nexilin (F actin binding protein) (NEXN) - coding DNA reference sequence

(used for variant description)

(last modified September 19, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_144573.3 in the NEXN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016625.1, covering NEXN transcript NM_144573.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    aacagctgcagccggcgctgggcccgcctggaatgcgggaacaggctgcacaccagg       c.-241

 .         .         .         .         .         .                g.5117
 acttttatggaaacttgctgctggagacggcggcggcggcggcggcagcggcagccagag       c.-181

 .         .         .         .         .         .                g.5177
 gactcccagcggctggagcagaagtgttagcggccagagctcccagacccctacccacag       c.-121

 .         .         .         .         .         .                g.5237
 ccaggcgggacgcgcacagtccctccacgcggaaagaagtaccttcgccggtcaccggct       c.-61

 .        | 02.         .         .         .         .             g.32592
 cctgcagg | gtgcaaatatatacagagcttcataatcagcccaagaccacatagagcaaac    c.-1

          .         .        | 03.         .         .         .    g.34084
 ATGAATGATATTTCCCAAAAGGCTGAG | ATTCTGCTTTCTTCATCTAAACCTGTCCCAAAA    c.60
 M  N  D  I  S  Q  K  A  E   | I  L  L  S  S  S  K  P  V  P  K      p.20

          .         .         .         .         .         .       g.34144
 ACCTATGTACCAAAACTTGGCAAGGGTGATGTAAAGGATAAGTTTGAAGCCATGCAGAGA       c.120
 T  Y  V  P  K  L  G  K  G  D  V  K  D  K  F  E  A  M  Q  R         p.40

          .         .         .         .         .         .       g.34204
 GCCAGGGAAGAAAGAAATCAAAGGAGATCTAGAGACGAAAAACAAAGAAGAAAAGAACAA       c.180
 A  R  E  E  R  N  Q  R  R  S  R  D  E  K  Q  R  R  K  E  Q         p.60

          .         .         .          | 04        .         .    g.34466
 TATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAG | ATTAAAGAAATGCTTGCTTCT    c.240
 Y  I  R  E  R  E  W  N  R  R  K  Q  E   | I  K  E  M  L  A  S      p.80

          .         .         .         .         .         | 05    g.34612
 GATGATGAGGAAGATGTATCTTCTAAAGTAGAAAAGGCTTATGTTCCAAAATTAACAG | GA    c.300
 D  D  E  E  D  V  S  S  K  V  E  K  A  Y  V  P  K  L  T  G |       p.100

          .         .         .         .         .         .       g.34672
 ACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAGGAACAAAGGAAGAGA       c.360
 T  V  K  G  R  F  A  E  M  E  K  Q  R  Q  E  E  Q  R  K  R         p.120

          .         .         .         .         .         .       g.34732
 ACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAG       c.420
 T  E  E  E  R  K  R  R  I  E  Q  D  M  L  E  K  R  K  I  Q         p.140

          .         .        | 06.         .         .         .    g.41706
 CGTGAATTAGCAAAAAGGGCTGAACAG | ATTGAGGACATAAACAATACGGGAACTGAATCA    c.480
 R  E  L  A  K  R  A  E  Q   | I  E  D  I  N  N  T  G  T  E  S      p.160

           | 07        .         .         .         .         .    g.42950
 GCATCAGAG | GAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATATAAA    c.540
 A  S  E   | E  G  D  D  S  L  L  I  T  V  V  P  V  K  S  Y  K      p.180

          .         .         .         .         .         .       g.43010
 ACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAA       c.600
 T  S  G  K  M  K  K  N  F  E  D  L  E  K  E  R  E  E  K  E         p.200

          .         .         .         .         .         .       g.43070
 AGGATCAAGTACGAGGAAGATAAAAGAATAAGATATGAAGAACAACGACCATCTCTCAAG       c.660
 R  I  K  Y  E  E  D  K  R  I  R  Y  E  E  Q  R  P  S  L  K         p.220

          .         .        | 08.         .         .         .    g.43234
 GAAGCAAAGTGTCTTTCATTAGTTATG | GATGATGAAATAGAAAGTGAAGCAAAAAAAGAA    c.720
 E  A  K  C  L  S  L  V  M   | D  D  E  I  E  S  E  A  K  K  E      p.240

          .         .         .         .         .         .       g.43294
 TCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAA       c.780
 S  L  S  P  G  K  L  K  L  T  F  E  E  L  E  R  Q  R  Q  E         p.260

