myosin, heavy chain 11, smooth muscle (MYH11) - coding DNA reference sequence

(used for variant description)

(last modified February 14, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_001040113.1 in the MYH11 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009299.1, covering MYH11 transcript NM_001040113.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              gggagatttggacgctccggcctgggaggtgcgtcagatccgagctc       c.-61

 .         .         .         .         .   | 02     .             g.23778
 gccatccagtttcctctccactagtccccccagttggagatct | gggaccaacaaggcacc    c.-1

          .         .         .         .         .         .       g.23838
 ATGGCGCAGAAGGGCCAACTCAGTGACGATGAGAAGTTCCTCTTTGTGGACAAAAACTTC       c.60
 M  A  Q  K  G  Q  L  S  D  D  E  K  F  L  F  V  D  K  N  F         p.20

          .         .         .         .         .         .       g.23898
 ATCAACAGCCCAGTGGCCCAGGCTGACTGGGCCGCCAAGAGACTCGTCTGGGTCCCCTCG       c.120
 I  N  S  P  V  A  Q  A  D  W  A  A  K  R  L  V  W  V  P  S         p.40

          .         .         .         .         .         .       g.23958
 GAGAAGCAGGGCTTCGAGGCAGCCAGCATTAAGGAGGAGAAGGGGGATGAGGTGGTTGTG       c.180
 E  K  Q  G  F  E  A  A  S  I  K  E  E  K  G  D  E  V  V  V         p.60

          .         .         .         .         .         .       g.24018
 GAGCTGGTGGAGAATGGCAAGAAGGTCACGGTTGGGAAAGATGACATCCAGAAGATGAAC       c.240
 E  L  V  E  N  G  K  K  V  T  V  G  K  D  D  I  Q  K  M  N         p.80

          .         .         .         .         .         .       g.24078
 CCACCCAAGTTCTCCAAGGTGGAGGACATGGCGGAGCTGACGTGCCTCAACGAAGCCTCC       c.300
 P  P  K  F  S  K  V  E  D  M  A  E  L  T  C  L  N  E  A  S         p.100

          .         .         .         .      | 03  .         .    g.38634
 GTGCTACACAACCTGAGGGAGCGGTACTTCTCAGGGCTAATATAT | ACGTACTCTGGCCTC    c.360
 V  L  H  N  L  R  E  R  Y  F  S  G  L  I  Y   | T  Y  S  G  L      p.120

          .         .         .         .         .         .       g.38694
 TTCTGCGTGGTGGTCAACCCCTATAAACACCTGCCCATCTACTCGGAGAAGATCGTCGAC       c.420
 F  C  V  V  V  N  P  Y  K  H  L  P  I  Y  S  E  K  I  V  D         p.140

          .         .         .         .         .         .       g.38754
 ATGTACAAGGGCAAGAAGAGGCACGAGATGCCGCCTCACATCTACGCCATCGCAGACACG       c.480
 M  Y  K  G  K  K  R  H  E  M  P  P  H  I  Y  A  I  A  D  T         p.160

          .         .   | 04     .         .         . | 05       . g.75308
 GCCTACCGGAGCATGCTTCAAG | ATCGGGAGGACCAGTCCATTCTATGCAC | AGGCGAGTCT c.540
 A  Y  R  S  M  L  Q  D |   R  E  D  Q  S  I  L  C  T  |  G  E  S   p.180

          .         .         .         .         .         .       g.75368
 GGAGCCGGGAAAACCGAAAACACCAAGAAGGTCATTCAGTACCTGGCCGTGGTGGCCTCC       c.600
 G  A  G  K  T  E  N  T  K  K  V  I  Q  Y  L  A  V  V  A  S         p.200

          .         .         .    | 06    .         .     | 07   . g.79559
 TCCCACAAGGGCAAGAAAGACACAAGTATCACG | CAAGGCCCATCTTTTGCCTAC | GGAGAG c.660
 S  H  K  G  K  K  D  T  S  I  T   | Q  G  P  S  F  A  Y   | G  E   p.220

