neuronal differentiation 2 (NEUROD2) - coding DNA reference sequence

(used for variant description)

(last modified May 30, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_006160.3 in the NEUROD2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering NEUROD2 transcript NM_006160.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         gtagagatgccacactcgct       c.-181

 .         .         .         .         .         .                g.5080
 ccgcggttcgcatggcgctctgaagacgccggcgcccgccgccttgaggagccgctgccc       c.-121

 .         .         .         .         .         .                g.5140
 ccgctccctgaagatgggggaacaatgaaataagcgagaagatccctcttctcccccctc       c.-61

 .         .         .         .         .         .     | 02       g.6323
 tctctcttgccccctccccccctcccctcccctctccccttgactcctctccgag | gcacc    c.-1

          .         .         .         .         .         .       g.6383
 ATGCTGACCCGCCTGTTCAGCGAGCCCGGCCTTCTCTCGGACGTGCCCAAGTTCGCCAGC       c.60
 M  L  T  R  L  F  S  E  P  G  L  L  S  D  V  P  K  F  A  S         p.20

          .         .         .         .         .         .       g.6443
 TGGGGCGACGGCGAAGACGACGAGCCGAGGAGCGACAAGGGCGACGCGCCGCCACCGCCA       c.120
 W  G  D  G  E  D  D  E  P  R  S  D  K  G  D  A  P  P  P  P         p.40

          .         .         .         .         .         .       g.6503
 CCGCCTGCGCCCGGGCCAGGGGCTCCGGGGCCAGCCCGGGCGGCCAAGCCAGTCCCTCTC       c.180
 P  P  A  P  G  P  G  A  P  G  P  A  R  A  A  K  P  V  P  L         p.60

          .         .         .         .         .         .       g.6563
 CGTGGAGAAGAGGGGACGGAGGCCACGTTGGCCGAGGTCAAGGAGGAAGGCGAGCTGGGG       c.240
 R  G  E  E  G  T  E  A  T  L  A  E  V  K  E  E  G  E  L  G         p.80

          .         .         .         .         .         .       g.6623
 GGAGAGGAGGAGGAGGAAGAGGAGGAGGAAGAAGGACTGGACGAGGCGGAGGGCGAGCGG       c.300
 G  E  E  E  E  E  E  E  E  E  E  G  L  D  E  A  E  G  E  R         p.100

          .         .         .         .         .         .       g.6683
 CCCAAGAAGCGCGGGCCCAAGAAGCGCAAGATGACCAAGGCGCGCTTGGAGCGCTCCAAG       c.360
 P  K  K  R  G  P  K  K  R  K  M  T  K  A  R  L  E  R  S  K         p.120

          .         .         .         .         .         .       g.6743
 CTTCGGCGGCAGAAGGCGAACGCGCGGGAGCGCAACCGCATGCACGACCTGAACGCAGCC       c.420
 L  R  R  Q  K  A  N  A  R  E  R  N  R  M  H  D  L  N  A  A         p.140

          .         .         .         .         .         .       g.6803
 CTGGACAACCTGCGCAAGGTGGTGCCCTGCTACTCCAAGACGCAGAAGCTGTCCAAGATC       c.480
 L  D  N  L  R  K  V  V  P  C  Y  S  K  T  Q  K  L  S  K  I         p.160

          .         .         .         .         .         .       g.6863
 GAGACGCTGCGCCTAGCCAAGAACTATATCTGGGCGCTCTCGGAGATCCTGCGCTCCGGC       c.540
 E  T  L  R  L  A  K  N  Y  I  W  A  L  S  E  I  L  R  S  G         p.180

          .         .         .         .         .         .       g.6923
 AAGCGGCCAGACCTAGTGTCCTACGTGCAGACTCTGTGCAAGGGTCTGTCGCAGCCCACC       c.600
 K  R  P  D  L  V  S  Y  V  Q  T  L  C  K  G  L  S  Q  P  T         p.200

          .         .         .         .         .         .       g.6983
 ACCAATCTGGTGGCCGGCTGTCTGCAGCTCAACTCTCGCAACTTCCTCACGGAGCAAGGC       c.660
 T  N  L  V  A  G  C  L  Q  L  N  S  R  N  F  L  T  E  Q  G         p.220

          .         .         .         .         .         .       g.7043
 GCCGACGGTGCCGGCCGCTTCCACGGCTCGGGCGGCCCGTTCGCCATGCACCCCTACCCG       c.720
 A  D  G  A  G  R  F  H  G  S  G  G  P  F  A  M  H  P  Y  P         p.240

          .         .         .         .         .         .       g.7103
 TACCCGTGCTCGCGCCTGGCGGGCGCACAGTGCCAGGCGGCCGGCGGCCTGGGCGGCGGC       c.780
 Y  P  C  S  R  L  A  G  A  Q  C  Q  A  A  G  G  L  G  G  G         p.260

          .         .         .         .         .         .       g.7163
 GCGGCGCACGCCCTGCGGACCCACGGCTACTGCGCCGCCTACGAGACGCTGTATGCGGCG       c.840
 A  A  H  A  L  R  T  H  G  Y  C  A  A  Y  E  T  L  Y  A  A         p.280

          .         .         .         .         .         .       g.7223
 GCAGGCGGTGGCGGCGCGAGCCCGGACTACAACAGCTCCGAGTACGAGGGCCCGCTCAGC       c.900
 A  G  G  G  G  A  S  P  D  Y  N  S  S  E  Y  E  G  P  L  S         p.300

          .         .         .         .         .         .       g.7283
 CCCCCGCTCTGTCTCAATGGCAACTTCTCACTCAAGCAGGACTCCTCGCCCGACCACGAG       c.960
 P  P  L  C  L  N  G  N  F  S  L  K  Q  D  S  S  P  D  H  E         p.320

