mechanistic target of rapamycin (serine/threonine kinase) (MTOR) - coding DNA reference sequence

(used for variant description)

(last modified January 21, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_004958.3 in the MTOR gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033239.1, covering MTOR transcript NM_004958.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            g       c.-121

 .         .         .         .         .         .                g.5061
 ctcccggcttagaggacagcggggaaggcgggcggtggggcagggggcctgaagcggcgg       c.-61

 .         .         .         .         .      | 02  .             g.8142
 taccggtgctggcggcggcagctgaggccttggccgaagccgcgcg | aacctcagggcaag    c.-1

          .         .         .         .         .         .       g.8202
 ATGCTTGGAACCGGACCTGCCGCCGCCACCACCGCTGCCACCACATCTAGCAATGTGAGC       c.60
 M  L  G  T  G  P  A  A  A  T  T  A  A  T  T  S  S  N  V  S         p.20

          .         .         .         .         .         .       g.8262
 GTCCTGCAGCAGTTTGCCAGTGGCCTAAAGAGCCGGAATGAGGAAACCAGGGCCAAAGCC       c.120
 V  L  Q  Q  F  A  S  G  L  K  S  R  N  E  E  T  R  A  K  A         p.40

          .         .         .         .   | 03     .         .    g.8976
 GCCAAGGAGCTCCAGCACTATGTCACCATGGAACTCCGAGAG | ATGAGTCAAGAGGAGTCT    c.180
 A  K  E  L  Q  H  Y  V  T  M  E  L  R  E   | M  S  Q  E  E  S      p.60

          .         .         .         .         .         .       g.9036
 ACTCGCTTCTATGACCAACTGAACCATCACATTTTTGAATTGGTTTCCAGCTCAGATGCC       c.240
 T  R  F  Y  D  Q  L  N  H  H  I  F  E  L  V  S  S  S  D  A         p.80

          .         .         .  | 04      .         .         .    g.10415
 AATGAGAGGAAAGGTGGCATCTTGGCCATAG | CTAGCCTCATAGGAGTGGAAGGTGGGAAT    c.300
 N  E  R  K  G  G  I  L  A  I  A |   S  L  I  G  V  E  G  G  N      p.100

          .         .         .         .         .         .       g.10475
 GCCACCCGAATTGGCAGATTTGCCAACTATCTTCGGAACCTCCTCCCCTCCAATGACCCA       c.360
 A  T  R  I  G  R  F  A  N  Y  L  R  N  L  L  P  S  N  D  P         p.120

          .         .         .         .         .         .       g.10535
 GTTGTCATGGAAATGGCATCCAAGGCCATTGGCCGTCTTGCCATGGCAGGGGACACTTTT       c.420
 V  V  M  E  M  A  S  K  A  I  G  R  L  A  M  A  G  D  T  F         p.140

          .         .         .         .         .         .       g.10595
 ACCGCTGAGTACGTGGAATTTGAGGTGAAGCGAGCCCTGGAATGGCTGGGTGCTGACCGC       c.480
 T  A  E  Y  V  E  F  E  V  K  R  A  L  E  W  L  G  A  D  R         p.160

          .         .     | 05   .         .         .         .    g.11395
 AATGAGGGCCGGAGACATGCAGCT | GTCCTGGTTCTCCGTGAGCTGGCCATCAGCGTCCCT    c.540
 N  E  G  R  R  H  A  A   | V  L  V  L  R  E  L  A  I  S  V  P      p.180

          .         .         .         .         .         .       g.11455
 ACCTTCTTCTTCCAGCAAGTGCAACCCTTCTTTGACAACATTTTTGTGGCCGTGTGGGAC       c.600
 T  F  F  F  Q  Q  V  Q  P  F  F  D  N  I  F  V  A  V  W  D         p.200

          .         .         .         .         .         .       g.11515
 CCCAAACAGGCCATCCGTGAGGGAGCTGTAGCCGCCCTTCGTGCCTGTCTGATTCTCACA       c.660
 P  K  Q  A  I  R  E  G  A  V  A  A  L  R  A  C  L  I  L  T         p.220

          .         .         .         .      | 06  .         .    g.13593
 ACCCAGCGTGAGCCGAAGGAGATGCAGAAGCCTCAGTGGTACAGG | CACACATTTGAAGAA    c.720
 T  Q  R  E  P  K  E  M  Q  K  P  Q  W  Y  R   | H  T  F  E  E      p.240

          .         .         .         .         .         .       g.13653
 GCAGAGAAGGGATTTGATGAGACCTTGGCCAAAGAGAAGGGCATGAATCGGGATGATCGG       c.780
 A  E  K  G  F  D  E  T  L  A  K  E  K  G  M  N  R  D  D  R         p.260

          .         .         .         .         .         .       g.13713
 ATCCATGGAGCCTTGTTGATCCTTAACGAGCTGGTCCGAATCAGCAGCATGGAGGGAGAG       c.840
 I  H  G  A  L  L  I  L  N  E  L  V  R  I  S  S  M  E  G  E         p.280

  | 07       .         .         .         .         .         .    g.19517
  | CGTCTGAGAGAAGAAATGGAAGAAATCACACAGCAGCAGCTGGTACACGACAAGTACTGC    c.900
  | R  L  R  E  E  M  E  E  I  T  Q  Q  Q  L  V  H  D  K  Y  C      p.300

          .         .         .         .         .         .       g.19577
 AAAGATCTCATGGGCTTCGGAACAAAACCTCGTCACATTACCCCCTTCACCAGTTTCCAG       c.960
 K  D  L  M  G  F  G  T  K  P  R  H  I  T  P  F  T  S  F  Q         p.320

