myosin light chain kinase 2 (MYLK2) - coding DNA reference sequence

(used for variant description)

(last modified September 19, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_033118.3 in the MYLK2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012847.1, covering MYLK2 transcript NM_033118.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5042
                   cctgagcagccgctgggagacagacggcaaccaggttgcccc       c.-61

 .         .  | 02      .         .         .         .             g.5206
 tctttgctccag | ctagaaagacttgagttagacaagcagcagcacacgcctccctacctc    c.-1

          .         .         .         .         .   | 03     .    g.5759
 ATGGCGACAGAAAATGGAGCAGTTGAGCTGGGAATTCAGAACCCATCAACAG | ACAAGGCA    c.60
 M  A  T  E  N  G  A  V  E  L  G  I  Q  N  P  S  T  D |   K  A      p.20

          .         .         .         .         .         .       g.5819
 CCTAAAGGTCCCACAGGTGAAAGACCCCTGGCTGCAGGGAAAGACCCTGGCCCCCCAGAC       c.120
 P  K  G  P  T  G  E  R  P  L  A  A  G  K  D  P  G  P  P  D         p.40

          .         .         .         .         .         .       g.5879
 CCAAAGAAAGCTCCGGATCCACCCACCCTGAAGAAAGATGCCAAAGCCCCTGCCTCAGAG       c.180
 P  K  K  A  P  D  P  P  T  L  K  K  D  A  K  A  P  A  S  E         p.60

          .         .         .         .         .         .       g.5939
 AAAGGGGATGGTACCCTGGCCCAACCCTCAACTAGCAGCCAAGGCCCCAAAGGAGAGGGT       c.240
 K  G  D  G  T  L  A  Q  P  S  T  S  S  Q  G  P  K  G  E  G         p.80

          .         .         .         .         .         .       g.5999
 GACAGGGGCGGGGGGCCCGCGGAGGGCAGTGCTGGGCCCCCGGCAGCCCTGCCCCAGCAG       c.300
 D  R  G  G  G  P  A  E  G  S  A  G  P  P  A  A  L  P  Q  Q         p.100

          .         .         .         .         .         .       g.6059
 ACTGCGACACCTGAGACCAGCGTCAAGAAGCCCAAGGCTGAGCAGGGAGCCTCAGGCAGC       c.360
 T  A  T  P  E  T  S  V  K  K  P  K  A  E  Q  G  A  S  G  S         p.120

          .         .         .         .         .         .       g.6119
 CAGGATCCTGGAAAGCCCAGGGTGGGCAAGAAGGCAGCAGAGGGCCAAGCAGCAGCCAGG       c.420
 Q  D  P  G  K  P  R  V  G  K  K  A  A  E  G  Q  A  A  A  R         p.140

          .         .         .         .         .    | 04    .    g.7071
 AGGGGCTCACCTGCCTTTCTGCATAGCCCCAGCTGTCCTGCCATCATCTCCAG | TTCTGAG    c.480
 R  G  S  P  A  F  L  H  S  P  S  C  P  A  I  I  S  S  |  S  E      p.160

          .         .         .         .         .         .       g.7131
 AAGCTGCTGGCCAAGAAGCCCCCAAGCGAGGCATCAGAGCTCACCTTTGAAGGGGTGCCC       c.540
 K  L  L  A  K  K  P  P  S  E  A  S  E  L  T  F  E  G  V  P         p.180

          .         .         .         .         .         .       g.7191
 ATGACCCACAGCCCCACGGATCCCAGGCCAGCCAAGGCAGAAGAAGGAAAGAACATCCTG       c.600
 M  T  H  S  P  T  D  P  R  P  A  K  A  E  E  G  K  N  I  L         p.200

          .         .         .         .         .         .       g.7251
 GCAGAGAGCCAGAAGGAAGTGGGAGAGAAAACCCCAGGCCAGGCTGGCCAGGCTAAGATG       c.660
 A  E  S  Q  K  E  V  G  E  K  T  P  G  Q  A  G  Q  A  K  M         p.220

