5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) - coding DNA reference sequence

(used for variant description)

(last modified September 27, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_002454.2 in the MTRR gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering MTRR transcript NM_002454.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5017
                                            ggagctttctattggtc       c.-121

 .         .         .         .         .         .                g.5077
 ctgggtaccgagcatgggcgctgcgtcagtgcgcgctggcgcaaggttggtggaagtcgc       c.-61

 .         .         .         .     | 02   .         .             g.6691
 gttgtgcaggttcgtgcccggctggcgcggcgtgg | tttcactgttacatgccttgaagtg    c.-1

          .         .         .         .         .         .       g.6751
 ATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGGACAGGCAAAGGCCATCGCAGAA       c.60
 M  R  R  F  L  L  L  Y  A  T  Q  Q  G  Q  A  K  A  I  A  E         p.20

          .         .         .         .         .         .       g.6811
 GAAATATGTGAGCAAGCTGTGGTACATGGATTTTCTGCAGATCTTCACTGTATTAGTGAA       c.120
 E  I  C  E  Q  A  V  V  H  G  F  S  A  D  L  H  C  I  S  E         p.40

           | 03        .         .         .         .         .    g.9320
 TCCGATAAG | TATGACCTAAAAACCGAAACAGCTCCTCTTGTTGTTGTGGTTTCTACCACG    c.180
 S  D  K   | Y  D  L  K  T  E  T  A  P  L  V  V  V  V  S  T  T      p.60

          .         .         .         .         .         .       g.9380
 GGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGTTAAGGAAATACAGAACCAAACA       c.240
 G  T  G  D  P  P  D  T  A  R  K  F  V  K  E  I  Q  N  Q  T         p.80

          .         .         .         .    | 04    .         .    g.11171
 CTGCCGGTTGATTTCTTTGCTCACCTGCGGTATGGGTTACTGG | GTCTCGGTGATTCAGAA    c.300
 L  P  V  D  F  F  A  H  L  R  Y  G  L  L  G |   L  G  D  S  E      p.100

          .         .         .         .         .         .       g.11231
 TACACCTACTTTTGCAATGGGGGGAAGATAATTGATAAACGACTTCAAGAGCTTGGAGCC       c.360
 Y  T  Y  F  C  N  G  G  K  I  I  D  K  R  L  Q  E  L  G  A         p.120

          .         .         .         .  | 05      .         .    g.13859
 CGGCATTTCTATGACACTGGACATGCAGATGACTGTGTAGG | TTTAGAACTTGTGGTTGAG    c.420
 R  H  F  Y  D  T  G  H  A  D  D  C  V  G  |  L  E  L  V  V  E      p.140

          .         .         .         .         .         .       g.13919
 CCGTGGATTGCTGGACTCTGGCCAGCCCTCAGAAAGCATTTTAGGTCAAGCAGAGGACAA       c.480
 P  W  I  A  G  L  W  P  A  L  R  K  H  F  R  S  S  R  G  Q         p.160

          .         .         .         .         .         .       g.13979
 GAGGAGATAAGTGGCGCACTCCCGGTGGCATCACCTGCATCCTCGAGGACAGACCTTGTG       c.540
 E  E  I  S  G  A  L  P  V  A  S  P  A  S  S  R  T  D  L  V         p.180

          .         .         .         .         .         .       g.14039
 AAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCTTCTGAGATTCGATGATTCAGGA       c.600
 K  S  E  L  L  H  I  E  S  Q  V  E  L  L  R  F  D  D  S  G         p.200

          .         .         .         .         .         .       g.14099
 AGAAAGGATTCTGAGGTTTTGAAGCAAAATGCAGTGAACAGCAACCAATCCAATGTTGTA       c.660
 R  K  D  S  E  V  L  K  Q  N  A  V  N  S  N  Q  S  N  V  V         p.220

          .         .         .         .         .         .       g.14159
 ATTGAAGACTTTGAGTCCTCACTTACCCGTTCGGTACCCCCACTCTCACAAGCCTCTCTG       c.720
 I  E  D  F  E  S  S  L  T  R  S  V  P  P  L  S  Q  A  S  L         p.240

          .         .         .         .         .         .       g.14219
 AATATTCCTGGTTTACCCCCAGAATATTTACAGGTACATCTGCAGGAGTCTCTTGGCCAG       c.780
 N  I  P  G  L  P  P  E  Y  L  Q  V  H  L  Q  E  S  L  G  Q         p.260

  | 06       .         .         .         .         .         .    g.19111
  | GAGGAAAGCCAAGTATCTGTGACTTCAGCAGATCCAGTTTTTCAAGTGCCAATTTCAAAG    c.840
  | E  E  S  Q  V  S  V  T  S  A  D  P  V  F  Q  V  P  I  S  K      p.280

