nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1) - coding DNA reference sequence

(used for variant description)

(last modified November 20, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_003998.3 in the NFKB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering NFKB1 transcript NM_003998.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              gtgagagagtgagcgagacagaaagagagagaagtgcaccagcgagc       c.-421

 .         .         .         .         .         .                g.5107
 cggggcaggaagaggaggtttcgccaccggagcggcccggcgacgcgctgacagcttccc       c.-361

 .         .         .         .         .         .                g.5167
 ctgcccttcccgtcggtcgggccgccagccgccgcagccctcggcctgcacgcagccacc       c.-301

 .         .         .         .         .         .                g.5227
 ggccccgctcccggagcccagcgccgccgaggccgcagccgcccggccagtaaggcggcg       c.-241

 .         .         .         .         .         .                g.5287
 ccgccgcccggccaccgcgcgccctgcgcttccctccgcccgcgctgcggccatggcgcg       c.-181

 .         .         .         .         .         .                g.5347
 gcgctgactggcctggcccggccccgccgcgctcccgctcgccccgacccgcactcgggc       c.-121

 .         .         .         .         .         .                g.5407
 ccgcccgggctccggcctgccgccgcctcttccttctccagccggcaggcccgcgccgct       c.-61

 .         .         .         .         .         .   | 02         g.29190
 taggagggagagcccacccgcgccaggaggccgaacgcggactcgccacccgg | cttcaga    c.-1

          .         .         .          | 03        .         .    g.33528
 ATGGCAGAAGATGATCCATATTTGGGAAGGCCTGAACAA | ATGTTTCATTTGGATCCTTCT    c.60
 M  A  E  D  D  P  Y  L  G  R  P  E  Q   | M  F  H  L  D  P  S      p.20

          .         .         .         .         .         | 04    g.37518
 TTGACTCATACAATATTTAATCCAGAAGTATTTCAACCACAGATGGCACTGCCAACAG | CA    c.120
 L  T  H  T  I  F  N  P  E  V  F  Q  P  Q  M  A  L  P  T  A |       p.40

          .         .         .          | 05        .         .    g.41550
 GATGGCCCATACCTTCAAATATTAGAGCAACCTAAACAG | AGAGGATTTCGTTTCCGTTAT    c.180
 D  G  P  Y  L  Q  I  L  E  Q  P  K  Q   | R  G  F  R  F  R  Y      p.60

          .         .         .         .         .         .       g.41610
 GTATGTGAAGGCCCATCCCATGGTGGACTACCTGGTGCCTCTAGTGAAAAGAACAAGAAG       c.240
 V  C  E  G  P  S  H  G  G  L  P  G  A  S  S  E  K  N  K  K         p.80

          .         | 06         .         .         .         .    g.70700
 TCTTACCCTCAGGTCAAA | ATCTGCAACTATGTGGGACCAGCAAAGGTTATTGTTCAGTTG    c.300
 S  Y  P  Q  V  K   | I  C  N  Y  V  G  P  A  K  V  I  V  Q  L      p.100

          .         .         .         .         .         .       g.70760
 GTCACAAATGGAAAAAATATCCACCTGCATGCCCACAGCCTGGTGGGAAAACACTGTGAG       c.360
 V  T  N  G  K  N  I  H  L  H  A  H  S  L  V  G  K  H  C  E         p.120

          .         .         .         .        | 07.         .    g.80560
 GATGGGATCTGCACTGTAACTGCTGGACCCAAGGACATGGTGGTCGG | CTTCGCAAACCTG    c.420
 D  G  I  C  T  V  T  A  G  P  K  D  M  V  V  G  |  F  A  N  L      p.140

          .         .         .         .         .         .       g.80620
 GGTATACTTCATGTGACAAAGAAAAAAGTATTTGAAACACTGGAAGCACGAATGACAGAG       c.480
 G  I  L  H  V  T  K  K  K  V  F  E  T  L  E  A  R  M  T  E         p.160

          .         .         .         .         .         .       g.80680
 GCGTGTATAAGGGGCTATAATCCTGGACTCTTGGTGCACCCTGACCTTGCCTATTTGCAA       c.540
 A  C  I  R  G  Y  N  P  G  L  L  V  H  P  D  L  A  Y  L  Q         p.180

          .         .         .  | 08      .         .         .    g.82581
 GCAGAAGGTGGAGGGGACCGGCAGCTGGGAG | ATCGGGAAAAAGAGCTAATCCGCCAAGCA    c.600
 A  E  G  G  G  D  R  Q  L  G  D |   R  E  K  E  L  I  R  Q  A      p.200

