mitochondrial methionyl-tRNA formyltransferase (MTFMT) - coding DNA reference sequence

(used for variant description)

(last modified September 23, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_139242.3 in the MTFMT gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering MTFMT transcript NM_139242.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5026
                                   agggccggccgccggcggccgaggcg       c.-1

          .         .         .         .         .         .       g.5086
 ATGAGGGTGTTGGTGCGGCGCTGTTGGGGTCCTCCGCTGGCTCATGGCGCCAGGCGTGGG       c.60
 M  R  V  L  V  R  R  C  W  G  P  P  L  A  H  G  A  R  R  G         p.20

          .         .         .         .         .         .       g.5146
 AGGCCGAGTCCCCAGTGGCGAGCACTGGCCCGACTCGGCTGGGAGGACTGCCGGGACTCC       c.120
 R  P  S  P  Q  W  R  A  L  A  R  L  G  W  E  D  C  R  D  S         p.40

          .         .         .         .         .         .       g.5206
 AGAGTCCGCGAGAAGCCTCCCTGGCGGGTGCTCTTCTTCGGCACGGACCAGTTCGCCCGC       c.180
 R  V  R  E  K  P  P  W  R  V  L  F  F  G  T  D  Q  F  A  R         p.60

          .         .          | 02        .         .         .    g.7630
 GAGGCGCTGCGGGCGCTGCACGCCGCCAG | GGAAAACAAAGAAGAAGAGTTAATCGACAAA    c.240
 E  A  L  R  A  L  H  A  A  R  |  E  N  K  E  E  E  L  I  D  K      p.80

          .         .         .         .         .         .       g.7690
 CTGGAGGTGGTCACAATGCCTTCCCCATCACCAAAAGGACTGCCAGTGAAGCAATATGCT       c.300
 L  E  V  V  T  M  P  S  P  S  P  K  G  L  P  V  K  Q  Y  A         p.100

          .         .         .         .         .         .       g.7750
 GTGCAGTCTCAGCTTCCCGTATATGAGTGGCCGGATGTGGGATCTGGAGAATATGATGTT       c.360
 V  Q  S  Q  L  P  V  Y  E  W  P  D  V  G  S  G  E  Y  D  V         p.120

          .         .         .         .         .          | 03    g.10846
 GGAGTAGTGGCTTCGTTTGGCCGACTTTTGAATGAGGCTCTTATTCTTAAATTTCCCTA | T    c.420
 G  V  V  A  S  F  G  R  L  L  N  E  A  L  I  L  K  F  P  Y  |      p.140

          .         .         .         .         .         .       g.10906
 GGCATATTGAATGTTCATCCCAGTTGCCTCCCGAGATGGCGTGGCCCAGCCCCTGTAATC       c.480
 G  I  L  N  V  H  P  S  C  L  P  R  W  R  G  P  A  P  V  I         p.160

          .         .         .         .         .         .       g.10966
 CATACAGTGCTTCACGGAGACACAGTTACTGGAGTAACAATTATGCAAATTAGACCTAAA       c.540
 H  T  V  L  H  G  D  T  V  T  G  V  T  I  M  Q  I  R  P  K         p.180

    | 04     .         .         .         .         .         .    g.13081
 AG | GTTTGATGTAGGCCCAATTCTCAAACAAGAAACTGTTCCTGTGCCACCCAAGAGCACT    c.600
 R  |  F  D  V  G  P  I  L  K  Q  E  T  V  P  V  P  P  K  S  T      p.200

          .         .         .         .      | 05  .         .    g.14382
 GCAAAGGAATTGGAAGCAGTGTTGTCAAGACTGGGTGCCAACATG | CTCATTTCAGTTTTG    c.660
 A  K  E  L  E  A  V  L  S  R  L  G  A  N  M   | L  I  S  V  L      p.220

          .         .         .         .         .         .       g.14442
 AAAAATTTGCCTGAAAGTCTGAGCAATGGAAGGCAGCAGCCAATGGAGGGGGCGACTTAC       c.720
 K  N  L  P  E  S  L  S  N  G  R  Q  Q  P  M  E  G  A  T  Y         p.240

   | 06      .         .         .         .         .         .    g.18171
 G | CCCCTAAGATTTCTGCTGGTACCAGTTGTATAAAATGGGAGGAACAAACTTCAGAACAA    c.780
 A |   P  K  I  S  A  G  T  S  C  I  K  W  E  E  Q  T  S  E  Q      p.260

          .         .         .    | 07    .         .         .    g.28475
 ATATTCAGACTTTACCGTGCCATTGGAAATATA | ATTCCGTTGCAGACGCTCTGGATGGCG    c.840
 I  F  R  L  Y  R  A  I  G  N  I   | I  P  L  Q  T  L  W  M  A      p.280

          .         .         .         .         .   | 08     .    g.29711
 AATACCATTAAACTTCTGGATTTGGTAGAAGTTAACAGTTCAGTCCTTGCTG | ATCCAAAA    c.900
 N  T  I  K  L  L  D  L  V  E  V  N  S  S  V  L  A  D |   P  K      p.300

          .         .         .         .         .         .       g.29771
 TTAACGGGACAGGCTCTTATTCCAGGATCAGTAATATACCACAAACAGTCACAAATACTA       c.960
 L  T  G  Q  A  L  I  P  G  S  V  I  Y  H  K  Q  S  Q  I  L         p.320

