microsomal triglyceride transfer protein (MTTP) - coding DNA reference sequence

(used for variant description)

(last modified November 16, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000253.2 in the MTTP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011469.1, covering MTTP transcript NM_000253.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             tttcgaacccgcaatg       c.-241

 .         .         .         .         .         .                g.5076
 gaagaaaggggaggggtttatgcggggcggggtctggagttagtgttttgggagtgggag       c.-181

 .         .         .         .         .         .                g.5136
 gtagttacagtgatgtctgttttttcccgttcaagaattaagtgtgtacctgcagacgtg       c.-121

 .         .         | 02         .         .         .             g.15767
 tattcattcatatattctt | gttctgaagagggtcactccctcactggctgccattgaaag    c.-61

 .         .         .         .         .         .                g.15827
 agtccacttctcagtgactcctagctgggcactggatgcagttgaggattgctggtcaat       c.-1

          .         .         .         .         .         .       g.15887
 ATGATTCTTCTTGCTGTGCTTTTTCTCTGCTTCATTTCCTCATATTCAGCTTCTGTTAAA       c.60
 M  I  L  L  A  V  L  F  L  C  F  I  S  S  Y  S  A  S  V  K         p.20

   | 03      .         .         .         .         .         .    g.22881
 G | GTCACACAACTGGTCTCTCATTAAATAATGACCGGCTGTACAAGCTCACGTACTCCACT    c.120
 G |   H  T  T  G  L  S  L  N  N  D  R  L  Y  K  L  T  Y  S  T      p.40

          .         .         .         .         .         .       g.22941
 GAAGTTCTTCTTGATCGGGGCAAAGGAAAACTGCAAGACAGCGTGGGCTACCGCATTTCC       c.180
 E  V  L  L  D  R  G  K  G  K  L  Q  D  S  V  G  Y  R  I  S         p.60

          .         .         .         .         .         .       g.23001
 TCCAACGTGGATGTGGCCTTACTATGGAGGAATCCTGATGGTGATGATGACCAGTTGATC       c.240
 S  N  V  D  V  A  L  L  W  R  N  P  D  G  D  D  D  Q  L  I         p.80

           | 04        .         .         .         .         .    g.24342
 CAAATAACG | ATGAAGGATGTAAATGTTGAAAATGTGAATCAGCAGAGAGGAGAGAAGAGC    c.300
 Q  I  T   | M  K  D  V  N  V  E  N  V  N  Q  Q  R  G  E  K  S      p.100

          .         .         .         .         .         .       g.24402
 ATCTTCAAAGGAAAAAGCCCATCTAAAATAATGGGAAAGGAAAACTTGGAAGCTCTGCAA       c.360
 I  F  K  G  K  S  P  S  K  I  M  G  K  E  N  L  E  A  L  Q         p.120

          .         .         .    | 05    .         .         .    g.30587
 AGACCTACGCTCCTTCATCTAATCCATGGAAAG | GTCAAAGAGTTCTACTCATATCAAAAT    c.420
 R  P  T  L  L  H  L  I  H  G  K   | V  K  E  F  Y  S  Y  Q  N      p.140

          .         .         .         .         .         .       g.30647
 GAGGCAGTGGCCATAGAAAATATCAAGAGAGGTCTGGCTAGCCTATTTCAGACACAGTTA       c.480
 E  A  V  A  I  E  N  I  K  R  G  L  A  S  L  F  Q  T  Q  L         p.160

          .         .  | 06      .         .         .         .    g.32191
 AGCTCTGGAACCACCAATGAG | GTAGATATCTCTGGAAATTGTAAAGTGACCTACCAGGCT    c.540
 S  S  G  T  T  N  E   | V  D  I  S  G  N  C  K  V  T  Y  Q  A      p.180

          .         .         .         .         .         .       g.32251
 CATCAAGACAAAGTGATCAAAATTAAGGCCTTGGATTCATGCAAAATAGCGAGGTCTGGA       c.600
 H  Q  D  K  V  I  K  I  K  A  L  D  S  C  K  I  A  R  S  G         p.200

          .         | 07         .         .         .         .    g.32610
 TTTACGACCCCAAATCAG | GTCTTGGGTGTCAGTTCAAAAGCTACATCTGTCACCACCTAT    c.660
 F  T  T  P  N  Q   | V  L  G  V  S  S  K  A  T  S  V  T  T  Y      p.220

          .         .         .         .         .         .       g.32670
 AAGATAGAAGACAGCTTTGTTATAGCTGTGCTTGCTGAAGAAACACACAATTTTGGACTG       c.720
 K  I  E  D  S  F  V  I  A  V  L  A  E  E  T  H  N  F  G  L         p.240

