myosin IA (MYO1A) - coding DNA reference sequence

(used for variant description)

(last modified November 6, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_005379.3 in the MYO1A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering MYO1A transcript NM_005379.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5659
                                                  gactggcacag       c.-241

 .         .         .         .         .         .                g.5719
 ggagcctgggctggaagaggcagcaaaagggaaaatcagaagagtggacactggcaagag       c.-181

 .         .         .         .         .         .                g.5779
 gagggcagcctttttcccagcttccttgcaccatggacagctcccattaagccacctctc       c.-121

 .         .         .         .         .         .                g.5839
 catcctggggccaggactcttatgccccattcctgtcaaattgagatttcatccaccatt       c.-61

 .         .         .         .          | 02        .             g.7442
 ctccaaggacagtgaagttataccctagttccagtgttgg | gatcagtggcccctctggac    c.-1

          .         .         .         .         .         .       g.7502
 ATGCCTCTCCTGGAAGGTTCTGTGGGGGTGGAGGATCTTGTCCTCCTGGAACCCTTGGTG       c.60
 M  P  L  L  E  G  S  V  G  V  E  D  L  V  L  L  E  P  L  V         p.20

          .         .         .         .         .     | 03   .    g.7667
 GAGGAGTCACTGCTCAAGAATCTTCAGCTTCGCTATGAAAACAAGGAGATTTAT | ACCTAC    c.120
 E  E  S  L  L  K  N  L  Q  L  R  Y  E  N  K  E  I  Y   | T  Y      p.40

          .         .         .         .         .         .       g.7727
 ATTGGGAATGTGGTGATCTCAGTGAATCCCTATCAACAGCTTCCCATCTATGGGCCAGAG       c.180
 I  G  N  V  V  I  S  V  N  P  Y  Q  Q  L  P  I  Y  G  P  E         p.60

          .         .         .         .         . | 04       .    g.8054
 TTCATTGCCAAATATCAAGACTATACTTTCTATGAGCTGAAGCCCCATAT | CTACGCATTG    c.240
 F  I  A  K  Y  Q  D  Y  T  F  Y  E  L  K  P  H  I  |  Y  A  L      p.80

          .         .         .         .         .         .       g.8114
 GCAAATGTGGCGTACCAGTCACTGAGGGACAGGGACCGAGACCAGTGTATCCTCATCACA       c.300
 A  N  V  A  Y  Q  S  L  R  D  R  D  R  D  Q  C  I  L  I  T         p.100

          .         .      | 05  .         .         .         .    g.8393
 GGCGAGAGTGGATCAGGGAAGACTG | AGGCCAGCAAGCTGGTGATGTCTTATGTGGCTGCC    c.360
 G  E  S  G  S  G  K  T  E |   A  S  K  L  V  M  S  Y  V  A  A      p.120

          .         .         .         .         .         .       g.8453
 GTCTGTGGGAAAGGAGAGCAGGTGAACTCTGTGAAGGAGCAGCTGCTACAGTCTAACCCA       c.420
 V  C  G  K  G  E  Q  V  N  S  V  K  E  Q  L  L  Q  S  N  P         p.140

          . | 06       .         .         .         .        | 07. g.8842
 GTGCTGGAGG | CTTTTGGCAATGCCAAGACCATTCGCAACAACAATTCCTCCCGATTT | GGA c.480
 V  L  E  A |   F  G  N  A  K  T  I  R  N  N  N  S  S  R  F   | G   p.160

          .         .         .         .         .         .       g.8902
 AAATACATGGATATTGAATTTGACTTCAAGGGATCCCCCCTCGGTGGTGTCATCACAAAC       c.540
 K  Y  M  D  I  E  F  D  F  K  G  S  P  L  G  G  V  I  T  N         p.180

   | 08      .         .         .         .         .         .    g.9174
 T | ATCTGCTTGAGAAATCCCGATTAGTGAAGCAGCTCAAAGGAGAAAGGAACTTCCACATC    c.600
 Y |   L  L  E  K  S  R  L  V  K  Q  L  K  G  E  R  N  F  H  I      p.200

          .         .         .         . | 09       .         .    g.11576
 TTCTATCAGCTGCTGGCTGGAGCAGATGAACAGCTGCTGA | AGGCCCTGAAGCTTGAGCGG    c.660
 F  Y  Q  L  L  A  G  A  D  E  Q  L  L  K |   A  L  K  L  E  R      p.220

          .         .         .         .         .         .       g.11636
 GATACAACTGGCTATGCCTATCTGAATCATGAAGTATCCAGAGTGGATGGCATGGACGAC       c.720
 D  T  T  G  Y  A  Y  L  N  H  E  V  S  R  V  D  G  M  D  D         p.240