          .         .         .         .         .         .       g.43354
 AACCGAAAGAAGCAAGCTGAAGAGGAAGCAAGAAAACGTTTAGAAGAAGAGAAGCGTGCT       c.840
 N  R  K  K  Q  A  E  E  E  A  R  K  R  L  E  E  E  K  R  A         p.280

          .         .     | 09   .         .         .         .    g.45837
 TTTGAAGAAGCAAGGCGGCAAATG | GTAAATGAAGATGAGGAAAACCAAGACACAGCAAAA    c.900
 F  E  E  A  R  R  Q  M   | V  N  E  D  E  E  N  Q  D  T  A  K      p.300

          .         .         .         .         .         .       g.45897
 ATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAA       c.960
 I  F  K  G  Y  R  P  G  K  L  K  L  S  F  E  E  M  E  R  Q         p.320

          .         .         .         .         .         .       g.45957
 AGAAGAGAAGATGAAAAAAGGAAAGCAGAAGAAGAAGCCAGAAGGAGAATAGAGGAAGAA       c.1020
 R  R  E  D  E  K  R  K  A  E  E  E  A  R  R  R  I  E  E  E         p.340

          .         .         .    | 10    .         .         .    g.49794
 AAGAAGGCGTTTGCTGAAGCAAGGAGAAATATG | GTAGTAGATGATGACTCCCCAGAGATG    c.1080
 K  K  A  F  A  E  A  R  R  N  M   | V  V  D  D  D  S  P  E  M      p.360

          .         .         .         .         .         .       g.49854
 TATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAA       c.1140
 Y  K  T  I  S  Q  E  F  L  T  P  G  K  L  E  I  N  F  E  E         p.380

          .         .         .         .         .         .       g.49914
 TTATTAAAACAAAAAATGGAAGAAGAAAAACGACGAACAGAGGAGGAACGGAAGCATAAG       c.1200
 L  L  K  Q  K  M  E  E  E  K  R  R  T  E  E  E  R  K  H  K         p.400

          .         .         .         .         .  | 11      .    g.52317
 CTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAG | GAAGAGGAA    c.1260
 L  E  M  E  K  Q  E  F  E  Q  L  R  Q  E  M  G  E   | E  E  E      p.420

          .         .         .         .         .         .       g.52377
 GAAAATGAAACCTTTGGATTGAGCAGAGAATATGAAGAACTGATCAAATTAAAAAGGAGT       c.1320
 E  N  E  T  F  G  L  S  R  E  Y  E  E  L  I  K  L  K  R  S         p.440

          .         .         .         .         .         .       g.52437
 GGCTCTATTCAAGCTAAAAACCTAAAAAGCAAGTTTGAAAAAATTGGACAGTTGTCTGAA       c.1380
 G  S  I  Q  A  K  N  L  K  S  K  F  E  K  I  G  Q  L  S  E         p.460

          .         .         .         .         .         .       g.52497
 AAAGAAATACAGAAAAAAATAGAAGAAGAGCGAGCAAGAAGGAGAGCAATTGACCTTGAA       c.1440
 K  E  I  Q  K  K  I  E  E  E  R  A  R  R  R  A  I  D  L  E         p.480

          .         .         .    | 12    .         .         .    g.58535
 ATTAAAGAGCGAGAAGCTGAAAATTTTCATGAG | GAAGATGATGTTGATGTTAGGCCTGCA    c.1500
 I  K  E  R  E  A  E  N  F  H  E   | E  D  D  V  D  V  R  P  A      p.500

          .         .         .         .         .         .       g.58595
 AGAAAAAGCGAGGCTCCATTTACTCACAAAGTGAATATGAAAGCTAGATTTGAACAAATG       c.1560
 R  K  S  E  A  P  F  T  H  K  V  N  M  K  A  R  F  E  Q  M         p.520

          .         .         .         .         .         .       g.58655
 GCTAAGGCAAGAGAAGAAGAAGAACAAAGAAGAATTGAAGAACAAAAGTTACTACGCATG       c.1620
 A  K  A  R  E  E  E  E  Q  R  R  I  E  E  Q  K  L  L  R  M         p.540

          .         .         .          | 13        .         .    g.58967
 CAGTTTGAACAAAGGGAAATTGATGCAGCACTACAAAAG | AAAAGAGAAGAGGAGGAGGAG    c.1680
 Q  F  E  Q  R  E  I  D  A  A  L  Q  K   | K  R  E  E  E  E  E      p.560

