAGCATGCTACAAACTTACTA       c.1380
 N  A  I  I  E  E  E  R  L  K  L  L  K  E  H  A  T  N  L  L         p.460

          .      | 10  .         .         .         .         .    g.40989
 GGCTATCTCCCTAAA | GGAGTATTTAAAAAAGAGGATGATATTGATCTGCTTGGTGAAGAG    c.1440
 G  Y  L  P  K   | G  V  F  K  K  E  D  D  I  D  L  L  G  E  E      p.480

          .         .         .         .                           g.41037
 TTCAGGAAAGTATATCAACAAAGGAGTGAAATTTGTGAAGAGAAATGA                   c.1488
 F  R  K  V  Y  Q  Q  R  S  E  I  C  E  E  K  X                     p.495

          .         .         .         .         .         .       g.41097
 tatcatcaaaattgggtaaagcatagattttttgcatgttaccactagatgtcagcataa       c.*60

          .         .         .         .         .         .       g.41157
 cttttgttttacagttcagtggcattaggtatccattgtctgtttggattttgtaaatca       c.*120

          .         .         .         .         .         .       g.41217
 tcactgaatttcataacttgtaaacaattatcagatacaaattaattttaatcaagctgt       c.*180

          .         .         .         .         .         .       g.41277
 tatttttgtactgataatttcaaaatccgatttctacaacactacagagcactgtttgca       c.*240

          .         .         .         .         .         .       g.41337
 tccccatcctcaagacagtatatttaccttgactaatacagaactctaccccaaagtgaa       c.*300

          .         .         .         .         .         .       g.41397
 ctgccttctgtctgtgtttacgaactttacttacttgatttagccagggaaataaatatt       c.*360

          .                                                         g.41407
 tggaattttc                                                         c.*370

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Meiosis-specific nuclear structural 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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