          .         .         .         .         .         .       g.79619
 CTGGAAAAGCAGCTTCTACAAGCAAACCCGATTCTGGAGGCTTTCGGCAACGCCAAAACA       c.720
 L  E  K  Q  L  L  Q  A  N  P  I  L  E  A  F  G  N  A  K  T         p.240

          .         .        | 08.         .         .         .    g.83220
 GTGAAGAACGACAACTCCTCACGATTC | GGCAAATTCATCCGCATCAACTTCGACGTCACG    c.780
 V  K  N  D  N  S  S  R  F   | G  K  F  I  R  I  N  F  D  V  T      p.260

          .         .         .  | 09      .         .         .    g.85883
 GGTTACATCGTGGGAGCCAACATTGAGACCT | ATCTGCTAGAAAAATCACGGGCAATTCGC    c.840
 G  Y  I  V  G  A  N  I  E  T  Y |   L  L  E  K  S  R  A  I  R      p.280

          .         .         .         .         .         .       g.85943
 CAAGCCAGAGACGAGAGGACATTCCACATCTTTTACTACATGATTGCTGGAGCCAAGGAG       c.900
 Q  A  R  D  E  R  T  F  H  I  F  Y  Y  M  I  A  G  A  K  E         p.300

          . | 10       .         .         .         .         .    g.90368
 AAGATGAGAA | GTGACTTGCTTTTGGAGGGCTTCAACAACTACACCTTCCTCTCCAATGGC    c.960
 K  M  R  S |   D  L  L  L  E  G  F  N  N  Y  T  F  L  S  N  G      p.320

          .         .         .         .         .         .       g.90428
 TTTGTGCCCATCCCAGCAGCCCAGGATGATGAGATGTTCCAGGAAACCGTGGAGGCCATG       c.1020
 F  V  P  I  P  A  A  Q  D  D  E  M  F  Q  E  T  V  E  A  M         p.340

          .         .         .     | 11   .         .         .    g.98165
 GCAATCATGGGTTTCAGCGAGGAGGAGCAGCTAT | CCATATTGAAGGTGGTATCATCGGTC    c.1080
 A  I  M  G  F  S  E  E  E  Q  L  S |   I  L  K  V  V  S  S  V      p.360

          .         .         .         .         .         .       g.98225
 CTGCAGCTTGGAAATATCGTCTTCAAGAAGGAAAGAAACACAGACCAGGCGTCCATGCCA       c.1140
 L  Q  L  G  N  I  V  F  K  K  E  R  N  T  D  Q  A  S  M  P         p.380

          . | 12       .         .         .         .         .    g.101422
 GATAACACAG | CTGCTCAGAAAGTTTGCCACCTCATGGGAATTAATGTGACAGATTTCACC    c.1200
 D  N  T  A |   A  Q  K  V  C  H  L  M  G  I  N  V  T  D  F  T      p.400

          .         .         .         .         .         .       g.101482
 AGATCCATCCTCACTCCTCGTATCAAGGTTGGGCGAGATGTGGTACAGAAAGCTCAGACA       c.1260
 R  S  I  L  T  P  R  I  K  V  G  R  D  V  V  Q  K  A  Q  T         p.420

           | 13        .         .         .         .         .    g.102353
 AAAGAACAG | GCTGACTTTGCTGTAGAGGCTTTGGCCAAGGCAACATATGAGCGCCTTTTC    c.1320
 K  E  Q   | A  D  F  A  V  E  A  L  A  K  A  T  Y  E  R  L  F      p.440

          .         .         .         .         .         .       g.102413
 CGCTGGATACTCACCCGCGTGAACAAAGCCCTGGACAAGACCCATCGGCAAGGGGCTTCC       c.1380
 R  W  I  L  T  R  V  N  K  A  L  D  K  T  H  R  Q  G  A  S         p.460

          .         .         .         .   | 14     .         .    g.104048
 TTCCTGGGGATCCTGGATATAGCTGGATTTGAGATCTTTGAG | GTGAACTCCTTCGAGCAG    c.1440
 F  L  G  I  L  D  I  A  G  F  E  I  F  E   | V  N  S  F  E  Q      p.480

          .         .         .         .         .         .       g.104108
 CTGTGCATCAACTACACCAACGAGAAGCTGCAGCAGCTCTTCAACCACACCATGTTCATC       c.1500
 L  C  I  N  Y  T  N  E  K  L  Q  Q  L  F  N  H  T  M  F  I         p.500