          .         .         .         .         .         .       g.19637
 GCTGTACAGCCCCAGCAGTCAAATGCCTTGGTGGGGCTGCTGGGGTACAGCTCTCACCAA       c.1020
 A  V  Q  P  Q  Q  S  N  A  L  V  G  L  L  G  Y  S  S  H  Q         p.340

          .         .         .         .         .         .       g.19697
 GGCCTCATGGGATTTGGGACCTCCCCCAGTCCAGCTAAGTCCACCCTGGTGGAGAGCCGG       c.1080
 G  L  M  G  F  G  T  S  P  S  P  A  K  S  T  L  V  E  S  R         p.360

          .         .         .       | 08 .         .         .    g.19842
 TGTTGCAGAGACTTGATGGAGGAGAAATTTGATCAG | GTGTGCCAGTGGGTGCTGAAATGC    c.1140
 C  C  R  D  L  M  E  E  K  F  D  Q   | V  C  Q  W  V  L  K  C      p.380

          .         .         .         .         .         .       g.19902
 AGGAATAGCAAGAACTCGCTGATCCAAATGACAATCCTTAATTTGTTGCCCCGCTTGGCT       c.1200
 R  N  S  K  N  S  L  I  Q  M  T  I  L  N  L  L  P  R  L  A         p.400

          .         .      | 09  .         .         .         .    g.24286
 GCATTCCGACCTTCTGCCTTCACAG | ATACCCAGTATCTCCAAGATACCATGAACCATGTC    c.1260
 A  F  R  P  S  A  F  T  D |   T  Q  Y  L  Q  D  T  M  N  H  V      p.420

          .         .         .         .         .         .       g.24346
 CTAAGCTGTGTCAAGAAGGAGAAGGAACGTACAGCGGCCTTCCAAGCCCTGGGGCTACTT       c.1320
 L  S  C  V  K  K  E  K  E  R  T  A  A  F  Q  A  L  G  L  L         p.440

          .         .         .         .         .         .       g.24406
 TCTGTGGCTGTGAGGTCTGAGTTTAAGGTCTATTTGCCTCGCGTGCTGGACATCATCCGA       c.1380
 S  V  A  V  R  S  E  F  K  V  Y  L  P  R  V  L  D  I  I  R         p.460

          .         .         .   | 10     .         .         .    g.25898
 GCGGCCCTGCCCCCAAAGGACTTCGCCCATAA | GAGGCAGAAGGCAATGCAGGTGGATGCC    c.1440
 A  A  L  P  P  K  D  F  A  H  K  |  R  Q  K  A  M  Q  V  D  A      p.480

          .         .         .         .         .         .       g.25958
 ACAGTCTTCACTTGCATCAGCATGCTGGCTCGAGCAATGGGGCCAGGCATCCAGCAGGAT       c.1500
 T  V  F  T  C  I  S  M  L  A  R  A  M  G  P  G  I  Q  Q  D         p.500

          .         .         .         .  | 11      .         .    g.27023
 ATCAAGGAGCTGCTGGAGCCCATGCTGGCAGTGGGACTAAG | CCCTGCCCTCACTGCAGTG    c.1560
 I  K  E  L  L  E  P  M  L  A  V  G  L  S  |  P  A  L  T  A  V      p.520

          .         .         .         .         .         .       g.27083
 CTCTACGACCTGAGCCGTCAGATTCCACAGCTAAAGAAGGACATTCAAGATGGGCTACTG       c.1620
 L  Y  D  L  S  R  Q  I  P  Q  L  K  K  D  I  Q  D  G  L  L         p.540

          .         .         .         .         .         .       g.27143
 AAAATGCTGTCCCTGGTCCTTATGCACAAACCCCTTCGCCACCCAGGCATGCCCAAGGGC       c.1680
 K  M  L  S  L  V  L  M  H  K  P  L  R  H  P  G  M  P  K  G         p.560

          .         .         .         .         .         .       g.27203
 CTGGCCCATCAGCTGGCCTCTCCTGGCCTCACGACCCTCCCTGAGGCCAGCGATGTGGGC       c.1740
 L  A  H  Q  L  A  S  P  G  L  T  T  L  P  E  A  S  D  V  G         p.580

          .         .         .         .       | 12 .         .    g.28948
 AGCATCACTCTTGCCCTCCGAACGCTTGGCAGCTTTGAATTTGAAG | GCCACTCTCTGACC    c.1800
 S  I  T  L  A  L  R  T  L  G  S  F  E  F  E  G |   H  S  L  T      p.600

          .         .         .         .         .         .       g.29008
 CAATTTGTTCGCCACTGTGCGGATCATTTCCTGAACAGTGAGCACAAGGAGATCCGCATG       c.1860
 Q  F  V  R  H  C  A  D  H  F  L  N  S  E  H  K  E  I  R  M         p.620

          .         .         .         .         .         .       g.29068
 GAGGCTGCCCGCACCTGCTCCCGCCTGCTCACACCCTCCATCCACCTCATCAGTGGCCAT       c.1920
 E  A  A  R  T  C  S  R  L  L  T  P  S  I  H  L  I  S  G  H         p.640

          .         .         .         .         .         .       g.29128
 GCTCATGTGGTTAGCCAGACCGCAGTGCAAGTGGTGGCAGATGTGCTTAGCAAACTGCTC       c.1980
 A  H  V  V  S  Q  T  A  V  Q  V  V  A  D  V  L  S  K  L  L         p.660

