mitochondrial ribosomal protein L3 (MRPL3) - coding DNA reference sequence

(used for variant description)

(last modified May 19, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_007208.3 in the MRPL3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029207.1, covering MRPL3 transcript NM_007208.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5015
                                              attgtaaaacgcacc       c.-181

 .         .         .         .         .         .                g.5075
 ggaagtgggtccggcggctttctttccgtcgcagagagcatcggccggcgaccgttccgg       c.-121

 .         .         .         .         .         .                g.5135
 cggccattgcgaaaacttccccacggctactgcgtccacgtggcggtggcgtggggactc       c.-61

 .         .         .         .         .         .                g.5195
 cctgaaagcagagcggcagggcgcccggaagtcgtgagtcgagtcttcccgggctaatcc       c.-1

          .         .         .         .         .         .       g.5255
 ATGCCGGGTTGGAGGCTGCTGACGCAGGTCGGCGCCCAGGTGCTGGGTCGACTCGGGGAC       c.60
 M  P  G  W  R  L  L  T  Q  V  G  A  Q  V  L  G  R  L  G  D         p.20

          .         .         .   | 02     .         .         .    g.6329
 GGCCTGGGTGCTGCCCTGGGCCCGGGGAACAG | AACACACATCTGGCTTTTTGTTAGAGGT    c.120
 G  L  G  A  A  L  G  P  G  N  R  |  T  H  I  W  L  F  V  R  G      p.40

          .         .         .         .         .         .       g.6389
 CTTCATGGAAAGAGTGGTACATGGTGGGATGAGCATCTTTCTGAAGAAAATGTCCCATTC       c.180
 L  H  G  K  S  G  T  W  W  D  E  H  L  S  E  E  N  V  P  F         p.60

          .         .         .         .         .         .       g.6449
 ATTAAGCAGTTGGTCTCTGATGAAGATAAAGCCCAATTAGCAAGTAAACTGTGTCCTCTG       c.240
 I  K  Q  L  V  S  D  E  D  K  A  Q  L  A  S  K  L  C  P  L         p.80

          .         .         .        | 03.         .         .    g.7518
 AAAGATGAACCATGGCCTATACATCCTTGGGAACCAG | GTTCCTTTAGAGTTGGTCTTATT    c.300
 K  D  E  P  W  P  I  H  P  W  E  P  G |   S  F  R  V  G  L  I      p.100

          .         .         .         .         .         .       g.7578
 GCCTTGAAGCTGGGCATGATGCCTTTATGGACCAAGGATGGTCAAAAGCATGTGGTCACA       c.360
 A  L  K  L  G  M  M  P  L  W  T  K  D  G  Q  K  H  V  V  T         p.120

           | 04        .         .         .         .         .    g.9790
 TTACTTCAG | GTACAAGACTGTCATGTCTTAAAATATACGTCAAAGGAAAACTGTAATGGA    c.420
 L  L  Q   | V  Q  D  C  H  V  L  K  Y  T  S  K  E  N  C  N  G      p.140

          .         .         .         .         | 05         .    g.17948
 AAAATGGCAACCCTGTCTGTAGGAGGAAAAACTGTATCACGTTTTCGT | AAAGCTACATCC    c.480
 K  M  A  T  L  S  V  G  G  K  T  V  S  R  F  R   | K  A  T  S      p.160

          .         .         .         .         .         .       g.18008
 ATATTGGAATTTTACCGGGAACTTGGATTGCCGCCGAAACAGACAGTTAAAATCTTTAAT       c.540
 I  L  E  F  Y  R  E  L  G  L  P  P  K  Q  T  V  K  I  F  N         p.180

          .         .         | 06         .         .         .    g.20308
 ATAACAGATAATGCTGCAATTAAACCAG | GCACTCCTCTTTATGCTGCTCACTTTCGTCCA    c.600
 I  T  D  N  A  A  I  K  P  G |   T  P  L  Y  A  A  H  F  R  P      p.200