          .         .     | 10   .         .         .         .    g.11798
 GCCTCCAGCTTCAGGGCTGTACAG | AGTGCAATGGCAGTGATTGGGTTCTCGGAGGAGGAG    c.780
 A  S  S  F  R  A  V  Q   | S  A  M  A  V  I  G  F  S  E  E  E      p.260

          .         .         .         .         .         .       g.11858
 ATTCGACAAGTGCTAGAGGTGACATCCATGGTGCTAAAGCTGGGGAACGTGTTGGTGGCT       c.840
 I  R  Q  V  L  E  V  T  S  M  V  L  K  L  G  N  V  L  V  A         p.280

          .         .         .         .         .   | 11     .    g.12415
 GATGAGTTCCAGGCCAGTGGGATACCAGCAAGTGGCATCCGTGATGGGAGAG | GTGTTCGG    c.900
 D  E  F  Q  A  S  G  I  P  A  S  G  I  R  D  G  R  G |   V  R      p.300

          .         .         .         .         .         .       g.12475
 GAGATTGGGGAGATGGTGGGCTTGAATTCAGAAGAAGTAGAGAGAGCTTTGTGCTCGAGG       c.960
 E  I  G  E  M  V  G  L  N  S  E  E  V  E  R  A  L  C  S  R         p.320

          .         .         .         .         .  | 12      .    g.12616
 ACCATGGAAACAGCCAAGGAAAAGGTGGTCACTGCACTGAATGTTATGCAG | GCTCAGTAT    c.1020
 T  M  E  T  A  K  E  K  V  V  T  A  L  N  V  M  Q   | A  Q  Y      p.340

          .         .         .         .         .         .       g.12676
 GCTCGGGACGCCCTGGCTAAGAACATCTACAGCCGCCTCTTTGACTGGATAGTGAATCGA       c.1080
 A  R  D  A  L  A  K  N  I  Y  S  R  L  F  D  W  I  V  N  R         p.360

          .         | 13         .         .         .         .    g.14310
 ATCAATGAGAGCATCAAG | GTGGGCATCGGGGAAAAGAAGAAGGTAATGGGAGTCCTTGAT    c.1140
 I  N  E  S  I  K   | V  G  I  G  E  K  K  K  V  M  G  V  L  D      p.380

          .         .     | 14   .         .         .         .    g.14513
 ATCTACGGTTTTGAGATATTAGAG | GATAATAGCTTTGAGCAATTTGTGATCAACTACTGC    c.1200
 I  Y  G  F  E  I  L  E   | D  N  S  F  E  Q  F  V  I  N  Y  C      p.400

          .         .         .         .         .         .       g.14573
 AATGAGAAGCTGCAGCAGGTGTTCATAGAGATGACCCTGAAAGAAGAGCAAGAGGAATAT       c.1260
 N  E  K  L  Q  Q  V  F  I  E  M  T  L  K  E  E  Q  E  E  Y         p.420

           | 15        .         .         .         .         .    g.16542
 AAGAGAGAA | GGCATACCGTGGACAAAGGTGGACTACTTTGATAATGGCATCATTTGTAAG    c.1320
 K  R  E   | G  I  P  W  T  K  V  D  Y  F  D  N  G  I  I  C  K      p.440

          .   | 16     .         .         .         .         .    g.16804
 CTCATTGAGCAT | AATCAGCGAGGTATCCTGGCCATGTTGGATGAGGAGTGCCTGCGGCCT    c.1380
 L  I  E  H   | N  Q  R  G  I  L  A  M  L  D  E  E  C  L  R  P      p.460

          .         .         .         .         .         .       g.16864
 GGGGTGGTCAGTGACTCCACTTTCCTAGCAAAGCTGAACCAGCTCTTCTCCAAGCATGGC       c.1440
 G  V  V  S  D  S  T  F  L  A  K  L  N  Q  L  F  S  K  H  G         p.480

          .         .         .         .         .         .       g.16924
 CACTACGAGAGCAAAGTCACCCAGAATGCCCAGCGTCAGTATGACCACACCATGGGCCTC       c.1500
 H  Y  E  S  K  V  T  Q  N  A  Q  R  Q  Y  D  H  T  M  G  L         p.500

          .         .         .    | 17    .         .         .    g.17154
 AGCTGCTTCCGCATCTGCCACTATGCGGGCAAG | GTGACATACAACGTGACCAGCTTTATT    c.1560
 S  C  F  R  I  C  H  Y  A  G  K   | V  T  Y  N  V  T  S  F  I      p.520

