myosin binding protein C, slow type (MYBPC1) - coding DNA reference sequence

(used for variant description)

(last modified July 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_002465.3 in the MYBPC1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031912.1, covering MYBPC1 transcript NM_002465.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         agaggcagtataaaagcact       c.-121

 .         .         .         .         .         .                g.5080
 gggtttctccccaactgcttgtcacaccgacctgcaccatctctcgcctgcctgtggggt       c.-61

 .         .         .         .         .         .                g.5140
 ttctgtcaactagtcgtggagggaaggagactctttaaagaataacatcttattgtggcc       c.-1

          .         .      | 02  .         .         .         .    g.24600
 ATGCCAGAACCCACTAAGAAAGAGG | AAAATGAAGTGCCAGCCCCAGCCCCACCCCCGGAA    c.60
 M  P  E  P  T  K  K  E  E |   N  E  V  P  A  P  A  P  P  P  E      p.20

   | 03      .         .         .         .    | 04    .         . g.36958
 G | AACCAAGTAAAGAGAAGGAGGCCGGAACTACACCAGCAAAAG | ATGAAGAGGAAGTCTCC c.120
 E |   P  S  K  E  K  E  A  G  T  T  P  A  K  D |   E  E  E  V  S   p.40

          .         .   | 05     .         .         .         | 06 g.39505
 CCGCCTAGCGCCTTGCCTCCAG | GTTTGGGTAGTCGGGCCCTGGAGAGAAAAGATTCAG | AC c.180
 P  P  S  A  L  P  P  G |   L  G  S  R  A  L  E  R  K  D  S  D |    p.60

          .         .         .         .         .         .       g.39565
 TGGACCCTTGTCGAAACTCCTCCTGGGGAGGAACAAGCCAAGCAGAATGCCAACTCCCAG       c.240
 W  T  L  V  E  T  P  P  G  E  E  Q  A  K  Q  N  A  N  S  Q         p.80

          .         .         .         .          | 07        .    g.41651
 CTGTCCATCTTGTTCATTGAAAAACCTCAAGGAGGAACAGTGAAAGTTG | GTGAAGATATC    c.300
 L  S  I  L  F  I  E  K  P  Q  G  G  T  V  K  V  G |   E  D  I      p.100

          .         .         .         .         .         .       g.41711
 ACCTTCATAGCCAAAGTCAAGGCTGAAGATCTTCTGAGAAAACCCACTATCAAATGGTTC       c.360
 T  F  I  A  K  V  K  A  E  D  L  L  R  K  P  T  I  K  W  F         p.120

          .         .         .         .         .         .       g.41771
 AAAGGAAAATGGATGGACCTGGCCAGCAAAGCCGGGAAGCACCTTCAGCTGAAGGAAACC       c.420
 K  G  K  W  M  D  L  A  S  K  A  G  K  H  L  Q  L  K  E  T         p.140

          .         | 08         .         .         .         .    g.42132
 TTTGAGAGGCACAGTCGG | GTGTACACATTTGAGATGCAGATCATCAAGGCCAAAGATAAC    c.480
 F  E  R  H  S  R   | V  Y  T  F  E  M  Q  I  I  K  A  K  D  N      p.160

          .         .         .         .         .         .       g.42192
 TTTGCAGGAAATTACAGATGCGAGGTCACCTATAAGGATAAGTTTGACAGCTGTTCATTT       c.540
 F  A  G  N  Y  R  C  E  V  T  Y  K  D  K  F  D  S  C  S  F         p.180

          .       | 09 .         .         .         .         .    g.44667
 GATCTTGAAGTGCACG | AATCTACTGGGACTACTCCAAACATTGACATCAGATCTGCTTTC    c.600
 D  L  E  V  H  E |   S  T  G  T  T  P  N  I  D  I  R  S  A  F      p.200

          | 10         .         .         .         .         .    g.46793
 AAGAGAAG | TGGAGAAGGTCAAGAGGATGCAGGAGAACTTGACTTTAGTGGTCTCCTGAAA    c.660
 K  R  S  |  G  E  G  Q  E  D  A  G  E  L  D  F  S  G  L  L  K      p.220

       | 11  .         .         .         .         .         .    g.52543
 CGTAG | GGAGGTGAAGCAGCAGGAGGAAGAACCCCAGGTGGACGTATGGGAGTTGCTGAAG    c.720
 R  R  |  E  V  K  Q  Q  E  E  E  P  Q  V  D  V  W  E  L  L  K      p.240

