NLR family, pyrin domain containing 2 (NLRP2) - coding DNA reference sequence

(used for variant description)

(last modified November 8, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_017852.3 in the NLRP2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering NLRP2 transcript NM_017852.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.6081
                                       agtgctcagcaacgattacgcc       c.-121

 .         .         .         .         .         .                g.6141
 ccgagggccaatcacagggctgcggccgagagagaagccttattagagctttctcaacct       c.-61

 .         .         .         .         .   | 02     .             g.9732
 gcagccctcatctccgccggcgagtagggccaggtgttgggag | ctcccacgtgggacaag    c.-1

          .         .         .         .         .         .       g.9792
 ATGGTGTCTTCGGCGCAGATGGGCTTCAACCTGCAGGCTCTCCTGGAGCAGCTCAGCCAG       c.60
 M  V  S  S  A  Q  M  G  F  N  L  Q  A  L  L  E  Q  L  S  Q         p.20

          .         .         .         .         .         .       g.9852
 GATGAGTTGAGCAAGTTCAAGTATCTGATCACGACCTTCTCCCTGGCACACGAGCTCCAG       c.120
 D  E  L  S  K  F  K  Y  L  I  T  T  F  S  L  A  H  E  L  Q         p.40

          .         .         .         .         .         .       g.9912
 AAGATCCCCCACAAGGAGGTAGACAAGGCTGATGGGAAGCAACTGGTAGAAATCCTCACC       c.180
 K  I  P  H  K  E  V  D  K  A  D  G  K  Q  L  V  E  I  L  T         p.60

          .         .         .         .         .         .       g.9972
 ACCCATTGTGACAGCTACTGGGTGGAGATGGCGAGCCTCCAGGTCTTTGAAAAGATGCAC       c.240
 T  H  C  D  S  Y  W  V  E  M  A  S  L  Q  V  F  E  K  M  H         p.80

          .         .         .         . | 03       .         .    g.14236
 CGAATGGATCTGTCTGAGAGAGCAAAGGATGAAGTCAGAG | AAGCAGCTTTGAAATCCTTT    c.300
 R  M  D  L  S  E  R  A  K  D  E  V  R  E |   A  A  L  K  S  F      p.100

          .         .      | 04  .         .         .         .    g.17503
 AATAAAAGGAAGCCTCTATCATTAG | GGATAACACGGAAAGAACGACCACCTCTAGACGTG    c.360
 N  K  R  K  P  L  S  L  G |   I  T  R  K  E  R  P  P  L  D  V      p.120

          .         .         .        | 05.         .         .    g.21356
 GACGAAATGCTGGAGCGCTTCAAAACAGAAGCACAAG | CGTTTACAGAAACGAAAGGAAAT    c.420
 D  E  M  L  E  R  F  K  T  E  A  Q  A |   F  T  E  T  K  G  N      p.140

          .         .         .         .    | 06    .         .    g.21895
 GTCATCTGCCTGGGTAAAGAAGTCTTTAAAGGAAAAAAGCCAG | ACAAAGACAATAGGTGC    c.480
 V  I  C  L  G  K  E  V  F  K  G  K  K  P  D |   K  D  N  R  C      p.160

          .         .         .         .         .         .       g.21955
 AGGTATATATTGAAGACGAAGTTCCGGGAGATGTGGAAGAGCTGGCCTGGAGATAGCAAA       c.540
 R  Y  I  L  K  T  K  F  R  E  M  W  K  S  W  P  G  D  S  K         p.180

          .         .         .         .         .         .       g.22015
 GAGGTCCAGGTTATGGCTGAGAGATACAAGATGCTGATCCCATTCAGCAACCCCAGGGTG       c.600
 E  V  Q  V  M  A  E  R  Y  K  M  L  I  P  F  S  N  P  R  V         p.200

          .         .         .         .         .         .       g.22075
 CTTCCCGGGCCCTTCTCATACACGGTGGTGCTGTATGGTCCTGCAGGCCTTGGGAAAACC       c.660
 L  P  G  P  F  S  Y  T  V  V  L  Y  G  P  A  G  L  G  K  T         p.220

