non imprinted in Prader-Willi/Angelman syndrome 2 (NIPA2) - coding DNA reference sequence

(used for variant description)

(last modified March 2, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_030922.6 in the NIPA2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021303.1, covering NIPA2 transcript NM_030922.6.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5032
                             gtcatttagccgcgcctaggttttccggcgcc       c.-601

 .         .         .         .         .         .                g.5092
 ggccctaggtcccggcagcggtggtgacggcggtgccggaggttgtccttggcaggtttt       c.-541

 .         .         .         .         .         .                g.5152
 cctcggcgcttctccatggaggaggcggtgcgaacggcttcagccccgaatgctcgcatc       c.-481

 .         .         .         .         .         .                g.5212
 tcccactggacggcgacgaaggcggtggccgtgcgagcgcaggactgggcggcctgtgtg       c.-421

 .         .         .         .         .         .                g.5272
 ggggtgtgagccgcggtgcccaaggctgcgccggcgaggggaagccgcgcggccggccgg       c.-361

 .         | 02         .         .         .         .             g.6065
 ccgactagg | gctggagctactcggccagggtttaagactttaaatgagaataaagggtgg    c.-301

 .         .         .         .         .         .                g.6125
 tatttacgaggaaatgagagtgaataagtcatctctaacctctcccagcctttttttcat       c.-241

 .         .         .     | 03   .         .         .             g.11540
 aagagagaccatattaaacttacat | gctctcccggctgtgatagaccttcagttacagag    c.-181

 .         .         .         .         .         .                g.11600
 agagggagcagagtgggaccaggtctgagaatagtgaagcaactcattcctttcaggaca       c.-121

 .         .         .       | 04 .         .         .             g.18031
 ttccctctgatgtcctattttcaaact | gtttgaagactgcttcattctgcctctagtacc    c.-61

 .         .         .         .         .         .                g.18091
 agcggtttctctgttctgtgatcaatgtgattcacaggaactccttaagtaacaaacgaa       c.-1

          .         .         .         .         .         .       g.18151
 ATGAGCCAGGGGCGTGGAAAATATGACTTCTATATTGGTCTGGGATTGGCTATGAGCTCC       c.60
 M  S  Q  G  R  G  K  Y  D  F  Y  I  G  L  G  L  A  M  S  S         p.20

          .         .         .         .         .         .       g.18211
 AGCATTTTCATTGGAGGAAGTTTCATTTTGAAAAAAAAGGGCCTCCTTCGACTTGCCAGG       c.120
 S  I  F  I  G  G  S  F  I  L  K  K  K  G  L  L  R  L  A  R         p.40

          .          | 05        .         .         .         .    g.19612
 AAAGGCTCTATGAGAGCAG | GTCAAGGTGGCCATGCATATCTTAAGGAATGGTTGTGGTGG    c.180
 K  G  S  M  R  A  G |   Q  G  G  H  A  Y  L  K  E  W  L  W  W      p.60

          .       | 06 .         .         .         .         .    g.24943
 GCTGGACTGCTGTCAA | TGGGAGCTGGTGAGGTGGCCAACTTCGCTGCGTATGCGTTTGCA    c.240
 A  G  L  L  S  M |   G  A  G  E  V  A  N  F  A  A  Y  A  F  A      p.80

          .         .         .         .        | 07.         .    g.27001
 CCAGCCACTCTAGTGACTCCACTAGGAGCTCTCAGCGTGCTAGTAAG | TGCCATTCTTTCT    c.300
 P  A  T  L  V  T  P  L  G  A  L  S  V  L  V  S  |  A  I  L  S      p.100

          .         .         .         .         .         .       g.27061
 TCATACTTTCTCAATGAAAGACTTAATCTTCATGGGAAAATTGGGTGTTTGCTAAGTATT       c.360
 S  Y  F  L  N  E  R  L  N  L  H  G  K  I  G  C  L  L  S  I         p.120

