asparaginyl-tRNA synthetase 2, mitochondrial (putative) (NARS2) - coding DNA reference sequence

(used for variant description)

(last modified October 11, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_024678.5 in the NARS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering NARS2 transcript NM_024678.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             gtagcgtgatgacgta       c.-361

 .         .         .         .         .         .                g.5076
 agcggcgttggcgtggtgtggtaggagtggttgcgcgtgttgcggcccgggttctgttcg       c.-301

 .         .         .         .         .         .                g.5136
 taggtttacaattgtcgcgggtagtggggcgccccagctgccaactgcacgtggtttctt       c.-241

 .         .         .         .         .         .                g.5196
 tctggcgtttgcctagtgtcctgtccattccgccccgttgggaagtgggaagcggagagg       c.-181

 .         .         .         .         .         .                g.5256
 ttctgtggggacagagctgggagtcctgaaggagaaagcgcgcagccgaggggctctgga       c.-121

 .         .         .         .         .         .                g.5316
 gtgccttagagcagagctgcggccgcggaaggggagcagctgagaaaggagggccgctgc       c.-61

 .         .         .         .         .         .                g.5376
 aggcggggttcgaaccgtggggtctgggctgctcccgcggagggcctgggcggacgcggg       c.-1

          .         .         .         .         .         .       g.5436
 ATGCTGGGGGTCCGCTGCCTGCTGCGGTCCGTGCGCTTCTGTTCCTCCGCCCCCTTCCCC       c.60
 M  L  G  V  R  C  L  L  R  S  V  R  F  C  S  S  A  P  F  P         p.20

          .         .         .         .         .         .       g.5496
 AAGCACAAACCTTCAGCCAAACTGAGCGTGCGGGACGCTCTCGGGGCTCAGAACGCGAGT       c.120
 K  H  K  P  S  A  K  L  S  V  R  D  A  L  G  A  Q  N  A  S         p.40

          .         .  | 02      .         .         .         .    g.8459
 GGGGAGCGCATTAAGATCCAG | GGATGGATTCGTTCTGTCCGATCCCAGAAGGAAGTCTTG    c.180
 G  E  R  I  K  I  Q   | G  W  I  R  S  V  R  S  Q  K  E  V  L      p.60

          .         .         .         .         .         .       g.8519
 TTCCTGCATGTAAATGATGGGTCATCTTTGGAAAGCCTTCAGGTTGTTGCAGATTCAGGC       c.240
 F  L  H  V  N  D  G  S  S  L  E  S  L  Q  V  V  A  D  S  G         p.80

          .  | 03      .         .         .         .         .    g.11160
 CTTGACAGTAG | AGAATTAAATTTTGGGAGTTCTGTGGAAGTACAAGGGCAGCTGATAAAA    c.300
 L  D  S  R  |  E  L  N  F  G  S  S  V  E  V  Q  G  Q  L  I  K      p.100

          .         .         .         .         .         .       g.11220
 AGTCCATCCAAAAGGCAAAATGTGGAACTGAAGGCAGAAAAAATTAAAGTTATTGGAAAT       c.360
 S  P  S  K  R  Q  N  V  E  L  K  A  E  K  I  K  V  I  G  N         p.120

          .   | 04     .         .         .         .         .    g.13639
 TGTGATGCCAAG | GATTTCCCCATCAAATATAAAGAGAGGCATCCTCTGGAGTATCTGCGA    c.420
 C  D  A  K   | D  F  P  I  K  Y  K  E  R  H  P  L  E  Y  L  R      p.140

          .         .         .         .         .         .       g.13699
 CAATATCCTCACTTTAGGTGTAGGACTAACGTTCTGGGTTCTATATTGAGGATTCGCAGT       c.480
 Q  Y  P  H  F  R  C  R  T  N  V  L  G  S  I  L  R  I  R  S         p.160

          .         .         .    | 05    .         .         .    g.20271
 GAAGCGACAGCTGCTATTCATTCTTTCTTTAAG | GACAGTGGCTTTGTACATATTCATACT    c.540
 E  A  T  A  A  I  H  S  F  F  K   | D  S  G  F  V  H  I  H  T      p.180

          .         .         .         .         .     | 06   .    g.50933
 CCAATAATCACATCCAATGACTCTGAGGGAGCTGGAGAACTTTTTCAACTTGAA | CCTTCA    c.600
 P  I  I  T  S  N  D  S  E  G  A  G  E  L  F  Q  L  E   | P  S      p.200

          .         .         .         .         .         .       g.50993
 GGCAAACTTAAGGTACCTGAGGAGAATTTCTTCAATGTTCCTGCTTTCTTAACTGTCTCA       c.660
 G  K  L  K  V  P  E  E  N  F  F  N  V  P  A  F  L  T  V  S         p.220

          .         .          | 07        .         .         .    g.86699
 GGACAACTTCATCTAGAAGTGATGTCAGG | AGCTTTTACTCAAGTGTTTACCTTTGGTCCG    c.720
 G  Q  L  H  L  E  V  M  S  G  |  A  F  T  Q  V  F  T  F  G  P      p.240

