myotubularin related protein 2 (MTMR2) - coding DNA reference sequence

(used for variant description)

(last modified December 28, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_016156.5 in the MTMR2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008333.1, covering MTMR2 transcript NM_016156.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                agatgtcgcgcgg       c.-241

 .         .         .         .         .         .                g.5073
 ccggacacagccagcacggagagtcgatgccggcgtctgagctgcgcagtggggtcttcc       c.-181

 .         .         .         .         .         .                g.5133
 cgctgcccagcagcctacaggcgcggtgcactctgggggaacatggccgcttccggtctc       c.-121

 .         .         .         .         .         .                g.5193
 cctcccgggccggcgctggcctgactgcggccccggtccgtagcactccgccctccgctt       c.-61

 .         .         .         .         .         .                g.5253
 ctcccgccctgtagccgcgaagactgcttcagcctttccctgtgctgcccctgccgcgcg       c.-1

          .         .         .         .         .         .       g.5313
 ATGGAGAAGAGCTCGAGCTGCGAGAGTCTTGGCTCCCAGCCGGCGGCGGCTCGGCCGCCC       c.60
 M  E  K  S  S  S  C  E  S  L  G  S  Q  P  A  A  A  R  P  P         p.20

          .         . | 02       .         .         .         .    g.40986
 AGCGTGGACTCCTTGTCCAG | TGCCTCCACTTCTCATTCAGAGAATTCAGTGCATACAAAA    c.120
 S  V  D  S  L  S  S  |  A  S  T  S  H  S  E  N  S  V  H  T  K      p.40

          .         .         .         .         .         .       g.41046
 TCAGCTTCTGTTGTATCATCAGATTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGAT       c.180
 S  A  S  V  V  S  S  D  S  I  S  T  S  A  D  N  F  S  P  D         p.60

        | 03 .         .         .         .         .         .    g.63585
 TTGAGG | GTCCTGAGGGAGTCTAACAAGTTAGCAGAAATGGAAGAACCACCCTTGCTTCCA    c.240
 L  R   | V  L  R  E  S  N  K  L  A  E  M  E  E  P  P  L  L  P      p.80

          .         .   | 04     .         .         .         .    g.66879
 GGAGAAAATATTAAAGACATGG | CCAAAGATGTAACTTATATATGTCCATTCACTGGCGCT    c.300
 G  E  N  I  K  D  M  A |   K  D  V  T  Y  I  C  P  F  T  G  A      p.100

          .         .         .         .         .        | 05.    g.67108
 GTACGAGGAACTCTGACTGTCACGAATTATAGGTTATATTTCAAAAGCATGGAACGG | GAT    c.360
 V  R  G  T  L  T  V  T  N  Y  R  L  Y  F  K  S  M  E  R   | D      p.120

          .         .         .         .         .         .       g.67168
 CCCCCATTTGTTTTAGATGCTTCCCTTGGTGTGATAAATAGAGTAGAAAAAATTGGTGGT       c.420
 P  P  F  V  L  D  A  S  L  G  V  I  N  R  V  E  K  I  G  G         p.140

          .         .         .         .         | 06         .    g.70587
 GCTTCTAGTCGAGGTGAAAATTCTTATGGACTAGAAACTGTGTGTAAG | GATATTAGGAAT    c.480
 A  S  S  R  G  E  N  S  Y  G  L  E  T  V  C  K   | D  I  R  N      p.160

          .         .         .         .         .         .       g.70647
 TTACGATTTGCTCATAAACCTGAGGGGCGGACAAGAAGATCCATATTTGAGAATCTAATG       c.540
 L  R  F  A  H  K  P  E  G  R  T  R  R  S  I  F  E  N  L  M         p.180

          .         .         . | 07       .         .         .    g.71602
 AAATATGCATTTCCTGTCTCTAATAACCTG | CCTCTTTTTGCTTTTGAATACAAAGAAGTA    c.600
 K  Y  A  F  P  V  S  N  N  L   | P  L  F  A  F  E  Y  K  E  V      p.200

          .         .         .         .         .     | 08   .    g.78464
 TTCCCTGAAAATGGGTGGAAGCTATATGACCCTCTTTTAGAGTATAGAAGGCAG | GGAATT    c.660
 F  P  E  N  G  W  K  L  Y  D  P  L  L  E  Y  R  R  Q   | G  I      p.220

