nicotinamide phosphoribosyltransferase (NAMPT) - coding DNA reference sequence

(used for variant description)

(last modified December 10, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_005746.2 in the NAMPT gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering NAMPT transcript NM_005746.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5008
                                                     gctgccgc       c.-301

 .         .         .         .         .         .                g.5068
 gccccgccctttctcggcccccggagggtgacggggtgaaggcgggggaaccgaggtggg       c.-241

 .         .         .         .         .         .                g.5128
 gagtccgccagagctcccagactgcgagcacgcgagccgccgcagccgtcacccgcgccg       c.-181

 .         .         .         .         .         .                g.5188
 cgtcacggctcccgggcccgccctcctctgacccctcccctctctccgtttccccctctc       c.-121

 .         .         .         .         .         .                g.5248
 cccctcctccgccgaccgagcagtgacttaagcaacggagcgcggtgaagctcatttttc       c.-61

 .         .         .         .         .         .                g.5308
 tccttcctcgcagccgcgccagggagctcgcggcgcgcggcccctgtcctccggcccgag       c.-1

          .         .         .         .         .        | 02.    g.13016
 ATGAATCCTGCGGCAGAAGCCGAGTTCAACATCCTCCTGGCCACCGACTCCTACAAG | GTT    c.60
 M  N  P  A  A  E  A  E  F  N  I  L  L  A  T  D  S  Y  K   | V      p.20

          .         .         .         .         .         .       g.13076
 ACTCACTATAAACAATATCCACCCAACACAAGCAAAGTTTATTCCTACTTTGAATGCCGT       c.120
 T  H  Y  K  Q  Y  P  P  N  T  S  K  V  Y  S  Y  F  E  C  R         p.40

          .         .         .         .         .         .       g.13136
 GAAAAGAAGACAGAAAACTCCAAATTAAGGAAGGTGAAATATGAGGAAACAGTATTTTAT       c.180
 E  K  K  T  E  N  S  K  L  R  K  V  K  Y  E  E  T  V  F  Y         p.60

          .         .         .     | 03   .         .         .    g.15169
 GGGTTGCAGTACATTCTTAATAAGTACTTAAAAG | GTAAAGTAGTAACCAAAGAGAAAATC    c.240
 G  L  Q  Y  I  L  N  K  Y  L  K  G |   K  V  V  T  K  E  K  I      p.80

          .         .         .         .         .         .       g.15229
 CAGGAAGCCAAAGATGTCTACAAAGAACATTTCCAAGATGATGTCTTTAATGAAAAGGGA       c.300
 Q  E  A  K  D  V  Y  K  E  H  F  Q  D  D  V  F  N  E  K  G         p.100

          .         | 04         .         .         .         .    g.17576
 TGGAACTACATTCTTGAG | AAGTATGATGGGCATCTTCCAATAGAAATAAAAGCTGTTCCT    c.360
 W  N  Y  I  L  E   | K  Y  D  G  H  L  P  I  E  I  K  A  V  P      p.120

          .         .         .         .         .         .       g.17636
 GAGGGCTTTGTCATTCCCAGAGGAAATGTTCTCTTCACGGTGGAAAACACAGATCCAGAG       c.420
 E  G  F  V  I  P  R  G  N  V  L  F  T  V  E  N  T  D  P  E         p.140

          .         .        | 05.         .         .         .    g.20913
 TGTTACTGGCTTACAAATTGGATTGAG | ACTATTCTTGTTCAGTCCTGGTATCCAATCACA    c.480
 C  Y  W  L  T  N  W  I  E   | T  I  L  V  Q  S  W  Y  P  I  T      p.160

          .         .         .         .         .         .       g.20973
 GTGGCCACAAATTCTAGAGAGCAGAAGAAAATATTGGCCAAATATTTGTTAGAAACTTCT       c.540
 V  A  T  N  S  R  E  Q  K  K  I  L  A  K  Y  L  L  E  T  S         p.180

