N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA) - coding DNA reference sequence

(used for variant description)

(last modified December 19, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_016256.3 in the NAGPA gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_028152.1, covering NAGPA transcript NM_016256.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5027
                                  ccacatgacccgaggccccggtccaat       c.-1

          .         .         .         .         .         .       g.5087
 ATGGCGACCTCCACGGGTCGCTGGCTTCTCCTCCGGCTTGCACTATTCGGCTTCCTCTGG       c.60
 M  A  T  S  T  G  R  W  L  L  L  R  L  A  L  F  G  F  L  W         p.20

          .         .       | 02 .         .         .         .    g.5247
 GAAGCGTCCGGCGGCCTCGACTCGGG | GGCCTCCCGCGACGACGACTTGCTACTGCCCTAT    c.120
 E  A  S  G  G  L  D  S  G  |  A  S  R  D  D  D  L  L  L  P  Y      p.40

          .         .         .         .         .         .       g.5307
 CCACGCGCGCGCGCGCGCCTCCCCCGGGACTGCACACGGGTGCGCGCCGGCAACCGCGAG       c.180
 P  R  A  R  A  R  L  P  R  D  C  T  R  V  R  A  G  N  R  E         p.60

          .         .         .         .         .         .       g.5367
 CACGAGAGTTGGCCTCCGCCTCCCGCGACTCCCGGCGCCGGCGGTCTGGCCGTGCGCACC       c.240
 H  E  S  W  P  P  P  P  A  T  P  G  A  G  G  L  A  V  R  T         p.80

          .         .         .         .         .         .       g.5427
 TTCGTGTCGCACTTCAGGGACCGCGCGGTGGCCGGCCACCTGACGCGGGCCGTTGAGCCC       c.300
 F  V  S  H  F  R  D  R  A  V  A  G  H  L  T  R  A  V  E  P         p.100

          .         .         .         .         .         .       g.5487
 CTGCGCACCTTCTCGGTGCTGGAGCCCGGTGGACCCGGCGGCTGCGCGGCGAGACGACGC       c.360
 L  R  T  F  S  V  L  E  P  G  G  P  G  G  C  A  A  R  R  R         p.120

          .         .         .         .         .         .       g.5547
 GCCACCGTGGAGGAGACGGCGCGGGCGGCCGACTGCCGTGTCGCCCAGAACGGCGGCTTC       c.420
 A  T  V  E  E  T  A  R  A  A  D  C  R  V  A  Q  N  G  G  F         p.140

          .         .         .         .         .         .       g.5607
 TTCCGCATGAACTCGGGCGAGTGCCTGGGGAACGTGGTGAGCGACGAGCGGCGGGTGAGC       c.480
 F  R  M  N  S  G  E  C  L  G  N  V  V  S  D  E  R  R  V  S         p.160

          .         .         .         .         .         .       g.5667
 AGCTCCGGGGGGCTGCAGAACGCGCAGTTCGGGATCCGCCGCGACGGGACCCTGGTCACC       c.540
 S  S  G  G  L  Q  N  A  Q  F  G  I  R  R  D  G  T  L  V  T         p.180

    | 03     .         .         .         .         .         .    g.7115
 GG | GTACCTGTCTGAGGAGGAGGTGCTGGACACTGAGAACCCATTTGTGCAGCTGCTGAGT    c.600
 G  |  Y  L  S  E  E  E  V  L  D  T  E  N  P  F  V  Q  L  L  S      p.200

          .         .         .         .         .         .       g.7175
 GGGGTCGTGTGGCTGATTCGTAATGGAAGCATCTACATCAACGAGAGCCAAGCCACAGAG       c.660
 G  V  V  W  L  I  R  N  G  S  I  Y  I  N  E  S  Q  A  T  E         p.220

          .         .   | 04     .         .         .         .    g.8486
 TGTGACGAGACACAGGAGACAG | GTTCCTTTAGCAAATTTGTGAATGTGATATCAGCCAGG    c.720
 C  D  E  T  Q  E  T  G |   S  F  S  K  F  V  N  V  I  S  A  R      p.240

          .         .         .         .         .         .       g.8546
 ACGGCCATTGGCCACGACCGGAAAGGGCAGCTGGTGCTCTTTCATGCAGACGGCCAAACG       c.780
 T  A  I  G  H  D  R  K  G  Q  L  V  L  F  H  A  D  G  Q  T         p.260

          .  | 05      .         .         .         .         .    g.9982
 GAGCAGCGTGG | CATCAACCTGTGGGAAATGGCGGAGTTCCTGCTGAAACAGGACGTGGTC    c.840
 E  Q  R  G  |  I  N  L  W  E  M  A  E  F  L  L  K  Q  D  V  V      p.280

          .         .         .         .         .         .       g.10042
 AACGCCATCAACCTGGATGGGGGTGGCTCTGCCACCTTTGTGCTCAACGGGACCTTGGCC       c.900
 N  A  I  N  L  D  G  G  G  S  A  T  F  V  L  N  G  T  L  A         p.300

