Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa (MTBP) - coding DNA reference sequence

(used for variant description)

(last modified July 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_022045.4 in the MTBP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033151.1, covering MTBP transcript NM_022045.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                gaaatgcgtcata       c.-61

 .         .         .         .         .         .                g.5073
 gcgcgcgtctgtttggatgtggaagccgagacctaaagttggggggtgatctctgaggag       c.-1

          .         .         .         .         .         .       g.5133
 ATGGATCGGTACCTGCTGCTGGTGATCTGGGGGGAAGGAAAATTCCCGTCGGCGGCCAGT       c.60
 M  D  R  Y  L  L  L  V  I  W  G  E  G  K  F  P  S  A  A  S         p.20

          .         .         .         .         .         | 02    g.6037
 AGGGAGGCAGAACATGGGCCAGAGGTGTCGTCGGGTGAGGGTACTGAGAATCAGCCGG | AC    c.120
 R  E  A  E  H  G  P  E  V  S  S  G  E  G  T  E  N  Q  P  D |       p.40

          .         .         .         .         .         .       g.6097
 TTCACAGCAGCAAATGTTTATCACCTCTTGAAAAGAAGCATTAGTGCTTCAATTAATCCA       c.180
 F  T  A  A  N  V  Y  H  L  L  K  R  S  I  S  A  S  I  N  P         p.60

          .          | 03        .         .         .         .    g.10646
 GAAGATAGTACTTTCCCTG | CCTGTTCAGTGGGAGGTATACCTGGTTCCAAGAAGTGGTTC    c.240
 E  D  S  T  F  P  A |   C  S  V  G  G  I  P  G  S  K  K  W  F      p.80

          .         .         .    | 04    .         .         .    g.10800
 TTTGCAGTGCAGGCAATATATGGATTTTATCAG | TTTTGTAGTTCTGATTGGCAAGAGATA    c.300
 F  A  V  Q  A  I  Y  G  F  Y  Q   | F  C  S  S  D  W  Q  E  I      p.100

          .         .         .         .         .         .       g.10860
 CATTTTGATACAGAAAAAGATAAAATTGAAGATGTTCTTCAAACGAATATCGAAGAATGT       c.360
 H  F  D  T  E  K  D  K  I  E  D  V  L  Q  T  N  I  E  E  C         p.120

          .         .         .         .         .         .       g.10920
 TTGGGTGCTGTTGAGTGTTTTGAAGAAGAAGACAGTAATAGCAGGGAATCATTATCCTTG       c.420
 L  G  A  V  E  C  F  E  E  E  D  S  N  S  R  E  S  L  S  L         p.140

       | 05  .         .         .         .         .         .    g.13504
 GCTGA | TCTCTATGAAGAAGCTGCAGAAAATTTGCATCAGCTGTCAGACAAGCTTCCTGCT    c.480
 A  D  |  L  Y  E  E  A  A  E  N  L  H  Q  L  S  D  K  L  P  A      p.160

      | 06   .         .         .         .         .         .    g.15093
 CCTG | GTAGAGCAATGGTAGATATAATACTGTTGCTTTCTGACAAAGATCCTCCTAAATTG    c.540
 P  G |   R  A  M  V  D  I  I  L  L  L  S  D  K  D  P  P  K  L      p.180

          .         .         .         .         .         .       g.15153
 AAAGACTATTTACCTACTGTAGGAGCATTAAAACATTTGAGAGAATGGTATTCAGCAAAG       c.600
 K  D  Y  L  P  T  V  G  A  L  K  H  L  R  E  W  Y  S  A  K         p.200

          .         .          | 07        .         .         .    g.16186
 ATCACTATAGCAGGAAATCATTGTGAAAT | AAACTGTCAGAAAATTGCAGAATACCTTTCT    c.660
 I  T  I  A  G  N  H  C  E  I  |  N  C  Q  K  I  A  E  Y  L  S      p.220