          .         .         .         .         .         .       g.82641
 GCTCTGCAGCAGACCAAGGAGATGGACCTCAGCGTGGTGCGGCTCATGTTTACAGCTTTT       c.660
 A  L  Q  Q  T  K  E  M  D  L  S  V  V  R  L  M  F  T  A  F         p.220

          .         .         .         .         .         .       g.82701
 CTTCCGGATAGCACTGGCAGCTTCACAAGGCGCCTGGAACCCGTGGTATCAGACGCCATC       c.720
 L  P  D  S  T  G  S  F  T  R  R  L  E  P  V  V  S  D  A  I         p.240

          . | 09       .         .         .         .         .    g.84256
 TATGACAGTA | AAGCCCCCAATGCATCCAACTTGAAAATTGTAAGAATGGACAGGACAGCT    c.780
 Y  D  S  K |   A  P  N  A  S  N  L  K  I  V  R  M  D  R  T  A      p.260

          .         .         .         .         .      | 10  .    g.86542
 GGATGTGTGACTGGAGGGGAGGAAATTTATCTTCTTTGTGACAAAGTTCAGAAAG | ATGAC    c.840
 G  C  V  T  G  G  E  E  I  Y  L  L  C  D  K  V  Q  K  D |   D      p.280

          .         .         .         .         .         .       g.86602
 ATCCAGATTCGATTTTATGAAGAGGAAGAAAATGGTGGAGTCTGGGAAGGATTTGGAGAT       c.900
 I  Q  I  R  F  Y  E  E  E  E  N  G  G  V  W  E  G  F  G  D         p.300

          .         .        | 11.         .         .         .    g.88386
 TTTTCCCCCACAGATGTTCATAGACAA | TTTGCCATTGTCTTCAAAACTCCAAAGTATAAA    c.960
 F  S  P  T  D  V  H  R  Q   | F  A  I  V  F  K  T  P  K  Y  K      p.320

          .         .         .         .         .         .       g.88446
 GATATTAATATTACAAAACCAGCCTCTGTGTTTGTCCAGCTTCGGAGGAAATCTGACTTG       c.1020
 D  I  N  I  T  K  P  A  S  V  F  V  Q  L  R  R  K  S  D  L         p.340

          .         .         .         .       | 12 .         .    g.97110
 GAAACTAGTGAACCAAAACCTTTCCTCTACTATCCTGAAATCAAAG | ATAAAGAAGAAGTG    c.1080
 E  T  S  E  P  K  P  F  L  Y  Y  P  E  I  K  D |   K  E  E  V      p.360

          .         .         .         .         .         .       g.97170
 CAGAGGAAACGTCAGAAGCTCATGCCCAATTTTTCGGATAGTTTCGGCGGTGGTAGTGGT       c.1140
 Q  R  K  R  Q  K  L  M  P  N  F  S  D  S  F  G  G  G  S  G         p.380

          .         .         .         .         .         .       g.97230
 GCTGGAGCTGGAGGCGGAGGCATGTTTGGTAGTGGCGGTGGAGGAGGGGGCACTGGAAGT       c.1200
 A  G  A  G  G  G  G  M  F  G  S  G  G  G  G  G  G  T  G  S         p.400

          . | 13       .         .         .         .         .    g.98613
 ACAGGTCCAG | GGTATAGCTTCCCACACTATGGATTTCCTACTTATGGTGGGATTACTTTC    c.1260
 T  G  P  G |   Y  S  F  P  H  Y  G  F  P  T  Y  G  G  I  T  F      p.420

          .         .         .         . | 14       .         .    g.99829
 CATCCTGGAACTACTAAATCTAATGCTGGGATGAAGCATG | GAACCATGGACACTGAATCT    c.1320
 H  P  G  T  T  K  S  N  A  G  M  K  H  G |   T  M  D  T  E  S      p.440

          .         .         .         .         .         .       g.99889
 AAAAAGGACCCTGAAGGTTGTGACAAAAGTGATGACAAAAACACTGTAAACCTCTTTGGG       c.1380
 K  K  D  P  E  G  C  D  K  S  D  D  K  N  T  V  N  L  F  G         p.460

          .         .         .         .         .         .       g.99949
 AAAGTTATTGAAACCACAGAGCAAGATCAGGAGCCCAGCGAGGCCACCGTTGGGAATGGT       c.1440
 K  V  I  E  T  T  E  Q  D  Q  E  P  S  E  A  T  V  G  N  G         p.480

          .         .         .         .         .      | 15  .    g.101196
 GAGGTCACTCTAACGTATGCAACAGGAACAAAAGAAGAGAGTGCTGGAGTTCAGG | ATAAC    c.1500
 E  V  T  L  T  Y  A  T  G  T  K  E  E  S  A  G  V  Q  D |   N      p.500