          .         . | 06       .         .         .         .    g.10796
 AGTTACCCGTCAGATCACTG | CCAGGACAACATGTGGCGCTGTCCCCGCCAAGTGTCCACC    c.960
 S  Y  P  S  D  H  C  |  Q  D  N  M  W  R  C  P  R  Q  V  S  T      p.320

          .         .         .         .         .         .       g.10856
 GTGGTGTGTGTGCACGAACCCCGCTGCCAGCCGCCTGACTGCCACGGCCACGGGACCTGC       c.1020
 V  V  C  V  H  E  P  R  C  Q  P  P  D  C  H  G  H  G  T  C         p.340

          .         .         .         .         .         .       g.10916
 GTGGACGGGCACTGCCAATGCACCGGGCACTTCTGGCGGGGTCCCGGCTGTGATGAGCTG       c.1080
 V  D  G  H  C  Q  C  T  G  H  F  W  R  G  P  G  C  D  E  L         p.360

          .         .         .         .       | 07 .         .    g.11062
 GACTGTGGCCCCTCTAACTGCAGCCAGCACGGACTGTGCACGGAGA | CCGGCTGCCGCTGT    c.1140
 D  C  G  P  S  N  C  S  Q  H  G  L  C  T  E  T |   G  C  R  C      p.380

          .         .         .     | 08   .         .         .    g.11588
 GATGCCGGATGGACCGGGTCCAACTGCAGTGAAG | AGTGTCCCCTTGGCTGGCATGGGCCG    c.1200
 D  A  G  W  T  G  S  N  C  S  E  E |   C  P  L  G  W  H  G  P      p.400

          .         .         .         .         .         .       g.11648
 GGCTGCCAGAGGCCTTGTAAGTGTGAGCACCATTGTCCCTGTGACCCCAAGACTGGCAAC       c.1260
 G  C  Q  R  P  C  K  C  E  H  H  C  P  C  D  P  K  T  G  N         p.420

          .       | 09 .         .         .         .         .    g.11787
 TGCAGCGTCTCCAGAG | TAAAGCAGTGTCTCCAGCCACCTGAAGCCACCCTGAGGGCGGGA    c.1320
 C  S  V  S  R  V |   K  Q  C  L  Q  P  P  E  A  T  L  R  A  G      p.440

          .         . | 10       .         .         .         .    g.13296
 GAACTCTCCTTTTTCACCAG | GACCGCCTGGCTAGCCCTCACCCTGGCGCTGGCCTTCCTC    c.1380
 E  L  S  F  F  T  R  |  T  A  W  L  A  L  T  L  A  L  A  F  L      p.460

          .         .         .         .         .         .       g.13356
 CTGCTGATCAGCACTGCAGCAAACCTGTCCTTGCTCCTGTCCAGAGCAGAGAGGAACCGG       c.1440
 L  L  I  S  T  A  A  N  L  S  L  L  L  S  R  A  E  R  N  R         p.480

          .         .         .         .         .         .       g.13416
 CGCCTGCATGGGGACTATGCATACCACCCGCTGCAGGAGATGAACGGGGAGCCTCTGGCC       c.1500
 R  L  H  G  D  Y  A  Y  H  P  L  Q  E  M  N  G  E  P  L  A         p.500

          .         .         .         .                           g.13464
 GCAGAGAAGGAGCAGCCAGGGGGCGCCCACAACCCCTTCAAGGACTGA                   c.1548
 A  E  K  E  Q  P  G  G  A  H  N  P  F  K  D  X                     p.515

          .         .         .         .         .         .       g.13524
 agcctcaagctgcccggggtggcacgtcgcgaaagcttgtttccccacggtctggcttct       c.*60

          .         .         .         .         .         .       g.13584
 gcaggggaaatttcaaggccactggcgtggaccatctgggtgtcctcagcccctgtgggg       c.*120

          .         .         .         .         .         .       g.13644
 cagccaagttcctgatagcacttgtgcctcagcccctcacctggccacctgccagggcac       c.*180

          .         .         .         .         .         .       g.13704
 ctgcaaccctagcaataccatgctcgctggagaggctcagctgcctgcttctggcctgcc       c.*240

          .         .         .         .         .         .       g.13764
 tgtgtctgctgccgagaagcccgtgcccccgggagggctgccgcactgccaaagagtctc       c.*300

          .         .         .         .         .         .       g.13824
 cctcctcctggggaaggggctgccaacgaaccagactcagtgaccacgtcatgacagaac       c.*360

          .         .         .         .         .         .       g.13884
 agcacatcctggccagcacccctggctggagtgggttaaagggacgagtctgccttcctg       c.*420

          .         .         .         .         .         .       g.13944
 gctgtgacacgggaccccttttctacagacctcatcactggatttgccaactagaattcg       c.*480

          .         .         .         .         .         .       g.14004
 atttcctgtcataggaagctccttggaagaagggatggggggatgagatcatgtttacag       c.*540

          .         .         .         .         .         .       g.14064
 acctgttttgtcatcctgctgccaagaagttttttaatcacttgaataaattgatataat       c.*600

          .         .         .                                     g.14098
 aaaaggagccaccaggtggtgtgtggattctgaa                                 c.*634

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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