mitochondrial translation optimization 1 homolog (S. cerevisiae) (MTO1) - coding DNA reference sequence

(used for variant description)

(last modified February 25, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_133645.2 in the MTO1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering MTO1 transcript NM_133645.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         gtag       c.-121

 .         .         .         .         .         .                g.5064
 acgtcctaccccgtgatattaaagcaagatggccgcgccctgcagattgtctcttgttgc       c.-61

 .         .         .         .         .         .                g.5124
 gtaagtttttttgaccgtcactcgtgtcagcttcaaagtcagatagatttttctcccagc       c.-1

          .         .         .         .         .         .       g.5184
 ATGTTCTACTTCCGAGGCTGTGGCCGTTGGGTCGCGGTTTCCTTCACCAAGCAGCAATTT       c.60
 M  F  Y  F  R  G  C  G  R  W  V  A  V  S  F  T  K  Q  Q  F         p.20

          .         .         .         .         .         .       g.5244
 CCGTTGGCACGGTTGAGCAGTGACAGCGCGGCGCCCCGGACTCCGCACTTCGACGTGATA       c.120
 P  L  A  R  L  S  S  D  S  A  A  P  R  T  P  H  F  D  V  I         p.40

          .         .         .         .         .         .       g.5304
 GTCATTGGTGGAGGACATGCCGGGACTGAGGCAGCCACCGCCGCCGCTCGGTGCGGCTCT       c.180
 V  I  G  G  G  H  A  G  T  E  A  A  T  A  A  A  R  C  G  S         p.60

          .         .         .        | 02.         .         .    g.9501
 CGGACTCTGCTCCTCACTCACCGCGTGGACACGATCG | GTCAGATGTCATGTAATCCTTCC    c.240
 R  T  L  L  L  T  H  R  V  D  T  I  G |   Q  M  S  C  N  P  S      p.80

          .         .         .         .         .         .       g.9561
 TTTGGTGGCATCGGAAAGGGACATTTAATGAGGGAAGTAGATGCCTTGGATGGCCTGTGT       c.300
 F  G  G  I  G  K  G  H  L  M  R  E  V  D  A  L  D  G  L  C         p.100

          .         .         .         .         .         .       g.9621
 TCTCGCATCTGTGACCAGTCTGGTGTACATTATAAAGTATTAAACCGGCGTAAGGGACCA       c.360
 S  R  I  C  D  Q  S  G  V  H  Y  K  V  L  N  R  R  K  G  P         p.120

          .         .         .         .         .        | 03.    g.9761
 GCTGTGTGGGGTCTGAGAGCTCAGATTGATAGGAAACTCTATAAACAGAACATGCAG | AAA    c.420
 A  V  W  G  L  R  A  Q  I  D  R  K  L  Y  K  Q  N  M  Q   | K      p.140

          .         .         .         .         .         .       g.9821
 GAAATCTTGAATACACCACTGCTTACTGTTCAGGAGGGAGCTGTAGAAGATCTTATTCTT       c.480
 E  I  L  N  T  P  L  L  T  V  Q  E  G  A  V  E  D  L  I  L         p.160

          .         .         .         .         .      | 04  .    g.16639
 ACAGAACCAGAGCCTGAACACACTGGGAAATGCCGTGTCAGTGGGGTTGTTTTGG | TGGAT    c.540
 T  E  P  E  P  E  H  T  G  K  C  R  V  S  G  V  V  L  V |   D      p.180

          .         .         .         .         .         .       g.16699
 GGAAGCACAGTATATGCAGAGAGTGTGATTCTGACTACTGGGACATTTCTGAGAGGCATG       c.600
 G  S  T  V  Y  A  E  S  V  I  L  T  T  G  T  F  L  R  G  M         p.200

          .         .         .         .         .         .       g.16759
 ATTGTAATTGGATTGGAGACGCATCCAGCAGGACGTTTAGGGGATCAGCCTTCTATAGGA       c.660
 I  V  I  G  L  E  T  H  P  A  G  R  L  G  D  Q  P  S  I  G         p.220

          .         .         .         .         .         .       g.16819
 TTGGCTCAGACACTGGAGAAGTTAGGGTTTGTGGTGGGAAGGTTGAAGACTGGGACTCCA       c.720
 L  A  Q  T  L  E  K  L  G  F  V  V  G  R  L  K  T  G  T  P         p.240

          .         .         .         .         .         .       g.16879
 CCCCGAATTGCCAAAGAGTCCATTAATTTCAGTATTCTAAACAAGCATATACCGGACAAT       c.780
 P  R  I  A  K  E  S  I  N  F  S  I  L  N  K  H  I  P  D  N         p.260