          .         .         .         .         .         .       g.59027
 GAAGAAGGTAGCATCATGAATGGCTCCACTGCTGAAGATGAAGAGCAAACCAGATCAGGA       c.1740
 E  E  G  S  I  M  N  G  S  T  A  E  D  E  E  Q  T  R  S  G         p.580

          .         .         .         .         .         .       g.59087
 GCTCCATGGTTCAAGAAGCCTCTTAAAAACACATCAGTTGTAGACAGTGAGCCAGTCAGA       c.1800
 A  P  W  F  K  K  P  L  K  N  T  S  V  V  D  S  E  P  V  R         p.600

          .         .         .         .         .         .       g.59147
 TTTACGGTTAAAGTAACAGGAGAACCCAAACCAGAAATTACATGGTGGTTTGAAGGAGAA       c.1860
 F  T  V  K  V  T  G  E  P  K  P  E  I  T  W  W  F  E  G  E         p.620

          .         .         .         .         .         .       g.59207
 ATACTGCAGGATGGAGAAGACTATCAATATATTGAAAGGGGAGAAACTTACTGCCTTTAC       c.1920
 I  L  Q  D  G  E  D  Y  Q  Y  I  E  R  G  E  T  Y  C  L  Y         p.640

          .         .         .         .         .         .       g.59267
 TTACCAGAAACTTTCCCAGAAGATGGAGGAGAGTATATGTGTAAAGCAGTCAACAATAAA       c.1980
 L  P  E  T  F  P  E  D  G  G  E  Y  M  C  K  A  V  N  N  K         p.660

          .         .         .         .                           g.59315
 GGATCTGCAGCTAGTACCTGTATTCTTACCATTGAAAGTAAGAATTAA                   c.2028
 G  S  A  A  S  T  C  I  L  T  I  E  S  K  N  X                     p.675

          .         .         .         .         .         .       g.59375
 tcactctttttatcttttattctattaatttttttttccttaaaatcacttttcttcttc       c.*60

          .         .         .         .         .         .       g.59435
 tcttttttagctgatgactactagctcccctcccctctccctggaactttctctttcact       c.*120

          .         .         .         .         .         .       g.59495
 ccaactttcttactacatccatcttttctgtggcggggccaaaaaaggaaaccaggagtg       c.*180

          .         .         .         .         .         .       g.59555
 ccactatgctgacttcttattccttttcataacagtcttcaaagcacagctcatctaaag       c.*240

          .         .         .         .         .         .       g.59615
 aatgcctacttcttttccaaataagcatcagatttatcgcctattatgcagtaacagtca       c.*300

          .         .         .         .         .         .       g.59675
 ataaaatgtacttatgggggggaattactcaattattctatcagaacctattataaagac       c.*360

          .         .         .         .         .         .       g.59735
 tgtatttcccatagacgtttacagcaactatgtttaaaaaacaaaaacaaaaaaaaaaca       c.*420

          .         .         .         .         .         .       g.59795
 cacaaacctaagtagaatacattattttgcatgaaggaatgtcatttctgagctttttac       c.*480

          .         .         .         .         .         .       g.59855
 acctaaaattaggctgaaatagctgagataattaatttggaacctatcaatttgagtgga       c.*540

          .         .         .         .         .         .       g.59915
 ctttttctttagtagtacaccattttggttgttgtagtttcaaagtctttctgaagcaga       c.*600

          .         .         .         .         .         .       g.59975
 tatattgggattggagcggggtggggaaaactgtcactcctttcagaggaaaaggggagg       c.*660

          .         .         .         .         .         .       g.60035
 agcatggagaaaaacaaaaattaaaggacttaaagaatggctatacagtgttgagtgttg       c.*720

          .         .         .         .         .         .       g.60095
 aggatattaaacatgttatttttcaaacgtatgtaatatatattaaatttataaagcaaa       c.*780

          .         .         .         .         .         .       g.60155
 tttatgttgtgatcttgcctgaacaaattatattttaatgaaaaaactttctattaatag       c.*840

          .         .         .         .         .         .       g.60215
 ttcacgcaagagaaaacactttcaacatagtcgaaggcttcaagatctaagtgtatcaga       c.*900

          .         .         .         .         .         .       g.60275
 cttagggaaaaagtggcacaaccttcgatttaaaattctagtctttaaaatgagtttgta       c.*960

          .         .         .         .         .         .       g.60335
 aataattagctattacgttctattaagttgttttatattttaattttctggaagacaatt       c.*1020

          .         .         .         .                           g.60381
 ttattttacaacgtgaacccaaataaagtaacttctgtatttaaaa                     c.*1066

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nexilin (F actin binding protein) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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