neutrophil cytosolic factor 2 (NCF2) - coding DNA reference sequence

(used for variant description)

(last modified August 13, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_000433.3 in the NCF2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering NCF2 transcript NM_000433.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5352
                          acactccacccctactcgccctctctctctctgct       c.-241

 .         .         .         .         .         .                g.5412
 tctttccttttctctctcatggtagggttatgagtcagttgccaaaaggtggggacattt       c.-181

 .         .         .         .         .         .                g.5472
 cctgatgcatttgcaacactgagaagttatcttaagggaggctgggccccattctactca       c.-121

 .         .         .         .         .         .                g.5532
 tctggcccagaaagtgaacaccttgggggccactaaggcagccctgctaggggagacgct       c.-61

 .         .         .         .         .         .                g.5592
 ccaacctgtcttctctctgtctcctggcagctctcttggcctcctagtttctacctaatc       c.-1

          .         .         .         .         .         .       g.5652
 ATGTCCCTGGTGGAGGCCATCAGCCTCTGGAATGAAGGGGTGCTGGCAGCGGACAAGAAG       c.60
 M  S  L  V  E  A  I  S  L  W  N  E  G  V  L  A  A  D  K  K         p.20

          .         .         .         .         .         .       g.5712
 GACTGGAAGGGAGCCCTGGATGCCTTCAGTGCCGTCCAGGACCCCCACTCCCGGATTTGC       c.120
 D  W  K  G  A  L  D  A  F  S  A  V  Q  D  P  H  S  R  I  C         p.40

          .         .         .         .         .     | 02   .    g.8950
 TTCAACATTGGCTGCATGTACACTATCCTGAAGAACATGACTGAAGCAGAGAAG | GCCTTT    c.180
 F  N  I  G  C  M  Y  T  I  L  K  N  M  T  E  A  E  K   | A  F      p.60

          .         .         .         .         .         .       g.9010
 ACCAGAAGCATTAACCGAGACAAGCACTTGGCAGTGGCTTACTTCCAACGAGGGATGCTC       c.240
 T  R  S  I  N  R  D  K  H  L  A  V  A  Y  F  Q  R  G  M  L         p.80

          .        | 03.         .         .         .         .    g.18257
 TACTACCAGACAGAGAA | ATATGATTTGGCTATCAAAGACCTTAAAGAAGCCTTGATTCAG    c.300
 Y  Y  Q  T  E  K  |  Y  D  L  A  I  K  D  L  K  E  A  L  I  Q      p.100

          .         .         .         .         .         .       g.18317
 CTTCGAGGGAACCAGCTGATAGACTATAAGATCCTGGGGCTCCAGTTCAAGCTGTTTGCC       c.360
 L  R  G  N  Q  L  I  D  Y  K  I  L  G  L  Q  F  K  L  F  A         p.120

        | 04 .         .         .         .         .         .    g.21354
 TGTGAG | GTGTTATATAACATTGCTTTCATGTATGCCAAGAAGGAGGAATGGAAAAAAGCT    c.420
 C  E   | V  L  Y  N  I  A  F  M  Y  A  K  K  E  E  W  K  K  A      p.140

          .         .         .         .         .         .       g.21414
 GAAGAACAGTTAGCATTGGCCACGAGCATGAAGTCTGAGCCCAGACATTCCAAAATCGAC       c.480
 E  E  Q  L  A  L  A  T  S  M  K  S  E  P  R  H  S  K  I  D         p.160

          .         .  | 05      .         .         .         .    g.22668
 AAGGCGATGGAGTGTGTCTGG | AAGCAGAAGCTATATGAGCCAGTGGTGATCCCTGTGGGC    c.540
 K  A  M  E  C  V  W   | K  Q  K  L  Y  E  P  V  V  I  P  V  G      p.180

          .         .         .         .         .         .       g.22728
 AAGCTGTTTCGACCAAATGAGAGACAAGTGGCTCAGCTGGCCAAGAAGGATTACCTAGGC       c.600
 K  L  F  R  P  N  E  R  Q  V  A  Q  L  A  K  K  D  Y  L  G         p.200

           | 06        .         .         .         .         .    g.25133
 AAGGCGACG | GTCGTGGCATCTGTGGTGGATCAAGACAGTTTCTCTGGGTTTGCCCCTCTG    c.660
 K  A  T   | V  V  A  S  V  V  D  Q  D  S  F  S  G  F  A  P  L      p.220

           | 07        .         .         .         .    | 08    . g.28583
 CAACCACAG | GCAGCTGAGCCTCCACCCAGACCGAAAACCCCAGAGATCTTCAG | GGCTCTG c.720
 Q  P  Q   | A  A  E  P  P  P  R  P  K  T  P  E  I  F  R  |  A  L   p.240

          .         .         .         .         .         .       g.28643
 GAAGGGGAGGCTCACCGTGTGCTATTTGGGTTTGTGCCTGAGACAAAAGAAGAGCTCCAG       c.780
 E  G  E  A  H  R  V  L  F  G  F  V  P  E  T  K  E  E  L  Q         p.260

          .         .         .         .         .         .       g.28703
 GTCATGCCAGGGAACATTGTCTTTGTCTTGAAGAAGGGCAATGATAACTGGGCCACGGTC       c.840
 V  M  P  G  N  I  V  F  V  L  K  K  G  N  D  N  W  A  T  V         p.280

