N-acetylglutamate synthase (NAGS) - coding DNA reference sequence

(used for variant description)

(last modified January 28, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_153006.2 in the NAGS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008106.1, covering NAGS transcript NM_153006.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
          .         .         .         .         .         .       g.60
 ATGGCGACGGCGCTGATGGCTGTGGTTCTGCGGGCAGCTGCTGTAGCCCCGAGGCTGAGA       c.60
 M  A  T  A  L  M  A  V  V  L  R  A  A  A  V  A  P  R  L  R         p.20

          .         .         .         .         .         .       g.120
 GGCCGGGGAGGCACTGGGGGCGCCCGAAGGCTGAGCTGTGGCGCGCGGCGGCGGGCGGCG       c.120
 G  R  G  G  T  G  G  A  R  R  L  S  C  G  A  R  R  R  A  A         p.40

          .         .         .         .         .         .       g.180
 AGGGGCACCAGCCCGGGGCGCCGGCTCAGCACCGCCTGGTCGCAGCCCCAGCCCCCGCCC       c.180
 R  G  T  S  P  G  R  R  L  S  T  A  W  S  Q  P  Q  P  P  P         p.60

          .         .         .         .         .         .       g.240
 GAGGAGTACGCGGGCGCGGACGACGTCTCCCAGTCGCCCGTCGCCGAGGAGCCGTCGTGG       c.240
 E  E  Y  A  G  A  D  D  V  S  Q  S  P  V  A  E  E  P  S  W         p.80

          .         .         .         .         .         .       g.300
 GTGCCGAGTCCCAGGCCCCCGGTGCCCCACGAGTCCCCAGAGCCTCCTTCGGGCCGCTCG       c.300
 V  P  S  P  R  P  P  V  P  H  E  S  P  E  P  P  S  G  R  S         p.100

          .         .         .         .         .         .       g.360
 CTGGTGCAGCGGGACATCCAGGCCTTCCTGAACCAGTGCGGGGCCAGCCCTGGGGAGGCG       c.360
 L  V  Q  R  D  I  Q  A  F  L  N  Q  C  G  A  S  P  G  E  A         p.120

          .         .         .         .         .         .       g.420
 CGCCACTGGCTCACGCAGTTCCAGACCTGCCATCACTCCGCGGACAAGCCCTTCGCCGTC       c.420
 R  H  W  L  T  Q  F  Q  T  C  H  H  S  A  D  K  P  F  A  V         p.140

        | 02 .         .         .         .         .         .    g.1027
 ATCGAG | GTGGACGAGGAGGTGCTCAAGTGCCAGCAGGGCGTATCCAGTCTGGCCTTTGCC    c.480
 I  E   | V  D  E  E  V  L  K  C  Q  Q  G  V  S  S  L  A  F  A      p.160

          .         .         .         .         .         .       g.1087
 CTGGCCTTCTTGCAGCGCATGGACATGAAGCCGCTGGTGGTCCTGGGGCTGCCGGCCCCT       c.540
 L  A  F  L  Q  R  M  D  M  K  P  L  V  V  L  G  L  P  A  P         p.180

          .         .         .         .         .         .       g.1147
 ACGGCTCCCTCGGGCTGTCTTTCCTTCTGGGAGGCCAAGGCGCAGCTGGCCAAGAGCTGC       c.600
 T  A  P  S  G  C  L  S  F  W  E  A  K  A  Q  L  A  K  S  C         p.200

          .         .         .         .         .         .       g.1207
 AAGGTGCTGGTAGACGCGCTTCGACACAACGCCGCCGCTGCTGTGCCATTTTTTGGCGGC       c.660
 K  V  L  V  D  A  L  R  H  N  A  A  A  A  V  P  F  F  G  G         p.220

          .         .         .         .  | 03      .         .    g.1379
 GGGTCTGTGCTACGCGCTGCCGAGCCGGCTCCCCATGCCAG | CTACGGCGGCATCGTCTCG    c.720
 G  S  V  L  R  A  A  E  P  A  P  H  A  S  |  Y  G  G  I  V  S      p.240

          .         .         .         .         .         .       g.1439
 GTGGAGACAGACCTGCTGCAGTGGTGCCTGGAGTCGGGCAGCATCCCCATCCTGTGCCCC       c.780
 V  E  T  D  L  L  Q  W  C  L  E  S  G  S  I  P  I  L  C  P         p.260

          .         .         .         .         .         .       g.1499
 ATCGGGGAGACGGCCGCGCGCCGCTCCGTGCTTCTCGACTCCCTGGAGGTGACCGCGTCG       c.840
 I  G  E  T  A  A  R  R  S  V  L  L  D  S  L  E  V  T  A  S         p.280

          .         .         .         .         .         .       g.1559
 CTGGCCAAGGCGCTGCGGCCCACCAAAATCATCTTCCTCAATAACACAGGCGGCCTGCGC       c.900
 L  A  K  A  L  R  P  T  K  I  I  F  L  N  N  T  G  G  L  R         p.300