          .         .   | 13     .         .         .         .    g.29541
 GTAGTTGGGATAACAGATCCTG | ACCCTGACATTCGCTACTGTGTCTTGGCGTCCCTGGAC    c.2040
 V  V  G  I  T  D  P  D |   P  D  I  R  Y  C  V  L  A  S  L  D      p.680

          .         .         .         .         .         .       g.29601
 GAGCGCTTTGATGCACACCTGGCCCAGGCGGAGAACTTGCAGGCCTTGTTTGTGGCTCTG       c.2100
 E  R  F  D  A  H  L  A  Q  A  E  N  L  Q  A  L  F  V  A  L         p.700

          .         .         .         .         .         .       g.29661
 AATGACCAGGTGTTTGAGATCCGGGAGCTGGCCATCTGCACTGTGGGCCGACTCAGTAGC       c.2160
 N  D  Q  V  F  E  I  R  E  L  A  I  C  T  V  G  R  L  S  S         p.720

          .         .         .         .         | 14         .    g.33298
 ATGAACCCTGCCTTTGTCATGCCTTTCCTGCGCAAGATGCTCATCCAG | ATTTTGACAGAG    c.2220
 M  N  P  A  F  V  M  P  F  L  R  K  M  L  I  Q   | I  L  T  E      p.740

          .         .         .         .         .         .       g.33358
 TTGGAGCACAGTGGGATTGGAAGAATCAAAGAGCAGAGTGCCCGCATGCTGGGGCACCTG       c.2280
 L  E  H  S  G  I  G  R  I  K  E  Q  S  A  R  M  L  G  H  L         p.760

          .         .         .         .         .  | 15      .    g.34073
 GTCTCCAATGCCCCCCGACTCATCCGCCCCTACATGGAGCCTATTCTGAAG | GCATTAATT    c.2340
 V  S  N  A  P  R  L  I  R  P  Y  M  E  P  I  L  K   | A  L  I      p.780

          .         .         .         .         .         .       g.34133
 TTGAAACTGAAAGATCCAGACCCTGATCCAAACCCAGGTGTGATCAATAATGTCCTGGCA       c.2400
 L  K  L  K  D  P  D  P  D  P  N  P  G  V  I  N  N  V  L  A         p.800

          .         .  | 16      .         .         .         .    g.35062
 ACAATAGGAGAATTGGCACAG | GTTAGTGGCCTGGAAATGAGGAAATGGGTTGATGAACTT    c.2460
 T  I  G  E  L  A  Q   | V  S  G  L  E  M  R  K  W  V  D  E  L      p.820

          .         .         .         .         .     | 17   .    g.36123
 TTTATTATCATCATGGACATGCTCCAGGATTCCTCTTTGTTGGCCAAAAGGCAG | GTGGCT    c.2520
 F  I  I  I  M  D  M  L  Q  D  S  S  L  L  A  K  R  Q   | V  A      p.840

          .         .         .         .         .         .       g.36183
 CTGTGGACCCTGGGACAGTTGGTGGCCAGCACTGGCTATGTAGTAGAGCCCTACAGGAAG       c.2580
 L  W  T  L  G  Q  L  V  A  S  T  G  Y  V  V  E  P  Y  R  K         p.860

          .         .         .         .         .         .       g.36243
 TACCCTACTTTGCTTGAGGTGCTACTGAATTTTCTGAAGACTGAGCAGAACCAGGGTACA       c.2640
 Y  P  T  L  L  E  V  L  L  N  F  L  K  T  E  Q  N  Q  G  T         p.880

           | 18        .         .         .         .         .    g.36548
 CGCAGAGAG | GCCATCCGTGTGTTAGGGCTTTTAGGGGCTTTGGATCCTTACAAGCACAAA    c.2700
 R  R  E   | A  I  R  V  L  G  L  L  G  A  L  D  P  Y  K  H  K      p.900

          .         .         .         .         .         .       g.36608
 GTGAACATTGGCATGATAGACCAGTCCCGGGATGCCTCTGCTGTCAGCCTGTCAGAATCC       c.2760
 V  N  I  G  M  I  D  Q  S  R  D  A  S  A  V  S  L  S  E  S         p.920

          .          | 19        .         .         .         .    g.38674
 AAGTCAAGTCAGGATTCCT | CTGACTATAGCACTAGTGAAATGCTGGTCAACATGGGAAAC    c.2820
 K  S  S  Q  D  S  S |   D  Y  S  T  S  E  M  L  V  N  M  G  N      p.940

          .         .         .         .         .         .       g.38734
 TTGCCTCTGGATGAGTTCTACCCAGCTGTGTCCATGGTGGCCCTGATGCGGATCTTCCGA       c.2880
 L  P  L  D  E  F  Y  P  A  V  S  M  V  A  L  M  R  I  F  R         p.960

          .         .         .         .         .         .       g.38794
 GACCAGTCACTCTCTCATCATCACACCATGGTTGTCCAGGCCATCACCTTCATCTTCAAG       c.2940
 D  Q  S  L  S  H  H  H  T  M  V  V  Q  A  I  T  F  I  F  K         p.980

          .         .         .         .         .         .       g.38854
 TCCCTGGGACTCAAATGTGTGCAGTTCCTGCCCCAGGTCATGCCCACGTTCCTTAACGTC       c.3000
 S  L  G  L  K  C  V  Q  F  L  P  Q  V  M  P  T  F  L  N  V         p.1000

