v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN) - coding DNA reference sequence

(used for variant description)

(last modified March 24, 2026)


This file was created to facilitate the description of sequence variants on transcript NM_005378.4 in the MYCN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering MYCN transcript NM_005378.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 gtcatctgtctggacgcgctgggtggatgcggggggctcctgggaactgtgttggagccg       c.-241

 .         .         .         .         .         .                g.5120
 agcaagcgctagccaggcgcaagcgcgcacagactgtagccatccgaggacacccccgcc       c.-181

 .         .         .         .         .         .                g.5180
 cccccggcccacccggagacacccgcgcagaatcgcctccggatcccctgcagtcggcgg       c.-121

 .   | 02     .         .         .         .         .             g.6444
 gag | tgttggaggtcggcgccggcccccgccttccgcgccccccacgggaaggaagcaccc    c.-61

 .         .         .         .         .         .                g.6504
 ccggtattaaaacgaacggggcggaaagaagccctcagtcgccggccgggaggcgagccg       c.-1

          .         .         .         .         .         .       g.6564
 ATGCCGAGCTGCTCCACGTCCACCATGCCGGGCATGATCTGCAAGAACCCAGACCTCGAG       c.60
 M  P  S  C  S  T  S  T  M  P  G  M  I  C  K  N  P  D  L  E         p.20

          .         .         .         .         .         .       g.6624
 TTTGACTCGCTACAGCCCTGCTTCTACCCGGACGAAGATGACTTCTACTTCGGCGGCCCC       c.120
 F  D  S  L  Q  P  C  F  Y  P  D  E  D  D  F  Y  F  G  G  P         p.40

          .         .         .         .         .         .       g.6684
 GACTCGACCCCCCCGGGGGAGGACATCTGGAAGAAGTTTGAGCTGCTGCCCACGCCCCCG       c.180
 D  S  T  P  P  G  E  D  I  W  K  K  F  E  L  L  P  T  P  P         p.60

          .         .         .         .         .         .       g.6744
 CTGTCGCCCAGCCGTGGCTTCGCGGAGCACAGCTCCGAGCCCCCGAGCTGGGTCACGGAG       c.240
 L  S  P  S  R  G  F  A  E  H  S  S  E  P  P  S  W  V  T  E         p.80

          .         .         .         .         .         .       g.6804
 ATGCTGCTTGAGAACGAGCTGTGGGGCAGCCCGGCCGAGGAGGACGCGTTCGGCCTGGGG       c.300
 M  L  L  E  N  E  L  W  G  S  P  A  E  E  D  A  F  G  L  G         p.100

          .         .         .         .         .         .       g.6864
 GGACTGGGTGGCCTCACCCCCAACCCGGTCATCCTCCAGGACTGCATGTGGAGCGGCTTC       c.360
 G  L  G  G  L  T  P  N  P  V  I  L  Q  D  C  M  W  S  G  F         p.120

          .         .         .         .         .         .       g.6924
 TCCGCCCGCGAGAAGCTGGAGCGCGCCGTGAGCGAGAAGCTGCAGCACGGCCGCGGGCCG       c.420
 S  A  R  E  K  L  E  R  A  V  S  E  K  L  Q  H  G  R  G  P         p.140

          .         .         .         .         .         .       g.6984
 CCAACCGCCGGTTCCACCGCCCAGTCCCCGGGAGCCGGCGCCGCCAGCCCTGCGGGTCGC       c.480
 P  T  A  G  S  T  A  Q  S  P  G  A  G  A  A  S  P  A  G  R         p.160

          .         .         .         .         .         .       g.7044
 GGGCACGGCGGGGCTGCGGGAGCCGGCCGCGCCGGGGCCGCCCTGCCCGCCGAGCTCGCC       c.540
 G  H  G  G  A  A  G  A  G  R  A  G  A  A  L  P  A  E  L  A         p.180

          .         .         .         .         .         .       g.7104
 CACCCGGCCGCCGAGTGCGTGGATCCCGCCGTGGTCTTCCCCTTTCCCGTGAACAAGCGC       c.600
 H  P  A  A  E  C  V  D  P  A  V  V  F  P  F  P  V  N  K  R         p.200

          .         .         .         .         .         .       g.7164
 GAGCCAGCGCCCGTGCCCGCAGCCCCGGCCAGTGCCCCGGCGGCGGGCCCTGCGGTCGCC       c.660
 E  P  A  P  V  P  A  A  P  A  S  A  P  A  A  G  P  A  V  A         p.220

          .         .         .         .         .         .       g.7224
 TCGGGGGCGGGTATTGCCGCCCCAGCCGGGGCCCCGGGGGTCGCCCCTCCGCGCCCAGGC       c.720
 S  G  A  G  I  A  A  P  A  G  A  P  G  V  A  P  P  R  P  G         p.240

          .         .         .         .         .         .       g.7284
 GGCCGCCAGACCAGCGGCGGCGACCACAAGGCCCTCAGTACCTCCGGAGAGGACACCCTG       c.780
 G  R  Q  T  S  G  G  D  H  K  A  L  S  T  S  G  E  D  T  L         p.260

          . | 03       .         .         .         .         .    g.9982
 AGCGATTCAG | ATGATGAAGATGATGAAGAGGAAGATGAAGAGGAAGAAATCGACGTGGTC    c.840
 S  D  S  D |   D  E  D  D  E  E  E  D  E  E  E  E  I  D  V  V      p.280

