metastasis suppressor 1-like (MTSS1L) - coding DNA reference sequence

(used for variant description)

(last modified September 13, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_138383.2 in the MTSS1L gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering MTSS1L transcript NM_138383.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         tccccgcgccgaggctgcgc       c.-241

 .         .         .         .         .         .                g.5080
 cgcgagctgcccgcgccgcgccccccgcgccgcccgccagccccgctgcgacatggcccg       c.-181

 .         .         .         .         .         .                g.5140
 cgccgcccgccggaggcccgcgaccccggagcgcggcgcggccggccgctgagcgcagcc       c.-121

 .         .         .         .         .         .                g.5200
 tggaggcgggaggcccggcccggcctcggagcgagcgcccgcgcggcctggccccctccc       c.-61

 .         .         .         .         .         .                g.5260
 ttgcgctgctccccgcgctccgtgcgcctagccgccgccgcggcccggcccagccagagc       c.-1

          .         .         .         .         .         .       g.5320
 ATGGAGACGGCGGAGAAGGAGTGCGGCGCCCTGGGCGGGCTCTTCCAGGCCATAGTCAAC       c.60
 M  E  T  A  E  K  E  C  G  A  L  G  G  L  F  Q  A  I  V  N         p.20

           | 02        .         .         .         .         .    g.10077
 GACATGAAG | AGCTCCTACCCTATCTGGGAGGACTTCAACTCCAAGGCCACGAAGCTGCAT    c.120
 D  M  K   | S  S  Y  P  I  W  E  D  F  N  S  K  A  T  K  L  H      p.40

          .  | 03      .         .         .         .         .    g.10233
 TCCCAGCTGAG | GACCACCGTGCTGGCTGCTGTGGCCTTCCTGGATGCCTTCCAGAAAGTG    c.180
 S  Q  L  R  |  T  T  V  L  A  A  V  A  F  L  D  A  F  Q  K  V      p.60

          .         .      | 04  .         .         .         .    g.11031
 GCTGACATGGCTACCAACACCCGAG | GGGCCACGAGGGACATCGGCTCGGCGCTCACACGC    c.240
 A  D  M  A  T  N  T  R  G |   A  T  R  D  I  G  S  A  L  T  R      p.80

          .         .         .         .         . | 05       .    g.11184
 ATGTGCATGCGCCACCGCAGCATCGAGACCAAGCTGCGGCAGTTCACCAA | CGCACTGCTG    c.300
 M  C  M  R  H  R  S  I  E  T  K  L  R  Q  F  T  N  |  A  L  L      p.100

          .         .         .         .         .         .       g.11244
 GAGAGCCTCATCAACCCGCTGCAGGAGCGCATCGAGGACTGGAAGAAGGCGGCCAACCAG       c.360
 E  S  L  I  N  P  L  Q  E  R  I  E  D  W  K  K  A  A  N  Q         p.120

          .         .   | 06     .         .         .         .    g.11385
 CTGGACAAGGACCACGCGAAAG | AGTACAAACGAGCCCGGCATGAGATCAAAAAGAAGTCG    c.420
 L  D  K  D  H  A  K  E |   Y  K  R  A  R  H  E  I  K  K  K  S      p.140

          .         .         .        | 07.       | 08 .         . g.12656
 TCGGACACGCTGAAGCTGCAGAAGAAGGCGCGCAAAG | AGCTACTTG | GGAAAGGAGACCTG c.480
 S  D  T  L  K  L  Q  K  K  A  R  K  E |   L  L  G |   K  G  D  L   p.160

          .         .         .         .         .         .       g.12716
 CAGCCCCAGCTGGACAGTGCCCTGCAGGACGTCAACGACATGTACCTGCTGCTGGAGGAG       c.540
 Q  P  Q  L  D  S  A  L  Q  D  V  N  D  M  Y  L  L  L  E  E         p.180