          .         .         .         .         .         .       g.19171
 GCAGTTCAACTTACTACGAATGATGCCATAAAAACCACTCTGCTGGTAGAATTGGACATT       c.900
 A  V  Q  L  T  T  N  D  A  I  K  T  T  L  L  V  E  L  D  I         p.300

     | 07    .         .         .         .         .         .    g.21654
 TCA | AATACAGACTTTTCCTATCAGCCTGGAGATGCCTTCAGCGTGATCTGCCCTAACAGT    c.960
 S   | N  T  D  F  S  Y  Q  P  G  D  A  F  S  V  I  C  P  N  S      p.320

          .         .         .         .         .         .       g.21714
 GATTCTGAGGTACAAAGCCTACTCCAAAGACTGCAGCTTGAAGATAAAAGAGAGCACTGC       c.1020
 D  S  E  V  Q  S  L  L  Q  R  L  Q  L  E  D  K  R  E  H  C         p.340

          .         .         .        | 08.         .         .    g.22534
 GTCCTTTTGAAAATAAAGGCAGACACAAAGAAGAAAG | GAGCTACCTTACCCCAGCATATA    c.1080
 V  L  L  K  I  K  A  D  T  K  K  K  G |   A  T  L  P  Q  H  I      p.360

          .         .         .         .         .         .       g.22594
 CCTGCGGGATGTTCTCTCCAGTTCATTTTTACCTGGTGTCTTGAAATCCGAGCAATTCCT       c.1140
 P  A  G  C  S  L  Q  F  I  F  T  W  C  L  E  I  R  A  I  P         p.380

        | 09 .         .         .         .         .         .    g.25045
 AAAAAG | GCATTTTTGCGAGCCCTTGTGGACTATACCAGTGACAGTGCTGAAAAGCGCAGG    c.1200
 K  K   | A  F  L  R  A  L  V  D  Y  T  S  D  S  A  E  K  R  R      p.400

          .         .         .         .         .         .       g.25105
 CTACAGGAGCTGTGCAGTAAACAAGGGGCAGCCGATTATAGCCGCTTTGTACGAGATGCC       c.1260
 L  Q  E  L  C  S  K  Q  G  A  A  D  Y  S  R  F  V  R  D  A         p.420

          .         .         .         .         .         .       g.25165
 TGTGCCTGCTTGTTGGATCTCCTCCTCGCTTTCCCTTCTTGCCAGCCACCACTCAGTCTC       c.1320
 C  A  C  L  L  D  L  L  L  A  F  P  S  C  Q  P  P  L  S  L         p.440

         | 10.         .         .         .         . | 11       . g.28633
 CTGCTCG | AACATCTTCCTAAACTTCAACCCAGACCATATTCGTGTGCAAG | CTCAAGTTTA c.1380
 L  L  E |   H  L  P  K  L  Q  P  R  P  Y  S  C  A  S  |  S  S  L   p.460

          .         .         .         .         .         .       g.28693
 TTTCACCCAGGAAAGCTCCATTTTGTCTTCAACATTGTGGAATTTCTGTCTACTGCCACA       c.1440
 F  H  P  G  K  L  H  F  V  F  N  I  V  E  F  L  S  T  A  T         p.480

          .         .         .         .         .         .       g.28753
 ACAGAGGTTCTGCGGAAGGGAGTATGTACAGGCTGGCTGGCCTTGTTGGTTGCTTCAGTT       c.1500
 T  E  V  L  R  K  G  V  C  T  G  W  L  A  L  L  V  A  S  V         p.500

          .         .         .         .         .        | 12.    g.31633
 CTTCAGCCAAACATACATGCATCCCATGAAGACAGCGGGAAAGCCCTGGCTCCTAAG | ATA    c.1560
 L  Q  P  N  I  H  A  S  H  E  D  S  G  K  A  L  A  P  K   | I      p.520

          .         .         .         .         .         .       g.31693
 TCCATCTCTCCTCGAACAACAAATTCTTTCCACTTACCAGATGACCCCTCAATCCCCATC       c.1620
 S  I  S  P  R  T  T  N  S  F  H  L  P  D  D  P  S  I  P  I         p.540

          .         .         .         .         .       | 13 .    g.32764
 ATAATGGTGGGTCCAGGAACCGGCATAGCCCCGTTTATTGGGTTCCTACAACATAG | AGAG    c.1680
 I  M  V  G  P  G  T  G  I  A  P  F  I  G  F  L  Q  H  R  |  E      p.560

          .         .         .         .         .         .       g.32824
 AAACTCCAAGAACAACACCCAGATGGAAATTTTGGAGCAATGTGGTTGTTTTTTGGCTGC       c.1740
 K  L  Q  E  Q  H  P  D  G  N  F  G  A  M  W  L  F  F  G  C         p.580