          .         .         . | 20       .         .         .    g.51347
 ATTCGAGTCTGTGATGGGGCCATCCGGGAA | TTTTTGTTCCAGCAGCTGGGAATGTTGGTG    c.3060
 I  R  V  C  D  G  A  I  R  E   | F  L  F  Q  Q  L  G  M  L  V      p.1020

          .         .         .         .         .        | 21.    g.53988
 TCCTTTGTGAAGAGCCACATCAGACCTTATATGGATGAAATAGTCACCCTCATGAGA | GAA    c.3120
 S  F  V  K  S  H  I  R  P  Y  M  D  E  I  V  T  L  M  R   | E      p.1040

          .         .         .         .         .         .       g.54048
 TTCTGGGTCATGAACACCTCAATTCAGAGCACGATCATTCTTCTCATTGAGCAAATTGTG       c.3180
 F  W  V  M  N  T  S  I  Q  S  T  I  I  L  L  I  E  Q  I  V         p.1060

          .         .         .         .         .         .       g.54108
 GTAGCTCTTGGGGGTGAATTTAAGCTCTACCTGCCCCAGCTGATCCCACACATGCTGCGT       c.3240
 V  A  L  G  G  E  F  K  L  Y  L  P  Q  L  I  P  H  M  L  R         p.1080

          .         .         .         .      | 22  .         .    g.54658
 GTCTTCATGCATGACAACAGCCCAGGCCGCATTGTCTCTATCAAG | TTACTGGCTGCAATC    c.3300
 V  F  M  H  D  N  S  P  G  R  I  V  S  I  K   | L  L  A  A  I      p.1100

          .         .         .         .         .         .       g.54718
 CAGCTGTTTGGCGCCAACCTGGATGACTACCTGCATTTACTGCTGCCTCCTATTGTTAAG       c.3360
 Q  L  F  G  A  N  L  D  D  Y  L  H  L  L  L  P  P  I  V  K         p.1120

          .         .         .         | 23         .         .    g.55099
 TTGTTTGATGCCCCTGAAGCTCCACTGCCATCTCGAAA | GGCAGCGCTAGAGACTGTGGAC    c.3420
 L  F  D  A  P  E  A  P  L  P  S  R  K  |  A  A  L  E  T  V  D      p.1140

          .         .         .         .         .         .       g.55159
 CGCCTGACGGAGTCCCTGGATTTCACTGACTATGCCTCCCGGATCATTCACCCTATTGTT       c.3480
 R  L  T  E  S  L  D  F  T  D  Y  A  S  R  I  I  H  P  I  V         p.1160

          .         .         .         .         .         .       g.55219
 CGAACACTGGACCAGAGCCCAGAACTGCGCTCCACAGCCATGGACACGCTGTCTTCACTT       c.3540
 R  T  L  D  Q  S  P  E  L  R  S  T  A  M  D  T  L  S  S  L         p.1180

          .         .  | 24      .         .         .         .    g.56684
 GTTTTTCAGCTGGGGAAGAAG | TACCAAATTTTCATTCCAATGGTGAATAAAGTTCTGGTG    c.3600
 V  F  Q  L  G  K  K   | Y  Q  I  F  I  P  M  V  N  K  V  L  V      p.1200

          .         .         .         .         .     | 25   .    g.58099
 CGACACCGAATCAATCATCAGCGCTATGATGTGCTCATCTGCAGAATTGTCAAG | GGATAC    c.3660
 R  H  R  I  N  H  Q  R  Y  D  V  L  I  C  R  I  V  K   | G  Y      p.1220

          .         .         .         .         .         .       g.58159
 ACACTTGCTGATGAAGAGGAGGATCCTTTGATTTACCAGCATCGGATGCTTAGGAGTGGC       c.3720
 T  L  A  D  E  E  E  D  P  L  I  Y  Q  H  R  M  L  R  S  G         p.1240

          .         .         .         .         .         .       g.58219
 CAAGGGGATGCATTGGCTAGTGGACCAGTGGAAACAGGACCCATGAAGAAACTGCACGTC       c.3780
 Q  G  D  A  L  A  S  G  P  V  E  T  G  P  M  K  K  L  H  V         p.1260

          .         .  | 26      .         .         .         .    g.62887
 AGCACCATCAACCTCCAAAAG | GCCTGGGGCGCTGCCAGGAGGGTCTCCAAAGATGACTGG    c.3840
 S  T  I  N  L  Q  K   | A  W  G  A  A  R  R  V  S  K  D  D  W      p.1280

          .         .         .         .         .         .       g.62947
 CTGGAATGGCTGAGACGGCTGAGCCTGGAGCTGCTGAAGGACTCATCATCGCCCTCCCTG       c.3900
 L  E  W  L  R  R  L  S  L  E  L  L  K  D  S  S  S  P  S  L         p.1300

          .         .         .         .     | 27   .         .    g.67864
 CGCTCCTGCTGGGCCCTGGCACAGGCCTACAACCCGATGGCCAG | GGATCTCTTCAATGCT    c.3960
 R  S  C  W  A  L  A  Q  A  Y  N  P  M  A  R  |  D  L  F  N  A      p.1320

          .         .         .         .         .         .       g.67924
 GCATTTGTGTCCTGCTGGTCTGAACTGAATGAAGATCAACAGGATGAGCTCATCAGAAGC       c.4020
 A  F  V  S  C  W  S  E  L  N  E  D  Q  Q  D  E  L  I  R  S         p.1340