          .         .         .         .         .         .       g.12776
 ACGGAGAAGCAGGCCGTGCGCCGGGCGCTGATCGAGGAGCGGGGCCGCTTCTGCACCTTC       c.600
 T  E  K  Q  A  V  R  R  A  L  I  E  E  R  G  R  F  C  T  F         p.200

          .         .     | 09   .         .         .         .    g.13188
 ATCACCTTCCTGCAGCCTGTGGTG | AATGGAGAGCTGACCATGCTGGGAGAGATCACCCAC    c.660
 I  T  F  L  Q  P  V  V   | N  G  E  L  T  M  L  G  E  I  T  H      p.220

          .         .         .         .         .         .       g.13248
 CTGCAGGGCATCATCGACGACTTGGTGGTGCTGACAGCAGAACCCCACAAACTGCCTCCC       c.720
 L  Q  G  I  I  D  D  L  V  V  L  T  A  E  P  H  K  L  P  P         p.240

          .   | 10     .         .         .         .         .    g.14121
 GCCAGCGAGCAG | GTAATCAAAGACCTAAAGGGCTCGGACTACAGCTGGTCCTACCAGACC    c.780
 A  S  E  Q   | V  I  K  D  L  K  G  S  D  Y  S  W  S  Y  Q  T      p.260

          .         .         .         .         . | 11       .    g.16533
 CCACCCTCATCACCCAGCAGCTCCAGCTCCCGGAAGTCCAGCATGTGCAG | TGCCCCCAGC    c.840
 P  P  S  S  P  S  S  S  S  S  R  K  S  S  M  C  S  |  A  P  S      p.280

          .         .         .         .         .         .       g.16593
 AGCAGTAGCAGTGCCAAGGGTGGCGGAGCCCCATGGCCTGGGGGTGCCCAAACATACTCA       c.900
 S  S  S  S  A  K  G  G  G  A  P  W  P  G  G  A  Q  T  Y  S         p.300

          .         .         .         .         .         .       g.16653
 CCCAGTTCCACCTGTCGCTACCGCAGCCTGGCGCAGCCAGCCACCACCACCGCTCGCCTC       c.960
 P  S  S  T  C  R  Y  R  S  L  A  Q  P  A  T  T  T  A  R  L         p.320

          .         .         .         .         .         .       g.16713
 TCCAGCGTTTCCTCCCATGACTCTGGCTTCGTCTCCCAGGACGCCACCTACTCCAAGCCC       c.1020
 S  S  V  S  S  H  D  S  G  F  V  S  Q  D  A  T  Y  S  K  P         p.340

          .         .         .    | 12    .         .         .    g.25538
 CCCTCGCCTATGCCTTCAGACATCACCAGCCAG | AAGTCCTCCAGCTCTGCATCTTCCGAG    c.1080
 P  S  P  M  P  S  D  I  T  S  Q   | K  S  S  S  S  A  S  S  E      p.360

          .         .         .         .         | 13         .    g.25967
 GCCTCGGAAACCTGCCAGTCCGTTAGCGAGTGCAGCTCCCCCACCTCG | GACTGGTCCAAG    c.1140
 A  S  E  T  C  Q  S  V  S  E  C  S  S  P  T  S   | D  W  S  K      p.380

          .         .         .         .         .         .       g.26027
 GTCGGCTCCCATGAGCAGCCCTCAGGCGCCACTCTGCAGCGGAGGAAGGACCGAGTGGAG       c.1200
 V  G  S  H  E  Q  P  S  G  A  T  L  Q  R  R  K  D  R  V  E         p.400

          .         .         .         .         .         .       g.26087
 CTCCTGCGAGACACAGAGCCAGGCCCTGCCAGTGGGGGCACCCTGGGCCCCAGCGGGGAA       c.1260
 L  L  R  D  T  E  P  G  P  A  S  G  G  T  L  G  P  S  G  E         p.420