          .         .         .         .         .         .       g.10042
 ACTGTGGAGAAGCGGCGTTCCTCCTCCAACACCAAGGCTGTCACCACATTCACCATCACT       c.900
 T  V  E  K  R  R  S  S  S  N  T  K  A  V  T  T  F  T  I  T         p.300

          .         .         .         .         .         .       g.10102
 GTGCGTCCCAAGAACGCAGCCCTGGGTCCCGGGAGGGCTCAGTCCAGCGAGCTGATCCTC       c.960
 V  R  P  K  N  A  A  L  G  P  G  R  A  Q  S  S  E  L  I  L         p.320

          .         .         .         .         .         .       g.10162
 AAACGATGCCTTCCCATCCACCAGCAGCACAACTATGCCGCCCCCTCTCCCTACGTGGAG       c.1020
 K  R  C  L  P  I  H  Q  Q  H  N  Y  A  A  P  S  P  Y  V  E         p.340

          .         .         .         .         .         .       g.10222
 AGTGAGGATGCACCCCCACAGAAGAAGATAAAGAGCGAGGCGTCCCCACGTCCGCTCAAG       c.1080
 S  E  D  A  P  P  Q  K  K  I  K  S  E  A  S  P  R  P  L  K         p.360

          .         .         .         .         .         .       g.10282
 AGTGTCATCCCCCCAAAGGCTAAGAGCTTGAGCCCCCGAAACTCTGACTCGGAGGACAGT       c.1140
 S  V  I  P  P  K  A  K  S  L  S  P  R  N  S  D  S  E  D  S         p.380

          .         .         .         .         .         .       g.10342
 GAGCGTCGCAGAAACCACAACATCCTGGAGCGCCAGCGCCGCAACGACCTTCGGTCCAGC       c.1200
 E  R  R  R  N  H  N  I  L  E  R  Q  R  R  N  D  L  R  S  S         p.400

          .         .         .         .         .         .       g.10402
 TTTCTCACGCTCAGGGACCACGTGCCGGAGTTGGTAAAGAATGAGAAGGCCGCCAAGGTG       c.1260
 F  L  T  L  R  D  H  V  P  E  L  V  K  N  E  K  A  A  K  V         p.420

          .         .         .         .         .         .       g.10462
 GTCATTTTGAAAAAGGCCACTGAGTATGTCCACTCCCTCCAGGCCGAGGAGCACCAGCTT       c.1320
 V  I  L  K  K  A  T  E  Y  V  H  S  L  Q  A  E  E  H  Q  L         p.440

          .         .         .         .         .         .       g.10522
 TTGCTGGAAAAGGAAAAATTGCAGGCAAGACAGCAGCAGTTGCTAAAGAAAATTGAACAC       c.1380
 L  L  E  K  E  K  L  Q  A  R  Q  Q  Q  L  L  K  K  I  E  H         p.460

          .                                                         g.10537
 GCTCGGACTTGCTAG                                                    c.1395
 A  R  T  C  X                                                      p.464

          .         .         .         .         .         .       g.10597
 acgcttctcaaaactggacagtcactgccactttgcacattttgattttttttttaaaca       c.*60

          .         .         .         .         .         .       g.10657
 aacattgtgttgacattaagaatgttggtttactttcaaatcggtcccctgtcgagttcg       c.*120

          .         .         .         .         .         .       g.10717
 gctctgggtgggcagtaggaccaccagtgtggggttctgctgggaccttggagagcctgc       c.*180

          .         .         .         .         .         .       g.10777
 atcccaggatgctgggtggccctgcagcctcctccacctcacctccatgacagcgctaaa       c.*240

          .         .         .         .         .         .       g.10837
 cgttggtgacggttgggagcctctggggctgttgaagtcaccttgtgtgttccaagtttc       c.*300

          .         .         .         .         .         .       g.10897
 caaacaacagaaagtcattccttctttttaaaatggtgcttaagttccagcagatgccac       c.*360

          .         .         .         .         .         .       g.10957
 ataaggggtttgccatttgatacccctggggaacatttctgtaaataccattgacacatc       c.*420

          .         .         .         .         .         .       g.11017
 cgccttttgtatacatcctgggtaatgagaggtggcttttgcggccagtattagactgga       c.*480

          .         .         .         .         .         .       g.11077
 agttcatacctaagtactgtaataatacctcaatgtttgaggagcatgttttgtatacaa       c.*540

          .         .         .         .         .         .       g.11137
 atatattgttaatctctgttatgtactgtactaattcttacactgcctgtatactttagt       c.*600

          .         .         .         .         .         .       g.11197
 atgacgctgatacataactaaatttgatacttatattttcgtatgaaaatgagttgtgaa       c.*660

          .         .         .         .         .         .       g.11257
 agttttgagtagatattactttatcactttttgaactaagaaacttttgtaaagaaattt       c.*720

          .         .         .         .         .         .       g.11317
 actatatatatatgcctttttcctagcctgtttcttcctgttaatgtatttgttcatgtt       c.*780

          .         .         .         .         .         .       g.11377
 tggtgcatagaactgggtaaatgcaaagttctgtgtttaatttcttcaaaatgtatatat       c.*840

          .         .         .         .         .         .       g.11437
 ttagtgctgcatcttatagcactttgaaatacctcatgtttatgaaaataaatagcttaa       c.*900

          .                                                         g.11447
 aattaaatga                                                         c.*910

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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