          .         .         .         .      | 05  .         .    g.23016
 CCATCCATACCATTCAGCTTTACCAATGAGACAGTATGGATTAAG | CCAGAAGATCAGCTG    c.840
 P  S  I  P  F  S  F  T  N  E  T  V  W  I  K   | P  E  D  Q  L      p.280

          .         .         .         .         .         .       g.23076
 CCATGTTACTTGACTCACACCAACCCTAGAGTGGATGAGATTGTCCTTAAGAACCTTCAC       c.900
 P  C  Y  L  T  H  T  N  P  R  V  D  E  I  V  L  K  N  L  H         p.300

          .         .         .         | 06         .         .    g.23227
 CTTAATAGTCATGTTAAAGAAACGACAAGAGGACCTCG | ATACTGTCCCTCCATTGAATCA    c.960
 L  N  S  H  V  K  E  T  T  R  G  P  R  |  Y  C  P  S  I  E  S      p.320

          .         .         .         .         .         .       g.23287
 AAAGTTTTGCGTTTTCCAAACCGTCTACATCAGGTTTGGTTGGAACCTGAAGGAATGGAT       c.1020
 K  V  L  R  F  P  N  R  L  H  Q  V  W  L  E  P  E  G  M  D         p.340

          .         .         .         .         .         .       g.23347
 TCTGACCTTATCTACCCACAGGGGTTATCTATGACGCTACCAGCTGAGTTACAAGAGAAA       c.1080
 S  D  L  I  Y  P  Q  G  L  S  M  T  L  P  A  E  L  Q  E  K         p.360

          .         .         .         .          | 07        .    g.23573
 ATGATCACATGCATCAGAGGCTTGGAGAAAGCTAAAGTGATTCAGCCAG | ACGGAGTTTTG    c.1140
 M  I  T  C  I  R  G  L  E  K  A  K  V  I  Q  P  D |   G  V  L      p.380

          .         .         .         .         .         .       g.23633
 CTCTTGTTGCCCAGGATGGAGTGCAATGGTGCGATCTCGGCTCACCACAACCTCCCCCTG       c.1200
 L  L  L  P  R  M  E  C  N  G  A  I  S  A  H  H  N  L  P  L         p.400

      | 08   .         .         .         .         .         .    g.24000
 CCAG | GCTACGGTGTTCAGTATGATTACTTAGATCCCCGTCAGATCACCCCTTCCTTGGAG    c.1260
 P  G |   Y  G  V  Q  Y  D  Y  L  D  P  R  Q  I  T  P  S  L  E      p.420

          .         .         .         .         .         .       g.24060
 ACTCATTTGGTTCAACGACTCTTCTTTGCTGGACAGATCAATGGCACCACTGGTTATGAG       c.1320
 T  H  L  V  Q  R  L  F  F  A  G  Q  I  N  G  T  T  G  Y  E         p.440

          .      | 09  .         .         .         .         .    g.25354
 GAAGCTGCAGCTCAA | GGTGTGATAGCCGGAATCAACGCCAGTCTTCGGGTCAGTCGCAAG    c.1380
 E  A  A  A  Q   | G  V  I  A  G  I  N  A  S  L  R  V  S  R  K      p.460

          .         .         .         .         .         .       g.25414
 CCTCCCTTTGTGGTTAGCCGAACAGAAGGTTACATAGGAGTCTTGATTGATGACCTCACT       c.1440
 P  P  F  V  V  S  R  T  E  G  Y  I  G  V  L  I  D  D  L  T         p.480

          .         .         .         .         .         .       g.25474
 ACTCTGGGCACCAGTGAACCATACCGCATGTTTACCAGCCGAGTAGAGTTCCGTTTGTCA       c.1500
 T  L  G  T  S  E  P  Y  R  M  F  T  S  R  V  E  F  R  L  S         p.500

          .         .         .         . | 10       .         .    g.25738
 CTGCGCCCTGATAATGCTGACAGCCGGCTCACACTGCGAG | GGTATAAAGACGCTGGCTGT    c.1560
 L  R  P  D  N  A  D  S  R  L  T  L  R  G |   Y  K  D  A  G  C      p.520

          .         .         .         .         .         .       g.25798
 GTGTCCCAACAACGATATGAAAGAGCTTGTTGGATGAAGTCTTCTTTAGAAGAAGGCATT       c.1620
 V  S  Q  Q  R  Y  E  R  A  C  W  M  K  S  S  L  E  E  G  I         p.540

          .         .         .         .         .         .       g.25858
 TCTGTGTTGAAATCTATTGAGTTTTTGAGCTCTAAATGGAAAAAATTAATCCCAGAGGCT       c.1680
 S  V  L  K  S  I  E  F  L  S  S  K  W  K  K  L  I  P  E  A         p.560