          .         .         .         .         .         .       g.104168
 CTGGAGCAGGAGGAGTACCAGCGCGAGGGCATCGAGTGGAACTTCATCGACTTTGGGCTG       c.1560
 L  E  Q  E  E  Y  Q  R  E  G  I  E  W  N  F  I  D  F  G  L         p.520

          .         .         .       | 15 .         .         .    g.105540
 GACCTACAGCCCTGCATCGAGCTCATCGAGCGACCG | AACAACCCTCCAGGTGTGCTGGCC    c.1620
 D  L  Q  P  C  I  E  L  I  E  R  P   | N  N  P  P  G  V  L  A      p.540

          .         .         .         .         .         .       g.105600
 CTGCTGGACGAGGAATGCTGGTTCCCCAAAGCCACGGACAAGTCTTTCGTGGAGAAGCTG       c.1680
 L  L  D  E  E  C  W  F  P  K  A  T  D  K  S  F  V  E  K  L         p.560

          .         .         .         .         .         .       g.105660
 TGCACGGAGCAGGGCAGCCACCCCAAGTTCCAGAAGCCCAAGCAGCTCAAGGACAAGACT       c.1740
 C  T  E  Q  G  S  H  P  K  F  Q  K  P  K  Q  L  K  D  K  T         p.580

          .         .         . | 16       .         .         .    g.108552
 GAGTTCTCCATCATCCATTATGCTGGGAAG | GTGGACTATAATGCGAGTGCCTGGCTGACC    c.1800
 E  F  S  I  I  H  Y  A  G  K   | V  D  Y  N  A  S  A  W  L  T      p.600

          .         .         .         .         .         .       g.108612
 AAGAATATGGACCCGCTGAATGACAACGTGACTTCCCTGCTCAATGCCTCCTCCGACAAG       c.1860
 K  N  M  D  P  L  N  D  N  V  T  S  L  L  N  A  S  S  D  K         p.620

          .         .      | 17  .         .         .         .    g.111734
 TTTGTGGCCGACCTGTGGAAGGACG | TGGACCGCATCGTGGGCCTGGACCAGATGGCCAAG    c.1920
 F  V  A  D  L  W  K  D  V |   D  R  I  V  G  L  D  Q  M  A  K      p.640

          .         .         .         .         .         .       g.111794
 ATGACGGAGAGCTCGCTGCCCAGCGCCTCCAAGACCAAGAAGGGCATGTTCCGCACAGTG       c.1980
 M  T  E  S  S  L  P  S  A  S  K  T  K  K  G  M  F  R  T  V         p.660

          .         .         .         .         .         .       g.111854
 GGGCAGCTGTACAAGGAGCAGCTGGGCAAGCTGATGACCACGCTACGCAACACCACGCCC       c.2040
 G  Q  L  Y  K  E  Q  L  G  K  L  M  T  T  L  R  N  T  T  P         p.680

          .         .         .          | 18        .         .    g.113883
 AACTTCGTGCGCTGCATCATCCCCAACCACGAGAAGAGG | TCCGGCAAGCTGGATGCGTTC    c.2100
 N  F  V  R  C  I  I  P  N  H  E  K  R   | S  G  K  L  D  A  F      p.700

          .         .         .         .         .         .       g.113943
 CTGGTGCTGGAGCAGCTGCGGTGCAATGGGGTGCTGGAAGGCATTCGCATCTGCCGGCAG       c.2160
 L  V  L  E  Q  L  R  C  N  G  V  L  E  G  I  R  I  C  R  Q         p.720

          .         .         .         .  | 19      .         .    g.114106
 GGCTTCCCCAACCGGATCGTCTTCCAGGAGTTCCGCCAACG | CTACGAGATCCTGGCGGCG    c.2220
 G  F  P  N  R  I  V  F  Q  E  F  R  Q  R  |  Y  E  I  L  A  A      p.740

          .         .         .         .         .  | 20      .    g.114309
 AATGCCATCCCCAAAGGCTTCATGGACGGGAAGCAGGCCTGCATTCTCATG | ATCAAAGCC    c.2280
 N  A  I  P  K  G  F  M  D  G  K  Q  A  C  I  L  M   | I  K  A      p.760