          .         .         .         .      | 14  .         .    g.26303
 GAGGCACCGCGACCCCGGATGTCCCCTGCCACCATCGCAGCCAAG | CACGGTGAGGAGGTG    c.1320
 E  A  P  R  P  R  M  S  P  A  T  I  A  A  K   | H  G  E  E  V      p.440

          .         .         .         .         .         .       g.26363
 TCCCCCGCCGCCAGTGACCTGGCCATGGTGCTGACGCGGGGCCTGAGCCTGGAGCACCAG       c.1380
 S  P  A  A  S  D  L  A  M  V  L  T  R  G  L  S  L  E  H  Q         p.460

          .         .         .         .         .         .       g.26423
 AAGAGCAGCCGGGACTCGCTGCAGTACTCCAGCGGCTACAGCACGCAGACCACCACGCCC       c.1440
 K  S  S  R  D  S  L  Q  Y  S  S  G  Y  S  T  Q  T  T  T  P         p.480

          .         .         .  | 15      .         .         .    g.26631
 TCCTGCTCTGAGGACACCATCCCCTCCCAAG | GCTCCGACTACGACTGCTACTCCGTGAAT    c.1500
 S  C  S  E  D  T  I  P  S  Q  G |   S  D  Y  D  C  Y  S  V  N      p.500

          .         .         .         .         .         .       g.26691
 GGGGATGCGGACAGCGAGGGCCCGCCCGAGTTTGACAAGTCATCCACCATCCCGCGCAAC       c.1560
 G  D  A  D  S  E  G  P  P  E  F  D  K  S  S  T  I  P  R  N         p.520

          .         .         .         .         .         .       g.26751
 AGCAACATCGCCCAGAACTACCGCCGCCTGATCCAGACCAAGCGCCCAGCCTCCACTGCT       c.1620
 S  N  I  A  Q  N  Y  R  R  L  I  Q  T  K  R  P  A  S  T  A         p.540

          .         .         .         .         .         .       g.26811
 GGGCTGCCCACCGCGGGGCTGCCCACGGCCACTGGCCTGCCCTCGGGCGCACCCCCCGGC       c.1680
 G  L  P  T  A  G  L  P  T  A  T  G  L  P  S  G  A  P  P  G         p.560

          .         .         .         .         .         .       g.26871
 GTGGCCACCATCCGCCGCACACCCTCCACCAAGCCCACCGTGCGCCGCGCCCTGTCCAGC       c.1740
 V  A  T  I  R  R  T  P  S  T  K  P  T  V  R  R  A  L  S  S         p.580

          .         .         .         .         .         .       g.26931
 GCTGGCCCCATCCCCATCCGGCCGCCCATCGTCCCTGTGAAGACGCCCACGGTGCCTGAC       c.1800
 A  G  P  I  P  I  R  P  P  I  V  P  V  K  T  P  T  V  P  D         p.600

          .         .         .         .         .         .       g.26991
 TCCCCCGGCTACATGGGGCCCACACGGGCGGGCAGTGAGGAGTGCGTCTTCTATACCGAC       c.1860
 S  P  G  Y  M  G  P  T  R  A  G  S  E  E  C  V  F  Y  T  D         p.620

          .         .         .         .         .         .       g.27051
 GAGACCGCCTCACCCCTGGCACCGGACCTCGCCAAGGCCTCCCCAAAGAGGCTCAGCCTG       c.1920
 E  T  A  S  P  L  A  P  D  L  A  K  A  S  P  K  R  L  S  L         p.640

          .         .         .         .         .         .       g.27111
 CCCAACACAGCCTGGGGCAGCCCATCCCCAGAGGCAGCCGGGTACCCCGGGGCAGGGGCC       c.1980
 P  N  T  A  W  G  S  P  S  P  E  A  A  G  Y  P  G  A  G  A         p.660

          .         .         .         .         .         .       g.27171
 GAGGACGAGCAGCAGCAGCTGGCGGCCAACCGGCACAGCCTGGTGGAGAAGCTGGGGGAG       c.2040
 E  D  E  Q  Q  Q  L  A  A  N  R  H  S  L  V  E  K  L  G  E         p.680