          .      | 09  .         .         .         .         .    g.28978
 ATGTTCAACGGGCAG | AAGGGGCTTGTTCCCTGCAACTACCTTGAACCAGTTGAGCTGCGG    c.900
 M  F  N  G  Q   | K  G  L  V  P  C  N  Y  L  E  P  V  E  L  R      p.300

          .         .     | 10   .         .         .         .    g.30178
 ATCCACCCTCAGCAGCAGCCCCAG | GAGGAAAGCTCTCCGCAGTCCGACATCCCAGCTCCT    c.960
 I  H  P  Q  Q  Q  P  Q   | E  E  S  S  P  Q  S  D  I  P  A  P      p.320

          .         .         .         . | 11       .         .    g.31911
 CCTAGTTCCAAAGCCCCTGGAAGACCCCAGCTGTCACCAG | GCCAGAAACAAAAAGAAGAG    c.1020
 P  S  S  K  A  P  G  R  P  Q  L  S  P  G |   Q  K  Q  K  E  E      p.340

        | 12 .         .         .         .         .         .    g.32390
 CCTAAG | GAAGTGAAGCTCAGTGTTCCCATGCCCTACACACTCAAGGTGCACTACAAGTAC    c.1080
 P  K   | E  V  K  L  S  V  P  M  P  Y  T  L  K  V  H  Y  K  Y      p.360

          .         .         .         .         .         .       g.32450
 ACGGTAGTCATGAAGACTCAGCCCGGGCTCCCCTACAGCCAGGTCCGGGACATGGTGTCT       c.1140
 T  V  V  M  K  T  Q  P  G  L  P  Y  S  Q  V  R  D  M  V  S         p.380

          .         .         .         | 13         .         .    g.32637
 AAGAAACTGGAGCTCCGGCTGGAACACACTAAGCTGAG | CTATCGGCCTCGGGACAGCAAT    c.1200
 K  K  L  E  L  R  L  E  H  T  K  L  S  |  Y  R  P  R  D  S  N      p.400

          .         .         .         .         .         .       g.32697
 GAGCTGGTGCCCCTTTCAGAAGACAGCATGAAGGATGCCTGGGGCCAGGTGAAAAACTAC       c.1260
 E  L  V  P  L  S  E  D  S  M  K  D  A  W  G  Q  V  K  N  Y         p.420

          .         .         . | 14       .         .         .    g.35678
 TGCCTGACTCTGTGGTGTGAGAACACAGTG | GGTGACCAAGGCTTTCCAGATGAACCCAAG    c.1320
 C  L  T  L  W  C  E  N  T  V   | G  D  Q  G  F  P  D  E  P  K      p.440

          .         .         .         .         .         .       g.35738
 GAAAGTGAAAAAGCTGATGCTAATAACCAGACAACAGAACCTCAGCTTAAGAAAGGCAGC       c.1380
 E  S  E  K  A  D  A  N  N  Q  T  T  E  P  Q  L  K  K  G  S         p.460

          .         .         .         .         .         .       g.35798
 CAAGTGGAGGCACTCTTCAGTTATGAGGCTACCCAACCAGAGGACCTGGAGTTTCAGGAA       c.1440
 Q  V  E  A  L  F  S  Y  E  A  T  Q  P  E  D  L  E  F  Q  E         p.480

          .         .         | 15         .         .         .    g.39723
 GGGGATATAATCCTGGTGTTATCAAAGG | TGAATGAAGAATGGCTGGAAGGGGAGTGCAAA    c.1500
 G  D  I  I  L  V  L  S  K  V |   N  E  E  W  L  E  G  E  C  K      p.500

          .         .         .         .         .         .       g.39783
 GGGAAGGTGGGCATTTTCCCCAAAGTTTTTGTTGAAGACTGCGCAACTACAGATTTGGAA       c.1560
 G  K  V  G  I  F  P  K  V  F  V  E  D  C  A  T  T  D  L  E         p.520

          .         .                                               g.39804
 AGCACTCGGAGAGAAGTCTAG                                              c.1581
 S  T  R  R  E  V  X                                                p.526

          .         .         .         .         .         .       g.39864
 gatgtttcacaaactacaaagctgaagaaaatgaagccctattacttgtttgtaagattt       c.*60

          .         .         .         .         .         .       g.39924
 agcacccttctgctgtatactgtactgagacattacagtttggaagtgttaactatttat       c.*120

          .         .         .         .         .         .       g.39984
 tccctgttaaaatttaacctactagacaatgatgtgagtacccaggatgatttcctgggg       c.*180

          .         .         .         .         .         .       g.40044
 cacagtgggtgaggagatggggacaggtgaatggaggagttaggggagaggaaaagtgga       c.*240

          .         .         .         .         .         .       g.40104
 tggaagtgtctggaaagggcacgagagagtcttccaggtactgatcctgtttcttgctct       c.*300

          .         .         .         .         .         .       g.40164
 gagtgctagctagccagctgtgttcacactgtaaacattcatcaagctgtacatttggtg       c.*360

          .         .         .         .         .         .       g.40224
 cacttttctgtgtcataccacaataaaaaaaaacctagcatcttacaaaaacaagacacc       c.*420

          .         .         .         .         .         .       g.40284
 caagtccaggcccaaggagtaagtacaaatattcctgtttctgaaccattactgtaattg       c.*480

          .         .         .         .         .         .       g.40344
 gctcttaaggcttgaagtaaccttataggttactcataaggcatatacaaataaacttgt       c.*540

          .                                                         g.40360
 ttgttttcttttttca                                                   c.*556

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Neutrophil cytosolic factor 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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