          .         .         .         .         .         .       g.78524
 CCAAATGAAAGCTGGAGAATAACAAAGATAAATGAACGATATGAACTTTGTGATACATAC       c.720
 P  N  E  S  W  R  I  T  K  I  N  E  R  Y  E  L  C  D  T  Y         p.240

          .         .         .         .         .         .       g.78584
 CCTGCCCTCCTGGTTGTGCCAGCAAATATTCCTGATGAAGAATTAAAGAGAGTGGCATCC       c.780
 P  A  L  L  V  V  P  A  N  I  P  D  E  E  L  K  R  V  A  S         p.260

          .         .     | 09   .         .         .         .    g.79381
 TTCAGATCAAGAGGCCGTATCCCA | GTTTTATCATGGATTCATCCTGAAAGTCAAGCCACA    c.840
 F  R  S  R  G  R  I  P   | V  L  S  W  I  H  P  E  S  Q  A  T      p.280

          .         .         .         .         .         .       g.79441
 ATCACTCGGTGTAGCCAGCCCATGGTTGGAGTGAGTGGAAAGCGAAGCAAAGAAGATGAA       c.900
 I  T  R  C  S  Q  P  M  V  G  V  S  G  K  R  S  K  E  D  E         p.300

          .         .         .         .         .         .       g.79501
 AAATACCTTCAAGCTATCATGGATTCCAATGCCCAGTCTCACAAAATCTTTATATTTGAT       c.960
 K  Y  L  Q  A  I  M  D  S  N  A  Q  S  H  K  I  F  I  F  D         p.320

          .         .         .    | 10    .         .         .    g.81335
 GCCCGGCCAAGTGTTAATGCTGTTGCCAACAAG | GCAAAGGGTGGAGGTTATGAAAGTGAA    c.1020
 A  R  P  S  V  N  A  V  A  N  K   | A  K  G  G  G  Y  E  S  E      p.340

          .         .         .         .         .         .       g.81395
 GATGCCTATCAAAATGCTGAACTAGTTTTCCTGGATATCCACAATATTCATGTTATGAGA       c.1080
 D  A  Y  Q  N  A  E  L  V  F  L  D  I  H  N  I  H  V  M  R         p.360

          .         .         .         .         .         .       g.81455
 GAATCATTACGAAAACTTAAGGAGATTGTGTACCCCAACATTGAGGAAACCCACTGGTTG       c.1140
 E  S  L  R  K  L  K  E  I  V  Y  P  N  I  E  E  T  H  W  L         p.380

          .         .         .          | 11        .         .    g.84069
 TCTAACTTGGAATCTACTCATTGGCTAGAACATATTAAG | CTTATTCTTGCAGGGGCTCTT    c.1200
 S  N  L  E  S  T  H  W  L  E  H  I  K   | L  I  L  A  G  A  L      p.400

          .         .         .         .         .         .       g.84129
 AGGATTGCTGACAAGGTAGAGTCAGGGAAGACGTCTGTGGTAGTGCATTGCAGTGATGGT       c.1260
 R  I  A  D  K  V  E  S  G  K  T  S  V  V  V  H  C  S  D  G         p.420

          .         .         .         .         .         .       g.84189
 TGGGATCGCACAGCTCAGCTCACTTCCCTTGCCATGCTCATGTTGGATGGATACTATCGA       c.1320
 W  D  R  T  A  Q  L  T  S  L  A  M  L  M  L  D  G  Y  Y  R         p.440

          .         .         .         .         .         .       g.84249
 ACCATCCGAGGATTTGAAGTCCTTGTGGAGAAAGAATGGCTAAGTTTTGGACATCGATTT       c.1380
 T  I  R  G  F  E  V  L  V  E  K  E  W  L  S  F  G  H  R  F         p.460

        | 12 .         .         .         .         .         .    g.87552
 CAACTA | AGAGTTGGCCATGGAGATAAGAACCATGCAGATGCAGACAGATCGCCTGTTTTT    c.1440
 Q  L   | R  V  G  H  G  D  K  N  H  A  D  A  D  R  S  P  V  F      p.480

          .         .         .          | 13        .         .    g.91021
 CTTCAATTTATTGACTGTGTCTGGCAGATGACAAGACAG | TTTCCTACCGCATTTGAATTC    c.1500
 L  Q  F  I  D  C  V  W  Q  M  T  R  Q   | F  P  T  A  F  E  F      p.500