          .         .         .         .         .         .       g.114369
 CTGGAACTTGACCCCAACTTATACAGGATAGGGCAGAGCAAAATCTTCTTCCGAACTGGC       c.2340
 L  E  L  D  P  N  L  Y  R  I  G  Q  S  K  I  F  F  R  T  G         p.780

          .         .         .         .         .         .       g.114429
 GTCCTGGCCCACCTAGAGGAGGAGCGAGATTTGAAGATCACCGATGTCATCATGGCCTTC       c.2400
 V  L  A  H  L  E  E  E  R  D  L  K  I  T  D  V  I  M  A  F         p.800

          .         .         .   | 21     .         .         .    g.116821
 CAGGCGATGTGTCGTGGCTACTTGGCCAGAAA | GGCTTTTGCCAAGAGGCAGCAGCAGCTG    c.2460
 Q  A  M  C  R  G  Y  L  A  R  K  |  A  F  A  K  R  Q  Q  Q  L      p.820

          .         .         .         .         .         .       g.116881
 ACCGCCATGAAGGTGATTCAGAGGAACTGCGCCGCCTACCTCAAGCTGCGGAACTGGCAG       c.2520
 T  A  M  K  V  I  Q  R  N  C  A  A  Y  L  K  L  R  N  W  Q         p.840

          .         .  | 22      .         .         .         .    g.120178
 TGGTGGAGGCTTTTCACCAAA | GTGAAGCCACTGCTGCAGGTGACACGGCAGGAGGAGGAG    c.2580
 W  W  R  L  F  T  K   | V  K  P  L  L  Q  V  T  R  Q  E  E  E      p.860

          .         .         .         .         .         .       g.120238
 ATGCAGGCCAAGGAGGATGAACTGCAGAAGACCAAGGAGCGGCAGCAGAAGGCAGAGAAT       c.2640
 M  Q  A  K  E  D  E  L  Q  K  T  K  E  R  Q  Q  K  A  E  N         p.880

          .         .         .    | 23    .         .         .    g.120388
 GAGCTTAAGGAGCTGGAACAGAAGCACTCGCAG | CTGACCGAGGAGAAGAACCTGCTACAG    c.2700
 E  L  K  E  L  E  Q  K  H  S  Q   | L  T  E  E  K  N  L  L  Q      p.900

          .         .         .         .         .         .       g.120448
 GAACAGCTGCAGGCAGAGACAGAGCTGTATGCAGAGGCTGAGGAGATGCGGGTGCGGCTG       c.2760
 E  Q  L  Q  A  E  T  E  L  Y  A  E  A  E  E  M  R  V  R  L         p.920

          .         .         .         .         .         .       g.120508
 GCGGCCAAGAAGCAGGAGCTGGAGGAGATACTGCATGAGATGGAGGCCCGCCTGGAGGAG       c.2820
 A  A  K  K  Q  E  L  E  E  I  L  H  E  M  E  A  R  L  E  E         p.940

          .         .         .         .         .         .       g.120568
 GAGGAAGACAGGGGCCAGCAGCTACAGGCTGAAAGGAAGAAGATGGCCCAGCAGATGCTG       c.2880
 E  E  D  R  G  Q  Q  L  Q  A  E  R  K  K  M  A  Q  Q  M  L         p.960

  | 24       .         .         .         .         .         .    g.121902
  | GACCTTGAAGAACAGCTGGAGGAGGAGGAAGCTGCCAGGCAGAAGCTGCAACTTGAGAAG    c.2940
  | D  L  E  E  Q  L  E  E  E  E  A  A  R  Q  K  L  Q  L  E  K      p.980

          .         .         .         .         .         .       g.121962
 GTCACGGCTGAGGCCAAGATCAAGAAACTGGAGGATGAGATCCTGGTCATGGATGATCAG       c.3000
 V  T  A  E  A  K  I  K  K  L  E  D  E  I  L  V  M  D  D  Q         p.1000