          .         .         .         .         .         .       g.17214
 GACAAGAATAATGACCTACTCTTCCGAGACCTGTTGCAGGCCATGTGGAAGGCCCAGCAC       c.1620
 D  K  N  N  D  L  L  F  R  D  L  L  Q  A  M  W  K  A  Q  H         p.540

          .         .         .         .         .         .       g.17274
 CCCCTCCTTCGGTCCTTGTTTCCTGAGGGCAATCCTAAGCAGGCATCTCTCAAACGCCCC       c.1680
 P  L  L  R  S  L  F  P  E  G  N  P  K  Q  A  S  L  K  R  P         p.560

          .         .         .         .         .         .       g.17334
 CCGACTGCTGGGGCCCAGTTCAAGAGTTCTGTGGCCATCCTCATGAAGAATCTGTATTCC       c.1740
 P  T  A  G  A  Q  F  K  S  S  V  A  I  L  M  K  N  L  Y  S         p.580

          .         . | 18       .         .         .         .    g.17736
 AAGAGCCCCAACTACATCAG | GTGCATAAAGCCCAATGAGCATCAGCAGCGAGGTCAGTTC    c.1800
 K  S  P  N  Y  I  R  |  C  I  K  P  N  E  H  Q  Q  R  G  Q  F      p.600

          .         .         .         .         .         .       g.17796
 TCTTCAGACCTGGTGGCAACCCAGGCTCGGTACCTGGGACTGCTGGAGAACGTACGGGTG       c.1860
 S  S  D  L  V  A  T  Q  A  R  Y  L  G  L  L  E  N  V  R  V         p.620

          .         .         .         .         .         .       g.17856
 CGACGGGCAGGCTATGCCCACCGCCAGGGTTATGGGCCCTTCCTGGAAAGGTACCGATTG       c.1920
 R  R  A  G  Y  A  H  R  Q  G  Y  G  P  F  L  E  R  Y  R  L         p.640

          .         .         .         .  | 19      .         .    g.18143
 CTGAGCCGGAGCACCTGGCCTCACTGGAATGGGGGAGACCG | GGAAGGTGTTGAGAAGGTC    c.1980
 L  S  R  S  T  W  P  H  W  N  G  G  D  R  |  E  G  V  E  K  V      p.660

          .         .         .         .         .         .       g.18203
 CTGGGGGAGCTGAGCATGTCCTCGGGGGAGCTGGCCTTTGGCAAGACAAAGATCTTCATT       c.2040
 L  G  E  L  S  M  S  S  G  E  L  A  F  G  K  T  K  I  F  I         p.680

          .      | 20  .         .         .         .         .    g.18719
 AGAAGCCCCAAGACT | CTTTTCTACCTCGAAGAACAGAGGCGCCTGAGACTCCAGCAGCTG    c.2100
 R  S  P  K  T   | L  F  Y  L  E  E  Q  R  R  L  R  L  Q  Q  L      p.700

          .         .         .         .         .         .       g.18779
 GCCACACTCATACAGAAGATTTACCGAGGCTGGCGCTGCCGCACCCACTACCAACTGATG       c.2160
 A  T  L  I  Q  K  I  Y  R  G  W  R  C  R  T  H  Y  Q  L  M         p.720

          .         .         .         .      | 21  .         .    g.18940
 CGAAAGAGTCAGATCCTCATCTCCTCTTGGTTTCGGGGAAACATG | CAAAAGAAATGCTAT    c.2220
 R  K  S  Q  I  L  I  S  S  W  F  R  G  N  M   | Q  K  K  C  Y      p.740

          .         .         .         .         .     | 22   .    g.19390
 GGGAAGATAAAGGCATCCGTGTTATTGATCCAGGCTTTTGTGAGAGGGTGGAAG | GCCCGA    c.2280
 G  K  I  K  A  S  V  L  L  I  Q  A  F  V  R  G  W  K   | A  R      p.760

          .         .         .         .         .         .       g.19450
 AAGAATTATCGCAAATATTTCCGGTCAGAGGCTGCCCTCACCTTGGCAGATTTCATCTAC       c.2340
 K  N  Y  R  K  Y  F  R  S  E  A  A  L  T  L  A  D  F  I  Y         p.780

           | 23        .         .         .         .         .    g.24642
 AAGAGCATG | GTACAGAAATTCCTACTGGGGCTGAAGAACAATTTGCCATCCACAAACGTC    c.2400
 K  S  M   | V  Q  K  F  L  L  G  L  K  N  N  L  P  S  T  N  V      p.800