          .         .         .         .         .         .       g.27121
 CTAGGATCTACAGTTATGGTCATTCATGCTCCAAAGGAAGAGGAGATTGAGACTTTAAAT       c.420
 L  G  S  T  V  M  V  I  H  A  P  K  E  E  E  I  E  T  L  N         p.140

          .         .         | 08         .         .         .    g.32604
 GAAATGTCTCACAAGCTAGGTGATCCAG | GTTTTGTGGTCTTTGCAACCCTTGTGGTCATT    c.480
 E  M  S  H  K  L  G  D  P  G |   F  V  V  F  A  T  L  V  V  I      p.160

          .         .         .         .         .         .       g.32664
 GTGGCCTTGATATTAATCTTCGTGGTGGGTCCTCGCCATGGACAGACAAACATTCTTGTG       c.540
 V  A  L  I  L  I  F  V  V  G  P  R  H  G  Q  T  N  I  L  V         p.180

          .         .         .         .         .         .       g.32724
 TACATAACAATCTGCTCTGTAATCGGCGCGTTTTCAGTCTCCTGTGTGAAGGGCCTGGGC       c.600
 Y  I  T  I  C  S  V  I  G  A  F  S  V  S  C  V  K  G  L  G         p.200

          .         .         .         .         .         .       g.32784
 ATTGCTATCAAGGAGCTGTTTGCAGGGAAGCCTGTGCTGCGGCATCCCCTGGCTTGGATT       c.660
 I  A  I  K  E  L  F  A  G  K  P  V  L  R  H  P  L  A  W  I         p.220

          .         .         .         .         .         .       g.32844
 CTGCTGCTGAGCCTCATCGTCTGTGTGAGCACACAGATTAATTACCTAAATAGGGCCCTG       c.720
 L  L  L  S  L  I  V  C  V  S  T  Q  I  N  Y  L  N  R  A  L         p.240

          .         .         .         .         .         .       g.32904
 GATATATTCAACACTTCCATTGTGACTCCAATATATTATGTATTCTTTACAACATCAGTT       c.780
 D  I  F  N  T  S  I  V  T  P  I  Y  Y  V  F  F  T  T  S  V         p.260

          .         .         .         .         .         .       g.32964
 TTAACTTGTTCAGCTATTCTTTTTAAGGAGTGGCAAGATATGCCTGTTGACGATGTCATT       c.840
 L  T  C  S  A  I  L  F  K  E  W  Q  D  M  P  V  D  D  V  I         p.280

          .         .         .         .         .         .       g.33024
 GGTACTTTGAGTGGCTTCTTTACAATCATTGTGGGGATATTCTTGTTGCATGCCTTTAAA       c.900
 G  T  L  S  G  F  F  T  I  I  V  G  I  F  L  L  H  A  F  K         p.300

          .         .         .         .         .         .       g.33084
 GACGTCAGCTTTAGTCTAGCAAGTCTGCCTGTGTCTTTTCGAAAAGACGAGAAAGCAATG       c.960
 D  V  S  F  S  L  A  S  L  P  V  S  F  R  K  D  E  K  A  M         p.320

          .         .         .         .         .         .       g.33144
 AATGGCAATCTCTCTAATATGTATGAAGTTCTTAATAATAATGAAGAAAGCTTAACCTGT       c.1020
 N  G  N  L  S  N  M  Y  E  V  L  N  N  N  E  E  S  L  T  C         p.340

          .         .         .         .         .         .       g.33204
 GGAATCGAACAACACACTGGTGAAAATGTCTCCCGAAGAAATGGAAATCTGACAGCTTTT       c.1080
 G  I  E  Q  H  T  G  E  N  V  S  R  R  N  G  N  L  T  A  F         p.360

                                                                    g.33207
 TAA                                                                c.1083
 X                                                                  p.360

          .         .         .         .         .         .       g.33267
 gaaaggtgtaattaaaggttaatctgtgattgttatgaagtgaatttgaatatcatcaga       c.*60

