asparaginyl-tRNA synthetase (NARS) - coding DNA reference sequence

(used for variant description)

(last modified June 17, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_004539.3 in the NARS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000018.9, covering NARS transcript NM_004539.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             atccggaagttgcctctgccctcaccaaagatggcggccccggcgccg       c.-181

 .         .         .         .         .         .                g.5108
 ctcgcccacctctcgtaaccaatggaaccgcggcgctcggccgattctcgcaggcgccct       c.-121

 .         .         .         .         .         .                g.5168
 cagatctacgctctctgatgcaacgccggaatcgcggaaaccgccggtgcacgttggagt       c.-61

 .         .         .         .         .         .                g.5228
 cataagacggcgtcggtgttgcagtctgtgtccttggaggtgaccagggccactgcaggc       c.-1

          . | 02       .         .         .         .         .    g.6344
 ATGGTGCTAG | CAGAGCTGTACGTCTCTGACCGAGAGGGAAGCGATGCCACGGGAGATGGA    c.60
 M  V  L  A |   E  L  Y  V  S  D  R  E  G  S  D  A  T  G  D  G      p.20

          .         .         .    | 03    .         .         .    g.10997
 ACCAAGGAGAAACCATTTAAAACAGGTCTAAAG | GCTTTGATGACAGTAGGGAAAGAACCA    c.120
 T  K  E  K  P  F  K  T  G  L  K   | A  L  M  T  V  G  K  E  P      p.40

          .         .         .         .         .         .       g.11057
 TTTCCTACCATTTACGTAGATTCACAAAAAGAAAATGAGAGGTGGAATGTTATTTCTAAA       c.180
 F  P  T  I  Y  V  D  S  Q  K  E  N  E  R  W  N  V  I  S  K         p.60

          .         .         .         .         .         .       g.11117
 TCACAGTTGAAGAACATTAAAAAGATGTGGCATAGGGAACAAATGAAGAGTGAATCCCGG       c.240
 S  Q  L  K  N  I  K  K  M  W  H  R  E  Q  M  K  S  E  S  R         p.80

          .   | 04     .         .         .         .         .    g.11263
 GAAAAGAAAGAG | GCAGAAGATAGTTTACGAAGAGAAAAGAACCTGGAAGAAGCAAAGAAG    c.300
 E  K  K  E   | A  E  D  S  L  R  R  E  K  N  L  E  E  A  K  K      p.100

          .         .         .         .   | 05     .         .    g.13283
 ATTACCATTAAAAATGATCCAAGTCTCCCAGAGCCAAAATGT | GTGAAGATTGGTGCGTTA    c.360
 I  T  I  K  N  D  P  S  L  P  E  P  K  C   | V  K  I  G  A  L      p.120

          .         .         .         .         .         .       g.13343
 GAAGGATATAGAGGCCAAAGAGTAAAGGTGTTTGGCTGGGTCCACAGGCTGCGCAGGCAA       c.420
 E  G  Y  R  G  Q  R  V  K  V  F  G  W  V  H  R  L  R  R  Q         p.140

   | 06      .         .         .         .         .         .    g.15297
 G | GAAAGAATTTAATGTTTCTGGTGTTGCGAGATGGTACAGGTTATCTTCAGTGTGTCTTG    c.480
 G |   K  N  L  M  F  L  V  L  R  D  G  T  G  Y  L  Q  C  V  L      p.160

          .   | 07     .         .         .         .         .    g.17550
 GCGGATGAGTTG | TGTCAGTGCTACAATGGAGTTCTCTTGTCCACGGAGAGCAGTGTTGCA    c.540
 A  D  E  L   | C  Q  C  Y  N  G  V  L  L  S  T  E  S  S  V  A      p.180

          .         .         .          | 08        .         .    g.19301
 GTGTATGGAATGCTAAATCTTACCCCAAAGGGCAAGCAG | GCTCCAGGTGGCCATGAGCTG    c.600
 V  Y  G  M  L  N  L  T  P  K  G  K  Q   | A  P  G  G  H  E  L      p.200