          .         .         .         .         .         .       g.101256
 CTCTTTCTAGAGAAGGCTATGCAGCTTGCAAAGAGGCATGCCAATGCCCTTTTCGACTAC       c.1560
 L  F  L  E  K  A  M  Q  L  A  K  R  H  A  N  A  L  F  D  Y         p.520

          .         .         .         .         .         .       g.101316
 GCGGTGACAGGAGACGTGAAGATGCTGCTGGCCGTCCAGCGCCATCTCACTGCTGTGCAG       c.1620
 A  V  T  G  D  V  K  M  L  L  A  V  Q  R  H  L  T  A  V  Q         p.540

          .        | 16.         .         .         .         .    g.104609
 GATGAGAATGGGGACAG | TGTCTTACACTTAGCAATCATCCACCTTCATTCTCAACTTGTG    c.1680
 D  E  N  G  D  S  |  V  L  H  L  A  I  I  H  L  H  S  Q  L  V      p.560

          .         .         .         .         .         .       g.104669
 AGGGATCTACTAGAAGTCACATCTGGTTTGATTTCTGATGACATTATCAACATGAGAAAT       c.1740
 R  D  L  L  E  V  T  S  G  L  I  S  D  D  I  I  N  M  R  N         p.580

          .   | 17     .         .         .         .         .    g.110215
 GATCTGTACCAG | ACGCCCTTGCACTTGGCAGTGATCACTAAGCAGGAAGATGTGGTGGAG    c.1800
 D  L  Y  Q   | T  P  L  H  L  A  V  I  T  K  Q  E  D  V  V  E      p.600

          .         .         .         .         .         .       g.110275
 GATTTGCTGAGGGCTGGGGCCGACCTGAGCCTTCTGGACCGCTTGGGTAACTCTGTTTTG       c.1860
 D  L  L  R  A  G  A  D  L  S  L  L  D  R  L  G  N  S  V  L         p.620

          .         .         .         .         .         .       g.110335
 CACCTAGCTGCCAAAGAAGGACATGATAAAGTTCTCAGTATCTTACTCAAGCACAAAAAG       c.1920
 H  L  A  A  K  E  G  H  D  K  V  L  S  I  L  L  K  H  K  K         p.640

          .         .         .     | 18   .         .         .    g.110847
 GCAGCACTACTTCTTGACCACCCCAACGGGGACG | GTCTGAATGCCATTCATCTAGCCATG    c.1980
 A  A  L  L  L  D  H  P  N  G  D  G |   L  N  A  I  H  L  A  M      p.660

          .         .         .         .         .         .       g.110907
 ATGAGCAATAGCCTGCCATGTTTGCTGCTGCTGGTGGCCGCTGGGGCTGACGTCAATGCT       c.2040
 M  S  N  S  L  P  C  L  L  L  L  V  A  A  G  A  D  V  N  A         p.680

          .         .         .         .         .         .       g.110967
 CAGGAGCAGAAGTCCGGGCGCACAGCACTGCACCTGGCTGTGGAGCACGACAACATCTCA       c.2100
 Q  E  Q  K  S  G  R  T  A  L  H  L  A  V  E  H  D  N  I  S         p.700

          .         .     | 19   .         .         .         .    g.111356
 TTGGCAGGCTGCCTGCTCCTGGAG | GGTGATGCCCATGTGGACAGTACTACCTACGATGGA    c.2160
 L  A  G  C  L  L  L  E   | G  D  A  H  V  D  S  T  T  Y  D  G      p.720

          .         .         .         .         .         .       g.111416
 ACCACACCCCTGCATATAGCAGCTGGGAGAGGGTCCACCAGGCTGGCAGCTCTTCTCAAA       c.2220
 T  T  P  L  H  I  A  A  G  R  G  S  T  R  L  A  A  L  L  K         p.740

         | 20.         .         .         .         .         .    g.114299
 GCAGCAG | GAGCAGATCCCCTGGTGGAGAACTTTGAGCCTCTCTATGACCTGGATGACTCT    c.2280
 A  A  G |   A  D  P  L  V  E  N  F  E  P  L  Y  D  L  D  D  S      p.760

          .         .         .         .         .         .       g.114359
 TGGGAAAATGCAGGAGAGGATGAAGGAGTTGTGCCTGGAACCACGCCTCTAGATATGGCC       c.2340
 W  E  N  A  G  E  D  E  G  V  V  P  G  T  T  P  L  D  M  A         p.780

          .   | 21     .         .         .         .         .    g.115763
 ACCAGCTGGCAG | GTATTTGACATATTAAATGGGAAACCATATGAGCCAGAGTTTACATCT    c.2400
 T  S  W  Q   | V  F  D  I  L  N  G  K  P  Y  E  P  E  F  T  S      p.800