          .         .         .         .         .         .       g.67984
 ATCGAGTTGGCCCTCACCTCACAAGACATCGCTGAAGTCACACAGACCCTCTTAAACTTG       c.4080
 I  E  L  A  L  T  S  Q  D  I  A  E  V  T  Q  T  L  L  N  L         p.1360

          .         .        | 28.         .         .         .    g.68181
 GCTGAATTCATGGAACACAGTGACAAG | GGCCCCCTGCCACTGAGAGATGACAATGGCATT    c.4140
 A  E  F  M  E  H  S  D  K   | G  P  L  P  L  R  D  D  N  G  I      p.1380

          .         .         .         .         .         .       g.68241
 GTTCTGCTGGGTGAGAGAGCTGCCAAGTGCCGAGCATATGCCAAAGCACTACACTACAAA       c.4200
 V  L  L  G  E  R  A  A  K  C  R  A  Y  A  K  A  L  H  Y  K         p.1400

          .         .         .         .         .    | 29    .    g.100041
 GAACTGGAGTTCCAGAAAGGCCCCACCCCTGCCATTCTAGAATCTCTCATCAG | CATTAAT    c.4260
 E  L  E  F  Q  K  G  P  T  P  A  I  L  E  S  L  I  S  |  I  N      p.1420

          .         .         .         .         .         .       g.100101
 AATAAGCTACAGCAGCCGGAGGCAGCGGCCGGAGTGTTAGAATATGCCATGAAACACTTT       c.4320
 N  K  L  Q  Q  P  E  A  A  A  G  V  L  E  Y  A  M  K  H  F         p.1440

           | 30        .         .         .         .         .    g.110311
 GGAGAGCTG | GAGATCCAGGCTACCTGGTATGAGAAACTGCACGAGTGGGAGGATGCCCTT    c.4380
 G  E  L   | E  I  Q  A  T  W  Y  E  K  L  H  E  W  E  D  A  L      p.1460

          .         .         .         .         .         .       g.110371
 GTGGCCTATGACAAGAAAATGGACACCAACAAGGACGACCCAGAGCTGATGCTGGGCCGC       c.4440
 V  A  Y  D  K  K  M  D  T  N  K  D  D  P  E  L  M  L  G  R         p.1480

          .         .          | 31        .         .         .    g.117356
 ATGCGCTGCCTCGAGGCCTTGGGGGAATG | GGGTCAACTCCACCAGCAGTGCTGTGAAAAG    c.4500
 M  R  C  L  E  A  L  G  E  W  |  G  Q  L  H  Q  Q  C  C  E  K      p.1500

          .         .         .         .         .         .       g.117416
 TGGACCCTGGTTAATGATGAGACCCAAGCCAAGATGGCCCGGATGGCTGCTGCAGCTGCA       c.4560
 W  T  L  V  N  D  E  T  Q  A  K  M  A  R  M  A  A  A  A  A         p.1520

          . | 32       .         .         .         .         .    g.120810
 TGGGGTTTAG | GTCAGTGGGACAGCATGGAAGAATACACCTGTATGATCCCTCGGGACACC    c.4620
 W  G  L  G |   Q  W  D  S  M  E  E  Y  T  C  M  I  P  R  D  T      p.1540

          .         .         .         .         .         .       g.120870
 CATGATGGGGCATTTTATAGAGCTGTGCTGGCACTGCATCAGGACCTCTTCTCCTTGGCA       c.4680
 H  D  G  A  F  Y  R  A  V  L  A  L  H  Q  D  L  F  S  L  A         p.1560

        | 33 .         .         .         .         .         .    g.122560
 CAACAG | TGCATTGACAAGGCCAGGGACCTGCTGGATGCTGAATTAACTGCGATGGCAGGA    c.4740
 Q  Q   | C  I  D  K  A  R  D  L  L  D  A  E  L  T  A  M  A  G      p.1580

          .         .     | 34   .         .         .         .    g.122832
 GAGAGTTACAGTCGGGCATATGGG | GCCATGGTTTCTTGCCACATGCTGTCCGAGCTGGAG    c.4800
 E  S  Y  S  R  A  Y  G   | A  M  V  S  C  H  M  L  S  E  L  E      p.1600

          .         .         .         .         .         .       g.122892
 GAGGTTATCCAGTACAAACTTGTCCCCGAGCGACGAGAGATCATCCGCCAGATCTGGTGG       c.4860
 E  V  I  Q  Y  K  L  V  P  E  R  R  E  I  I  R  Q  I  W  W         p.1620

          .   | 35     .         .         .         .         .    g.127941
 GAGAGACTGCAG | GGCTGCCAGCGTATCGTAGAGGACTGGCAGAAAATCCTTATGGTGCGG    c.4920
 E  R  L  Q   | G  C  Q  R  I  V  E  D  W  Q  K  I  L  M  V  R      p.1640

          .         .         .         .         .         .       g.128001
 TCCCTTGTGGTCAGCCCTCATGAAGACATGAGAACCTGGCTCAAGTATGCAAGCCTGTGC       c.4980
 S  L  V  V  S  P  H  E  D  M  R  T  W  L  K  Y  A  S  L  C         p.1660

          .         | 36         .         .         .         .    g.128158
 GGCAAGAGTGGCAGGCTG | GCTCTTGCTCATAAAACTTTAGTGTTGCTCCTGGGAGTTGAT    c.5040
 G  K  S  G  R  L   | A  L  A  H  K  T  L  V  L  L  L  G  V  D      p.1680

