myocilin, trabecular meshwork inducible glucocorticoid response (MYOC) - coding DNA reference sequence

(used for variant description)

(last modified November 25, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000261.1 in the MYOC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008859.1, covering MYOC transcript NM_000261.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       gaagcctcaccaagcctctgca       c.-1

          .         .         .         .         .         .       g.5082
 ATGAGGTTCTTCTGTGCACGTTGCTGCAGCTTTGGGCCTGAGATGCCAGCTGTCCAGCTG       c.60
 M  R  F  F  C  A  R  C  C  S  F  G  P  E  M  P  A  V  Q  L         p.20

          .         .         .         .         .         .       g.5142
 CTGCTTCTGGCCTGCCTGGTGTGGGATGTGGGGGCCAGGACAGCTCAGCTCAGGAAGGCC       c.120
 L  L  L  A  C  L  V  W  D  V  G  A  R  T  A  Q  L  R  K  A         p.40

          .         .         .         .         .         .       g.5202
 AATGACCAGAGTGGCCGATGCCAGTATACCTTCAGTGTGGCCAGTCCCAATGAATCCAGC       c.180
 N  D  Q  S  G  R  C  Q  Y  T  F  S  V  A  S  P  N  E  S  S         p.60

          .         .         .         .         .         .       g.5262
 TGCCCAGAGCAGAGCCAGGCCATGTCAGTCATCCATAACTTACAGAGAGACAGCAGCACC       c.240
 C  P  E  Q  S  Q  A  M  S  V  I  H  N  L  Q  R  D  S  S  T         p.80

          .         .         .         .         .         .       g.5322
 CAACGCTTAGACCTGGAGGCCACCAAAGCTCGACTCAGCTCCCTGGAGAGCCTCCTCCAC       c.300
 Q  R  L  D  L  E  A  T  K  A  R  L  S  S  L  E  S  L  L  H         p.100

          .         .         .         .         .         .       g.5382
 CAATTGACCTTGGACCAGGCTGCCAGGCCCCAGGAGACCCAGGAGGGGCTGCAGAGGGAG       c.360
 Q  L  T  L  D  Q  A  A  R  P  Q  E  T  Q  E  G  L  Q  R  E         p.120

          .         .         .         .         .         .       g.5442
 CTGGGCACCCTGAGGCGGGAGCGGGACCAGCTGGAAACCCAAACCAGAGAGTTGGAGACT       c.420
 L  G  T  L  R  R  E  R  D  Q  L  E  T  Q  T  R  E  L  E  T         p.140

          .         .         .         .         .         .       g.5502
 GCCTACAGCAACCTCCTCCGAGACAAGTCAGTTCTGGAGGAAGAGAAGAAGCGACTAAGG       c.480
 A  Y  S  N  L  L  R  D  K  S  V  L  E  E  E  K  K  R  L  R         p.160

          .         .         .         .         .         .       g.5562
 CAAGAAAATGAGAATCTGGCCAGGAGGTTGGAAAGCAGCAGCCAGGAGGTAGCAAGGCTG       c.540
 Q  E  N  E  N  L  A  R  R  L  E  S  S  S  Q  E  V  A  R  L         p.180

          .         .         .         .         .         .       g.5622
 AGAAGGGGCCAGTGTCCCCAGACCCGAGACACTGCTCGGGCTGTGCCACCAGGCTCCAGA       c.600
 R  R  G  Q  C  P  Q  T  R  D  T  A  R  A  V  P  P  G  S  R         p.200

      | 02   .         .         .         .         .         .    g.18967
 GAAG | TTTCTACGTGGAATTTGGACACTTTGGCCTTCCAGGAACTGAAGTCCGAGCTAACT    c.660
 E  V |   S  T  W  N  L  D  T  L  A  F  Q  E  L  K  S  E  L  T      p.220

          .         .         .         .         .         .       g.19027
 GAAGTTCCTGCTTCCCGAATTTTGAAGGAGAGCCCATCTGGCTATCTCAGGAGTGGAGAG       c.720
 E  V  P  A  S  R  I  L  K  E  S  P  S  G  Y  L  R  S  G  E         p.240

          . | 03       .         .         .         .         .    g.20974
 GGAGACACCG | GATGTGGAGAACTAGTTTGGGTAGGAGAGCCTCTCACGCTGAGAACAGCA    c.780
 G  D  T  G |   C  G  E  L  V  W  V  G  E  P  L  T  L  R  T  A      p.260

          .         .         .         .         .         .       g.21034
 GAAACAATTACTGGCAAGTATGGTGTGTGGATGCGAGACCCCAAGCCCACCTACCCCTAC       c.840
 E  T  I  T  G  K  Y  G  V  W  M  R  D  P  K  P  T  Y  P  Y         p.280