          .         .         .         .         .         .       g.27231
 CTGGTGGCGGGTGCCCACGCACTGGGTGAGGGCCAGTTCCCCTTCCCCACTGCTCTGTCG       c.2100
 L  V  A  G  A  H  A  L  G  E  G  Q  F  P  F  P  T  A  L  S         p.700

          .         .         .         .         .         .       g.27291
 GCCACCCCCACGGAGGAGACGCCCACCCCACCCCCAGCCGCCACCAGCGACCCCCCGGCC       c.2160
 A  T  P  T  E  E  T  P  T  P  P  P  A  A  T  S  D  P  P  A         p.720

          .         .         .         .         .         .       g.27351
 GAAGACATGCTGGTGGCCATCCGGCGTGGGGTCCGGCTCCGCAGGACCGTCACCAACGAC       c.2220
 E  D  M  L  V  A  I  R  R  G  V  R  L  R  R  T  V  T  N  D         p.740

          .         .                                               g.27375
 AGGTCGGCGCCCCGCATCTTATGA                                           c.2244
 R  S  A  P  R  I  L  X                                             p.747

          .         .         .         .         .         .       g.27435
 tggcgccaccctccccatcctctcaggccccagtgcgagcaggtggcctggtctgtgagc       c.*60

          .         .         .         .         .         .       g.27495
 cgcaggcactcagagcaaaggcccagccaggagagaggacagagccagggcagaggccat       c.*120

          .         .         .         .         .         .       g.27555
 gccactttatggaaagacacctcacttggattccagcatttaaacaggaagtgacttctt       c.*180

          .         .         .         .         .         .       g.27615
 agcaagcctggccaggacggagcctgcaggcctgggcctggttcggggtctgttttatgc       c.*240

          .         .         .         .         .         .       g.27675
 tcttcggtccctcctcttcctcctctggggccctgcctcttccctacccataagcaccag       c.*300

          .         .         .         .         .         .       g.27735
 agccagggccgctgcccatgacagaggggccaggctggcctccctttcaccatcccggcc       c.*360

          .         .         .         .         .         .       g.27795
 tctcccagggctggtcctgcctcagctcctcctggaatgctggcccccctctcccctgcc       c.*420

          .         .         .         .         .         .       g.27855
 tgagccccctcctcccctcttgccttctctctgcctctcccaggcccctctccctccagg       c.*480

          .         .         .         .         .         .       g.27915
 aggcggggcggctgtggaggggccaggtgcacgctgggctggatgtctgctgggggctgg       c.*540

          .         .         .         .         .         .       g.27975
 gggccagggcggcaggttggagttgggcggccaggccccccgtgtgggaagggagttcca       c.*600

          .         .         .         .         .         .       g.28035
 gggcccacgccaagtctcagggaggaaaccaggggctgcttgggggggggggtcttgggg       c.*660

          .         .         .         .         .         .       g.28095
 gccctgtggtggctcccacccctcgcctcccccaccccgtgaggctggctggagggggcc       c.*720

          .         .         .         .         .         .       g.28155
 agagcagctctttggaaactagggcagcagggttaggaggccggaggccctggggtcacc       c.*780

          .         .         .         .         .         .       g.28215
 ggccagccacacaggcaccgttttcagatgtccacttctcattgggtacatcaatctttt       c.*840

          .         .         .         .         .         .       g.28275
 aactttgggggtcacagttttagccacctttcggggggtgactggagcagtaggaggtgt       c.*900

          .         .         .         .         .         .       g.28335
 ggggtcattttatgaatataataaaatggagctgactgtggacgaggactaagtgtgggg       c.*960

          .         .         .         .         .         .       g.28395
 gagaggggacgatacagggtgtgtgtctgggagtgcctgggggacagggaccccccggtg       c.*1020

