NFS1 nitrogen fixation 1 homolog (S. cerevisiae) (NFS1) - coding DNA reference sequence

(used for variant description)

(last modified May 13, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_021100.4 in the NFS1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033237.1, covering NFS1 transcript NM_021100.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5017
                                            agcgccgggcagcactt       c.-61

 .         .         .         .         .         .                g.5077
 ccgggagcctggggcccaggactgcagcggcttcggaaggtgggctctgccagcgggacc       c.-1

          .         .         .         .         .         .       g.5137
 ATGCTGCTCCGAGCCGCTTGGAGGCGGGCGGCAGTGGCGGTGACAGCGGCTCCAGGGCCG       c.60
 M  L  L  R  A  A  W  R  R  A  A  V  A  V  T  A  A  P  G  P         p.20

          .         .         .        | 02.         .         .    g.5798
 AAGCCCGCGGCGCCCACTCGGGGGCTGCGCCTGCGCG | TTGGAGACCGTGCTCCTCAGTCT    c.120
 K  P  A  A  P  T  R  G  L  R  L  R  V |   G  D  R  A  P  Q  S      p.40

          .         .         .         .         .         .       g.5858
 GCGGTTCCCGCAGATACAGCCGCTGCCCCGGAGGTGGGGCCAGTGCTGCGACCTCTCTAT       c.180
 A  V  P  A  D  T  A  A  A  P  E  V  G  P  V  L  R  P  L  Y         p.60

          .         .        | 03.         .         .         .    g.6598
 ATGGATGTGCAAGCTACAACTCCTCTG | GACCCCCGGGTGCTTGATGCCATGCTCCCTTAC    c.240
 M  D  V  Q  A  T  T  P  L   | D  P  R  V  L  D  A  M  L  P  Y      p.80

          .         .         .         .         .         .       g.6658
 CTAATCAACTACTATGGGAACCCACACTCCCGGACACATGCTTATGGCTGGGAGAGTGAG       c.300
 L  I  N  Y  Y  G  N  P  H  S  R  T  H  A  Y  G  W  E  S  E         p.100

          .         .     | 04   .         .         .         .    g.7941
 GCAGCCATGGAACGTGCTCGTCAG | CAAGTAGCATCTCTGATTGGAGCTGATCCTCGTGAG    c.360
 A  A  M  E  R  A  R  Q   | Q  V  A  S  L  I  G  A  D  P  R  E      p.120

          .         .         .         .         | 05         .    g.13812
 ATCATTTTTACTAGTGGTGCTACTGAATCCAACAACATAGCAATTAAG | GGGGTGGCCCGA    c.420
 I  I  F  T  S  G  A  T  E  S  N  N  I  A  I  K   | G  V  A  R      p.140

          .         .         .         .         .         .       g.13872
 TTCTACAGGTCACGGAAAAAGCACTTGATCACCACCCAGACAGAACACAAATGTGTCTTG       c.480
 F  Y  R  S  R  K  K  H  L  I  T  T  Q  T  E  H  K  C  V  L         p.160

          .         .         .         .         .         .       g.13932
 GACTCCTGCCGTTCACTGGAAGCTGAGGGCTTTCAGGTCACCTACCTCCCAGTGCAGAAG       c.540
 D  S  C  R  S  L  E  A  E  G  F  Q  V  T  Y  L  P  V  Q  K         p.180

          .         .  | 06      .         .         .         .    g.22423
 AGTGGGATCATTGACCTAAAG | GAACTAGAGGCTGCTATCCAGCCAGATACTAGCCTGGTG    c.600
 S  G  I  I  D  L  K   | E  L  E  A  A  I  Q  P  D  T  S  L  V      p.200

          .         .         .         .         .      | 07  .    g.23499
 TCAGTCATGACTGTGAACAATGAGATTGGAGTGAAGCAGCCTATTGCAGAAATAG | GGCGG    c.660
 S  V  M  T  V  N  N  E  I  G  V  K  Q  P  I  A  E  I  G |   R      p.220

          .         .         .         .         .         .       g.23559
 ATTTGCAGTTCCAGAAAGGTATATTTCCATACTGATGCAGCCCAGGCTGTTGGAAAAATC       c.720
 I  C  S  S  R  K  V  Y  F  H  T  D  A  A  Q  A  V  G  K  I         p.240

          .         .         .         .         .         .       g.23619
 CCACTTGATGTCAATGACATGAAAATTGATCTCATGAGCATTAGTGGTCACAAAATCTAC       c.780
 P  L  D  V  N  D  M  K  I  D  L  M  S  I  S  G  H  K  I  Y         p.260

          . | 08       .         .         .         .         .    g.29213
 GGTCCCAAAG | GGGTTGGTGCCATCTACATCCGTCGCCGGCCCCGTGTGCGTGTGGAGGCC    c.840
 G  P  K  G |   V  G  A  I  Y  I  R  R  R  P  R  V  R  V  E  A      p.280

          .         .         .         .         .         .       g.29273
 CTGCAGAGTGGAGGGGGGCAGGAGCGGGGTATGCGGTCTGGGACAGTGCCCACACCCTTA       c.900
 L  Q  S  G  G  G  Q  E  R  G  M  R  S  G  T  V  P  T  P  L         p.300