          .         | 25         .         .         .         .    g.123384
 AACAATAAACTATCAAAA | GAACGAAAACTCCTTGAGGAGAGGATTAGTGACTTAACGACA    c.3060
 N  N  K  L  S  K   | E  R  K  L  L  E  E  R  I  S  D  L  T  T      p.1020

          .         .         .         .         .         .       g.123444
 AATCTTGCAGAAGAGGAAGAAAAGGCCAAGAATCTTACCAAGCTGAAAAACAAGCATGAA       c.3120
 N  L  A  E  E  E  E  K  A  K  N  L  T  K  L  K  N  K  H  E         p.1040

          .         .   | 26     .         .         .         .    g.124448
 TCTATGATTTCAGAACTGGAAG | TGCGGCTAAAGAAGGAAGAGAAGAGCCGACAGGAGCTG    c.3180
 S  M  I  S  E  L  E  V |   R  L  K  K  E  E  K  S  R  Q  E  L      p.1060

          .         .         .         .         .         .       g.124508
 GAGAAGCTGAAACGGAAGCTGGAGGGTGATGCCAGCGACTTCCACGAGCAGATCGCTGAC       c.3240
 E  K  L  K  R  K  L  E  G  D  A  S  D  F  H  E  Q  I  A  D         p.1080

          .         .         .         .         .         .       g.124568
 CTCCAGGCGCAGATCGCAGAGCTCAAGATGCAGCTGGCCAAGAAGGAGGAGGAGCTGCAG       c.3300
 L  Q  A  Q  I  A  E  L  K  M  Q  L  A  K  K  E  E  E  L  Q         p.1100

          .     | 27   .         .         .         .         .    g.126498
 GCGGCCCTGGCCAG | GCTTGACGATGAAATCGCTCAGAAGAACAATGCCCTGAAGAAGATC    c.3360
 A  A  L  A  R  |  L  D  D  E  I  A  Q  K  N  N  A  L  K  K  I      p.1120

          .         .         .         .         .         .       g.126558
 CGGGAGCTGGAGGGCCACATCTCAGACCTCCAGGAGGACCTGGACTCAGAGCGGGCCGCC       c.3420
 R  E  L  E  G  H  I  S  D  L  Q  E  D  L  D  S  E  R  A  A         p.1140

          .         .         .         .         .         .       g.126618
 AGGAACAAGGCTGAAAAGCAGAAGCGAGACCTCGGCGAGGAGCTGGAGGCCCTAAAGACA       c.3480
 R  N  K  A  E  K  Q  K  R  D  L  G  E  E  L  E  A  L  K  T         p.1160

          .         .         .         .        | 28.         .    g.129335
 GAGCTGGAAGACACACTGGACAGCACAGCCACTCAGCAGGAGCTCAG | GGCCAAGAGGGAG    c.3540
 E  L  E  D  T  L  D  S  T  A  T  Q  Q  E  L  R  |  A  K  R  E      p.1180

          .         .         .         .         .         .       g.129395
 CAGGAGGTGACGGTGCTGAAGAAGGCCCTGGATGAAGAGACGCGGTCCCATGAGGCTCAG       c.3600
 Q  E  V  T  V  L  K  K  A  L  D  E  E  T  R  S  H  E  A  Q         p.1200

          .         .         .         .         .         .       g.129455
 GTCCAGGAGATGAGGCAGAAACACGCACAGGCGGTGGAGGAGCTCACAGAGCAGCTTGAG       c.3660
 V  Q  E  M  R  Q  K  H  A  Q  A  V  E  E  L  T  E  Q  L  E         p.1220

          .   | 29     .         .         .         .         .    g.135024
 CAGTTCAAGAGG | GCCAAGGCGAACCTAGACAAGAATAAGCAGACGCTGGAGAAAGAGAAC    c.3720
 Q  F  K  R   | A  K  A  N  L  D  K  N  K  Q  T  L  E  K  E  N      p.1240

          .         .         .         .         .         .       g.135084
 GCAGACCTGGCCGGGGAGCTGCGGGTCCTGGGCCAGGCCAAGCAGGAGGTGGAACATAAG       c.3780
 A  D  L  A  G  E  L  R  V  L  G  Q  A  K  Q  E  V  E  H  K         p.1260

