mitochondrial ribosomal protein L44 (MRPL44) - coding DNA reference sequence

(used for variant description)

(last modified June 8, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_022915.3 in the MRPL44 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_050679.1, covering MRPL44 transcript NM_022915.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.11523
                                                    ggggaagtg       c.-61

 .         .         .         .         .         .                g.11583
 tgttacggggacactggcccgactactttcgttccgtcttccatcgttttctctcgtgca       c.-1

          .         .         .         .         .         .       g.11643
 ATGGCGTCCGGGCTGGTAAGATTGCTGCAGCAGGGACATCGCTGCCTCCTGGCTCCAGTC       c.60
 M  A  S  G  L  V  R  L  L  Q  Q  G  H  R  C  L  L  A  P  V         p.20

          .         .         .         .         .         .       g.11703
 GCCCCCAAGCTGGTCCCTCCGGTTCGGGGAGTGAAGAAGGGATTCCGCGCCGCCTTCCGC       c.120
 A  P  K  L  V  P  P  V  R  G  V  K  K  G  F  R  A  A  F  R         p.40

          .         .         .         .         .          | 02    g.13645
 TTCCAGAAGGAGTTAGAGCGGCAGCGCCTTCTGCGGTGCCCGCCGCCGCCCGTGCGCCG | T    c.180
 F  Q  K  E  L  E  R  Q  R  L  L  R  C  P  P  P  P  V  R  R  |      p.60

          .         .         .         .         .         .       g.13705
 TCAGAGAAGCCGAACTGGGATTACCATGCAGAAATACAAGCTTTTGGACATCGGTTACAG       c.240
 S  E  K  P  N  W  D  Y  H  A  E  I  Q  A  F  G  H  R  L  Q         p.80

          .         .         .         .         .         .       g.13765
 GAAAACTTTTCCTTAGATCTTCTCAAAACTGCATTTGTTAATAGCTGCTATATTAAAAGT       c.300
 E  N  F  S  L  D  L  L  K  T  A  F  V  N  S  C  Y  I  K  S         p.100

          .         .         .         .         .         .       g.13825
 GAGGAGGCCAAACGCCAACAACTTGGGATAGAGAAAGAAGCTGTTCTTCTGAATCTTAAA       c.360
 E  E  A  K  R  Q  Q  L  G  I  E  K  E  A  V  L  L  N  L  K         p.120

          .         .         .         .         .         .       g.13885
 AGTAATCAAGAACTATCCGAACAAGGGACATCTTTTTCACAGACTTGCCTTACACAGTTT       c.420
 S  N  Q  E  L  S  E  Q  G  T  S  F  S  Q  T  C  L  T  Q  F         p.140

          .         .         .         .         .         .       g.13945
 CTTGAAGACGAGTACCCAGACATGCCCACTGAAGGCATAAAAAATCTTGTTGACTTTCTC       c.480
 L  E  D  E  Y  P  D  M  P  T  E  G  I  K  N  L  V  D  F  L         p.160

          .         .         .         .         .         .       g.14005
 ACTGGTGAGGAAGTCGTGTGTCACGTGGCTAGAAACTTGGCTGTGGAGCAGTTAACACTG       c.540
 T  G  E  E  V  V  C  H  V  A  R  N  L  A  V  E  Q  L  T  L         p.180

          .         .         .         .         .         .       g.14065
 AGTGAAGAATTCCCAGTGCCCCCAGCTGTGTTACAGCAGACTTTCTTTGCAGTTATTGGA       c.600
 S  E  E  F  P  V  P  P  A  V  L  Q  Q  T  F  F  A  V  I  G         p.200

          .         .         .         .         | 03         .    g.17878
 GCCCTGTTACAGAGCAGTGGACCTGAGAGGACTGCACTTTTCATCAGG | GACTTCTTAATT    c.660
 A  L  L  Q  S  S  G  P  E  R  T  A  L  F  I  R   | D  F  L  I      p.220

          .         .         .         .         .         .       g.17938
 ACTCAAATGACTGGAAAAGAGCTCTTTGAGATGTGGAAGATAATAAATCCCATGGGGCTA       c.720
 T  Q  M  T  G  K  E  L  F  E  M  W  K  I  I  N  P  M  G  L         p.240

          .         .         .         .         .         .       g.17998
 TTGGTAGAAGAACTGAAGAAAAGGAATGTTTCAGCTCCTGAATCAAGACTTACTAGGCAG       c.780
 L  V  E  E  L  K  K  R  N  V  S  A  P  E  S  R  L  T  R  Q         p.260

          .         .         .         .        | 04.         .    g.20986
 TCTGGTGGCACCACAGCTTTGCCTTTGTATTTTGTTGGCTTATACTG | TGATAAAAAGTTG    c.840
 S  G  G  T  T  A  L  P  L  Y  F  V  G  L  Y  C  |  D  K  K  L      p.280

          .         .         .         .         .         .       g.21046
 ATTGCAGAAGGACCTGGGGAAACAGTATTGGTTGCAGAAGAAGAGGCTGCTCGAGTGGCC       c.900
 I  A  E  G  P  G  E  T  V  L  V  A  E  E  E  A  A  R  V  A         p.300

          .         .         .         .         .         .       g.21106
 CTTAGAAAACTTTATGGATTCACAGAAAATAGACGGCCGTGGAACTATTCCAAGCCCAAA       c.960
 L  R  K  L  Y  G  F  T  E  N  R  R  P  W  N  Y  S  K  P  K         p.320

          .         .         .                                     g.21145
 GAAACCTTGAGAGCAGAAAAGAGCATCACTGCCAGCTAG                            c.999
 E  T  L  R  A  E  K  S  I  T  A  S  X                              p.332

          .         .         .         .         .         .       g.21205
 ccgccatggatgcagcagcctgaaacttgagagcgaaagtgagataaatgtcaaaggtgt       c.*60

          .         .         .         .         .         .       g.21265
 ttcaagccagacattttcacaattgtgaagaaatagatgttttgtttctgttttttactg       c.*120

          .         .         .         .         .         .       g.21325
 tgttcccaaaattaaataaatgttaaccaagtcacagtgtttttggttttgtttttctga       c.*180

          .         .         .         .         .         .       g.21385
 aatcttggtttgatcaaatctttttttttttctcttgagatggagtcttactctgtcgcc       c.*240

          .         .         .         .         .         .       g.21445
 caggctggactgcagtggtgcgatctcggctcactgcaacctccacctcacaggttcaag       c.*300

          .         .         .         .         .         .       g.21505
 cgattctcgtggctcagcctccctagtagctgggattacaggcacacaccaccatacctg       c.*360

          .         .         .         .         .         .       g.21565
 gctaatttttgtatttttggtagacatggggtttcaccaagttggctaggctagtcttga       c.*420

          .         .         .         .         .         .       g.21625
 actcctgacctcaggtgatccacccgccttggcctcccaaagtgctgggattacaggtgt       c.*480

          .         .         .         .         .         .       g.21685
 gagccactatacccgaccagatcaaatctttttttgacatttttgcaaaaaaattttcct       c.*540

          .         .         .         .         .         .       g.21745
 aatgttcttgatttaattgtatagaatttgtataattaggtgtattttatttgcgtctag       c.*600

          .         .         .         .         .         .       g.21805
 ctttgaggtatcataatttatgtatcttatgtgaattttttgctgtaataccaataaagt       c.*660

          .         .                                               g.21825
 tttttttctccacatgttaa                                               c.*680

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mitochondrial ribosomal protein L44 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 21
©2004-2018 Leiden University Medical Center