          .         .         .         .         .         .       g.21033
 GGTAACTTAGATGGTCTGGAATACAAGTTACATGATTTTGGCTACAGAGGAGTCTCTTCC       c.600
 G  N  L  D  G  L  E  Y  K  L  H  D  F  G  Y  R  G  V  S  S         p.200

        | 06 .         .         .         .         .         .    g.21646
 CAAGAG | ACTGCTGGCATAGGAGCATCTGCTCACTTGGTTAACTTCAAAGGAACAGATACA    c.660
 Q  E   | T  A  G  I  G  A  S  A  H  L  V  N  F  K  G  T  D  T      p.220

          .         .         .         .         .         .       g.21706
 GTAGCAGGACTTGCTCTAATTAAAAAATATTATGGAACGAAAGATCCTGTTCCAGGCTAT       c.720
 V  A  G  L  A  L  I  K  K  Y  Y  G  T  K  D  P  V  P  G  Y         p.240

          .         .    | 07    .         .         .         .    g.26612
 TCTGTTCCAGCAGCAGAACACAG | TACCATAACAGCTTGGGGGAAAGACCATGAAAAAGAT    c.780
 S  V  P  A  A  E  H  S  |  T  I  T  A  W  G  K  D  H  E  K  D      p.260

          .         .         .         .         .         .       g.26672
 GCTTTTGAACATATTGTAACACAGTTTTCATCAGTGCCTGTATCTGTGGTCAGCGATAGC       c.840
 A  F  E  H  I  V  T  Q  F  S  S  V  P  V  S  V  V  S  D  S         p.280

          .         .         .         .         .         .       g.26732
 TATGACATTTATAATGCGTGTGAGAAAATATGGGGTGAAGATCTAAGACATTTAATAGTA       c.900
 Y  D  I  Y  N  A  C  E  K  I  W  G  E  D  L  R  H  L  I  V         p.300

          .         .         .         .         .         .       g.26792
 TCAAGAAGTACACAGGCACCACTAATAATCAGACCTGATTCTGGAAACCCTCTTGACACT       c.960
 S  R  S  T  Q  A  P  L  I  I  R  P  D  S  G  N  P  L  D  T         p.320

           | 08        .         .         .         .         .    g.28536
 GTGTTAAAG | GTTTTGGAGATTTTAGGTAAGAAGTTTCCTGTTACTGAGAACTCAAAGGGT    c.1020
 V  L  K   | V  L  E  I  L  G  K  K  F  P  V  T  E  N  S  K  G      p.340

          .         .         .         .         .         .       g.28596
 TACAAGTTGCTGCCACCTTATCTTAGAGTTATTCAAGGGGATGGAGTAGATATTAATACC       c.1080
 Y  K  L  L  P  P  Y  L  R  V  I  Q  G  D  G  V  D  I  N  T         p.360

           | 09        .         .         .         .         .    g.35739
 TTACAAGAG | ATTGTAGAAGGCATGAAACAAAAAATGTGGAGTATTGAAAATATTGCCTTC    c.1140
 L  Q  E   | I  V  E  G  M  K  Q  K  M  W  S  I  E  N  I  A  F      p.380

          .         .         .         .         .         .       g.35799
 GGTTCTGGTGGAGGTTTGCTACAGAAGTTGACAAGAGATCTCTTGAATTGTTCCTTCAAG       c.1200
 G  S  G  G  G  L  L  Q  K  L  T  R  D  L  L  N  C  S  F  K         p.400

          .         .         . | 10       .         .         .    g.37071
 TGTAGCTATGTTGTAACTAATGGCCTTGGG | ATTAACGTCTTCAAGGACCCAGTTGCTGAT    c.1260
 C  S  Y  V  V  T  N  G  L  G   | I  N  V  F  K  D  P  V  A  D      p.420

          .         .         .         .         .         .       g.37131
 CCCAACAAAAGGTCCAAAAAGGGCCGATTATCTTTACATAGGACGCCAGCAGGGAATTTT       c.1320
 P  N  K  R  S  K  K  G  R  L  S  L  H  R  T  P  A  G  N  F         p.440