          .         .         .         .         .         .       g.135144
 AAGAAGAAGCTGGAGGCGCAGGTGCAGGAGCTGCAGTCCAAGTGCAGCGATGGGGAGCGG       c.3840
 K  K  K  L  E  A  Q  V  Q  E  L  Q  S  K  C  S  D  G  E  R         p.1280

          .         .         .          | 30        .         .    g.137059
 GCCCGGGCGGAGCTCAATGACAAAGTCCACAAGCTGCAG | AATGAAGTTGAGAGCGTCACA    c.3900
 A  R  A  E  L  N  D  K  V  H  K  L  Q   | N  E  V  E  S  V  T      p.1300

          .         .         .         .         .         .       g.137119
 GGGATGCTTAACGAGGCCGAGGGGAAGGCCATTAAGCTGGCCAAGGACGTGGCGTCCCTC       c.3960
 G  M  L  N  E  A  E  G  K  A  I  K  L  A  K  D  V  A  S  L         p.1320

          .         .     | 31   .         .         .         .    g.137267
 AGTTCCCAGCTCCAGGACACCCAG | GAGCTGCTTCAAGAAGAAACCCGGCAGAAGCTCAAC    c.4020
 S  S  Q  L  Q  D  T  Q   | E  L  L  Q  E  E  T  R  Q  K  L  N      p.1340

          .         .         .         .         .         .       g.137327
 GTGTCTACGAAGCTGCGCCAGCTGGAGGAGGAGCGGAACAGCCTGCAAGACCAGCTGGAC       c.4080
 V  S  T  K  L  R  Q  L  E  E  E  R  N  S  L  Q  D  Q  L  D         p.1360

          .         .         .         .         .        | 32.    g.137624
 GAGGAGATGGAGGCCAAGCAGAACCTGGAGCGCCACATCTCCACTCTCAACATCCAG | CTC    c.4140
 E  E  M  E  A  K  Q  N  L  E  R  H  I  S  T  L  N  I  Q   | L      p.1380

          .         .         .         .         .         .       g.137684
 TCCGACTCGAAGAAGAAGCTGCAGGACTTTGCCAGCACCGTGGAAGCTCTGGAAGAGGGG       c.4200
 S  D  S  K  K  K  L  Q  D  F  A  S  T  V  E  A  L  E  E  G         p.1400

          .         .         .         .         .         .       g.137744
 AAGAAGAGGTTCCAGAAGGAGATCGAGAACCTCACCCAGCAGTACGAGGAGAAGGCGGCC       c.4260
 K  K  R  F  Q  K  E  I  E  N  L  T  Q  Q  Y  E  E  K  A  A         p.1420

          .         .         .         .         .         .       g.137804
 GCTTATGATAAACTGGAAAAGACCAAGAACAGGCTTCAGCAGGAGCTGGACGACCTGGTT       c.4320
 A  Y  D  K  L  E  K  T  K  N  R  L  Q  Q  E  L  D  D  L  V         p.1440

          .         .         .         .         .         .       g.137864
 GTTGATTTGGACAACCAGCGGCAACTCGTGTCCAACCTGGAAAAGAAGCAGAGGAAATTT       c.4380
 V  D  L  D  N  Q  R  Q  L  V  S  N  L  E  K  K  Q  R  K  F         p.1460

        | 33 .         .         .         .         .         .    g.140450
 GATCAG | TTGTTAGCCGAGGAGAAAAACATCTCTTCCAAATACGCGGATGAGAGGGACAGA    c.4440
 D  Q   | L  L  A  E  E  K  N  I  S  S  K  Y  A  D  E  R  D  R      p.1480

          .         .         .         .         .         .       g.140510
 GCTGAGGCAGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTTGAA       c.4500
 A  E  A  E  A  R  E  K  E  T  K  A  L  S  L  A  R  A  L  E         p.1500

          .         .         .         .         .         .       g.140570
 GAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATGCTCAAAGCCGAAATG       c.4560
 E  A  L  E  A  K  E  E  L  E  R  T  N  K  M  L  K  A  E  M         p.1520