          .         .         .         | 08         .         .    g.35672
 AATTTCCTACAAACCATTAAGGGGAAAATAGTATCGAA | GCAGAAATTAGAGCTGAAGACA    c.780
 N  F  L  Q  T  I  K  G  K  I  V  S  K  |  Q  K  L  E  L  K  T      p.260

          .         .         .         .         .         .       g.35732
 ACCGAAGCAGGCCCAAGATTGATGTCTGGAAAGCAGGCTGCAGCCATAATCAAAGCAGTT       c.840
 T  E  A  G  P  R  L  M  S  G  K  Q  A  A  A  I  I  K  A  V         p.280

          .         .         .         .         .         .       g.35792
 GATTCAAAGTACACGGCCATTCCCATTGTGGGGCAGGTCTTCCAGAGCCACTGTAAAGGA       c.900
 D  S  K  Y  T  A  I  P  I  V  G  Q  V  F  Q  S  H  C  K  G         p.300

           | 09        .         .         .         .         .    g.38035
 TGTCCTTCT | CTCTCGGAGCTCTGGCGGTCCACCAGGAAATACCTGCAGCCTGACAACCTT    c.960
 C  P  S   | L  S  E  L  W  R  S  T  R  K  Y  L  Q  P  D  N  L      p.320

          .         .         .         .         .         .       g.38095
 TCCAAGGCTGAGGCTGTCAGAAACTTCCTGGCCTTCATTCAGCACCTCAGGACTGCGAAG       c.1020
 S  K  A  E  A  V  R  N  F  L  A  F  I  Q  H  L  R  T  A  K         p.340

          .         .         .         .        | 10.         .    g.41495
 AAAGAAGAGATCCTTCAAATACTAAAGATGGAAAATAAGGAAGTATT | ACCTCAGCTGGTG    c.1080
 K  E  E  I  L  Q  I  L  K  M  E  N  K  E  V  L  |  P  Q  L  V      p.360

          .         .         .         .         .         .       g.41555
 GATGCTGTCACCTCTGCTCAGACCTCAGACTCATTAGAAGCCATTTTGGACTTTTTGGAT       c.1140
 D  A  V  T  S  A  Q  T  S  D  S  L  E  A  I  L  D  F  L  D         p.380

          .         .         .         .         .         .       g.41615
 TTCAAAAGTGACAGCAGCATTATCCTCCAGGAGAGGTTTCTCTATGCCTGTGGATTTGCT       c.1200
 F  K  S  D  S  S  I  I  L  Q  E  R  F  L  Y  A  C  G  F  A         p.400

          .         .         .       | 11 .         .         .    g.42548
 TCTCATCCCAATGAAGAACTCCTGAGAGCCCTCATT | AGTAAGTTCAAAGGTTCTATTGGT    c.1260
 S  H  P  N  E  E  L  L  R  A  L  I   | S  K  F  K  G  S  I  G      p.420

          .         .         .         .         .         .       g.42608
 AGCAGTGACATCAGAGAAACTGTTATGATCATCACTGGGACACTTGTCAGAAAGTTGTGT       c.1320
 S  S  D  I  R  E  T  V  M  I  I  T  G  T  L  V  R  K  L  C         p.440

          .         .     | 12   .         .         .         .    g.47701
 CAGAATGAAGGCTGCAAACTCAAA | GCAGTAGTGGAAGCTAAGAAGTTAATCCTGGGAGGA    c.1380
 Q  N  E  G  C  K  L  K   | A  V  V  E  A  K  K  L  I  L  G  G      p.460

          .         .         .         .         .         .       g.47761
 CTTGAAAAAGCAGAGAAAAAAGAGGACACCAGGATGTATCTGCTGGCTTTGAAGAATGCC       c.1440
 L  E  K  A  E  K  K  E  D  T  R  M  Y  L  L  A  L  K  N  A         p.480

          .         .         .         .         .         .       g.47821
 CTGCTTCCAGAAGGCATCCCAAGTCTTCTGAAGTATGCAGAAGCAGGAGAAGGGCCCATC       c.1500
 L  L  P  E  G  I  P  S  L  L  K  Y  A  E  A  G  E  G  P  I         p.500

          .         .         .         .         .        | 13.    g.49686
 AGCCACCTGGCTACCACTGCTCTCCAGAGATATGATCTCCCTTTCATAACTGATGAG | GTG    c.1560
 S  H  L  A  T  T  A  L  Q  R  Y  D  L  P  F  I  T  D  E   | V      p.520