          .         .         .   | 11     .         .         .    g.35531
 TCTATAAGTACTAGTAGAAGTCTGCCTGTCAG | AGCTCTCGATGTTCTGAAGTATGAGGAA    c.1740
 S  I  S  T  S  R  S  L  P  V  R  |  A  L  D  V  L  K  Y  E  E      p.580

          .         .         .         .         .         .       g.35591
 GTTGACATGGATTCATTAGCCAAGGCTGTTCCAGAGCCCTTGAAGAAGTATACTAAATGT       c.1800
 V  D  M  D  S  L  A  K  A  V  P  E  P  L  K  K  Y  T  K  C         p.600

          .         .         .  | 12      .         .         .    g.41034
 AGAGAGCTGGCTGAAAGACTGAAAATAGAAG | CCACTTATGAATCAGTGTTGTTCCATCAA    c.1860
 R  E  L  A  E  R  L  K  I  E  A |   T  Y  E  S  V  L  F  H  Q      p.620

          .         .         .         .         .         .       g.41094
 CTACAAGAAATAAAGGGAGTTCAGCAAGATGAAGCTCTCCAACTGCCAAAAGACCTAGAT       c.1920
 L  Q  E  I  K  G  V  Q  Q  D  E  A  L  Q  L  P  K  D  L  D         p.640

          .         .         .         .         .         .       g.41154
 TATTTGACTATCAGGGATGTGTCTTTGTCCCATGAAGTTCGAGAGAAACTACATTTTAGT       c.1980
 Y  L  T  I  R  D  V  S  L  S  H  E  V  R  E  K  L  H  F  S         p.660

          .   | 13     .         .         .         .         .    g.43891
 CGTCCACAGACG | ATCGGGGCTGCTAGTCGCATACCCGGAGTAACACCTGCCGCCATCATC    c.2040
 R  P  Q  T   | I  G  A  A  S  R  I  P  G  V  T  P  A  A  I  I      p.680

          .         .         .         .         .         .       g.43951
 AATCTGCTGAGATTTGTGAAGACCACTCAACGAAGACAGTCGGCTATGAATGAATCATCC       c.2100
 N  L  L  R  F  V  K  T  T  Q  R  R  Q  S  A  M  N  E  S  S         p.700

          .         .         .         .         .                 g.44005
 AAGACTGATCAATACTTATGTGATGCAGACAGACTTCAAGAGAGAGAGTTATAG             c.2154
 K  T  D  Q  Y  L  C  D  A  D  R  L  Q  E  R  E  L  X               p.717

          .         .         .         .         .         .       g.44065
 ctttcaattcataaaagatttttaaagagcatataaataatttgatcaatacaacagtat       c.*60

          .         .         .         .         .         .       g.44125
 agataaaagaattatttagcacatgttaaaatagctttattaggttactatgggtttgcc       c.*120

          .         .         .         .         .         .       g.44185
 attaatttctgagtgggacagaaattataattgtgctttttcgtgtatatgaaaaaacta       c.*180

          .         .         .         .         .         .       g.44245
 gtcgtaaacaatttgtactctttctttaaggagctgtaatacaaataactttgtgcagtg       c.*240

          .         .         .         .         .         .       g.44305
 ttcatcaaagagagagacagtgaacctaaaactgaacctggaataaaactcaacatgcag       c.*300

          .         .         .         .         .         .       g.44365
 atttgcctactcatagggactttgcctattaagtctaccaaattaaaagtcttatcattc       c.*360

          .         .         .         .         .         .       g.44425
 agcgtgttttgagagttaataatcttttgcttggttatactaggctaggaagcaatatca       c.*420

          .         .         .         .         .         .       g.44485
 aagcccttaaattctcaagactaaagacttgagattatataaaattatccagaatcattc       c.*480

          .         .         .         .         .         .       g.44545
 agctaatactattggaatatagtatgtagggtgaaagttgacagaaatctgtacttcttc       c.*540

          .         .         .         .         .         .       g.44605
 aggaaatcctcactggtaattgttttgaacattaatgaaagccctataaaatagaaagat       c.*600

          .         .         .         .         .         .       g.44665
 tggaaatcaccattgtttcctattatccacagtgtggatggatacttatttggtgaccta       c.*660

          .         .         .         .         .         .       g.44725
 gttatgggagaattgagtaacgttagttattttatatcataccataaaaatattttctta       c.*720

                                                                    g.44726
 a                                                                  c.*721

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mitochondrial translation optimization 1 homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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