          .         .         .         .         .         .       g.91081
 AATGAGTATTTTCTCATTACCATTTTGGACCACCTATACAGCTGCTTATTCGGAACATTC       c.1560
 N  E  Y  F  L  I  T  I  L  D  H  L  Y  S  C  L  F  G  T  F         p.520

          .         .         .    | 14    .         .         .    g.92910
 CTCTGTAATAGTGAACAACAGAGAGGAAAAGAG | AATCTTCCTAAAAGGACTGTGTCACTG    c.1620
 L  C  N  S  E  Q  Q  R  G  K  E   | N  L  P  K  R  T  V  S  L      p.540

          .         .         .         .         .         .       g.92970
 TGGTCTTACATAAACAGCCAGCTGGAAGACTTCACTAATCCTCTCTATGGGAGCTATTCC       c.1680
 W  S  Y  I  N  S  Q  L  E  D  F  T  N  P  L  Y  G  S  Y  S         p.560

          .         .         .         .         .         .       g.93030
 AATCATGTCCTTTATCCAGTAGCCAGCATGCGCCACCTAGAGCTCTGGGTGGGATATTAC       c.1740
 N  H  V  L  Y  P  V  A  S  M  R  H  L  E  L  W  V  G  Y  Y         p.580

          .         .         . | 15       .         .         .    g.93786
 ATAAGGTGGAATCCACGGATGAAACCACAG | GAACCTATTCACAACAGATACAAAGAACTT    c.1800
 I  R  W  N  P  R  M  K  P  Q   | E  P  I  H  N  R  Y  K  E  L      p.600

          .         .         .         .         .         .       g.93846
 CTTGCTAAACGAGCAGAGCTTCAGAAAAAAGTAGAGGAACTACAGAGAGAGATTTCTAAC       c.1860
 L  A  K  R  A  E  L  Q  K  K  V  E  E  L  Q  R  E  I  S  N         p.620

          .         .         .         .         .         .       g.93906
 CGATCAACCTCATCCTCAGAGAGAGCCAGCTCTCCTGCACAGTGTGTCACTCCTGTCCAA       c.1920
 R  S  T  S  S  S  E  R  A  S  S  P  A  Q  C  V  T  P  V  Q         p.640

          .                                                         g.93918
 ACTGTTGTATAA                                                       c.1932
 T  V  V  X                                                         p.643

          .         .         .         .         .         .       g.93978
 aggactgtaagatcaggggcatcattgctatacactcttgattacactggcagctctatg       c.*60

          .         .         .         .         .         .       g.94038
 agtagaaagtcttcggaatttagaacccatctatgagagaaagttcagtcactttattta       c.*120

          .         .         .         .         .         .       g.94098
 ttttaaatctctctaggatgagtttagaactgtagcagtgcaggtggcttaagtgaagta       c.*180

          .         .         .         .         .         .       g.94158
 actccatatgtaattacatgattatgatactaatcttttaagtatccaaagaatattaaa       c.*240

          .         .         .         .         .         .       g.94218
 atacttcaatcctggattcacagtgggaacaagtttctattaaaaggcaaatgctgttac       c.*300

          .         .         .         .         .         .       g.94278
 aaatttttggcatctggtaatattaaaaccattttagaaatacactctgtgctcactgtg       c.*360

          .         .         .         .         .         .       g.94338
 cagaggaacatcagttttcaaaccaacactgaaattctgtggcatcacatatattgggcc       c.*420

          .         .         .         .         .         .       g.94398
 ttgatgtcatgacagatcaaaatcatttgatatccctttctccattctaggtttttcttt       c.*480

          .         .         .         .         .         .       g.94458
 ttttcagtaactgatttaccttgatcacttttcaacttccatattcttcatatagtaaaa       c.*540

          .         .         .         .         .         .       g.94518
 ggcaaagtgttgaagatactacggtgtggtagtagttgaaaattattgccgtcattattt       c.*600

          .         .         .         .         .         .       g.94578
 acatacttaagacatattagcaagttgatccaaaatgggaggccttatagatgtgcttgg       c.*660

          .         .         .         .         .         .       g.94638
 gggaaaatgaaggggagaaagtagccatacaggagttcaaagaattccatgcccttcaga       c.*720

          .         .         .         .         .         .       g.94698
 ttagcccaattaccagaaacatcatgaaagatattttaaaaactaattatttactacagt       c.*780