          .         .         .         .         .         .       g.21094
 ACCCAGGAGACCACGTGGAGAATCGACACAGTTGGCACGGATGTCCGCCAGGTTTTTGAG       c.900
 T  Q  E  T  T  W  R  I  D  T  V  G  T  D  V  R  Q  V  F  E         p.300

          .         .         .         .         .         .       g.21154
 TATGACCTCATCAGCCAGTTTATGCAGGGCTACCCTTCTAAGGTTCACATACTGCCTAGG       c.960
 Y  D  L  I  S  Q  F  M  Q  G  Y  P  S  K  V  H  I  L  P  R         p.320

          .         .         .         .         .         .       g.21214
 CCACTGGAAAGCACGGGTGCTGTGGTGTACTCGGGGAGCCTCTATTTCCAGGGCGCTGAG       c.1020
 P  L  E  S  T  G  A  V  V  Y  S  G  S  L  Y  F  Q  G  A  E         p.340

          .         .         .         .         .         .       g.21274
 TCCAGAACTGTCATAAGATATGAGCTGAATACCGAGACAGTGAAGGCTGAGAAGGAAATC       c.1080
 S  R  T  V  I  R  Y  E  L  N  T  E  T  V  K  A  E  K  E  I         p.360

          .         .         .         .         .         .       g.21334
 CCTGGAGCTGGCTACCACGGACAGTTCCCGTATTCTTGGGGTGGCTACACGGACATTGAC       c.1140
 P  G  A  G  Y  H  G  Q  F  P  Y  S  W  G  G  Y  T  D  I  D         p.380

          .         .         .         .         .         .       g.21394
 TTGGCTGTGGATGAAGCAGGCCTCTGGGTCATTTACAGCACCGATGAGGCCAAAGGTGCC       c.1200
 L  A  V  D  E  A  G  L  W  V  I  Y  S  T  D  E  A  K  G  A         p.400

          .         .         .         .         .         .       g.21454
 ATTGTCCTCTCCAAACTGAACCCAGAGAATCTGGAACTCGAACAAACCTGGGAGACAAAC       c.1260
 I  V  L  S  K  L  N  P  E  N  L  E  L  E  Q  T  W  E  T  N         p.420

          .         .         .         .         .         .       g.21514
 ATCCGTAAGCAGTCAGTCGCCAATGCCTTCATCATCTGTGGCACCTTGTACACCGTCAGC       c.1320
 I  R  K  Q  S  V  A  N  A  F  I  I  C  G  T  L  Y  T  V  S         p.440

          .         .         .         .         .         .       g.21574
 AGCTACACCTCAGCAGATGCTACCGTCAACTTTGCTTATGACACAGGCACAGGTATCAGC       c.1380
 S  Y  T  S  A  D  A  T  V  N  F  A  Y  D  T  G  T  G  I  S         p.460

          .         .         .         .         .         .       g.21634
 AAGACCCTGACCATCCCATTCAAGAACCGCTATAAGTACAGCAGCATGATTGACTACAAC       c.1440
 K  T  L  T  I  P  F  K  N  R  Y  K  Y  S  S  M  I  D  Y  N         p.480

          .         .         .         .         .         .       g.21694
 CCCCTGGAGAAGAAGCTCTTTGCCTGGGACAACTTGAACATGGTCACTTATGACATCAAG       c.1500
 P  L  E  K  K  L  F  A  W  D  N  L  N  M  V  T  Y  D  I  K         p.500

          .                                                         g.21709
 CTCTCCAAGATGTGA                                                    c.1515
 L  S  K  M  X                                                      p.504

          .         .         .         .         .         .       g.21769
 aaagcctccaagctgtacaggcaatggcagaaggagatgctcagggctcctggggggagc       c.*60

          .         .         .         .         .         .       g.21829
 aggctgaagggagagccagccagccagggcccaggcagctttgactgctttccaagtttt       c.*120

          .         .         .         .         .         .       g.21889
 cattaatccagaaggatgaacatggtcaccatctaactattcaggaattgtagtctgagg       c.*180

          .         .         .         .         .         .       g.21949
 gcgtagacaatttcatataataaatatcctttatcttctgtcagcatttatgggatgttt       c.*240

          .         .         .         .         .         .       g.22009
 aatgacatagttcaagttttcttgtgatttggggcaaaagctgtaaggcataatagtttc       c.*300

          .         .         .         .         .         .       g.22069
 ttcctgaaaaccattgctcttgcatgttacatggttaccacaagccacaataaaaagcat       c.*360

          .         .         .         .         .         .       g.22129
 aacttctaaaggaagcagaatagctcctctggccagcatcgaatataagtaagatgcatt       c.*420

          .         .         .         .         .         .       g.22189
 tactacagttggcttctaatgcttcagatagaatacagttgggtctcacataacccttta       c.*480

          .         .                                               g.22217
 cattgtgaaataaaattttcttacccaa                                       c.*508

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Myocilin, trabecular meshwork inducible glucocorticoid response protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 25b
©2004-2020 Leiden University Medical Center