          .         .          | 14        .         .         .    g.32992
 AGGCATAAGGATAGGGATTATCTATTCAG | AAAAGAGCTCAGACATTTCCTTAAGCATGGG    c.1800
 R  H  K  D  R  D  Y  L  F  R  |  K  E  L  R  H  F  L  K  H  G      p.600

          .         .         .         .         .         .       g.33052
 ATCTTAACTCATCTAAAGGTTTCCTTCTCAAGAGATGCTCCTGTTGGGGAGGAGGAAGCC       c.1860
 I  L  T  H  L  K  V  S  F  S  R  D  A  P  V  G  E  E  E  A         p.620

          .         .         .         .         .         .       g.33112
 CCAGCAAAGTATGTGCAAGACAACATCCAGCTTCATGGCCAGCAGGTGGCGAGAATCCTC       c.1920
 P  A  K  Y  V  Q  D  N  I  Q  L  H  G  Q  Q  V  A  R  I  L         p.640

          .         .         .   | 15     .         .         .    g.35838
 CTCCAGGAGAACGGCCATATTTATGTGTGTGG | AGATGCAAAGAATATGGCCAAGGATGTA    c.1980
 L  Q  E  N  G  H  I  Y  V  C  G  |  D  A  K  N  M  A  K  D  V      p.660

          .         .         .         .         .         .       g.35898
 CATGATGCCCTTGTGCAAATAATAAGCAAAGAGGTTGGAGTTGAAAAACTAGAAGCAATG       c.2040
 H  D  A  L  V  Q  I  I  S  K  E  V  G  V  E  K  L  E  A  M         p.680

          .         .         .         .         .                 g.35955
 AAAACCCTGGCCACTTTAAAAGAAGAAAAACGCTACCTTCAGGATATTTGGTCATAA          c.2097
 K  T  L  A  T  L  K  E  E  K  R  Y  L  Q  D  I  W  S  X            p.698

          .         .         .         .         .         .       g.36015
 aaccagaaattaaagaaagaggattaagcttttttgactgaaagtactaaaagtcagctt       c.*60

          .         .         .         .         .         .       g.36075
 tactagtgccaaacctttaaattttcaaaagaaaattttctttcaacatttcttgaagga       c.*120

          .         .         .         .         .         .       g.36135
 catggagtggagattggatcatttaacaatataacaaaacttcctgatttgattttacgt       c.*180

          .         .         .         .         .         .       g.36195
 atcttctatctacgcccttcctgtgcctgtgactctccccaaattgccctgttgccttga       c.*240

          .         .         .         .         .         .       g.36255
 gctcttctgagctaaggcagccttcagtccctatcagcgcctcctttacttcccagagaa       c.*300

          .         .         .         .         .         .       g.36315
 cttcacagagactctgtccttccatgcaaaggcttcctgaaatagggagactgactgagt       c.*360

          .         .         .         .         .         .       g.36375
 agctcattcttgtgacttacagtgccaacatttaaaaaagtatgaaaatgatttattttt       c.*420

          .         .         .         .         .         .       g.36435
 atatgatgtatacccataaagaatgctcatattaatgtacttaaattacacatgtagagc       c.*480

          .         .         .         .         .         .       g.36495
 atatctgttatatgtttatgtaactatcaaatggttatttgttactaaagctatatttct       c.*540

          .         .         .         .         .         .       g.36555
 gataaaaaatattttaggataattgcctacagagggatttatttttatgatgctggaaat       c.*600

          .         .         .         .         .         .       g.36615
 atgaaatgtattttaaaatttcactctggcatatgatttatctatcaccattactttttt       c.*660

          .         .         .         .         .         .       g.36675
 ttaagtcacaatttcagaattttgggacatttgcattcaatttacaggtaccagtacgta       c.*720

          .         .         .         .         .         .       g.36735
 catattttaatagaaagatacaacctttttattttcactccttttatttctgctgcttgg       c.*780

          .         .         .         .         .         .       g.36795
 cacatttttgagttttcccacattatttgtctccatgataccactcaagcagtgtgctgg       c.*840

          .         .         .         .         .         .       g.36855
 acctaaaatactgactttagttagtatccttggatttttagattcccagtgtctaattcc       c.*900

          .         .         .         .         .         .       g.36915
 ctgttataatttgcacaaacaaaacaaaatgttatgataatctttctccactgttctaat       c.*960

          .         .         .         .         .         .       g.36975
 atatattgtatttttatttgatagcttgggatttaaaacatctctgttgaaggcttttga       c.*1020

          .         .         .         .                           g.37021
 tccttttgagaaataaagatctgaaagaaatggcataatcttaaaa                     c.*1066

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The 5-methyltetrahydrofolate-homocysteine methyltransferase reductase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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