          .         .         .         .         .         .       g.86759
 ACCTTCCGAGCTGAAAATTCTCAGAGCCGGAGGCACCTGGCAGAGTTTTATATGATAGAA       c.780
 T  F  R  A  E  N  S  Q  S  R  R  H  L  A  E  F  Y  M  I  E         p.260

          .         .         .         .   | 08     .         .    g.101198
 GCAGAGATTTCTTTTGTTGACAGCCTTCAAGATCTTATGCAG | GTTATAGAGGAACTGTTC    c.840
 A  E  I  S  F  V  D  S  L  Q  D  L  M  Q   | V  I  E  E  L  F      p.280

          .         .         .         .         .         .       g.101258
 AAGGCTACAACAATGATGGTTCTCTCAAAATGTCCTGAAGATGTTGAACTCTGTCACAAA       c.900
 K  A  T  T  M  M  V  L  S  K  C  P  E  D  V  E  L  C  H  K         p.300

          .         .  | 09      .         .         .          | 10 g.110551
 TTCATAGCACCTGGCCAAAAG | GACAGATTAGAACATATGCTAAAAAACAACTTTTTAAT | C c.960
 F  I  A  P  G  Q  K   | D  R  L  E  H  M  L  K  N  N  F  L  I  |   p.320

          .         .         .         .         .         .       g.110611
 ATTTCTTATACTGAAGCAGTGGAGATCTTAAAGCAAGCATCCCAGAACTTCACCTTTACC       c.1020
 I  S  Y  T  E  A  V  E  I  L  K  Q  A  S  Q  N  F  T  F  T         p.340

        | 11 .         .         .         .         .         .    g.113904
 CCAGAG | TGGGGTGCTGACCTACGGACTGAACATGAAAAGTACCTGGTGAAGCACTGTGGC    c.1080
 P  E   | W  G  A  D  L  R  T  E  H  E  K  Y  L  V  K  H  C  G      p.360

          .         .         .         .         .         .       g.113964
 AACATACCTGTCTTCGTTATTAATTATCCATTAACACTCAAGCCTTTCTACATGAGGGAT       c.1140
 N  I  P  V  F  V  I  N  Y  P  L  T  L  K  P  F  Y  M  R  D         p.380

          .         .     | 12   .         .         .         .    g.136141
 AATGAAGATGGCCCTCAGCACACG | GTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTTGGG    c.1200
 N  E  D  G  P  Q  H  T   | V  A  A  V  D  L  L  V  P  G  V  G      p.400

          .         .         .         .         .         .       g.136201
 GAACTCTTTGGAGGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCC       c.1260
 E  L  F  G  G  G  L  R  E  E  R  Y  H  F  L  E  E  R  L  A         p.420

    | 13     .         .          | 14        .         .         . g.143080
 AG | ATCGGGACTTACAGAAGTCTACCAATG | GTATCTGGACCTTCGTCGATTTGGATCTGTG c.1320
 R  |  S  G  L  T  E  V  Y  Q  W  |  Y  L  D  L  R  R  F  G  S  V   p.440

          .         .         .         .         .         .       g.143140
 CCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTTGAC       c.1380
 P  H  G  G  F  G  M  G  F  E  R  Y  L  Q  C  I  L  G  V  D         p.460

          .         .         .         .         .                 g.143194
 AATATCAAAGATGTTATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAG             c.1434
 N  I  K  D  V  I  P  F  P  R  F  P  H  S  C  L  L  X               p.477

          .         .         .         .         .         .       g.143254
 ctggaagattggttaaggaaaagcaccccccatggcagagacactgcacatgattgtgca       c.*60

          .         .         .         .         .         .       g.143314
 tacagcagaatgcatgtttggattttagaaatgcagatttcaatatgtaattgttgtgcc       c.*120

          .         .         .         .         .         .       g.143374
 ataagatatcatagaaaaaatataagtggttgtgattttcttagaaagttgagggtattt       c.*180

          .         .         .         .         .         .       g.143434
 cacgtaaggatgagctcccgcaagaagaggtacttatagcaaggggactctcaaatccat       c.*240

          .         .         .         .         .         .       g.143494
 tacctcaattaagaaatgaagaaattgaattagtctcaaagtttcttttaaactctaaaa       c.*300

          .         .         .         .         .         .       g.143554
 cagaatgagataatgtattttacgttgtctataatcattaaatcactccctgtgtaattt       c.*360

          .         .         .         .         .         .       g.143614
 gtgagaaccatctagtagctcgaaataaaataatgttgcatcttttctcccttgccatat       c.*420

          .         .         .         .         .         .       g.143674
 actttgtgataaatccttatctcattttcagtacttcattaaacattgcagaaaaaaata       c.*480

          .         .         .         .         .         .       g.143734
 ttccttaaggtcttaattgatttaaagaagtagctattctgaattgaaatctcctttcat       c.*540

          .         .         .         .         .         .       g.143794
 tgaactggatgaaaaaatcatgtttaataactgttgcttttcaattttcaaagctgttga       c.*600

          .         .         .         .         .         .       g.143854
 gatattacattaagtatttcaactctttaatcactgttgttataatttgtttatatttga       c.*660

          .         .         .         .                           g.143903
 tgtttataatttgtctaataaaatagatttttttaatagacacctatgg                  c.*709

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Asparaginyl-tRNA synthetase 2, mitochondrial (putative) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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