          .         .         .         .         .         .       g.52603
 AACGCGAAACCCAGTGAGTACGAGAAGATCGCCTTCCAGTATGGAATCACCGACCTGCGC       c.780
 N  A  K  P  S  E  Y  E  K  I  A  F  Q  Y  G  I  T  D  L  R         p.260

          .         .         .         .         .   | 12     .    g.54741
 GGCATGCTCAAGCGACTCAAGCGCATGCGCAGAGAGGAGAAGAAGAGCGCAG | CTTTTGCA    c.840
 G  M  L  K  R  L  K  R  M  R  R  E  E  K  K  S  A  A |   F  A      p.280

          .         .         .         .         .         .       g.54801
 AAAATTCTTGATCCTGCATATCAGGTTGACAAAGGAGGCAGAGTGAGGTTTGTTGTGGAG       c.900
 K  I  L  D  P  A  Y  Q  V  D  K  G  G  R  V  R  F  V  V  E         p.300

          .         .         .         .         .         .       g.54861
 CTGGCAGATCCAAAGTTGGAGGTGAAATGGTATAAAAATGGTCAAGAAATTCGACCCAGT       c.960
 L  A  D  P  K  L  E  V  K  W  Y  K  N  G  Q  E  I  R  P  S         p.320

       | 13  .         .         .         .         .         .    g.56887
 ACCAA | ATACATCTTTGAACACAAAGGATGCCAGAGAATCCTGTTTATCAATAACTGTCAG    c.1020
 T  K  |  Y  I  F  E  H  K  G  C  Q  R  I  L  F  I  N  N  C  Q      p.340

          .         .         .         .         .         .       g.56947
 ATGACAGATGATTCAGAGTATTATGTGACAGCCGGTGATGAGAAATGTTCCACTGAGCTC       c.1080
 M  T  D  D  S  E  Y  Y  V  T  A  G  D  E  K  C  S  T  E  L         p.360

          . | 14       .         .         .         .         .    g.58164
 TTCGTAAGAG | AGCCTCCAATTATGGTGACCAAACAGCTGGAAGATACAACTGCTTATTGT    c.1140
 F  V  R  E |   P  P  I  M  V  T  K  Q  L  E  D  T  T  A  Y  C      p.380

          .         .         .         .         .       | 15 .    g.59333
 GGGGAGAGAGTGGAATTAGAATGTGAGGTGTCTGAAGATGATGCCAATGTAAAATG | GTTT    c.1200
 G  E  R  V  E  L  E  C  E  V  S  E  D  D  A  N  V  K  W  |  F      p.400

          .         .         .         .         .         .       g.59393
 AAGAATGGTGAAGAGATTATCCCTGGTCCAAAATCAAGATACCGAATTAGAGTTGAGGGT       c.1260
 K  N  G  E  E  I  I  P  G  P  K  S  R  Y  R  I  R  V  E  G         p.420

          .         .         .         .         .         .       g.59453
 AAAAAACACATCTTGATCATAGAGGGAGCAACAAAGGCTGATGCTGCAGAATATTCAGTA       c.1320
 K  K  H  I  L  I  I  E  G  A  T  K  A  D  A  A  E  Y  S  V         p.440

          .         .         .         .    | 16    .         .    g.61317
 ATGACAACAGGAGGACAATCATCTGCTAAACTTAGTGTTGACT | TGAAACCTCTGAAGATT    c.1380
 M  T  T  G  G  Q  S  S  A  K  L  S  V  D  L |   K  P  L  K  I      p.460