          .         .         .         .      | 11  .         .    g.39014
 GTTACACTGGAGGAAGGAAAAGGAGACCTTGAGGAATATGGTCAG | GATCTTCTCCATACT    c.1380
 V  T  L  E  E  G  K  G  D  L  E  E  Y  G  Q   | D  L  L  H  T      p.460

          .         .         .         .         .         .       g.39074
 GTCTTCAAGAATGGCAAGGTGACAAAAAGCTATTCATTTGATGAAATAAGAAAAAATGCA       c.1440
 V  F  K  N  G  K  V  T  K  S  Y  S  F  D  E  I  R  K  N  A         p.480

          .         .         .                                     g.39110
 CAGCTGAATATTGAACTGGAAGCAGCACATCATTAG                               c.1476
 Q  L  N  I  E  L  E  A  A  H  H  X                                 p.491

          .         .         .         .         .         .       g.39170
 gctttatgactgggtgtgtgttgtgtgtatgtaatacataatgtttattgtacagatgtg       c.*60

          .         .         .         .         .         .       g.39230
 tggggtttgtgttttatgatacattacagccaaattatttgttggtttatggacatactg       c.*120

          .         .         .         .         .         .       g.39290
 ccctttcattttttttcttttccagtgtttaggtgatctcaaattaggaaatgcatttaa       c.*180

          .         .         .         .         .         .       g.39350
 ccatgtaaaagatgagtgctaaagtaagctttttagggccctttgccaataggtagtcat       c.*240

          .         .         .         .         .         .       g.39410
 tcaatctggtattgatcttttcacaaataacagaactgagaaacttttatatataactga       c.*300

          .         .         .         .         .         .       g.39470
 tgatcacataaaacagatttgcataaaattaccatgattgctttatgtttatatttaact       c.*360

          .         .         .         .         .         .       g.39530
 tgtatttttgtacaaacaagattgtgtaagatatatttgaagtttcagtgatttaacagt       c.*420

          .         .         .         .         .         .       g.39590
 ctttccaacttttcatgatttttatgagcacagactttcaagaaaatacttgaaaataaa       c.*480

          .         .         .         .         .         .       g.39650
 ttacattgccttttgtccattaatcagcaaataaaacatggccttaacaaagttgtttgt       c.*540

          .         .         .         .         .         .       g.39710
 gttattgtacaatttgaaaattatgtcgggacataccctatagaattactaaccttactg       c.*600

          .         .         .         .         .         .       g.39770
 ccccttgtagaatatgtattaatcattctacattaaagaaaataatggttcttactggaa       c.*660

          .         .         .         .         .         .       g.39830
 tgtctaggcactgtacagttattatatatcttggttgttgtattgtaccagtgaaatgcc       c.*720

          .         .         .         .         .         .       g.39890
 aaatttgaaaggcctgtactgcaattttatatgtcagagattgcctgtggctctaatatg       c.*780

          .         .         .         .         .         .       g.39950
 cacctcaagattttaaggagataatgtttttagagagaatttctgcttccactatagaat       c.*840

          .         .         .         .         .         .       g.40010
 atatacataaatgtaaaatacttacaaaagtggaagtagtgtattttaaagtaattacac       c.*900

          .         .         .         .         .         .       g.40070
 ttctgaatttatttttcatattctatagttggtatgacttaaatgaattactggagtggg       c.*960

          .         .         .         .         .         .       g.40130
 tagtgagtgtacttaaatgtttcaattctgttatattttttattaagtttttaaaaaatt       c.*1020

          .         .         .         .         .         .       g.40190
 aaattggatattaaattgtatggacatcatttattaattttaaactgaatgccctcaata       c.*1080

          .         .         .         .         .         .       g.40250
 agtaatactgaagcacattcttaaatgaagataaattatctccaatgaaaagcatgacat       c.*1140

          .         .         .         .         .         .       g.40310
 gtgtttcaatagaagaatcttaagttggctaaattcaaagtgcttgacatcaaaatgttc       c.*1200

          .         .         .         .         .         .       g.40370
 tagagtgattagctactagattctgaatcatacatcacatctgactagagaccagtttct       c.*1260