          .         .         .         .         .         .       g.24702
 TTAGACAAGACATGGCCAGCCGCCCCCTACAAGTGCCTCAGCACAGCAAATCAGGAGCTG       c.2460
 L  D  K  T  W  P  A  A  P  Y  K  C  L  S  T  A  N  Q  E  L         p.820

          .         .     | 24   .         .         .         .    g.25485
 CAGCAGCTCTTCTACCAGTGGAAG | TGCAAGAGGTTCCGGGATCAGCTGTCCCCGAAGCAG    c.2520
 Q  Q  L  F  Y  Q  W  K   | C  K  R  F  R  D  Q  L  S  P  K  Q      p.840

          .         .         .         .         .         .       g.25545
 GTAGAGATCCTGAGGGAAAAGCTCTGTGCCAGTGAACTGTTCAAGGGCAAGAAGGCTTCA       c.2580
 V  E  I  L  R  E  K  L  C  A  S  E  L  F  K  G  K  K  A  S         p.860

          .  | 25      .         .         .         .         .    g.25942
 TATCCCCAGAG | TGTCCCCATTCCATTCTGTGGTGACTACATTGGGCTGCAAGGGAACCCC    c.2640
 Y  P  Q  S  |  V  P  I  P  F  C  G  D  Y  I  G  L  Q  G  N  P      p.880

          .         .         .         .         .         .       g.26002
 AAGCTGCAGAAGCTGAAAGGCGGGGAGGAGGGGCCTGTTCTGATGGCAGAGGCCGTGAAG       c.2700
 K  L  Q  K  L  K  G  G  E  E  G  P  V  L  M  A  E  A  V  K         p.900

          .         .     | 26   .         .         .         .    g.26214
 AAGGTCAATCGTGGCAATGGCAAG | ACTTCTTCTCGGATTCTCCTCCTGACCAAGGGCCAT    c.2760
 K  V  N  R  G  N  G  K   | T  S  S  R  I  L  L  L  T  K  G  H      p.920

          .         .         .         .         .         .       g.26274
 GTGATTCTCACAGACACCAAGAAGTCCCAGGCCAAAATTGTCATTGGGCTAGACAATGTG       c.2820
 V  I  L  T  D  T  K  K  S  Q  A  K  I  V  I  G  L  D  N  V         p.940

          .         .         .         .         .        | 27.    g.26509
 GCTGGGGTGTCAGTCACCAGCCTCAAGGATGGGCTCTTTAGCTTGCATCTGAGTGAG | ATG    c.2880
 A  G  V  S  V  T  S  L  K  D  G  L  F  S  L  H  L  S  E   | M      p.960

          .         .         .         .         .         .       g.26569
 TCATCGGTGGGCTCCAAGGGGGACTTCCTGCTGGTCAGCGAGCATGTGATTGAACTGCTG       c.2940
 S  S  V  G  S  K  G  D  F  L  L  V  S  E  H  V  I  E  L  L         p.980

          .         .         .         .         .         .       g.26629
 ACCAAAATGTACCGGGCTGTGCTGGATGCCACGCAGAGGCAGCTTACAGTCACCGTGACT       c.3000
 T  K  M  Y  R  A  V  L  D  A  T  Q  R  Q  L  T  V  T  V  T         p.1000

       | 28  .         .         .         .         .         .    g.26939
 GAGAA | GTTCTCAGTGAGGTTCAAGGAGAACAGTGTGGCTGTCAAGGTCGTCCAGGGCCCT    c.3060
 E  K  |  F  S  V  R  F  K  E  N  S  V  A  V  K  V  V  Q  G  P      p.1020

          .         .         .         .         .         .       g.26999
 GCAGGTGGTGACAACAGCAAGCTACGCTACAAAAAAAAGGGGAGTCATTGCTTGGAGGTG       c.3120
 A  G  G  D  N  S  K  L  R  Y  K  K  K  G  S  H  C  L  E  V         p.1040

          .                                                         g.27011
 ACTGTGCAGTGA                                                       c.3132
 T  V  Q  X                                                         p.1043

          .         .         .         .         .         .       g.27071
 ggagggggcaccatgcagagatggcagttgcttcctcctgaaccagcactaatccccctc       c.*60

          .         .         .         .         .         .       g.27131
 tgccctcctgtgtgggaggatctctaacccctctgatcgtggcgcatggcttggggatta       c.*120

          .         .         .         .         .         .       g.27191
 aactacccttgaagaggacccttgtcccaaacccttcttgttctctcctccaaaagtagc       c.*180

          .         .         .         .         .                 g.27249
 ttcctccaacccgcagcctctctgcacactaataaaacatgtggcttggaaaggttca         c.*238

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Myosin IA protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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