          .         .         .          | 34        .         .    g.141000
 GAAGACCTGGTCAGCTCCAAGGATGACGTGGGCAAGAAC | GTCCATGAGCTGGAGAAGTCC    c.4620
 E  D  L  V  S  S  K  D  D  V  G  K  N   | V  H  E  L  E  K  S      p.1540

          .         .         .         .         .         .       g.141060
 AAGCGGGCCCTGGAGACCCAGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGAC       c.4680
 K  R  A  L  E  T  Q  M  E  E  M  K  T  Q  L  E  E  L  E  D         p.1560

          .         .         .         .         .         .       g.141120
 GAGCTGCAAGCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAG       c.4740
 E  L  Q  A  T  E  D  A  K  L  R  L  E  V  N  M  Q  A  L  K         p.1580

          .         .         .         .         .         .       g.141180
 GGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAGAATGAGGAGAAGAGGAGGCAA       c.4800
 G  Q  F  E  R  D  L  Q  A  R  D  E  Q  N  E  E  K  R  R  Q         p.1600

          .   | 35     .         .         .         .         .    g.141766
 CTGCAGAGACAG | CTTCACGAGTATGAGACGGAACTGGAAGACGAGCGAAAGCAACGTGCC    c.4860
 L  Q  R  Q   | L  H  E  Y  E  T  E  L  E  D  E  R  K  Q  R  A      p.1620

          .         .         .         .         .         .       g.141826
 CTGGCAGCTGCAGCAAAGAAGAAGCTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCC       c.4920
 L  A  A  A  A  K  K  K  L  E  G  D  L  K  D  L  E  L  Q  A         p.1640

          .         .         .         .         .     | 36   .    g.142323
 GACTCTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAG | GCTCAG    c.4980
 D  S  A  I  K  G  R  E  E  A  I  K  Q  L  R  K  L  Q   | A  Q      p.1660

          .         .         .         .         .         .       g.142383
 ATGAAGGACTTTCAAAGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCTTTGCC       c.5040
 M  K  D  F  Q  R  E  L  E  D  A  R  A  S  R  D  E  I  F  A         p.1680

          .         .         .         .         .         .       g.142443
 ACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCATGCAGCTACAA       c.5100
 T  A  K  E  N  E  K  K  A  K  S  L  E  A  D  L  M  Q  L  Q         p.1700

     | 37    .         .         .         .         .         .    g.142779
 GAG | GACCTCGCCGCCGCTGAGAGGGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTG    c.5160
 E   | D  L  A  A  A  E  R  A  R  K  Q  A  D  L  E  K  E  E  L      p.1720

          .         .         .   | 38     .         .         .    g.143620
 GCAGAGGAGCTGGCCAGTAGCCTGTCGGGAAG | GAACGCACTCCAGGACGAGAAGCGCCGC    c.5220
 A  E  E  L  A  S  S  L  S  G  R  |  N  A  L  Q  D  E  K  R  R      p.1740

          .         .         .         .         .         .       g.143680
 CTGGAGGCCCGGATCGCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAG       c.5280
 L  E  A  R  I  A  Q  L  E  E  E  L  E  E  E  Q  G  N  M  E         p.1760

          .         .         .       | 39 .         .         .    g.144706
 GCCATGAGCGACCGGGTCCGCAAAGCCACACAGCAG | GCCGAGCAGCTCAGCAACGAGCTG    c.5340
 A  M  S  D  R  V  R  K  A  T  Q  Q   | A  E  Q  L  S  N  E  L      p.1780

          .         .         .         .         .         .       g.144766
 GCCACAGAGCGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCAG       c.5400
 A  T  E  R  S  T  A  Q  K  N  E  S  A  R  Q  Q  L  E  R  Q         p.1800

          .         .         .         .         .         .       g.144826
 AACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAAG       c.5460
 N  K  E  L  R  S  K  L  H  E  M  E  G  A  V  K  S  K  F  K         p.1820

          .         .         .         .         .         .       g.144886
 TCCACCATCGCGGCGCTGGAGGCCAAGATTGCACAGCTGGAGGAGCAGGTCGAGCAGGAG       c.5520
 S  T  I  A  A  L  E  A  K  I  A  Q  L  E  E  Q  V  E  Q  E         p.1840

       | 40  .         .         .         .         .         .    g.146813
 GCCAG | AGAGAAACAGGCGGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAGGAA    c.5580
 A  R  |  E  K  Q  A  A  T  K  S  L  K  Q  K  D  K  K  L  K  E      p.1860