          .         .         .         .         .         .       g.28455
 gtcctatggcaggatgagaagggagggacttggctcccccagagcccggtggaagctact       c.*1080

          .         .         .         .         .         .       g.28515
 gttctctccagtgtctcgagcgtagccaaaataaggttgggaggctcccggcctgtctgc       c.*1140

          .         .         .         .         .         .       g.28575
 tgtggtctgagctggctgcaagcccaggtgggggagcgagtctgggaagattggctttga       c.*1200

          .         .         .         .         .         .       g.28635
 ctctctgttgccggaggagatgccatcccagcacggcccccactgtagtccaggctcgtg       c.*1260

          .         .         .         .         .         .       g.28695
 gtggcagcgggggcaaggggaggggcaaggctgcccccaccccacgcaccaagtcacgcc       c.*1320

          .         .         .         .         .         .       g.28755
 aagtctcagcaggtaaaagcacgtgagcctagggcgagcggagggagtcctggtggcccc       c.*1380

          .         .         .         .         .         .       g.28815
 gcaggtcaggagggaaagcagggctcagagggcatcgtggccccagggcagggtcctacc       c.*1440

          .         .         .         .         .         .       g.28875
 tgggggtcaggagcaccttggtcttgatgattgattgattgattgatagaatggagctgg       c.*1500

          .         .         .         .         .         .       g.28935
 gtctgagcctcccaggcttgagctcctgggagttcttgtgcggtgagctgggcagctcct       c.*1560

          .         .         .         .         .         .       g.28995
 gggtaggtccgggcaccaagcaggccctgatgtggacagagtcccatcagagggagctga       c.*1620

          .         .         .         .         .         .       g.29055
 tgaagaatggtccctgtaagtaagtcactaggttcaacaactgcctggccgagcactcag       c.*1680

          .         .         .         .         .         .       g.29115
 cccgtggagctcaggccaacaccagagccccggttttaggggccaggagagcaggtgacc       c.*1740

          .         .         .         .         .         .       g.29175
 aattatttggggagtcttgggtagaatttccgccacacattctccccagggctgcagggg       c.*1800

          .         .         .         .         .         .       g.29235
 tcttccgaggcagggcggtggagcaggattcaggatgtggtgggaatagagtgaggggca       c.*1860

          .         .         .         .         .         .       g.29295
 gtgggtgggcagacctgggcgtcagaggtcctgatgggaaaggaggcaggggctacccag       c.*1920

          .         .         .         .         .         .       g.29355
 agaggggggctcgtgtggcacagcccccaccgactccgccgtccccctcccctgtgagcc       c.*1980

          .         .         .         .         .         .       g.29415
 ccgggggctgtacatactctactccatccccttgtccatccctgagaccacccccgccgc       c.*2040

          .         .         .         .         .         .       g.29475
 ccttgcgtcgacttagcaaccacctcataggcccacccacctcgggatccgagccaacca       c.*2100

          .         .         .         .         .         .       g.29535
 tcccacatcacaaactttggtttgggggactttacgttcgtttaatttctcattttgtac       c.*2160

          .         .         .         .         .         .       g.29595
 ggagaaatattcttttcaaaagcgtcttttgactgaagtaactttcctggtgctgttgtt       c.*2220

          .         .         .         .         .         .       g.29655
 aactcgttcctttttttaatttattcccccaccccaggcagccctcctggttcctactca       c.*2280

          .         .         .         .         .         .       g.29715
 ccctccccccctcccccaccctccgtcccatctgaaccatttgtttcttttctttccgtc       c.*2340

          .         .         .         .         .         .       g.29775
 agattttggaaaaattctcctctcctccccgccccctccacaccatcctccccgatttaa       c.*2400

          .         .         .         .         .         .       g.29835
 atatagtcactgctacaagtaacagatgcactgtgaagattccagtattaataaaggtgt       c.*2460

          .                                                         g.29848
 actgtaattaaca                                                      c.*2473

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Metastasis suppressor 1-like protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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