nibrin (NBN) - coding DNA reference sequence

(used for variant description)

(last modified July 17, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_002485.4 in the NBN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000008.10, covering NBN transcript NM_002485.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           gagcgcgcacgtcccggagcccatgccgaccgcaggcgccgtatccgcgc       c.-61

 .         .         .         .         .         .                g.5110
 tcgtctagcagccccggttacgcggttgcacgtcggccccagccctgaggagccggaccg       c.-1

          .         .         .        | 02.         .         .    g.6839
 ATGTGGAAACTGCTGCCCGCCGCGGGCCCGGCAGGAG | GAGAACCATACAGACTTTTGACT    c.60
 M  W  K  L  L  P  A  A  G  P  A  G  G |   E  P  Y  R  L  L  T      p.20

          .         .         .         .         .         .       g.6899
 GGCGTTGAGTACGTTGTTGGAAGGAAAAACTGTGCCATTCTGATTGAAAATGATCAGTCG       c.120
 G  V  E  Y  V  V  G  R  K  N  C  A  I  L  I  E  N  D  Q  S         p.40

          .         .         .         .         .  | 03      .    g.8157
 ATCAGCCGAAATCATGCTGTGTTAACTGCTAACTTTTCTGTAACCAACCTG | AGTCAAACA    c.180
 I  S  R  N  H  A  V  L  T  A  N  F  S  V  T  N  L   | S  Q  T      p.60

          .         .         .         .         .         .       g.8217
 GATGAAATCCCTGTATTGACATTAAAAGATAATTCTAAGTATGGTACCTTTGTTAATGAG       c.240
 D  E  I  P  V  L  T  L  K  D  N  S  K  Y  G  T  F  V  N  E         p.80

          .         .         .         .         .         .       g.8277
 GAAAAAATGCAGAATGGCTTTTCCCGAACTTTGAAGTCGGGGGATGGTATTACTTTTGGA       c.300
 E  K  M  Q  N  G  F  S  R  T  L  K  S  G  D  G  I  T  F  G         p.100

          .         . | 04       .         .         .         .    g.8818
 GTGTTTGGAAGTAAATTCAG | AATAGAGTATGAGCCTTTGGTTGCATGCTCTTCTTGTTTA    c.360
 V  F  G  S  K  F  R  |  I  E  Y  E  P  L  V  A  C  S  S  C  L      p.120

          .         .         .         .         .         .       g.8878
 GATGTCTCTGGGAAAACTGCTTTAAATCAAGCTATATTGCAACTTGGAGGATTTACTGTA       c.420
 D  V  S  G  K  T  A  L  N  Q  A  I  L  Q  L  G  G  F  T  V         p.140

          .         .         .         .         .         .       g.8938
 AACAATTGGACAGAAGAATGCACTCACCTTGTCATGGTATCAGTGAAAGTTACCATTAAA       c.480
 N  N  W  T  E  E  C  T  H  L  V  M  V  S  V  K  V  T  I  K         p.160

  | 05       .         .         .         .         .         .    g.11408
  | ACAATATGTGCACTCATTTGTGGACGTCCAATTGTAAAGCCAGAATATTTTACTGAATTC    c.540
  | T  I  C  A  L  I  C  G  R  P  I  V  K  P  E  Y  F  T  E  F      p.180

          .         .         .         .     | 06   .         .    g.18397
 CTGAAAGCAGTTGAGTCCAAGAAGCAGCCTCCACAAATTGAAAG | TTTTTACCCACCTCTT    c.600
 L  K  A  V  E  S  K  K  Q  P  P  Q  I  E  S  |  F  Y  P  P  L      p.200

          .         .         .         .         .         .       g.18457
 GATGAACCATCTATTGGAAGTAAAAATGTTGATCTGTCAGGACGGCAGGAAAGAAAACAA       c.660
 D  E  P  S  I  G  S  K  N  V  D  L  S  G  R  Q  E  R  K  Q         p.220

          .         .         .         .   | 07     .         .    g.19132
 ATCTTCAAAGGGAAAACATTTATATTTTTGAATGCCAAACAG | CATAAGAAATTGAGTTCC    c.720
 I  F  K  G  K  T  F  I  F  L  N  A  K  Q   | H  K  K  L  S  S      p.240

          .         .         .         .         .         .       g.19192
 GCAGTTGTCTTTGGAGGTGGGGAAGCTAGGTTGATAACAGAAGAGAATGAAGAAGAACAT       c.780
 A  V  V  F  G  G  G  E  A  R  L  I  T  E  E  N  E  E  E  H         p.260