          .      | 04  .         .         .         .         .    g.1910
 GACAGCAGTCATAAG | GTCCTGAGTAACGTGAACCTGCCCGCCGACCTGGACCTGGTGTGC    c.960
 D  S  S  H  K   | V  L  S  N  V  N  L  P  A  D  L  D  L  V  C      p.320

          .         .         .         .         .         .       g.1970
 AACGCCGAGTGGGTGAGCACAAAAGAACGGCAGCAGATGCGGCTCATCGTGGACGTGCTC       c.1020
 N  A  E  W  V  S  T  K  E  R  Q  Q  M  R  L  I  V  D  V  L         p.340

          .         .         .         .         .         .       g.2030
 AGCCGCCTGCCCCACCACTCCTCGGCCGTCATCACCGCCGCTAGCACGCTGCTCACTGAG       c.1080
 S  R  L  P  H  H  S  S  A  V  I  T  A  A  S  T  L  L  T  E         p.360

          .       | 05 .         .         .         .         .    g.2703
 CTCTTTAGCAACAAGG | GGTCCGGGACCCTGTTCAAGAACGCCGAGCGAATGCTACGGGTG    c.1140
 L  F  S  N  K  G |   S  G  T  L  F  K  N  A  E  R  M  L  R  V      p.380

          .         .         .         .         .         .       g.2763
 CGCAGCCTGGACAAGCTGGACCAGGGCCGTCTAGTGGACCTGGTCAACGCCAGCTTCGGC       c.1200
 R  S  L  D  K  L  D  Q  G  R  L  V  D  L  V  N  A  S  F  G         p.400

          .         .         .         .         .         .       g.2823
 AAGAAGCTCAGGGACGACTACCTGGCCTCGCTGCGCCCGCGGCTGCACTCCATCTACGTC       c.1260
 K  K  L  R  D  D  Y  L  A  S  L  R  P  R  L  H  S  I  Y  V         p.420

          | 06         .         .         .         .         .    g.2979
 TCCGAGGG | GTACAACGCCGCCGCCATTCTGACCATGGAGCCCGTCCTGGGGGGCACCCCG    c.1320
 S  E  G  |  Y  N  A  A  A  I  L  T  M  E  P  V  L  G  G  T  P      p.440

          .         .         .         .         .         .       g.3039
 TACCTGGACAAATTTGTGGTGAGCTCCAGCCGCCAGGGCCAAGGCTCCGGCCAGATGCTG       c.1380
 Y  L  D  K  F  V  V  S  S  S  R  Q  G  Q  G  S  G  Q  M  L         p.460

          .         .         .         .         .         .       g.3099
 TGGGAGTGCCTGCGGCGGGACCTTCAGACACTTTTCTGGCGCTCCCGGGTCACCAACCCC       c.1440
 W  E  C  L  R  R  D  L  Q  T  L  F  W  R  S  R  V  T  N  P         p.480

          .  | 07      .         .         .         .         .    g.3833
 ATCAATCCCTG | GTACTTCAAACACAGTGATGGCAGCTTCTCCAACAAGCAGTGGATCTTC    c.1500
 I  N  P  W  |  Y  F  K  H  S  D  G  S  F  S  N  K  Q  W  I  F      p.500

          .         .         .         .         .         .       g.3893
 TTCTGGTTTGGCCTGGCTGATATCCGGGACTCCTATGAGTTGGTCAACCACGCCAAGGGA       c.1560
 F  W  F  G  L  A  D  I  R  D  S  Y  E  L  V  N  H  A  K  G         p.520

          .         .         .         .                           g.3938
 CTGCCAGACTCCTTTCACAAGCCAGCTTCTGACCCAGGCAGCTGA                      c.1605
 L  P  D  S  F  H  K  P  A  S  D  P  G  S  X                        p.534

          .         .         .         .         .         .       g.3998
 ccctcaccatggacactacaggccctggaatggccagggtggaccaaaagccatgccagc       c.*60

          .         .         .         .         .         .       g.4058
 tgggcatgaccccaggcagccagccacaggctgaagggggcttgttggctgagtgatctg       c.*120

          .         .         .         .         .         .       g.4118
 cagaggagaaagcagccccagctctgcccagaggaggcgctgaagtgggacaagcacagg       c.*180

          .         .         .         .         .         .       g.4178
 aaagaaggggaccagtctaggaccccaactcgactcactctaaagctacaaccaaatggc       c.*240

          .         .         .         .         .         .       g.4238
 cttcgattttcaacctggggattaggggaggggagggtgccttccagggctctactcagg       c.*300

          .         .         .         .         .         .       g.4298
 actaaccctaagggtgagctagtttctgtgcctctgtgctatgttttgaggctcccttac       c.*360

          .         .         .         .         .         .       g.4358
 ccaaaataatacccctgcctgcgtgatattctaccattcattttaattcctttgggtctt       c.*420

          .         .         .         .                           g.4405
 gcagtttttcaggaggccttgattaaaatgcaaatacttgtctgaga                    c.*467

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The N-acetylglutamate synthase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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