          .         .          | 07        .         .         .    g.36768
 GGACAGTATGTGGATGTCACAGCCAAAAC | TATTGGTAAAGGTTTTCAAGGTGTCATGAAA    c.660
 G  Q  Y  V  D  V  T  A  K  T  |  I  G  K  G  F  Q  G  V  M  K      p.220

          .         .         .         .         .         .       g.36828
 AGATGGGGATTTAAAGGCCAGCCTGCTACGCATGGTCAAACGAAAACCCACAGGAGACCT       c.720
 R  W  G  F  K  G  Q  P  A  T  H  G  Q  T  K  T  H  R  R  P         p.240

          .         | 08         .         .         .         .    g.38285
 GGAGCTGTTGCAACTGGT | GATATTGGCAGAGTCTGGCCTGGAACTAAAATGCCTGGAAAA    c.780
 G  A  V  A  T  G   | D  I  G  R  V  W  P  G  T  K  M  P  G  K      p.260

          .         .         .       | 09 .         .         .    g.39872
 ATGGGAAACATATACAGGACAGAATATGGACTGAAA | GTGTGGAGAATAAACACAAAGCAC    c.840
 M  G  N  I  Y  R  T  E  Y  G  L  K   | V  W  R  I  N  T  K  H      p.280

          .         .         .         .         .     | 10   .    g.45147
 AACATAATCTATGTAAATGGCTCTGTACCTGGACATAAAAATTGCTTAGTAAAG | GTCAAA    c.900
 N  I  I  Y  V  N  G  S  V  P  G  H  K  N  C  L  V  K   | V  K      p.300

          .         .         .         .         .         .       g.45207
 GATTCTAAACTGCCTGCATATAAGGATCTCGGTAAAAATCTACCATTCCCTACATATTTT       c.960
 D  S  K  L  P  A  Y  K  D  L  G  K  N  L  P  F  P  T  Y  F         p.320

          .         .         .         .         .         .       g.45267
 CCTGATGGAGATGAAGAGGAACTGCCAGAAGATTTGTATGATGAAAACGTGTGTCAGCCC       c.1020
 P  D  G  D  E  E  E  L  P  E  D  L  Y  D  E  N  V  C  Q  P         p.340

          .         .                                               g.45294
 GGTGCGCCTTCTATTACATTTGCCTAA                                        c.1047
 G  A  P  S  I  T  F  A  X                                          p.348

          .         .         .         .         .         .       g.45354
 catctttggacgtggcagaaccttacatattctgtgagcttcgatgagccagagtgatat       c.*60

          .         .         .         .         .         .       g.45414
 cataaccaccagaaatcatactctcctttcttagtcacaacaaaatcacacatgtcatct       c.*120

          .         .         .         .         .         .       g.45474
 ttgtcaagggcataaatatatcattcatacccccattaaattttgttagaaaaattacca       c.*180

          .         .         .         .         .         .       g.45534
 cattaaatatatgagttaagtagattggatttgctgaaattggtgttgggcatattagca       c.*240

          .         .         .         .         .         .       g.45594
 aaatattcttaatttgtggactcgattcttttttactacatatttcccaagttatcttaa       c.*300

          .         .         .         .         .         .       g.45654
 gatgtctgtaaatttaacttttattaaagttttgtcaatctttgtgaaatagtggttgtg       c.*360

          .         .         .         .         .         .       g.45714
 gaacagtagaaaaccatatggggactatagtgcaacctatttgggtaaagaaaccatttg       c.*420

          .         .         .         .         .         .       g.45774
 ctaaaatggagaaagtaaatagatttttatttaaattacagaaacatgttaaaggccgga       c.*480

          .         .         .         .                           g.45816
 caaaggaaagacaataaaatcataaattatcggtcctgttta                         c.*522

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mitochondrial ribosomal protein L3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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