          .         .         .         .         .     | 41   .    g.146955
 ATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAAGGAGCAG | GCAGAG    c.5640
 I  L  L  Q  V  E  D  E  R  K  M  A  E  Q  Y  K  E  Q   | A  E      p.1880

          .         .         .         .         .         .       g.147015
 AAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTCC       c.5700
 K  G  N  A  R  V  K  Q  L  K  R  Q  L  E  E  A  E  E  E  S         p.1900

          .         .         .         .         .         .       g.147075
 CAGCGCATCAACGCCAACCGCAGGAAGCTGCAGCGGGAGCTGGATGAGGCCACGGAGAGC       c.5760
 Q  R  I  N  A  N  R  R  K  L  Q  R  E  L  D  E  A  T  E  S         p.1920

          .         .         .         .        | 42.         .    g.153202
 AACGAGGCCATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAG | AGGGCCCCCCCCA    c.5820
 N  E  A  M  G  R  E  V  N  A  L  K  S  K  L  R  |  G  P  P  P      p.1940

          .                                                     g.153220
 CAGGAAACTTCGCAGTGA |                                              c.5839
 Q  E  T  S  Q  X                                                p.1945

          | 43         .         .         .         .         .    g.157959
 tgcaccag | gcgaggaaacgagacctctttcgttccttctagaaggtctggaggacgtaga    c.*60

          .         .         .         .         .         .       g.158019
 gttattgaaaatgcagatggttctgaggaggaaacggacactcgagacgcagacttcaat       c.*120

          .         .         .         .         .         .       g.158079
 ggaaccaaggccagtgaataagcaactttctacagttttgcaccacggcaagaaaaccaa       c.*180

          .         .         .         .         .         .       g.158139
 aaaccaaaacaaacaaacaaaaaaaacccaacaacaacccagaacaaagcaaaacccagc       c.*240

          .         .         .         .         .         .       g.158199
 agactgtacttagcattgtctaaatccattctcaaattccaaatatcacagacacccctc       c.*300

          .         .         .         .         .         .       g.158259
 acacaaggaatataaaaaccaccaccctccagcctgggcaacgtagtaaaacctcatcta       c.*360

          .         .         .         .         .         .       g.158319
 tacaagaatttaaaaataagctgggcgtggtggtacacacctgtggtcccagctactagg       c.*420

          .         .         .         .         .         .       g.158379
 gaggctgagccaggaagaacgctccagcccaggacttcgaggctgcaatgagctataatt       c.*480

          .         .         .         .         .         .       g.158439
 gcatcattgcactccagcctgggcaacagagaccctgtctcaaccaccaccaccaccacc       c.*540

          .         .         .         .         .         .       g.158499
 acccctactacccctgtattcaaggtaaaaattgaagtttgtatgatgtaagagatgaga       c.*600

          .         .         .         .         .         .       g.158559
 aaaacccaacaggaaacacagacacatcctccagttctatcaatggattgtgcagacact       c.*660

          .         .         .         .         .         .       g.158619
 gagtttttagaaaaacatatccacggtaaccggtccctggcaattctgtttacatgaaat       c.*720

          .         .         .         .         .         .       g.158679
 ggggagaaagtcaccgaaatgggtgccgccggcccccactcccaattcattccctaacct       c.*780

          .         .         .         .         .         .       g.158739
 gcaaacctttccaacttctcacgtcaggcctttgagaattctttccccctctcctggttt       c.*840

          .         .         .         .         .         .       g.158799
 ccacacctcagacacgcacagttcaccaagtgccttctgtagtcacatgaattgaaaagg       c.*900

          .         .         .         .         .         .       g.158859
 agacgctgctcccacggaggggagcaggaatgctgcactgtttacaccctgactgtgctt       c.*960

          .         .         .                                     g.158896
 aaaaacactttcactaataaatggttataaatcacaa                              c.*997

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Myosin, heavy chain 11, smooth muscle protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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