          .         .         .         .         .         .       g.7343
 AAAAGCTACCACTACTCTATGCACTACTCGGCGCTGCCCGGTTCGCGGCCCACGGGCCAC       c.1020
 K  S  Y  H  Y  S  M  H  Y  S  A  L  P  G  S  R  P  T  G  H         p.340

          .         .         .         .         .         .       g.7403
 GGGCTAGTCTTCGGCTCGTCGGCTGTGCGCGGGGGCGTCCACTCGGAGAATCTCTTGTCT       c.1080
 G  L  V  F  G  S  S  A  V  R  G  G  V  H  S  E  N  L  L  S         p.360

          .         .         .         .         .         .       g.7463
 TACGATATGCACCTTCACCACGACCGGGGCCCCATGTACGAGGAGCTCAATGCGTTTTTT       c.1140
 Y  D  M  H  L  H  H  D  R  G  P  M  Y  E  E  L  N  A  F  F         p.380

                                                                    g.7472
 CATAACTGA                                                          c.1149
 H  N  X                                                            p.382

          .         .         .         .         .         .       g.7532
 gacttcgcgccggctcccttctttttcttttgcctttgcccgcccccctgtccccagccc       c.*60

          .         .         .         .         .         .       g.7592
 ccagagcgcagggacacccccatcctaccccggcgccgggcgcggggagcgggccaccgg       c.*120

          .         .         .         .         .         .       g.7652
 tcctgccgctctcctggggcagcgcagtcctgttacctgtgggtggcctgtcccaggggc       c.*180

          .         .         .         .         .         .       g.7712
 ctcgcttcccccaggggactcgccttctctctccccaaggggttccctcctcctctctcc       c.*240

          .         .         .         .         .         .       g.7772
 caaggagtgcttctccagggacctctctccgggggctccctggaggcacccctcccccat       c.*300

          .         .         .         .         .         .       g.7832
 tcccaatatcttcgctgaggtttcctcctccccctcctccctgcaggcccaaggcgttgg       c.*360

          .         .         .         .         .         .       g.7892
 taagggggcagctgagcaatggaacgcgtttccccctctcattattattttaaaaacaga       c.*420

          .         .         .         .         .         .       g.7952
 cacccagctgccgaggcaaaaaggagccaggcgctccctctttcttgaagagggtagaag       c.*480

          .         .         .         .         .         .       g.8012
 ttagggcgccggagcccgggcctggaacgccctcacccccaacctccagtctccgcgttt       c.*540

          .         .         .         .         .         .       g.8072
 tgcgattttaattttggcgggaggggaagtggattgagaggaaagagagaggccaagaca       c.*600

          .         .         .         .         .         .       g.8132
 atttgtaactagaatccgtttttcccttttcctttttttaaacaaacaaacatacaaaaa       c.*660

          .         .         .         .         .         .       g.8192
 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaagctaagaggcgacggaagccgaacg       c.*720

          .         .         .         .         .         .       g.8252
 cagagtccggatcggagagaaaacgcagtaaggacttttagaagcaataaaaggcaaaaa       c.*780

          .         .         .         .         .         .       g.8312
 aaacaaaaaacaaaaaaacaaacaaaaaaaaaccactactaccaataatcaaagacacaa       c.*840

          .         .         .         .         .         .       g.8372
 atatctatgcaaggaggctccactgagcctcgcggcccggcccggccccgggatgccccg       c.*900

          .         .         .         .         .         .       g.8432
 cccggcctgcgggccgccccgcccgagcgcggatctgtgcactttggtgaagtgggggcc       c.*960

          .         .         .         .         .         .       g.8492
 cgcgccgccccctccccctccccaggttcttacaatcagtgactcggagatttggggccc       c.*1020

          .         .         .         .         .         .       g.8552
 cagtgccactgccctcccccgccccgtccccgttgtgcgtcatgctgttttttaaaaacc       c.*1080

          .         .         .         .         .         .       g.8612
 tgtttccaaatttgtatggaatggcaaactgttggggggtcggtttggggagggagggtt       c.*1140

          .         .         .         .         .         .       g.8672
 tgcatgaaagacacacgcacaccacaccgcacgcacaagcaggcccggcgccggcgtccg       c.*1200

          .         .         .         .         .         .       g.8732
 gggggcagaaggaggtgagctcgccggctcctcctccccgcggccattctgtcccctcct       c.*1260

          .         .         .         .         .         .       g.8792
 ggggtgaggggtggggatggagacctgggggcagccccacccctgcccggactgtgcctc       c.*1320

          .         .         .         .         .         .       g.8852
 ggtgggtgccacctggcgatttccggtgtctggagagagtattttttggtccaaggagtc       c.*1380

          .         .         .         .         .         .       g.8912
 ctcttggctttagctggtgggtgggcggggagaggtctgagggctcctactggaggttcc       c.*1440

          .         .         .         .         .         .       g.8972
 cccaaaaaggggcaaaaggagaccctctgcccaccggaggcaggggatcaggcatccaaa       c.*1500

          .         .         .         .         .         .       g.9032
 tacacgatgcaaaaatgcaatcccacaggcgacacacccacacactcacccacacacacg       c.*1560

          .         .         .         .         .         .       g.9092
 caattttaccttcctcttgtagcgaagatgaaactcccgtcggacacccgaagtgcattg       c.*1620

          .         .         .         .         .         .       g.9152
 cgtgtttctgttcagtttaatgacgattaataaatatttatgtaaatgagatgcaaagcc       c.*1680

                                                                    g.9155
 gga                                                                c.*1683

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Neuronal differentiation 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 27
©2004-2022 Leiden University Medical Center