          .         .         .         .         .         .       g.19252
 AATTTCTTTTTGGCTCCGGGAACGTGTGTTGTTGATACAGGAATAACAAACTCACAGACC       c.840
 N  F  F  L  A  P  G  T  C  V  V  D  T  G  I  T  N  S  Q  T         p.280

          .         .         .         .         .       | 08 .    g.25168
 TTAATTCCTGACTGTCAGAAGAAATGGATTCAGTCAATAATGGATATGCTCCAAAG | GCAA    c.900
 L  I  P  D  C  Q  K  K  W  I  Q  S  I  M  D  M  L  Q  R  |  Q      p.300

          .         .         .         .         .         .       g.25228
 GGTCTTAGACCTATTCCTGAAGCAGAAATTGGATTGGCGGTGATTTTCATGACTACAAAG       c.960
 G  L  R  P  I  P  E  A  E  I  G  L  A  V  I  F  M  T  T  K         p.320

          .         .         .     | 09   .         .         .    g.30843
 AATTACTGTGATCCTCAGGGCCATCCCAGTACAG | GATTAAAGACAACAACTCCAGGACCA    c.1020
 N  Y  C  D  P  Q  G  H  P  S  T  G |   L  K  T  T  T  P  G  P      p.340

          .         .         .         .         .         .       g.30903
 AGCCTTTCACAAGGCGTGTCAGTTGATGAAAAACTAATGCCAAGCGCCCCAGTGAACACT       c.1080
 S  L  S  Q  G  V  S  V  D  E  K  L  M  P  S  A  P  V  N  T         p.360

          .         .         .         .     | 10   .         .    g.34132
 ACAACATACGTAGCTGACACAGAATCAGAGCAAGCAGATACATG | GGATTTGAGTGAAAGG    c.1140
 T  T  Y  V  A  D  T  E  S  E  Q  A  D  T  W  |  D  L  S  E  R      p.380

          .         .         .         .         .         .       g.34192
 CCAAAAGAAATCAAAGTCTCCAAAATGGAACAAAAATTCAGAATGCTTTCACAAGATGCA       c.1200
 P  K  E  I  K  V  S  K  M  E  Q  K  F  R  M  L  S  Q  D  A         p.400

          .         .         .         .         .         .       g.34252
 CCCACTGTAAAGGAGTCCTGCAAAACAAGCTCTAATAATAATAGTATGGTATCAAATACT       c.1260
 P  T  V  K  E  S  C  K  T  S  S  N  N  N  S  M  V  S  N  T         p.420

          .         .         .         .         .         .       g.34312
 TTGGCTAAGATGAGAATCCCAAACTATCAGCTTTCACCAACTAAATTGCCAAGTATAAAT       c.1320
 L  A  K  M  R  I  P  N  Y  Q  L  S  P  T  K  L  P  S  I  N         p.440

          .         .         .         .         .         .       g.34372
 AAAAGTAAAGATAGGGCTTCTCAGCAGCAGCAGACCAACTCCATCAGAAACTACTTTCAG       c.1380
 K  S  K  D  R  A  S  Q  Q  Q  Q  T  N  S  I  R  N  Y  F  Q         p.460

          .        | 11.         .         .         .         .    g.36023
 CCGTCTACCAAAAAAAG | GGAAAGGGATGAAGAAAATCAAGAAATGTCTTCATGCAAATCA    c.1440
 P  S  T  K  K  R  |  E  R  D  E  E  N  Q  E  M  S  S  C  K  S      p.480

          .         .         .         .         .         .       g.36083
 GCAAGAATAGAAACGTCTTGTTCTCTTTTAGAACAAACACAACCTGCTACACCCTCATTG       c.1500
 A  R  I  E  T  S  C  S  L  L  E  Q  T  Q  P  A  T  P  S  L         p.500

          .         .         .         .         .         .       g.36143
 TGGAAAAATAAGGAGCAGCATCTATCTGAGAATGAGCCTGTGGACACAAACTCAGACAAT       c.1560
 W  K  N  K  E  Q  H  L  S  E  N  E  P  V  D  T  N  S  D  N         p.520

          .         .         .         .         .         .       g.36203
 AACTTATTTACAGATACAGATTTAAAATCTATTGTGAAAAATTCTGCCAGTAAATCTCAT       c.1620
 N  L  F  T  D  T  D  L  K  S  I  V  K  N  S  A  S  K  S  H         p.540

          .         .         .         .         .         .       g.36263
 GCTGCAGAAAAGCTAAGATCAAATAAAAAAAGGGAAATGGATGATGTGGCCATAGAAGAT       c.1680
 A  A  E  K  L  R  S  N  K  K  R  E  M  D  D  V  A  I  E  D         p.560