          .         .         .         .         .         .       g.33327
 atgtgtctgaaaaaacattgtcctcaaataatgttctttaaaggcaatctttttaaagat       c.*120

          .         .         .         .         .         .       g.33387
 ttcactaatttggaccaagaaattacttttcttgtatttaaacaaacaatggtagctcac       c.*180

          .         .         .         .         .         .       g.33447
 taaaatgacctcagcacatgacgatttctattaacattttattgttgtagaagtatttta       c.*240

          .         .         .         .         .         .       g.33507
 cattttcatcccttctccaaaagccgaatgcactaatgacagttttaagtctatgaaaat       c.*300

          .         .         .         .         .         .       g.33567
 gctttattttttcattggtgatgaaagtctgaaatgtgcatttgtcatccccactccatc       c.*360

          .         .         .         .         .         .       g.33627
 aatccctgaccatgtaaggcttttttattttaaaaaaacagagttatcccaatacattat       c.*420

          .         .         .         .         .         .       g.33687
 cctgtgatttaccttacctacaaaagtggctcctgtttgtttgatgatgattggttttat       c.*480

          .         .         .         .         .         .       g.33747
 ttttgaaatatttattaagggaaaactaagttactgaatgaaggaacctctttcttacaa       c.*540

          .         .         .         .         .         .       g.33807
 aacaaaaaaaagggcagaaatcaccccaaggaacgatttctcaggttgagatgatcaccg       c.*600

          .         .         .         .         .         .       g.33867
 tgaatccggcttcctctgagcattcgatggccttagcacctcatcaagccagcacatcct       c.*660

          .         .         .         .         .         .       g.33927
 gcctgctgttgcagcctggctgggtttattcttcagttaccctaatcccatgatgcctgg       c.*720

          .         .         .         .         .         .       g.33987
 aaccttgattaccgttttacatcagctcttgtacttttcagtatattttcataatgagtt       c.*780

          .         .         .         .         .         .       g.34047
 atattgtcatttagactttgaacagctctgggaaatagaagactagggttgtttcttaaa       c.*840

          .         .         .         .         .         .       g.34107
 tttagctcatgttataataaaaagttgaaatgaagttcttattctaaaagtctgaatgct       c.*900

          .         .         .         .         .         .       g.34167
 tagaacaaacttaacatgtttatagaatatggtctctttgtaccaagtactttgcttaag       c.*960

          .         .         .         .         .         .       g.34227
 agctcctttgggccactacatattttggtttctagaaaatgtttgtttatgaagaagtcg       c.*1020

          .         .         .         .         .         .       g.34287
 atggaaaactgcaaacatatgcagaaaaggtagaataataaaaaaggtctaatgaactcc       c.*1080

          .         .         .         .         .         .       g.34347
 attcagctttgaacctatccactcataaccattgactggcctttaaaaaaaagtattggc       c.*1140

          .         .         .         .         .         .       g.34407
 agaattaatttccacctaggtgatgggaagaaagtgttcgcctgttccagcctgtggctc       c.*1200

          .         .         .         .         .         .       g.34467
 ctgcctggaggttacccagtggtgcgccagcgccaagccatcactccccgagggcctccc       c.*1260

          .         .         .         .         .         .       g.34527
 ctgccaatggtgctggtatcccatgcagctcaccactggctgcgtggaaactcccttttt       c.*1320

          .         .         .         .         .         .       g.34587
 tccaactttattattggccttctaaggagctgttttagatgttttttctaactgcctcct       c.*1380

          .         .         .         .         .         .       g.34647
 cccatgccattttaatactacagatgtactacgtatctgtttatatactgtacctacatc       c.*1440

          .         .         .         .         .         .       g.34707
 tgtgctttgtacataaaagaaccagttttctcccccttgaggacagagactcatttgaac       c.*1500

          .         .         .                                     g.34744
 atgcataggttaataaataataaattcttatttaaca                              c.*1537

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Non imprinted in Prader-Willi/Angelman syndrome 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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