          .         .         .         .         .         .       g.16246
 GCTAATGTTGTATCTTTAGAAGATCTCAGAAATGTTATTGACTCAAAGGAATTATGGAGG       c.720
 A  N  V  V  S  L  E  D  L  R  N  V  I  D  S  K  E  L  W  R         p.240

          .         .        | 08.         .         .         .    g.18850
 GGGAAAATACAGATATGGGAAAGAAAG | TTTGGATTTGAAATTAGTTTTCCTGAATTTTGT    c.780
 G  K  I  Q  I  W  E  R  K   | F  G  F  E  I  S  F  P  E  F  C      p.260

          .         .         .         .         .         .       g.18910
 TTAAAGGGAGTCACACTTAAGAATTTTAGTACTTCTAATTTAAATACTGACTTCCTTGCC       c.840
 L  K  G  V  T  L  K  N  F  S  T  S  N  L  N  T  D  F  L  A         p.280

          .         .         .         .   | 09     .         .    g.20781
 AAAAAGATCATACCATCAAAGGATAAGAATATTTTGCCAAAG | GTTTTCCATTATTATGGC    c.900
 K  K  I  I  P  S  K  D  K  N  I  L  P  K   | V  F  H  Y  Y  G      p.300

          .         .         .         .         .         .       g.20841
 CCTGCTTTAGAATTTGTGCAGATGATAAAATTATCAGATCTACCCTCCTGCTATATGTCG       c.960
 P  A  L  E  F  V  Q  M  I  K  L  S  D  L  P  S  C  Y  M  S         p.320

          .        | 10.         .         .         .         .    g.23337
 GATATTGAATTTGAGTT | AGGATTGACAAACAGTACCAAACAGAATTCTGTGTTGCTGTTG    c.1020
 D  I  E  F  E  L  |  G  L  T  N  S  T  K  Q  N  S  V  L  L  L      p.340

          .         .        | 11.         .         .         .    g.30455
 GAGCAGATTTCTTCTCTGTGTAGCAAG | GTTGGTGCTCTTTTTGTATTGCCATGTACCATT    c.1080
 E  Q  I  S  S  L  C  S  K   | V  G  A  L  F  V  L  P  C  T  I      p.360

          .         .         .         .         .         .       g.30515
 AGTAACATACTGATTCCACCTCCCAACCAACTCAGTTCAAGAAAATGGAAGGAATATATA       c.1140
 S  N  I  L  I  P  P  P  N  Q  L  S  S  R  K  W  K  E  Y  I         p.380

          .         .      | 12  .         .         .         .    g.47796
 GCTAAAAAGCCTAAAACAATCAGTG | TTCCAGATGTTGAAGTGAAAGGAGAGTGTTCTAGC    c.1200
 A  K  K  P  K  T  I  S  V |   P  D  V  E  V  K  G  E  C  S  S      p.400

          .         .         .         .         .         .       g.47856
 TATTATCTCTTGTTACAAGGTAATGGCAATAGAAGATGTAAAGCCACATTGATTCACTCA       c.1260
 Y  Y  L  L  L  Q  G  N  G  N  R  R  C  K  A  T  L  I  H  S         p.420

          .         .         .         .         .         .       g.47916
 GCCAACCAGATCAATGGCTCATTTGCACTCAATTTAATTCATGGAAAGATGAAAACAAAG       c.1320
 A  N  Q  I  N  G  S  F  A  L  N  L  I  H  G  K  M  K  T  K         p.440

          .          | 13        .         .         .         .    g.50106
 ACAGAAGAAGCCAAATTGA | GTTTTCCTTTTGACTTATTATCACTTCCACATTTTTCTGGG    c.1380
 T  E  E  A  K  L  S |   F  P  F  D  L  L  S  L  P  H  F  S  G      p.460