          .         .         .         .         .         .       g.61377
 TTGACACCTCTGACTGATCAGACTGTAAATCTTGGAAAAGAAATCTGCCTGAAGTGTGAA       c.1440
 L  T  P  L  T  D  Q  T  V  N  L  G  K  E  I  C  L  K  C  E         p.480

          .         .         .         .         .         .       g.61437
 ATCTCTGAAAACATACCAGGAAAATGGACTAAAAATGGCCTACCTGTTCAGGAGAGTGAC       c.1500
 I  S  E  N  I  P  G  K  W  T  K  N  G  L  P  V  Q  E  S  D         p.500

          .         .       | 17 .         .         .         .    g.62781
 CGTCTAAAGGTGGTTCACAAGGGAAG | GATCCACAAGTTAGTGATAGCCAATGCCCTCACT    c.1560
 R  L  K  V  V  H  K  G  R  |  I  H  K  L  V  I  A  N  A  L  T      p.520

          .         .         .         .         .         .       g.62841
 GAAGATGAAGGTGATTATGTATTTGCACCTGATGCCTACAATGTTACTCTGCCTGCCAAA       c.1620
 E  D  E  G  D  Y  V  F  A  P  D  A  Y  N  V  T  L  P  A  K         p.540

          .    | 18    .         .         .         .         .    g.63231
 GTTCATGTTATTG | ATCCTCCTAAGATCATCCTGGATGGTCTTGATGCTGACAACACAGTG    c.1680
 V  H  V  I  D |   P  P  K  I  I  L  D  G  L  D  A  D  N  T  V      p.560

          .         .         .         .         .         .       g.63291
 ACAGTGATTGCAGGAAACAAGCTTCGTCTTGAGATCCCCATCAGCGGAGAACCACCTCCT       c.1740
 T  V  I  A  G  N  K  L  R  L  E  I  P  I  S  G  E  P  P  P         p.580

          .         .        | 19.         .         .         .    g.69774
 AAAGCCATGTGGAGCCGGGGAGATAAG | GCTATTATGGAAGGCAGTGGCCGGATAAGAACA    c.1800
 K  A  M  W  S  R  G  D  K   | A  I  M  E  G  S  G  R  I  R  T      p.600

          .         .         .         .         .         .       g.69834
 GAATCTTACCCTGATAGCAGCACTCTGGTCATTGATATAGCTGAAAGAGATGACTCTGGT       c.1860
 E  S  Y  P  D  S  S  T  L  V  I  D  I  A  E  R  D  D  S  G         p.620

          .         .         .         .         .         .       g.69894
 GTTTACCACATCAATCTGAAAAACGAAGCTGGAGAGGCACATGCAAGCATCAAGGTTAAA       c.1920
 V  Y  H  I  N  L  K  N  E  A  G  E  A  H  A  S  I  K  V  K         p.640

         | 20.         .         .         .         .         .    g.71280
 GTTGTGG | ACTTCCCTGATCCTCCAGTGGCACCGACTGTGACAGAGGTGGGAGATGACTGG    c.1980
 V  V  D |   F  P  D  P  P  V  A  P  T  V  T  E  V  G  D  D  W      p.660

          .         .         .         .         .   | 21     .    g.72435
 TGTATCATGAACTGGGAGCCTCCTGCCTACGACGGAGGCTCTCCAATCCTAG | GATATTTT    c.2040
 C  I  M  N  W  E  P  P  A  Y  D  G  G  S  P  I  L  G |   Y  F      p.680

          .         .         .         .         .         .       g.72495
 ATTGAGAGGAAGAAGAAACAAAGCTCCAGGTGGATGAGGCTGAATTTTGATCTCTGCAAA       c.2100
 I  E  R  K  K  K  Q  S  S  R  W  M  R  L  N  F  D  L  C  K         p.700

          .         .         .         .         .         .       g.72555
 GAAACAACTTTTGAGCCCAAGAAGATGATTGAAGGTGTGGCCTATGAGGTCCGCATCTTT       c.2160
 E  T  T  F  E  P  K  K  M  I  E  G  V  A  Y  E  V  R  I  F         p.720