          .         .         .         .         .         .       g.19361
 AGTTGTGACTTCTGGGAACTAATTGGGTTGGCCCCTGCTGGAGGAGCTGACAACCTGATC       c.660
 S  C  D  F  W  E  L  I  G  L  A  P  A  G  G  A  D  N  L  I         p.220

          .         .         .         .         .         .       g.19421
 AATGAGGAGTCTGACGTTGATGTCCAGCTCAACAACAGACACATGATGATCCGAGGAGAA       c.720
 N  E  E  S  D  V  D  V  Q  L  N  N  R  H  M  M  I  R  G  E         p.240

          .         .         .         .         .         .       g.19481
 AACATGTCCAAAATCCTAAAAGCACGATCCATGGTCACCAGGTGCTTTAGAGATCACTTC       c.780
 N  M  S  K  I  L  K  A  R  S  M  V  T  R  C  F  R  D  H  F         p.260

          .         .  | 09      .         .         .         .    g.19651
 TTTGATAGGGGGTACTATGAA | GTTACTCCTCCAACATTAGTGCAAACACAAGTAGAAGGT    c.840
 F  D  R  G  Y  Y  E   | V  T  P  P  T  L  V  Q  T  Q  V  E  G      p.280

          .         .         .         .         .         .       g.19711
 GGTGCCACACTCTTCAAGCTTGACTATTTTGGGGAAGAGGCATTTTTGACTCAATCCTCT       c.900
 G  A  T  L  F  K  L  D  Y  F  G  E  E  A  F  L  T  Q  S  S         p.300

          .         .         .         .         .         .       g.19771
 CAGTTGTACTTGGAGACCTGCCTCCCAGCCCTGGGAGATGTTTTTTGTATTGCTCAGTCA       c.960
 Q  L  Y  L  E  T  C  L  P  A  L  G  D  V  F  C  I  A  Q  S         p.320

          .         .         .         .  | 10      .         .    g.20213
 TACCGGGCAGAGCAGTCCAGAACACGAAGGCACCTGGCTGA | GTACACTCACGTGGAAGCT    c.1020
 Y  R  A  E  Q  S  R  T  R  R  H  L  A  E  |  Y  T  H  V  E  A      p.340

          .         .         .         .         .         .       g.20273
 GAGTGTCCTTTCCTGACTTTTGACGACCTCCTGAACCGGTTGGAGGACTTGGTTTGTGAT       c.1080
 E  C  P  F  L  T  F  D  D  L  L  N  R  L  E  D  L  V  C  D         p.360

          .         .         .         .         .        | 11.    g.20978
 GTGGTAGATCGAATATTGAAGTCACCTGCAGGGAGCATAGTGCATGAGCTCAACCCG | AAC    c.1140
 V  V  D  R  I  L  K  S  P  A  G  S  I  V  H  E  L  N  P   | N      p.380

          .         .         .         .         .         .       g.21038
 TTTCAGCCCCCCAAACGGCCTTTCAAACGGATGAACTATTCAGATGCTATCGTTTGGCTA       c.1200
 F  Q  P  P  K  R  P  F  K  R  M  N  Y  S  D  A  I  V  W  L         p.400

          .         .         .         .         .  | 12      .    g.24011
 AAAGAACATGATGTAAAGAAAGAAGATGGAACTTTCTATGAATTTGGAGAA | GATATCCCA    c.1260
 K  E  H  D  V  K  K  E  D  G  T  F  Y  E  F  G  E   | D  I  P      p.420

          .         .         .         .         .         .       g.24071
 GAAGCTCCTGAGAGACTGATGACAGACACCATTAATGAACCAATCTTGCTGTGTCGATTT       c.1320
 E  A  P  E  R  L  M  T  D  T  I  N  E  P  I  L  L  C  R  F         p.440

          .         .         .         .         .         .       g.24131
 CCTGTGGAGATCAAGTCCTTCTACATGCAGCGATGTCCTGAGGATTCCCGTCTTACTGAA       c.1380
 P  V  E  I  K  S  F  Y  M  Q  R  C  P  E  D  S  R  L  T  E         p.460

     | 13    .         .         .         .         .         .    g.24516
 TCT | GTCGACGTGTTGATGCCCAATGTTGGTGAGATTGTGGGAGGCTCAATGCGTATCTTT    c.1440
 S   | V  D  V  L  M  P  N  V  G  E  I  V  G  G  S  M  R  I  F      p.480