          .         .         .         .         .         .       g.49746
 AAGAAGACCTTAAACAGAATATACCACCAAAACCGTAAAGTTCATGAAAAGACTGTGCGC       c.1620
 K  K  T  L  N  R  I  Y  H  Q  N  R  K  V  H  E  K  T  V  R         p.540

          .         .         .         .         .         .       g.49806
 ACTGCTGCAGCTGCTATCATTTTAAATAACAATCCATCCTACATGGACGTCAAGAACATC       c.1680
 T  A  A  A  A  I  I  L  N  N  N  P  S  Y  M  D  V  K  N  I         p.560

          .         .         .         .         .         .       g.49866
 CTGCTGTCTATTGGGGAGCTTCCCCAAGAAATGAATAAATACATGCTCGCCATTGTTCAA       c.1740
 L  L  S  I  G  E  L  P  Q  E  M  N  K  Y  M  L  A  I  V  Q         p.580

          .         .          | 14        .         .         .    g.52091
 GACATCCTACGTTTTGAAATGCCTGCAAG | CAAAATTGTCCGTCGAGTTCTGAAGGAAATG    c.1800
 D  I  L  R  F  E  M  P  A  S  |  K  I  V  R  R  V  L  K  E  M      p.600

          .         .         .         .         .         .       g.52151
 GTCGCTCACAATTATGACCGTTTCTCCAGGAGTGGATCTTCTTCTGCCTACACTGGCTAC       c.1860
 V  A  H  N  Y  D  R  F  S  R  S  G  S  S  S  A  Y  T  G  Y         p.620

         | 15.         .         .         .         .         .    g.52302
 ATAGAAC | GTAGTCCCCGTTCGGCATCTACTTACAGCCTAGACATTCTCTACTCGGGTTCT    c.1920
 I  E  R |   S  P  R  S  A  S  T  Y  S  L  D  I  L  Y  S  G  S      p.640

          .         .         .         .         .         .       g.52362
 GGCATTCTAAGGAGAAGTAACCTGAACATCTTTCAGTACATTGGGAAGGCTGGTCTTCAC       c.1980
 G  I  L  R  R  S  N  L  N  I  F  Q  Y  I  G  K  A  G  L  H         p.660

           | 16        .         .         .         .         .    g.53881
 GGTAGCCAG | GTGGTTATTGAAGCCCAAGGACTGGAAGCCTTAATCGCAGCCACCCCTGAC    c.2040
 G  S  Q   | V  V  I  E  A  Q  G  L  E  A  L  I  A  A  T  P  D      p.680

          .         .         .         .         .         .       g.53941
 GAGGGGGAGGAGAACCTTGACTCCTATGCTGGTATGTCAGCCATCCTCTTTGATGTTCAG       c.2100
 E  G  E  E  N  L  D  S  Y  A  G  M  S  A  I  L  F  D  V  Q         p.700

          .         .         .         .         .         .       g.54001
 CTCAGACCTGTCACCTTTTTCAACGGATACAGTGATTTGATGTCCAAAATGCTGTCAGCA       c.2160
 L  R  P  V  T  F  F  N  G  Y  S  D  L  M  S  K  M  L  S  A         p.720

          .         .         .         .         .        | 17.    g.59894
 TCTGGCGACCCTATCAGTGTGGTGAAAGGACTTATTCTGCTAATAGATCATTCTCAG | GAA    c.2220
 S  G  D  P  I  S  V  V  K  G  L  I  L  L  I  D  H  S  Q   | E      p.740

          .         .         .         .         .         .       g.59954
 CTTCAGTTACAATCTGGACTAAAAGCCAATATAGAGGTCCAGGGTGGTCTAGCTATTGAT       c.2280
 L  Q  L  Q  S  G  L  K  A  N  I  E  V  Q  G  G  L  A  I  D         p.760

          .         .         .         .         .         .       g.60014
 ATTTCAGGTGCAATGGAGTTTAGCTTGTGGTATCGTGAGTCTAAAACCCGAGTGAAAAAT       c.2340
 I  S  G  A  M  E  F  S  L  W  Y  R  E  S  K  T  R  V  K  N         p.780

    | 18     .         .         .         .         .         .    g.62036
 AG | GGTGACTGTGGTAATAACCACTGACATCACAGTGGACTCCTCTTTTGTGAAAGCTGGC    c.2400
 R  |  V  T  V  V  I  T  T  D  I  T  V  D  S  S  F  V  K  A  G      p.800