          .         .         .         .         .         .       g.72615
 GCAGTCAATGCCATTGGCATCTCCAAGCCCAGTATGCCCTCCAGGCCTTTTGTTCCTTTG       c.2220
 A  V  N  A  I  G  I  S  K  P  S  M  P  S  R  P  F  V  P  L         p.740

   | 22      .         .         .         .         .         .    g.73554
 G | CTGTAACAAGCCCTCCTACTCTTCTGACTGTGGACTCTGTCACTGACACGACTGTCACG    c.2280
 A |   V  T  S  P  P  T  L  L  T  V  D  S  V  T  D  T  T  V  T      p.760

          .         .         .         .         .         .       g.73614
 ATGAGGTGGCGCCCCCCAGACCACATTGGTGCAGCAGGTTTAGATGGCTATGTGCTAGAG       c.2340
 M  R  W  R  P  P  D  H  I  G  A  A  G  L  D  G  Y  V  L  E         p.780

          .       | 23 .         .         .         .         .    g.77845
 TATTGCTTTGAAGGAA | CTGAGGACTGGATAGTTGCAAACAAAGATCTGATTGACAAGACG    c.2400
 Y  C  F  E  G  T |   E  D  W  I  V  A  N  K  D  L  I  D  K  T      p.800

          .         .         .         .         .         .       g.77905
 AAGTTCACCATCACAGGTCTGCCAACAGATGCAAAGATCTTTGTGCGTGTGAAGGCTGTT       c.2460
 K  F  T  I  T  G  L  P  T  D  A  K  I  F  V  R  V  K  A  V         p.820

          .         .         .         .         .         .       g.77965
 AATGCAGCTGGTGCCAGCGAGCCCAAGTACTATTCTCAGCCCATTCTCGTGAAGGAAATC       c.2520
 N  A  A  G  A  S  E  P  K  Y  Y  S  Q  P  I  L  V  K  E  I         p.840

      | 24   .         .         .         .         .         .    g.80446
 ATAG | AACCTCCAAAGATTCGCATTCCAAGACACCTGAAGCAAACCTATATCCGCAGAGTT    c.2580
 I  E |   P  P  K  I  R  I  P  R  H  L  K  Q  T  Y  I  R  R  V      p.860

          .         .         .    | 25    .         .         .    g.83523
 GGAGAAGCTGTCAATCTGGTTATACCTTTCCAG | GGAAAACCAAGACCAGAATTAACTTGG    c.2640
 G  E  A  V  N  L  V  I  P  F  Q   | G  K  P  R  P  E  L  T  W      p.880

          .         .         .         .         .         .       g.83583
 AAGAAGGATGGTGCAGAAATTGATAAGAATCAAATAAACATTCGCAACTCTGAGACTGAT       c.2700
 K  K  D  G  A  E  I  D  K  N  Q  I  N  I  R  N  S  E  T  D         p.900

          .         .         .         .         .         .       g.83643
 ACAATCATATTTATTAGAAAAGCAGAGAGGAGCCACTCTGGGAAATATGATCTGCAAGTC       c.2760
 T  I  I  F  I  R  K  A  E  R  S  H  S  G  K  Y  D  L  Q  V         p.920

          .         .         .         .          | 26        .    g.85372
 AAAGTGGACAAATTCGTGGAGACCGCATCAATTGACATCCAGATCATTG | ACCGTCCAGGT    c.2820
 K  V  D  K  F  V  E  T  A  S  I  D  I  Q  I  I  D |   R  P  G      p.940

          .         .         .         .         .         .       g.85432
 CCACCCCAAATTGTGAAGATTGAGGATGTCTGGGGAGAAAATGTCGCTCTCACATGGACT       c.2880
 P  P  Q  I  V  K  I  E  D  V  W  G  E  N  V  A  L  T  W  T         p.960