          .         .         .         .         .         .       g.36323
 GAAGTATTGGAACAGTTATTCAAGGACACAAAACCAGAGTTAGAAATTGATGTGAAAGTT       c.1740
 E  V  L  E  Q  L  F  K  D  T  K  P  E  L  E  I  D  V  K  V         p.580

          .         .         .         .         .         .       g.36383
 CAAAAACAGGAGGAAGATGTCAATGTTAGAAAAAGGCCAAGGATGGATATAGAAACAAAT       c.1800
 Q  K  Q  E  E  D  V  N  V  R  K  R  P  R  M  D  I  E  T  N         p.600

          .         .         .         .      | 12  .         .    g.41794
 GACACTTTCAGTGATGAAGCAGTACCAGAAAGTAGCAAAATATCT | CAAGAAAATGAAATT    c.1860
 D  T  F  S  D  E  A  V  P  E  S  S  K  I  S   | Q  E  N  E  I      p.620

          .         .         .         .         .     | 13   .    g.43382
 GGGAAGAAACGTGAACTCAAGGAAGACTCACTATGGTCAGCTAAAGAAATATCT | AACAAT    c.1920
 G  K  K  R  E  L  K  E  D  S  L  W  S  A  K  E  I  S   | N  N      p.640

          .         .         .         .         .         .       g.43442
 GACAAACTTCAGGATGATAGTGAGATGCTTCCAAAAAAGCTGTTATTGACTGAATTTAGA       c.1980
 D  K  L  Q  D  D  S  E  M  L  P  K  K  L  L  L  T  E  F  R         p.660

          .         .         .         .         .         .       g.43502
 TCACTGGTGATTAAAAACTCTACTTCCAGAAATCCATCTGGCATAAATGATGATTATGGT       c.2040
 S  L  V  I  K  N  S  T  S  R  N  P  S  G  I  N  D  D  Y  G         p.680

          .         .         . | 14       .         .         .    g.46335
 CAACTAAAAAATTTCAAGAAATTCAAAAAG | GTCACATATCCTGGAGCAGGAAAACTTCCA    c.2100
 Q  L  K  N  F  K  K  F  K  K   | V  T  Y  P  G  A  G  K  L  P      p.700

          .         .         .         .         .         .       g.46395
 CACATCATTGGAGGATCAGATCTAATAGCTCATCATGCTCGAAAGAATACAGAACTAGAA       c.2160
 H  I  I  G  G  S  D  L  I  A  H  H  A  R  K  N  T  E  L  E         p.720

          .         .     | 15   .         .         .         .    g.52632
 GAGTGGCTAAGGCAGGAAATGGAG | GTACAAAATCAACATGCAAAAGAAGAGTCTCTTGCT    c.2220
 E  W  L  R  Q  E  M  E   | V  Q  N  Q  H  A  K  E  E  S  L  A      p.740

          .     | 16   .         .         .                        g.54105
 GATGATCTTTTTAG | ATACAATCCTTATTTAAAAAGGAGAAGATAA                   c.2265
 D  D  L  F  R  |  Y  N  P  Y  L  K  R  R  R  X                     p.754

          .         .         .         .         .         .       g.54165
 ctgaggattttaaaaagaagccatggaaaaacttcctagtaagcatctacttcaggccaa       c.*60

          .         .         .         .         .         .       g.54225
 caaggttatatgaatatatagtgtatagaagcgatttaagttacaatgttttatggccta       c.*120

          .         .         .         .         .         .       g.54285
 aatttattaaataaaatgcacaaaactttgattcttttgtatgtaacaattgtttgttct       c.*180

          .         .         .         .         .         .       g.54345
 gttttcaggctttgtcattgcatctttttttcatttttaaatgtgttttgtttattaaat       c.*240

          .         .         .         .         .         .       g.54405
 agttaatatagtcacagttcaaaattctaaatgtacgtaaggtaaagactaaagtcaccc       c.*300

          .         .         .         .         .         .       g.54465
 ttccaccattgtcctagctacttggttcccctcagaaaaaaattcatgatactcatttct       c.*360

          .         .         .         .         .         .       g.54525
 tatgaatctttccagggatttttgagtcctattcaaattcctatttttaaataatttcct       c.*420

          .         .         .         .         .         .       g.54585
 acacaaatgatagcataacatatgcagtgttctacaccttgcttttttacttagtagatt       c.*480

          .         .         .         .         .         .       g.54645
 aaaaattataggaatatcaatataatgtttttaatattttttcttttccattatgctgta       c.*540