          .         .         .         .         .         .       g.24576
 GATAGTGAAGAAATACTGGCAGGTTATAAAAGGGAAGGGATTGACCCCACTCCCTATTAC       c.1500
 D  S  E  E  I  L  A  G  Y  K  R  E  G  I  D  P  T  P  Y  Y         p.500

          .      | 14  .         .         .         .         .    g.25207
 TGGTATACGGATCAG | AGAAAATACGGTACATGTCCCCATGGAGGATATGGCTTGGGCTTG    c.1560
 W  Y  T  D  Q   | R  K  Y  G  T  C  P  H  G  G  Y  G  L  G  L      p.520

          .         .         .         .         .         .       g.25267
 GAACGATTCTTAACGTGGATTCTGAATAGGTATCACATCCGAGACGTGTGCTTATACCCT       c.1620
 E  R  F  L  T  W  I  L  N  R  Y  H  I  R  D  V  C  L  Y  P         p.540

          .         .                                               g.25294
 CGATTTGTCCAGCGTTGCACGCCATAA                                        c.1647
 R  F  V  Q  R  C  T  P  X                                          p.548

          .         .         .         .         .         .       g.25354
 ccattttctccagaagcgtggaggaaagattatgaaaggaacaggctctttaaaaaagaa       c.*60

          .         .         .         .         .         .       g.25414
 aacaaaaagccagaatcttcctttttttgtttcattggggtttctctttctgtttttctt       c.*120

          .         .         .         .         .         .       g.25474
 tctactaccataaaaactatctcaaatcacctgaacatcaagtgatattaaggttgtcat       c.*180

          .         .         .         .         .         .       g.25534
 cttaagaaaaaatatccatttttttcttaagttcgggaaacaaagttcggggaaaatacc       c.*240

          .         .         .         .         .         .       g.25594
 tggcatgaaactgtagttagggatacatttcagcattttactcactttatccaagttatt       c.*300

          .         .         .         .         .         .       g.25654
 cattttattcaagttatatgtatgtataattcaacaattttagattatggtgtaagatac       c.*360

          .         .         .         .         .         .       g.25714
 tccagtaacttatctttctgtccttttaagtgtaccttgaattctttgatttattttatt       c.*420

          .         .         .         .         .         .       g.25774
 gcatcaatgaattaaaacaaaaatcttgggggaagaaattggcaatatcgtataaaaatc       c.*480

          .         .         .         .         .         .       g.25834
 tgctcatattagaacacagtataattcagcagtaaacactagaatcaaatgaatagcctt       c.*540

          .         .         .         .         .         .       g.25894
 ttgtatcagttattaatcttttctaactctgcttagctgctaataatcctgaggcataga       c.*600

          .         .         .         .         .         .       g.25954
 aattgaagaatttgtaaaaatagaattgccttaaaggatttgaagtaagaacataatttt       c.*660

          .         .         .         .         .         .       g.26014
 ggggagagttttttagtgattcacagtatccctcttagcattaatttaaggtaaagaggc       c.*720

          .         .         .         .         .         .       g.26074
 agattgattttccctctttcctggtaattcctaagtaattaagaataaataagttccaaa       c.*780

          .         .         .         .         .         .       g.26134
 agaaattgtagctggaatcttaataacaattgtgagtggctgtttgagttgcccccacca       c.*840

          .         .         .         .         .         .       g.26194
 tgtccttagatctaatctgtgctaccttattaactcacagcaggcttactgaatggcttc       c.*900

          .         .         .         .         .         .       g.26254
 atttcagatttagttgatttctccaccaaatgcatgtcatgtattctcaataggctgtat       c.*960

          .         .         .                                     g.26287
 tcccagcagtcaataaatgaacacccgtaaaaa                                  c.*993

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Asparaginyl-tRNA synthetase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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