          .         .         .         .         .         .       g.7311
 CAAGGGGACACCTCGAGGGGGATTGAGTTCCAGGCTGTTCCCTCAGAGAAATCCGAGGTG       c.720
 Q  G  D  T  S  R  G  I  E  F  Q  A  V  P  S  E  K  S  E  V         p.240

          .         .         .         .         .   | 05     .    g.9110
 GGGCAGGCCCTCTGTCTCACAGCCAGGGAGGAGGACTGCTTCCAGATTTTGG | ATGATTGC    c.780
 G  Q  A  L  C  L  T  A  R  E  E  D  C  F  Q  I  L  D |   D  C      p.260

          .         .         .         .         .         .       g.9170
 CCGCCACCTCCGGCCCCCTTCCCTCACCGCATGGTGGAGCTGAGGACCGGGAATGTCAGC       c.840
 P  P  P  P  A  P  F  P  H  R  M  V  E  L  R  T  G  N  V  S         p.280

          .         .         .         | 06         .         .    g.9906
 AGTGAATTCAGTATGAACTCCAAGGAGGCGCTCGGAGG | TGGCAAGTTTGGGGCAGTCTGT    c.900
 S  E  F  S  M  N  S  K  E  A  L  G  G  |  G  K  F  G  A  V  C      p.300

          .         .         .         .         .         .       g.9966
 ACCTGCATGGAGAAAGCCACAGGCCTCAAGCTGGCAGCCAAGGTCATCAAGAAACAGACT       c.960
 T  C  M  E  K  A  T  G  L  K  L  A  A  K  V  I  K  K  Q  T         p.320

          .   | 07     .         .         .         .         .    g.12278
 CCCAAAGACAAG | GAAATGGTGTTGCTGGAGATTGAGGTCATGAACCAGCTGAACCACCGC    c.1020
 P  K  D  K   | E  M  V  L  L  E  I  E  V  M  N  Q  L  N  H  R      p.340

          .         .         .         .         .         .       g.12338
 AATCTGATCCAGCTGTATGCAGCCATCGAGACTCCGCATGAGATCGTCCTGTTCATGGAG       c.1080
 N  L  I  Q  L  Y  A  A  I  E  T  P  H  E  I  V  L  F  M  E         p.360

    | 08     .         .         .         .         .         .    g.12480
 TA | CATCGAGGGCGGAGAGCTCTTCGAGAGGATTGTGGATGAGGACTACCATCTGACCGAG    c.1140
 Y  |  I  E  G  G  E  L  F  E  R  I  V  D  E  D  Y  H  L  T  E      p.380

          .         .         .         .         .         .       g.12540
 GTGGACACCATGGTGTTTGTCAGGCAGATCTGTGACGGGATCCTCTTCATGCACAAGATG       c.1200
 V  D  T  M  V  F  V  R  Q  I  C  D  G  I  L  F  M  H  K  M         p.400

          .         .     | 09   .         .         .         .    g.16480
 AGGGTTTTGCACCTGGACCTCAAG | CCAGAGAACATCCTGTGTGTCAACACCACCGGGCAT    c.1260
 R  V  L  H  L  D  L  K   | P  E  N  I  L  C  V  N  T  T  G  H      p.420

          .         .         .      | 10  .         .         .    g.16663
 TTGGTGAAGATCATTGACTTTGGCCTGGCACGGAG | GTATAACCCCAACGAGAAGCTGAAG    c.1320
 L  V  K  I  I  D  F  G  L  A  R  R  |  Y  N  P  N  E  K  L  K      p.440

          .         .         .         .         .         .       g.16723
 GTGAACTTTGGGACCCCAGAGTTCCTGTCACCTGAGGTGGTGAATTATGACCAAATCTCC       c.1380
 V  N  F  G  T  P  E  F  L  S  P  E  V  V  N  Y  D  Q  I  S         p.460

          .         .         .         .     | 11   .         .    g.17344
 GATAAGACAGACATGTGGAGTATGGGGGTGATCACCTACATGCT | GCTGAGCGGCCTCTCC    c.1440
 D  K  T  D  M  W  S  M  G  V  I  T  Y  M  L  |  L  S  G  L  S      p.480