          .         .         .         .         .         .       g.128218
 CCGTCTCGGCAACTTGACCATCCTCTGCCAACAGTTCACCCTCAGGTGACCTATGCCTAC       c.5100
 P  S  R  Q  L  D  H  P  L  P  T  V  H  P  Q  V  T  Y  A  Y         p.1700

          .         .         . | 37       .         .         .    g.133115
 ATGAAAAACATGTGGAAGAGTGCCCGCAAG | ATCGATGCCTTCCAGCACATGCAGCATTTT    c.5160
 M  K  N  M  W  K  S  A  R  K   | I  D  A  F  Q  H  M  Q  H  F      p.1720

          .         .         .         .         .         .       g.133175
 GTCCAGACCATGCAGCAACAGGCCCAGCATGCCATCGCTACTGAGGACCAGCAGCATAAG       c.5220
 V  Q  T  M  Q  Q  Q  A  Q  H  A  I  A  T  E  D  Q  Q  H  K         p.1740

          .         .       | 38 .         .         .         .    g.134388
 CAGGAACTGCACAAGCTCATGGCCCG | ATGCTTCCTGAAACTTGGAGAGTGGCAGCTGAAT    c.5280
 Q  E  L  H  K  L  M  A  R  |  C  F  L  K  L  G  E  W  Q  L  N      p.1760

          .         .         .         .         .         .       g.134448
 CTACAGGGCATCAATGAGAGCACAATCCCCAAAGTGCTGCAGTACTACAGCGCCGCCACA       c.5340
 L  Q  G  I  N  E  S  T  I  P  K  V  L  Q  Y  Y  S  A  A  T         p.1780

          .         .     | 39   .         .         .         .    g.136810
 GAGCACGACCGCAGCTGGTACAAG | GCCTGGCATGCGTGGGCAGTGATGAACTTCGAAGCT    c.5400
 E  H  D  R  S  W  Y  K   | A  W  H  A  W  A  V  M  N  F  E  A      p.1800

          .         .         .         .         .         .       g.136870
 GTGCTACACTACAAACATCAGAACCAAGCCCGCGATGAGAAGAAGAAACTGCGTCATGCC       c.5460
 V  L  H  Y  K  H  Q  N  Q  A  R  D  E  K  K  K  L  R  H  A         p.1820

          .         .         .         .         .         .       g.136930
 AGCGGGGCCAACATCACCAACGCCACCACTGCCGCCACCACGGCCGCCACTGCCACCACC       c.5520
 S  G  A  N  I  T  N  A  T  T  A  A  T  T  A  A  T  A  T  T         p.1840

          .         .         .         .         .         .       g.136990
 ACTGCCAGCACCGAGGGCAGCAACAGTGAGAGCGAGGCCGAGAGCACCGAGAACAGCCCC       c.5580
 T  A  S  T  E  G  S  N  S  E  S  E  A  E  S  T  E  N  S  P         p.1860

          .         .         .    | 40    .         .         .    g.137740
 ACCCCATCGCCGCTGCAGAAGAAGGTCACTGAG | GATCTGTCCAAAACCCTCCTGATGTAC    c.5640
 T  P  S  P  L  Q  K  K  V  T  E   | D  L  S  K  T  L  L  M  Y      p.1880

          .         .         .         .         .         .       g.137800
 ACGGTGCCTGCCGTCCAGGGCTTCTTCCGTTCCATCTCCTTGTCACGAGGCAACAACCTC       c.5700
 T  V  P  A  V  Q  G  F  F  R  S  I  S  L  S  R  G  N  N  L         p.1900

          .     | 41   .         .         .         .         .    g.138646
 CAGGATACACTCAG | AGTTCTCACCTTATGGTTTGATTATGGTCACTGGCCAGATGTCAAT    c.5760
 Q  D  T  L  R  |  V  L  T  L  W  F  D  Y  G  H  W  P  D  V  N      p.1920

          .         .         .         .         .  | 42      .    g.139008
 GAGGCCTTAGTGGAGGGGGTGAAAGCCATCCAGATTGATACCTGGCTACAG | GTTATACCT    c.5820
 E  A  L  V  E  G  V  K  A  I  Q  I  D  T  W  L  Q   | V  I  P      p.1940

          .         .         .         .         .         .       g.139068
 CAGCTCATTGCAAGAATTGATACGCCCAGACCCTTGGTGGGACGTCTCATTCACCAGCTT       c.5880
 Q  L  I  A  R  I  D  T  P  R  P  L  V  G  R  L  I  H  Q  L         p.1960

          .         .         . | 43       .         .         .    g.139455
 CTCACAGACATTGGTCGGTACCACCCCCAG | GCCCTCATCTACCCACTGACAGTGGCTTCT    c.5940
 L  T  D  I  G  R  Y  H  P  Q   | A  L  I  Y  P  L  T  V  A  S      p.1980

          .         .         .         .         .         .       g.139515
 AAGTCTACCACGACAGCCCGGCACAATGCAGCCAACAAGATTCTGAAGAACATGTGTGAG       c.6000
 K  S  T  T  T  A  R  H  N  A  A  N  K  I  L  K  N  M  C  E         p.2000

          .         .         .    | 44    .         .         .    g.139772
 CACAGCAACACCCTGGTCCAGCAGGCCATGATG | GTGAGCGAGGAGCTGATCCGAGTGGCC    c.6060
 H  S  N  T  L  V  Q  Q  A  M  M   | V  S  E  E  L  I  R  V  A      p.2020