          .         .         .         .         .         .       g.85492
 CCACCAAAGGATGATGGAAATGCTGCTATCACAGGCTATACCATTCAGAAGGCTGACAAG       c.2940
 P  P  K  D  D  G  N  A  A  I  T  G  Y  T  I  Q  K  A  D  K         p.980

           | 27        .         .         .         .         .    g.87355
 AAGAGCATG | GAATGGTTTACTGTCATTGAGCATTATCATCGAACCAGTGCCACCATTACT    c.3000
 K  S  M   | E  W  F  T  V  I  E  H  Y  H  R  T  S  A  T  I  T      p.1000

          .         .         .         .         .         .       g.87415
 GAATTGGTCATAGGGAATGAATATTACTTCCGGGTCTTTTCTGAAAACATGTGTGGCCTC       c.3060
 E  L  V  I  G  N  E  Y  Y  F  R  V  F  S  E  N  M  C  G  L         p.1020

          .         .         .         .          | 28        .    g.88182
 AGTGAGGATGCCACCATGACTAAAGAGAGTGCAGTGATCGCCAGGGATG | GTAAAATCTAC    c.3120
 S  E  D  A  T  M  T  K  E  S  A  V  I  A  R  D  G |   K  I  Y      p.1040

          .         .         .         .         .         .       g.88242
 AAAAATCCAGTGTATGAAGACTTTGATTTCTCAGAGGCACCCATGTTTACTCAGCCTTTG       c.3180
 K  N  P  V  Y  E  D  F  D  F  S  E  A  P  M  F  T  Q  P  L         p.1060

          .         .         .         .         .         .       g.88302
 GTTAACACCTATGCCATAGCTGGTTACAATGCCACCCTAAACTGCAGTGTGAGAGGAAAT       c.3240
 V  N  T  Y  A  I  A  G  Y  N  A  T  L  N  C  S  V  R  G  N         p.1080

        | 29 .         .         .         .         .         .    g.90466
 CCTAAG | CCTAAAATAACCTGGATGAAAAACAAAGTTGCTATTGTGGATGATCCAAGATAC    c.3300
 P  K   | P  K  I  T  W  M  K  N  K  V  A  I  V  D  D  P  R  Y      p.1100

          .         .         .         .         .         .       g.90526
 AGGATGTTCAGCAACCAGGGAGTCTGTACCCTGGAAATTCGCAAGCCCAGCCCCTATGAT       c.3360
 R  M  F  S  N  Q  G  V  C  T  L  E  I  R  K  P  S  P  Y  D         p.1120

          .         .         .         .         .         .       g.90586
 GGAGGCACTTACTGCTGCAAAGCAGTCAATGACCTTGGGACAGTGGAGATTGAATGCAAA       c.3420
 G  G  T  Y  C  C  K  A  V  N  D  L  G  T  V  E  I  E  C  K         p.1140

          .    | 30    .         .         .         .         .    g.92720
 CTGGAGGTGAAAG | TGATATATCAAGGAGTAAATACCCCTGGACAACCAGTCTTCCTGGAG    c.3480
 L  E  V  K  V |   I  Y  Q  G  V  N  T  P  G  Q  P  V  F  L  E      p.1160

          .   | 31     .         .                              g.94499
 GGGCAGCAACAG | TCATTGCACAATAAGGATTTTTGA |                         c.3517
 G  Q  Q  Q   | S  L  H  N  K  D  F  X                           p.1171

          .          | 32        .         .         .         .    g.95716
 atgtataatatcatctaag | gtgggctctccttctgcagactcctcttgcaaggcgtacct    c.*60

          .         .         .         .         .         .       g.95776
 ccaaacataattgattcgtatctgcgagacttacactcaagcaatcctgaggaatactga       c.*120

          .         .         .         .         .         .       g.95836
 gggagggcctggctactgtctctctgcactctgctgctttgaaatctggttgaaatgaga       c.*180

          .         .         .         .         .         .       g.95896
 aaaagcattttctgttttcccaccaggcccccaagtgtggtctttttctttcctcctaat       c.*240

          .         .         .         .         .         .       g.95956
 gttgaagagaaaaaaaaaaaaaaaagtttgcccagattgcttaattaaaaattgcaaaca       c.*300

          .                                                         g.95974
 aaatctcatttgaagtca                                                 c.*318

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Myosin binding protein C, slow type protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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