          .          | 22        .         .         .         .    g.116146
 GATGATTTACTAGCACAAG | GAGACATGAAACAGCTGGCTGAAGATGTGAAGCTGCAGCTG    c.2460
 D  D  L  L  A  Q  G |   D  M  K  Q  L  A  E  D  V  K  L  Q  L      p.820

          .         .         .         .         .         .       g.116206
 TATAAGTTACTAGAAATTCCTGATCCAGACAAAAACTGGGCTACTCTGGCGCAGAAATTA       c.2520
 Y  K  L  L  E  I  P  D  P  D  K  N  W  A  T  L  A  Q  K  L         p.840

          .         .         .         .         .         .       g.116266
 GGTCTGGGGATACTTAATAATGCCTTCCGGCTGAGTCCTGCTCCTTCCAAAACACTTATG       c.2580
 G  L  G  I  L  N  N  A  F  R  L  S  P  A  P  S  K  T  L  M         p.860

          .   | 23     .         .         .         .         .    g.117144
 GACAACTATGAG | GTCTCTGGGGGTACAGTCAGAGAGCTGGTGGAGGCCCTGAGACAAATG    c.2640
 D  N  Y  E   | V  S  G  G  T  V  R  E  L  V  E  A  L  R  Q  M      p.880

          .         .         .         .         .         .       g.117204
 GGCTACACCGAAGCAATTGAAGTGATCCAGGCAGCCTCCAGCCCAGTGAAGACCACCTCT       c.2700
 G  Y  T  E  A  I  E  V  I  Q  A  A  S  S  P  V  K  T  T  S         p.900

          .         .         .         .          | 24        .    g.120116
 CAGGCCCACTCGCTGCCTCTCTCGCCTGCCTCCACAAGGCAGCAAATAG | ACGAGCTCCGA    c.2760
 Q  A  H  S  L  P  L  S  P  A  S  T  R  Q  Q  I  D |   E  L  R      p.920

          .         .         .         .         .         .       g.120176
 GACAGTGACAGTGTCTGCGACAGCGGCGTGGAGACATCCTTCCGCAAACTCAGCTTTACC       c.2820
 D  S  D  S  V  C  D  S  G  V  E  T  S  F  R  K  L  S  F  T         p.940

          .         .         .         .         .         .       g.120236
 GAGTCTCTGACCAGTGGTGCCTCACTGCTAACTCTCAACAAAATGCCCCATGATTATGGG       c.2880
 E  S  L  T  S  G  A  S  L  L  T  L  N  K  M  P  H  D  Y  G         p.960

          .         .         .                                     g.120266
 CAGGAAGGACCTCTAGAAGGCAAAATTTAG                                     c.2910
 Q  E  G  P  L  E  G  K  I  X                                       p.969

          .         .         .         .         .         .       g.120326
 cctgctgacaatttcccacaccgtgtaaaccaaagccctaaaattccactgcgttgtcca       c.*60

          .         .         .         .         .         .       g.120386
 caagacagaagctgaagtgcatccaaaggtgctcagagagccggcccgcctgaatcattc       c.*120

          .         .         .         .         .         .       g.120446
 tcgatttaactcgagaccttttcaacttggcttcctttcttggttcataaatgaatttta       c.*180

          .         .         .         .         .         .       g.120506
 gtttggttcacttacagatagtatctagcaatcacaacactggctgagcggatgcatctg       c.*240

          .         .         .         .         .         .       g.120566
 gggatgaggttgcttactaagctttgccagctgctgctggatcacagctgctttctgttg       c.*300

          .         .         .         .         .         .       g.120626
 tcattgctgttgtccctctgctacgttcctattgtcattaaaggtatcacggtcgccacc       c.*360

          .         .         .         .         .         .       g.120686
 tggcattccttctgaccacagcatcattttgcattcaaattaagggttaagaaaagagat       c.*420

          .         .         .         .         .         .       g.120746
 attttaaaatgagagtcacttgatgtgccattttaaaaaaaaaggcatattgctttttct       c.*480

          .         .         .         .         .         .       g.120806
 aatgtggttatttctctgatttgcaaaaaaaaaaaaaaaaaaaatacttgtcaatattta       c.*540

          .         .         .         .         .         .       g.120866
 aacatggttacaatcattgctgaaaatggtattttcccccttttctgcattttgctattg       c.*600

          .         .         .         .         .         .       g.120926
 taaatatgttttttagatcaaatactttaaaggaaaaaatgttggatttataaatgctat       c.*660

          .         .         .         .                           g.120974
 tttttattttacttttataataaaaggaaaagcaaattgatgacctca                   c.*708

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 30b
©2004-2024 Leiden University Medical Center