          .         .         .         .         .         .       g.17404
 CCCTTCCTGGGAGATGATGACACAGAGACCCTAAACAACGTTCTATCTGGCAACTGGTAC       c.1500
 P  F  L  G  D  D  D  T  E  T  L  N  N  V  L  S  G  N  W  Y         p.500

          .         .         .         .         .         .       g.17464
 TTTGATGAAGAGACCTTTGAGGCCGTATCAGACGAGGCCAAAGACTTTGTCTCCAACCTC       c.1560
 F  D  E  E  T  F  E  A  V  S  D  E  A  K  D  F  V  S  N  L         p.520

          .        | 12.         .         .         .         .    g.17672
 ATCGTCAAGGACCAGAG | GGCCCGGATGAACGCTGCCCAGTGTCTCGCCCATCCCTGGCTC    c.1620
 I  V  K  D  Q  R  |  A  R  M  N  A  A  Q  C  L  A  H  P  W  L      p.540

          .         .         .         .         .         .       g.17732
 AACAACCTGGCGGAGAAAGCCAAACGCTGTAACCGACGCCTTAAGTCCCAGATCTTGCTT       c.1680
 N  N  L  A  E  K  A  K  R  C  N  R  R  L  K  S  Q  I  L  L         p.560

          .         .         . | 13       .         .         .    g.19372
 AAGAAATACCTCATGAAGAGGCGCTGGAAG | AAAAACTTCATTGCTGTCAGCGCTGCCAAC    c.1740
 K  K  Y  L  M  K  R  R  W  K   | K  N  F  I  A  V  S  A  A  N      p.580

          .         .         .         .         .                 g.19423
 CGCTTCAAGAAGATCAGCAGCTCGGGGGCACTGATGGCTCTGGGGGTCTGA                c.1791
 R  F  K  K  I  S  S  S  G  A  L  M  A  L  G  V  X                  p.596

          .         .         .         .         .         .       g.19483
 gccctgggcgcagctgaagcctggacgcagccacacagtggccggggctgaagccacaca       c.*60

          .         .         .         .         .         .       g.19543
 gcccagaaggccagaaaaggcagccagatccccagggcagcctcgttaggacaaggctgt       c.*120

          .         .         .         .         .         .       g.19603
 gccaggctgggaggctcggggctccccacgcccccatgcagtgaccgcttccccgatgtg       c.*180

          .         .         .         .         .         .       g.19663
 agccgcctcggagtgtggcctggatccatcctgctagcacctccccagacagggctccag       c.*240

          .         .         .         .         .         .       g.19723
 cctgtcggccacaccccagactccaggcccccgttgaagccgctcccggttccctcccca       c.*300

          .         .         .         .         .         .       g.19783
 gctcctcgtctttgaactgccgccgccgtggtgacccctgctttgccccactgggagagt       c.*360

          .         .         .         .         .         .       g.19843
 ccttagcctgggcctcctcctagctggagtgccatggctggggggtctcagcatgtaggg       c.*420

          .         .         .         .         .         .       g.19903
 cttctgtggttgtggatgggaggctcctggtggggcagaaaggctgcaacgctgattcct       c.*480

          .         .         .         .         .         .       g.19963
 aaggcccagctgccagggaagacagagcaggctttgtgagagaggacctccatgcccccg       c.*540

          .         .         .         .         .         .       g.20023
 ccacctccccactccagcagataaggccgagcccacaccatctggcccaggctggccccc       c.*600

          .         .         .         .         .         .       g.20083
 acccaccttccttgcgaccaccaacacacaggaactctgtgtgagagagagggcgcccag       c.*660

          .         .         .         .         .         .       g.20143
 cccaggcctggtggagggggaggggagaagccaagggacacaggagaccacccccgagct       c.*720

          .         .         .         .         .         .       g.20203
 tgcctcagggccaagccggcccaacccaaccactcggggcccccatcttgggggtcaccc       c.*780

          .         .         .         .         .         .       g.20263
 atggcctcagatgatggggtcagcaggcccaggagaattaggaaggccatggggcagcct       c.*840

          .         .         .         .         .         .       g.20323
 ccagtctgctctcagcttgtgccttgtaaataaatgtacaggttggatgtggcctccttc       c.*900

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Myosin light chain kinase 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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