          .         .         .         .         .         .       g.54705
 gtcttacctaaactctggtgatccaaacaaaatggcttcagtggtgcagatgtcacctac       c.*600

          .         .         .         .         .         .       g.54765
 atgttattctagtactagaaactgaagaccatgtggagacttcatcaaacatgggtttag       c.*660

          .         .         .         .         .         .       g.54825
 ttttcaccagaatggaaagacctgtacccctttttggtggtcttactgagctgggtgggt       c.*720

          .         .         .         .         .         .       g.54885
 gtctgttttgagcttatttagagtcctagttttcctacttataaagtagaaatggtgaga       c.*780

          .         .         .         .         .         .       g.54945
 ttgttttctttttctaccttaaagggagatggtaagaaacaatgaatgtcttttttcaaa       c.*840

          .         .         .         .         .         .       g.55005
 ctttattgacaagtgattttcaagtctgtgttcaaaaatatattcatgtacctgtgatcc       c.*900

          .         .         .         .         .         .       g.55065
 agcaagaagggagttccagtcaagagtcactacaactgattagttgtttagagaatgaga       c.*960

          .         .         .         .         .         .       g.55125
 aatggaacagtgaggaatggaggccatatttccatgacttcccttgtaaacagaagcaac       c.*1020

          .         .         .         .         .         .       g.55185
 agaagggacaagaggctggcctctacatcactctcaccttccaaatcttgtggaagtgca       c.*1080

          .         .         .         .         .         .       g.55245
 tctacttgccagaaccaaattaacttacttccaagttctggctgcttgcaggtggaactc       c.*1140

          .         .         .         .         .         .       g.55305
 cagctgcaagggagttagggaaatgaaggtctttttttaaaagcttctcagccttcctag       c.*1200

          .         .         .         .         .         .       g.55365
 ggaacagaaattgggtgagccaatctgcaatttctactacaggcattgagaccagttaga       c.*1260

          .         .         .         .         .         .       g.55425
 ttattgaaatattatagagagttatgaacacttaaattatgatagtggtatgacattgga       c.*1320

          .         .         .         .         .         .       g.55485
 tagaacatgggatactttagaagtagaattgacagggcatattagttgatgaaatggagt       c.*1380

          .         .         .         .         .         .       g.55545
 catttgagtctcttaatagccatgtatcataattaccaagtgaagctggtggaacatatg       c.*1440

          .         .         .         .         .         .       g.55605
 gtctccattttacagttaaggaatataatggacagattaatattgttctctgtcatgccc       c.*1500

          .         .         .         .         .         .       g.55665
 acaatccctttctaaggaagactgccctactatagcagtttttatatttgtcaatttatg       c.*1560

          .         .         .         .         .         .       g.55725
 aatataatgaatgagagttctggtacctcctgtctttacaaatattggtgttgtcagtat       c.*1620

          .         .         .         .         .         .       g.55785
 ttttcctttttaaccattccaatcggtgtgtagtgatgtttcattttggttttaatttgt       c.*1680

          .         .         .         .         .         .       g.55845
 atatccctgatagctataattgggtcatagaaattctttatacattctagatgcaagtct       c.*1740

          .         .         .         .         .         .       g.55905
 cttgtcggatatatgtattgagatattacacctagtctgtggcttgactgttttctttat       c.*1800

          .         .         .         .         .         .       g.55965
 gtcttttgatgaatagaagttttaaattttgacaaggtcaaatttatttttttcttttgt       c.*1860

          .         .         .         .         .         .       g.56025
 ttgatattttttctctccaatttaaccccaagatttcagatattctgctctattatataa       c.*1920

          .         .         .         .         .         .       g.56085
 actttatatttttatatttgtgatctaccttgaattgatatgtatgttgtgaattatgga       c.*1980

          .         .         .         .         .         .       g.56145
 tcagggttctttttttcccccatacaagtatccagtcattgtaacactgtttattgaaag       c.*2040

          .         .         .         .         .         .       g.56205
 aattatcctttcctcattaaattaccttgccaattagtaaaaaatcaattaaccataatg       c.*2100

          .         .         .         .         .         .       g.56265
 gtggatctgtttctggactttctgtttggttacactgaaatgtttgtccatccttgcact       c.*2160

          .         .         .         .         .         .       g.56325
 cactcataccatactgccttgaattactgtagctgcatagatgctccttaagttgggatt       c.*2220

          .         .                                               g.56351
 acattgtaataaacgcaatgtaagtt                                         c.*2246

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nibrin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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