          .         .         .         .         .         .       g.50166
 GAGCAGATTGTACAGAGAGAGAAACAGTTAGCTAATGTTCAAGTTTTAGCTTTGGAAGAA       c.1440
 E  Q  I  V  Q  R  E  K  Q  L  A  N  V  Q  V  L  A  L  E  E         p.480

         | 14.         .         .         .         .         .    g.57048
 TGCCTAA | AAAGACGAAAGTTGGCAAAGCAGCCTGAAACAGTTTCTGTTGCTGAACTCAAA    c.1500
 C  L  K |   R  R  K  L  A  K  Q  P  E  T  V  S  V  A  E  L  K      p.500

          .         .         .         .         .         .       g.57108
 AGTCTGTTAGTACTCACAAGGAAACACTTTTTAGATTATTTTGATGCTGTGATTCCTAAA       c.1560
 S  L  L  V  L  T  R  K  H  F  L  D  Y  F  D  A  V  I  P  K         p.520

          .         .         .         .          | 15        .    g.62105
 ATGATTCTAAGAAAGATGGACAAAATTAAAACCTTCAATATATTAAATG | ATTTTAGTCCA    c.1620
 M  I  L  R  K  M  D  K  I  K  T  F  N  I  L  N  D |   F  S  P      p.540

          .         .         .         .         .         .       g.62165
 GTGGAACCTAATTCCTCAAGTCTAATGGAAACCAATCCTCTGGAATGGCCAGAAAGGCAT       c.1680
 V  E  P  N  S  S  S  L  M  E  T  N  P  L  E  W  P  E  R  H         p.560

          .         .         .         .        | 16.         .    g.66321
 GTTCTTCAAAATTTGGAAACTTTTGAAAAAACTAAACAAAAAATGAG | AACTGGTTCATTA    c.1740
 V  L  Q  N  L  E  T  F  E  K  T  K  Q  K  M  R  |  T  G  S  L      p.580

          .         .         .         .         .         .       g.66381
 CCTCATTCATCTGAACAGTTGCTGGGCCACAAAGAGGGTCCTCGGGACTCAATCACATTG       c.1800
 P  H  S  S  E  Q  L  L  G  H  K  E  G  P  R  D  S  I  T  L         p.600

          .         .         .         .         .         .       g.66441
 TTGGATGCTAAAGAATTGCTGAAGTACTTTACCTCAGATGGATTACCCATTGGAGATCTT       c.1860
 L  D  A  K  E  L  L  K  Y  F  T  S  D  G  L  P  I  G  D  L         p.620

          .         .    | 17    .         .         .         .    g.69573
 CAACCTTTACCGATTCAAAAGGG | GGAAAAGACTTTTGTTTTGACACCAGAACTTAGTCCT    c.1920
 Q  P  L  P  I  Q  K  G  |  E  K  T  F  V  L  T  P  E  L  S  P      p.640

          .         .         .         .         .          | 18    g.75528
 GGGAAACTTCAGGTCTTACCTTTTGAGAAAGCCTCAGTATGTCATTATCATGGAATTGA | A    c.1980
 G  K  L  Q  V  L  P  F  E  K  A  S  V  C  H  Y  H  G  I  E  |      p.660

          .         .         .         .         .         .       g.75588
 TATTGCTTGGATGACCGAAAAGCTTTGGAAAGAGATGGAGGATTTTCTGAACTTCAGTCT       c.2040
 Y  C  L  D  D  R  K  A  L  E  R  D  G  G  F  S  E  L  Q  S         p.680

          .         .         .         .         .         .       g.75648
 CGTCTTATTCGTTATGAAACTCAAACTACCTGCACCAGAGAAAGTTTTCCAGTACCTACT       c.2100
 R  L  I  R  Y  E  T  Q  T  T  C  T  R  E  S  F  P  V  P  T         p.700