          .         .         .         .         .         .       g.139832
 ATCCTCTGGCATGAGATGTGGCATGAAGGCCTGGAAGAGGCATCTCGTTTGTACTTTGGG       c.6120
 I  L  W  H  E  M  W  H  E  G  L  E  E  A  S  R  L  Y  F  G         p.2040

          .         .         .         .         .         .       g.139892
 GAAAGGAACGTGAAAGGCATGTTTGAGGTGCTGGAGCCCTTGCATGCTATGATGGAACGG       c.6180
 E  R  N  V  K  G  M  F  E  V  L  E  P  L  H  A  M  M  E  R         p.2060

          .         .         .       | 45 .         .         .    g.140431
 GGCCCCCAGACTCTGAAGGAAACATCCTTTAATCAG | GCCTATGGTCGAGATTTAATGGAG    c.6240
 G  P  Q  T  L  K  E  T  S  F  N  Q   | A  Y  G  R  D  L  M  E      p.2080

          .         .         .         .         .         .       g.140491
 GCCCAAGAGTGGTGCAGGAAGTACATGAAATCAGGGAATGTCAAGGACCTCACCCAAGCC       c.6300
 A  Q  E  W  C  R  K  Y  M  K  S  G  N  V  K  D  L  T  Q  A         p.2100

          .         .         .         .         .  | 46      .    g.140764
 TGGGACCTCTATTATCATGTGTTCCGACGAATCTCAAAGCAGCTGCCTCAG | CTCACATCC    c.6360
 W  D  L  Y  Y  H  V  F  R  R  I  S  K  Q  L  P  Q   | L  T  S      p.2120

          .         .         .         .         .         .       g.140824
 TTAGAGCTGCAATATGTTTCCCCAAAACTTCTGATGTGCCGGGACCTTGAATTGGCTGTG       c.6420
 L  E  L  Q  Y  V  S  P  K  L  L  M  C  R  D  L  E  L  A  V         p.2140

          .         .         .         .         .         .       g.140884
 CCAGGAACATATGACCCCAACCAGCCAATCATTCGCATTCAGTCCATAGCACCGTCTTTG       c.6480
 P  G  T  Y  D  P  N  Q  P  I  I  R  I  Q  S  I  A  P  S  L         p.2160

          .         .         .         .       | 47 .         .    g.142932
 CAAGTCATCACATCCAAGCAGAGGCCCCGGAAATTGACACTTATGG | GCAGCAACGGACAT    c.6540
 Q  V  I  T  S  K  Q  R  P  R  K  L  T  L  M  G |   S  N  G  H      p.2180

          .         .         .         .         .         .       g.142992
 GAGTTTGTTTTCCTTCTAAAAGGCCATGAAGATCTGCGCCAGGATGAGCGTGTGATGCAG       c.6600
 E  F  V  F  L  L  K  G  H  E  D  L  R  Q  D  E  R  V  M  Q         p.2200

          .         .         .         .         .         .       g.143052
 CTCTTCGGCCTGGTTAACACCCTTCTGGCCAATGACCCAACATCTCTTCGGAAAAACCTC       c.6660
 L  F  G  L  V  N  T  L  L  A  N  D  P  T  S  L  R  K  N  L         p.2220

    | 48     .         .         .         .         .         .    g.145483
 AG | CATCCAGAGATACGCTGTCATCCCTTTATCGACCAACTCGGGCCTCATTGGCTGGGTT    c.6720
 S  |  I  Q  R  Y  A  V  I  P  L  S  T  N  S  G  L  I  G  W  V      p.2240

          .         .         .         .         .         .       g.145543
 CCCCACTGTGACACACTGCACGCCCTCATCCGGGACTACAGGGAGAAGAAGAAGATCCTT       c.6780
 P  H  C  D  T  L  H  A  L  I  R  D  Y  R  E  K  K  K  I  L         p.2260

          .         .         . | 49       .         .         .    g.146213
 CTCAACATCGAGCATCGCATCATGTTGCGG | ATGGCTCCGGACTATGACCACTTGACTCTG    c.6840
 L  N  I  E  H  R  I  M  L  R   | M  A  P  D  Y  D  H  L  T  L      p.2280

          .         .         .         .         .         .       g.146273
 ATGCAGAAGGTGGAGGTGTTTGAGCATGCCGTCAATAATACAGCTGGGGACGACCTGGCC       c.6900
 M  Q  K  V  E  V  F  E  H  A  V  N  N  T  A  G  D  D  L  A         p.2300

          .         .         .    | 50    .         .         .    g.150492
 AAGCTGCTGTGGCTGAAAAGCCCCAGCTCCGAG | GTGTGGTTTGACCGAAGAACCAATTAT    c.6960
 K  L  L  W  L  K  S  P  S  S  E   | V  W  F  D  R  R  T  N  Y      p.2320

          .         .         .         .         .       | 51 .    g.152087
 ACCCGTTCTTTAGCGGTCATGTCAATGGTTGGGTATATTTTAGGCCTGGGAGATAG | ACAC    c.7020
 T  R  S  L  A  V  M  S  M  V  G  Y  I  L  G  L  G  D  R  |  H      p.2340

          .         .         .         .         .         .       g.152147
 CCATCCAACCTGATGCTGGACCGTCTGAGTGGGAAGATCCTGCACATTGACTTTGGGGAC       c.7080
 P  S  N  L  M  L  D  R  L  S  G  K  I  L  H  I  D  F  G  D         p.2360

           | 52        .         .         .         .         .    g.152715
 TGCTTTGAG | GTTGCTATGACCCGAGAGAAGTTTCCAGAGAAGATTCCATTTAGACTAACA    c.7140
 C  F  E   | V  A  M  T  R  E  K  F  P  E  K  I  P  F  R  L  T      p.2380