          .         .         .         .         .         .       g.94758
 gtatttcacttgtcttgtgtgtctgaacacacagaagctaattagcaagtttttaagaag       c.*840

          .         .         .         .         .         .       g.94818
 tatttaaaaatcttactaggattgacattttttctgaattctgtataaatagcttatagt       c.*900

          .         .         .         .         .         .       g.94878
 gagaagtactgtgctcaaattttacatttttttcctttgcaaattctgtaatttcactca       c.*960

          .         .         .         .         .         .       g.94938
 acgattaagtctaccaaagaacacactgcatgtaaaagatgtattacaatctcaaagcca       c.*1020

          .         .         .         .         .         .       g.94998
 gtaaaagaaatcttgcttcactgttcacctgctacaagtaagagtttggtgctggtagaa       c.*1080

          .         .         .         .         .         .       g.95058
 acatttgactctgatgtctattttattctacataagagccatatgtaatgtactgtaaca       c.*1140

          .         .         .         .         .         .       g.95118
 aaggagcttcttgtccccttggtcttttaattaaaagaaattccaactgacttttaaact       c.*1200

          .         .         .         .         .         .       g.95178
 ttgttcttgtccaaagttgccatttcttttttttccccagaaatatttggaaattattgg       c.*1260

          .         .         .         .         .         .       g.95238
 aggaatatgcaccccagatgaaaatgttcagtttgtacccatttttccttaaccaacacc       c.*1320

          .         .         .         .         .         .       g.95298
 caaatcaaacaattaaaatatacagtgtttttccactcactaattcactatacagagagt       c.*1380

          .         .         .         .         .         .       g.95358
 ctgaaccttagcctccctcttggtcttgcagtgaggaagtttctattagtatatccaatt       c.*1440

          .         .         .         .         .         .       g.95418
 tagcaaaattggtaccaaaatgatttctttggtaattgtgtgaaatataagctttttaac       c.*1500

          .         .         .         .         .         .       g.95478
 agggcatttaagtggctagcaaatcagtaattaaaaattaagctttctactccaagtatt       c.*1560

          .         .         .         .         .         .       g.95538
 tcacaaacgcatctgccattttcctcatttaaaccttggttatcttggcctgataccaca       c.*1620

          .         .         .         .         .         .       g.95598
 taaaagaatgtagaatggctgaagagatcaagaatttaaagcttctagtcttaacatact       c.*1680

          .         .         .         .         .         .       g.95658
 tgcatccacttcaaattcaaatcaaaagccagggaaatctaagtgcaaccctaccacttc       c.*1740

          .         .         .         .         .         .       g.95718
 tctgctgagaaccttccagtggttcccctcaccttctgcagaagtctccaatatggagta       c.*1800

          .         .         .         .         .         .       g.95778
 catgcacttgggcatttaatatataccactggtgtgtgtgggagggagggaggaggaata       c.*1860

          .         .         .         .         .         .       g.95838
 ctagccctttttatatatttacacaagcaaaacttttaaatatttgaattgacagttaca       c.*1920

          .         .         .         .         .         .       g.95898
 tgtttcataactttgtatgtctattggttgtgcaggtgtaattttttccctttttgatta       c.*1980

          .         .         .         .         .         .       g.95958
 gggttacaaaatttagagaccagtatgattaagttgaagctccttagcctccttcgacct       c.*2040

          .         .         .         .         .         .       g.96018
 agtctctgcatacctcaacttttacgtaccaatgctactctgctgttcacaattgcctca       c.*2100

          .         .         .         .         .         .       g.96078
 tgtaatctgcagattcctgcctccccactttggttcagtctgtcttgtgcacctggaaca       c.*2160

          .         .         .         .         .         .       g.96138
 actgttctcccttgtgactaattcctattttctagagtttaggcatcatctcttcctttg       c.*2220

          .         .         .         .         .         .       g.96198
 ggaagttatctgattcacgactgccttctctgacatccccaccttcctctgtgcccccat       c.*2280

          .         .         .         .         .         .       g.96258
 agcactgtgtataccgctactaccactgcaattcacattatattggaatgaacaattcac       c.*2340

          .         .         .         .         .         .       g.96318
 atgtctaccacaagtctgtaaacataaccttatttgaaatgaattgcaataaagctctgt       c.*2400

          .                                                         g.96328
 tacaacgtaa                                                         c.*2410

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Myotubularin related protein 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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