          .         .         .         .         .         .       g.75708
 GTGTTGAGCCCTCTTCCATCTCCTGTAGTTTCGTCAGATCCTGGAAGTGTCCCTGACGGA       c.2160
 V  L  S  P  L  P  S  P  V  V  S  S  D  P  G  S  V  P  D  G         p.720

          .         .         .         .         .         .       g.75768
 GAAGTTTTACAAAATGAACTTCGAACTGAAGTATCCCGATTGAAACGGAGATCTAAAGAT       c.2220
 E  V  L  Q  N  E  L  R  T  E  V  S  R  L  K  R  R  S  K  D         p.740

          .         .       | 19 .         .         .         .    g.77487
 CTGAATTGCCTTTATCCCAGAAAAAG | ACTTGTGAAATCTGAAAGTTCAGAGTCTCTTCTT    c.2280
 L  N  C  L  Y  P  R  K  R  |  L  V  K  S  E  S  S  E  S  L  L      p.760

          .         .         .         .         .         .       g.77547
 TCTCAGACAACTGGTAATAGTAATCACTATCATCATCATGTGACATCCAGAAAGCCACAA       c.2340
 S  Q  T  T  G  N  S  N  H  Y  H  H  H  V  T  S  R  K  P  Q         p.780

          .         .         .         .         .         .       g.77607
 ACAGAACGGTCCTTACCAGTGACTTGTCCATTGGTTCCAATTCCTAGCTGTGAAACTCCA       c.2400
 T  E  R  S  L  P  V  T  C  P  L  V  P  I  P  S  C  E  T  P         p.800

          .         .         .         .         .         .       g.77667
 AAACTTGCTACAAAGACCAGTTCAGGTCAAAAAAGTATGCATGAATCAAAAACATCAAGG       c.2460
 K  L  A  T  K  T  S  S  G  Q  K  S  M  H  E  S  K  T  S  R         p.820

          .         .         .       | 20 .         .         .    g.78330
 CAAATTAAGGAATCAAGATCACAGAAACACACACGG | ATACTGAAAGAAGTAGTTACTGAA    c.2520
 Q  I  K  E  S  R  S  Q  K  H  T  R   | I  L  K  E  V  V  T  E      p.840

          .         .         .         .         .         .       g.78390
 ACCCTGAAGAAACACAGTATTACCGAGACTCATGAATGTTTCACTGCATGCAGCCAGCGT       c.2580
 T  L  K  K  H  S  I  T  E  T  H  E  C  F  T  A  C  S  Q  R         p.860

          .         .         . | 21       .         .         .    g.82286
 CTCTTTGAAATCTCTAAGTTCTATCTAAAG | GATCTTAAAACTTCAAGGGGTCTATTTGAA    c.2640
 L  F  E  I  S  K  F  Y  L  K   | D  L  K  T  S  R  G  L  F  E      p.880

          .         .         .       | 22 .         .         .    g.82924
 GAAATGAAGAAAACAGCAAACAACAATGCTGTACAG | GTGATTGACTGGGTATTAGAAAAG    c.2700
 E  M  K  K  T  A  N  N  N  A  V  Q   | V  I  D  W  V  L  E  K      p.900

          .                                                         g.82939
 ACAAGCAAGAAATGA                                                    c.2715
 T  S  K  K  X                                                      p.904

          .         .         .         .         .         .       g.82999
 tacataatcattctctttaagacaattataaattggatggagctattattcactacttct       c.*60

          .         .         .         .         .         .       g.83059
 tttcttagtttgaaaattataaacaaattttaagctttattcaaagaatagatgttatat       c.*120

          .         .         .         .         .         .       g.83119
 ttctaaagaatttcatgaatatatattctatatttgtatagtttgagggatgctatgtta       c.*180

          .         .         .         .         .         .       g.83179
 atgtatttttaattagatacatattttgtaaagtgttactatattttaaagttattttta       c.*240

          .         .         .         .         .                 g.83238
 tatgttttaaaatgtttactcttatttaattattacaataaacagaatttttttttttt        c.*299

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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