          .         .     | 53   .         .         .         .    g.153134
 AGAATGTTGACCAATGCTATGGAG | GTTACAGGCCTGGATGGCAACTACAGAATCACATGC    c.7200
 R  M  L  T  N  A  M  E   | V  T  G  L  D  G  N  Y  R  I  T  C      p.2400

          .         .         .         .         .         .       g.153194
 CACACAGTGATGGAGGTGCTGCGAGAGCACAAGGACAGTGTCATGGCCGTGCTGGAAGCC       c.7260
 H  T  V  M  E  V  L  R  E  H  K  D  S  V  M  A  V  L  E  A         p.2420

          .         .         .         . | 54       .         .    g.154654
 TTTGTCTATGACCCCTTGCTGAACTGGAGGCTGATGGACA | CAAATACCAAAGGCAACAAG    c.7320
 F  V  Y  D  P  L  L  N  W  R  L  M  D  T |   N  T  K  G  N  K      p.2440

          .         .         .         .       | 55 .         .    g.157836
 CGATCCCGAACGAGGACGGATTCCTACTCTGCTGGCCAGTCAGTCG | AAATTTTGGACGGT    c.7380
 R  S  R  T  R  T  D  S  Y  S  A  G  Q  S  V  E |   I  L  D  G      p.2460

          .         .         .         .         .         .       g.157896
 GTGGAACTTGGAGAGCCAGCCCATAAGAAAACGGGGACCACAGTGCCAGAATCTATTCAT       c.7440
 V  E  L  G  E  P  A  H  K  K  T  G  T  T  V  P  E  S  I  H         p.2480

         | 56.         .         .         .         .         .    g.158234
 TCTTTCA | TTGGAGACGGTTTGGTGAAACCAGAGGCCCTAAATAAGAAAGCTATCCAGATT    c.7500
 S  F  I |   G  D  G  L  V  K  P  E  A  L  N  K  K  A  I  Q  I      p.2500

          .         .         | 57         .         .         .    g.159297
 ATTAACAGGGTTCGAGATAAGCTCACTG | GTCGGGACTTCTCTCATGATGACACTTTGGAT    c.7560
 I  N  R  V  R  D  K  L  T  G |   R  D  F  S  H  D  D  T  L  D      p.2520

          .         .         .         .         .         .       g.159357
 GTTCCAACGCAAGTTGAGCTGCTCATCAAACAAGCGACATCCCATGAAAACCTCTGCCAG       c.7620
 V  P  T  Q  V  E  L  L  I  K  Q  A  T  S  H  E  N  L  C  Q         p.2540

          .     | 58   .         .                                  g.160097
 TGCTATATTGGCTG | GTGCCCTTTCTGGTAA                                  c.7650
 C  Y  I  G  W  |  C  P  F  W  X                                    p.2549

          .         .         .         .         .         .       g.160157
 ctggaggcccagatgtgcccatcacgttttttctgaggcttttgtactttagtaaatgct       c.*60

          .         .         .         .         .         .       g.160217
 tccactaaactgaaaccatggtgagaaagtttgactttgttaaatattttgaaatgtaaa       c.*120

          .         .         .         .         .         .       g.160277
 tgaaaagaactactgtatattaaaagttggtttgaaccaactttctagctgctgttgaag       c.*180

          .         .         .         .         .         .       g.160337
 aatatattgtcagaaacacaaggcttgatttggttcccaggacagtgaaacatagtaata       c.*240

          .         .         .         .         .         .       g.160397
 ccacgtaaatcaagccattcattttggggaacagaagatccataactttagaaatacggg       c.*300

          .         .         .         .         .         .       g.160457
 ttttgacttaactcacaagagaactcatcataagtacttgctgatggaagaatgacctag       c.*360

          .         .         .         .         .         .       g.160517
 ttgctcctctcaacatgggtacagcaaactcagcacagccaagaagcctcaggtcgtgga       c.*420

          .         .         .         .         .         .       g.160577
 gaacatggattaggatcctagactgtaaagacacagaagatgctgacctcacccctgcca       c.*480

          .         .         .         .         .         .       g.160637
 cctatcccaagacctcactggtctgtggacagcagcagaaatgtttgcaagataggccaa       c.*540

          .         .         .         .         .         .       g.160697
 aatgagtacaaaaggtctgtcttccatcagacccagtgatgctgcgactcacacgcttca       c.*600

          .         .         .         .         .         .       g.160757
 attcaagacctgaccgctagtagggaggtttattcagatcgctggcagcctcggctgagc       c.*660

          .         .         .         .         .         .       g.160817
 agatgcacagaggggatcactgtgcagtgggaccaccctcactggccttctgcagcaggg       c.*720

          .         .         .         .         .         .       g.160877
 ttctgggatgttttcagtggtcaaaatactctgtttagagcaagggctcagaaaacagaa       c.*780

          .         .         .         .         .         .       g.160937
 atactgtcatggaggtgctgaacacagggaaggtctggtacatattggaaattatgagca       c.*840

          .         .         .         .         .         .       g.160997
 gaacaaatactcaactaaatgcacaaagtataaagtgtagccatgtctagacaccatgtt       c.*900

          .         .         .         .         .                 g.161051
 gtatcagaataatttttgtgccaataaatgacatcagaattttaaacatatgta             c.*954

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Mechanistic target of rapamycin (serine/threonine kinase) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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