          .      | 09  .         .         .         .         .    g.31428
 TTGGTTTATTGCAAG | GATGGTTGGATTGGTGTTCGATCAGTGATGCTCAAGAAATCACTA    c.1020
 L  V  Y  C  K   | D  G  W  I  G  V  R  S  V  M  L  K  K  S  L      p.340

          .         .         .         .         .         .       g.31488
 ACAGCTACTGACTTCTACAATGGATATTTGCACCCCTGGTACCAGAAAAATTCCCAAGCT       c.1080
 T  A  T  D  F  Y  N  G  Y  L  H  P  W  Y  Q  K  N  S  Q  A         p.360

          .         .         .         .         .         .       g.31548
 CAACCAAGCCAATGCAGATTTCAGACTCTCAGACTTCCAACAAAGAAGAAGCAGAAAAAA       c.1140
 Q  P  S  Q  C  R  F  Q  T  L  R  L  P  T  K  K  K  Q  K  K         p.380

          .         .         .                                     g.31578
 ACTGTTGCTATGCAACAATGCATTGAGTAG                                     c.1170
 T  V  A  M  Q  Q  C  I  E  X                                       p.389

          .         .         .         .         .         .       g.31638
 ttaggaagaagatggataaaaacctattacatatttgtaatttattaaaaaccttattta       c.*60

          .         .         .         .         .         .       g.31698
 caaggaattatctggacttttttttttttttttttttttgagacagagtctcactctgtc       c.*120

          .         .         .         .         .         .       g.31758
 acccaggctggaatccagtggcactatctcagctcactgcaacctccgcctcccaggttc       c.*180

          .         .         .         .         .         .       g.31818
 aagcaattctcctgcctcagcctcctgagtagctgggattacaggcacacgccaccacac       c.*240

          .         .         .         .         .         .       g.31878
 gcagctaatttttgtatttttagtagagatggggtttcaccatgttggtcaggctggtct       c.*300

          .         .         .         .         .         .       g.31938
 cgaactcctgaccttgtgatctgcccacctcagcctcccaaagtgctatgattacagacg       c.*360

          .         .         .         .         .         .       g.31998
 tgagccaccgtgcctggcctggaattatctggactttcaaagaagatggcattattataa       c.*420

          .         .         .         .         .         .       g.32058
 gaagagaagattattgccgaaaagatggattgcctcactttccactttttatgtaacagt       c.*480

          .         .         .         .         .         .       g.32118
 agttaaaaaacagctttttttttacttgaattacaaaaaagtttaaataaaacttgtatt       c.*540

          .         .         .         .         .         .       g.32178
 tatgatacgaaactcaaggagattatctttccttaagaacaagggcaaccctaactggtg       c.*600

          .         .         .         .         .         .       g.32238
 tatgtatgtacctacatacatactgagaagaggttttttgtttttatttttatttttttg       c.*660

          .         .         .         .         .         .       g.32298
 agacggagtcttgttctgtggcccaggctggagtgcagtggcgtgatgtcagctcactgc       c.*720

          .         .         .         .         .         .       g.32358
 aagctccacctcccgggttcacaccattctcctgcctcagcctcccaagtagctgggact       c.*780

          .         .         .         .         .         .       g.32418
 acaggcgtccgccaccatgcctggctaatttttttttttgtatttttagtagagatgggg       c.*840

          .         .         .         .         .         .       g.32478
 tttcactgtgttagccaggatggtcttgatctcctgacctcgtgatccacccgccttggc       c.*900

          .         .         .         .         .         .       g.32538
 ctcccaaagtgctgggattacagctgtgagccaccgtgcctggccgagaagaggtttttt       c.*960

          .         .         .         .         .         .       g.32598
 taaaaacagtgcatctatttaattttttaaaaatcgtgtcaccactgacattttaggagt       c.*1020

          .         .         .         .         .         .       g.32658
 attgaatctgcattttttatttcctataagtagtaaatccagctctttacatttcactac       c.*1080

          .         .         .         .         .         .       g.32718
 cagctagatttaaccaagtagtaaacgtaggtaatatttaataatctctgccacattgat       c.*1140

          .         .         .         .         .         .       g.32778
 ctgtactataaattaacattttacatccagattttatttttttttattaatttttttaga       c.*1200

          .         .         .         .         .         .       g.32838
 gatggggtcttgctctctcacacagtctggagtccagtggcgtgaaacactgcttactgc       c.*1260

          .         .         .         .         .         .       g.32898
 atcttcaacctcctgggcttaagtgatcctccagcctcagcctcccaaagtggggccacc       c.*1320

          .         .         .         .         .         .       g.32958
 acgcctggctaattttctttcttagtttttaaaaaaaattttgtagagataggggtctca       c.*1380

          .         .         .         .         .         .       g.33018
 ctatgttgcttaggctggtcttgaactcctgggcccaagcaatcctcctgccttggcctc       c.*1440

          .         .         .         .         .         .       g.33078
 tcaaagtgctgggattacaagcatgaaccactgcacccggcccaggttttcttgaagtag       c.*1500

          .         .         .         .         .                 g.33128
 gaacgtgctaacatttttcaacttacttgtgcaataaaggttattgagca                 c.*1550

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mitochondrial methionyl-tRNA formyltransferase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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