          .         .         .         .         .         .       g.62096
 CTGGAAACCAGTACAGAAACAGAAGCAGGCTTGGAGTTTATCTCCACAGTGCAGTTTTCT       c.2460
 L  E  T  S  T  E  T  E  A  G  L  E  F  I  S  T  V  Q  F  S         p.820

          .         .         .         .         .    | 19    .    g.63601
 CAGTACCCATTCTTAGTTTGCATGCAGATGGACAAGGATGAAGCTCCATTCAG | GCAATTT    c.2520
 Q  Y  P  F  L  V  C  M  Q  M  D  K  D  E  A  P  F  R  |  Q  F      p.840

          .         .         .         .         .         .       g.63661
 GAGAAAAAGTACGAAAGGCTGTCCACAGGCAGAGGTTATGTCTCTCAGAAAAGAAAAGAA       c.2580
 E  K  K  Y  E  R  L  S  T  G  R  G  Y  V  S  Q  K  R  K  E         p.860

          .         .         .         .         .         .       g.63721
 AGCGTATTAGCAGGATGTGAATTCCCGCTCCATCAAGAGAACTCAGAGATGTGCAAAGTG       c.2640
 S  V  L  A  G  C  E  F  P  L  H  Q  E  N  S  E  M  C  K  V         p.880

          .         .         .         .                           g.63766
 GTGTTTGCCCCTCAGCCGGATAGTACTTCCAGCGGATGGTTTTGA                      c.2685
 V  F  A  P  Q  P  D  S  T  S  S  G  W  F  X                        p.894

          .         .         .         .         .         .       g.63826
 aactgacctgtgatattttacttgaatttgtctccccgaaagggacacaatgtggcatga       c.*60

          .         .         .         .         .         .       g.63886
 ctaagtacttgctctctgagagcacagcgtttacatatttacctgtatttaagatttttg       c.*120

          .         .         .         .         .         .       g.63946
 taaaaagctacaaaaaactgcagtttgatcaaatttgggtatatgcagtatgctacccac       c.*180

          .         .         .         .         .         .       g.64006
 agcgtcattttgaatcatcatgtgacgctttcaacaacgttcttagtttacttatacctc       c.*240

          .         .         .         .         .         .       g.64066
 tctcaaatctcatttggtacagtcagaatagttattctctaagaggaaactagtgtttgt       c.*300

          .         .         .         .         .         .       g.64126
 taaaaacaaaaataaaaacaaaaccacacaaggagaacccaattttgtttcaacaatttt       c.*360

          .         .         .         .         .         .       g.64186
 tgatcaatgtatatgaagctcttgataggacttccttaagcatgacgggaaaaccaaaca       c.*420

          .         .         .         .         .         .       g.64246
 cgttccctaatcaggaaaaaaaaaaaaaaaaaaagtaagacacaaacaaaccattttttt       c.*480

          .         .         .         .         .         .       g.64306
 tctctttttttggagttgggggcccagggagaagggacaagacttttaaaagacttgtta       c.*540

          .         .         .         .         .         .       g.64366
 gccaacttcaagaattaatatttatgtctctgttattgttagttttaagccttaaggtag       c.*600

          .         .         .         .         .         .       g.64426
 aaggcacatagaaataacatctcatctttctgctgaccattttagtgaggttgttccaaa       c.*660

          .         .         .         .         .         .       g.64486
 gacattcaggtctctacctccagccctgcaaaaatattggacctagcacagaggaatcag       c.*720

          .         .         .         .         .         .       g.64546
 gaaaattaatttcagaaactccatttgatttttcttttgctgtgtctttttgagactgta       c.*780

          .         .         .         .         .         .       g.64606
 atatggtacactgtcctctaagggacatcctcattttatctcacctttttgggggtgaga       c.*840

          .         .         .         .         .         .       g.64666
 gctctagttcatttaactgtactctgcacaatagctaggatgactaagagaacattgctt       c.*900

          .         .         .         .         .         .       g.64726
 caagaaactggtggatttggatttccaaaatatgaaataaggaaaaaaatgtttttattt       c.*960

          .         .         .         .         .         .       g.64786
 gtatgaattaaaagatccatgttgaacatttgcaaatatttattaataaacagatgtggt       c.*1020

          .         .         .         .         .         .       g.64846
 gataaacccaaaacaaatgacaggtccttattttccactaaacacagacacatgaaatga       c.*1080

          .         .         .         .         .         .       g.64906
 aagtttagctagcccactatttgttgtaaattgaaaacgaagtgtgataaaataaatatg       c.*1140

                                                                    g.64915
 tagaaatca                                                          c.*1149

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Microsomal triglyceride transfer protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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