          .         .         .         .         .         .       g.40430
 ttcgaatgattcttttatgtatgtagatctgttcttctgaggcagcggttggccaactat       c.*1320

          .         .         .         .         .         .       g.40490
 agcccaaaggccaaatttggacttctttttataaatgcagattgtctatggctgctttcc       c.*1380

          .         .         .         .         .         .       g.40550
 cactactccagcctaaggtaaacagctgcaatagaagccaaatgagaatcgcaaagccca       c.*1440

          .         .         .         .         .         .       g.40610
 aaatgtttattaacctgccctttacacaaaattacacaaaaagtttcctgatctctgttc       c.*1500

          .         .         .         .         .         .       g.40670
 taagaaaaggagtgtgccttgcatttaaaaggaaatgttggtttctagggaagggaggag       c.*1560

          .         .         .         .         .         .       g.40730
 gctaaataattgatacggaattttcctcttttgtcttcttttttctcacttaagaatccg       c.*1620

          .         .         .         .         .         .       g.40790
 atactggaagactgatttagaaaagtttttaacatgacattaaatgtgaaattttaaaaa       c.*1680

          .         .         .         .         .         .       g.40850
 ttgaaaagccataaatcatctgttttaaatagttacatgagaaaatgatcactagaataa       c.*1740

          .         .         .         .         .         .       g.40910
 cctaattagaagtgttatcttcattaaatgttttttgtaagtggtattagaaagaatatg       c.*1800

          .         .         .         .         .         .       g.40970
 tttttcagatggttctttaaacatgtagtgagaacaataagcattattcacttttagtaa       c.*1860

          .         .         .         .         .         .       g.41030
 gtcttctgtaatccatgatataaaataattttaaaatgattttttaatgtatttgagtaa       c.*1920

          .         .         .         .         .         .       g.41090
 agatgagtagtattaagaaaaacacacatttcttcacaaaatgtgctaaggggcgtgtaa       c.*1980

          .         .         .         .         .         .       g.41150
 agaatcaaaagaaactattaccaataatagttttgataatcacccataattttgtgttta       c.*2040

          .         .         .         .         .         .       g.41210
 aacattgaaattatagtacagacagtattctctgtgttctgtgaatttcagcagcttcag       c.*2100

          .         .         .         .         .         .       g.41270
 aatagagtttaatttagaaatttgcagtgaaaaaagctatctctttgttcacaaccataa       c.*2160

          .         .         .         .         .         .       g.41330
 atcaggagatggagattaattctattggctcttagtcacttggaactgattaattctgac       c.*2220

          .         .         .         .         .         .       g.41390
 tttctgtcactaagcacttggtatttggccatctccattctgagcaccaaacggttaaca       c.*2280

          .         .         .         .         .         .       g.41450
 cgaatgtccactagaactctgctgtgtgtcacccttaaatcagtctaaatcttccagaca       c.*2340

          .         .         .         .         .         .       g.41510
 aaagcaaatggcatttatggatttaagtcattagattttcaactgacattaattaatccc       c.*2400

          .         .         .         .         .         .       g.41570
 tcttgattgattatatcatcaagtatttatatcttaaataggaggtaggatttctgtgtt       c.*2460

          .         .         .         .         .         .       g.41630
 aagactcttatttgtaccctataattaaagtaaaatgttttttatgagtatcccttgttt       c.*2520

          .         .         .         .         .         .       g.41690
 tcccttcttaaattgttatcaaacaatttttataatgaaatctatcttggaaaattagaa       c.*2580

          .         .         .         .         .         .       g.41750
 agaaaaatggcaaggtatttattgttctgtttgccataatttagaactcacacttaagta       c.*2640

          .         .         .         .         .         .       g.41810
 ttttgtagttttacattcctttttaacccattcagtggagaatgtcagcttttctcccaa       c.*2700

          .         .         .         .         .         .       g.41870
 gttgtatgttaagtctattctaatatgtactcaacatcaagttataaacatgtaataaac       c.*2760

          .         .         .                                     g.41908
 atggaaataaagtttagctctattagtgaagtgttaaa                             c.*2798

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nicotinamide phosphoribosyltransferase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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