          .         .         .         .         | 09         .    g.29760
 GTGGTGGGGCTGGGGGCTGCGTGTGAGGTGGCACAGCAAGAGATGGAG | TATGACCACAAG    c.960
 V  V  G  L  G  A  A  C  E  V  A  Q  Q  E  M  E   | Y  D  H  K      p.320

          .         .         .         .         .         .       g.29820
 CGAATCTCAAAGTTGTCAGAGCGGCTGATACAGAATATAATGAAGAGCCTTCCAGATGTG       c.1020
 R  I  S  K  L  S  E  R  L  I  Q  N  I  M  K  S  L  P  D  V         p.340

          .         .         .     | 10   .         .         .    g.29960
 GTGATGAATGGGGACCCTAAGCACCATTATCCCG | GCTGTATCAACCTCTCCTTTGCATAT    c.1080
 V  M  N  G  D  P  K  H  H  Y  P  G |   C  I  N  L  S  F  A  Y      p.360

          .         .         .         .         .       | 11 .    g.30685
 GTGGAAGGGGAAAGTCTGCTGATGGCACTGAAGGACGTTGCCTTATCCTCAGGGAG | TGCC    c.1140
 V  E  G  E  S  L  L  M  A  L  K  D  V  A  L  S  S  G  S  |  A      p.380

          .         .         .         .         .         .       g.30745
 TGCACCTCTGCATCCCTGGAGCCCTCTTATGTGCTTAGAGCAATTGGCACTGATGAGGAT       c.1200
 C  T  S  A  S  L  E  P  S  Y  V  L  R  A  I  G  T  D  E  D         p.400

          .         . | 12       .         .         .         .    g.31561
 TTAGCGCACTCTTCTATCAG | GTTTGGAATTGGCCGCTTCACTACAGAGGAGGAAGTGGAC    c.1260
 L  A  H  S  S  I  R  |  F  G  I  G  R  F  T  T  E  E  E  V  D      p.420

          .         .         .         .         . | 13       .    g.34690
 TACACAGTGGAGAAATGCATTCAGCATGTGAAGCGTCTTCGAGAAATGAG | CCCTCTCTGG    c.1320
 Y  T  V  E  K  C  I  Q  H  V  K  R  L  R  E  M  S  |  P  L  W      p.440

          .         .         .         .         .                 g.34744
 GAGATGGTTCAGGATGGCATTGACCTCAAGAGCATCAAGTGGACCCAACACTAG             c.1374
 E  M  V  Q  D  G  I  D  L  K  S  I  K  W  T  Q  H  X               p.457

          .         .         .         .         .         .       g.34804
 aagaatagggccctgactttgtgctggtctggcccctcctgcctcaccaacccgtgcaca       c.*60

          .         .         .         .         .         .       g.34864
 accagacaccttgttacacctagtggatgctctagattggtatagaccagttgacttcag       c.*120

          .         .         .         .         .         .       g.34924
 catcagtccacctctatgacagaaacacaagaaaactgtctttccctagcttcagttcct       c.*180

          .         .         .         .         .         .       g.34984
 tgggtgtggagcactccccatttcttctcgggtcttaaagtgtgtggacattttcatccc       c.*240

          .         .         .         .         .         .       g.35044
 gaagccatagagacatttgctgtcatattgctgctgggcacatctgtgctcttggtgagg       c.*300

          .         .         .         .         .         .       g.35104
 agagcaagaggaaccagaagaagtctctttggtcagggaccatgatgctctacatggaca       c.*360

          .         .         .         .         .         .       g.35164
 tttgagtcttcgtcttctgctgctgctcggctggaccagcttctttaacagcaagcataa       c.*420

          .         .         .         .         .         .       g.35224
 tccacttcaatgtaatattttctgtagctccaaaggctatctcttcatattgactgcaga       c.*480

          .         .         .         .         .         .       g.35284
 cagactgaatggacagtttcttagagggcttgtctcctttctacccttgtcctctttcct       c.*540

          .         .         .         .         .         .       g.35344
 ttcctttgacctaatggagctagaaatatgtctgtgactccaccagttattctaataatt       c.*600

          .         .         .         .         .         .       g.35404
 tgttttcttgaaaattgttaatttcaagactggagaaataaactcaccttctatttactc       c.*660

          .         .         .         .         .         .       g.35464
 tgtgactttatgagaggttgagggaaaagtggaagctgtacttgggaattgtggagaaga       c.*720

          .         .         .         .         .         .       g.35524
 ccgccactccatctgatttgcataaatgactcagtgggcttttgtatctcttcatttaag       c.*780

          .         .         .         .         .         .       g.35584
 aattatttgaatgcctgccaggagccagatttgttctgggtattaggaatacactggtta       c.*840

          .         .         .         .         .         .       g.35644
 acaggaccaaaaaagaccctgccctcactgagttttaaattttagtggagagatggaaaa       c.*900

          .         .         .                                     g.35678
 taattaaacaaataaacaatgttatagattgtga                                 c.*934

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The NFS1 nitrogen fixation 1 homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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