          .         .         .         .         .         .       g.22135
 ACGCTGGCCCAGAAACTAATGCTAGACTGGGCAGAGGACAACCTCATCCACAAATTCAAA       c.720
 T  L  A  Q  K  L  M  L  D  W  A  E  D  N  L  I  H  K  F  K         p.240

          .         .         .         .         .         .       g.22195
 TATGCGTTCTACCTCAGCTGCAGGGAGCTCAGCCGCCTGGGCCCGTGCAGTTTTGCAGAG       c.780
 Y  A  F  Y  L  S  C  R  E  L  S  R  L  G  P  C  S  F  A  E         p.260

          .         .         .         .         .         .       g.22255
 CTGGTCTTCAGGGACTGGCCTGAATTGCAGGATGACATTCCACACATCCTAGCCCAAGCA       c.840
 L  V  F  R  D  W  P  E  L  Q  D  D  I  P  H  I  L  A  Q  A         p.280

          .         .         .         .         .         .       g.22315
 CGGAAAATCTTGTTCGTGATTGACGGCTTTGATGAGCTGGGAGCCGCACCTGGGGCGCTG       c.900
 R  K  I  L  F  V  I  D  G  F  D  E  L  G  A  A  P  G  A  L         p.300

          .         .         .         .         .         .       g.22375
 ATCGAGGACATCTGCGGGGACTGGGAGAAGAAGAAGCCGGTGCCCGTCCTCCTGGGGAGT       c.960
 I  E  D  I  C  G  D  W  E  K  K  K  P  V  P  V  L  L  G  S         p.320

          .         .         .         .         .         .       g.22435
 TTGCTGAACAGGGTGATGTTACCCAAGGCCGCCCTGCTGGTCACCACGCGGCCCAGGGCC       c.1020
 L  L  N  R  V  M  L  P  K  A  A  L  L  V  T  T  R  P  R  A         p.340

          .         .         .         .         .         .       g.22495
 CTGAGGGACCTCCGGATCCTGGCGGAGGAGCCGATCTACATAAGGGTGGAGGGCTTCCTG       c.1080
 L  R  D  L  R  I  L  A  E  E  P  I  Y  I  R  V  E  G  F  L         p.360

          .         .         .         .         .         .       g.22555
 GAGGAGGACAGGAGGGCCTATTTCCTGAGACACTTTGGAGACGAGGACCAAGCCATGCGT       c.1140
 E  E  D  R  R  A  Y  F  L  R  H  F  G  D  E  D  Q  A  M  R         p.380

          .         .         .         .         .         .       g.22615
 GCCTTTGAGCTAATGAGGAGCAACGCGGCCCTGTTCCAGCTGGGCTCGGCCCCCGCGGTG       c.1200
 A  F  E  L  M  R  S  N  A  A  L  F  Q  L  G  S  A  P  A  V         p.400

          .         .         .         .         .         .       g.22675
 TGCTGGATCGTGTGCACGACTCTGAAGCTGCAGATGGAGAAGGGGGAGGACCCGGTCCCC       c.1260
 C  W  I  V  C  T  T  L  K  L  Q  M  E  K  G  E  D  P  V  P         p.420

          .         .         .         .         .         .       g.22735
 ACCTGCCTCACCCGCACGGGGCTGTTCCTGCGTTTCCTCTGCAGCCGGTTCCCGCAGGGC       c.1320
 T  C  L  T  R  T  G  L  F  L  R  F  L  C  S  R  F  P  Q  G         p.440

          .         .         .         .         .         .       g.22795
 GCACAGCTGCGGGGCGCGCTGCGGACGCTGAGCCTCCTGGCCGCGCAGGGCCTGTGGGCG       c.1380
 A  Q  L  R  G  A  L  R  T  L  S  L  L  A  A  Q  G  L  W  A         p.460

          .         .         .         .         .         .       g.22855
 CAGACGTCCGTGCTTCACCGAGAGGATCTGGAAAGGCTCGGGGTGCAGGAGTCCGACCTC       c.1440
 Q  T  S  V  L  H  R  E  D  L  E  R  L  G  V  Q  E  S  D  L         p.480

          .         .         .         .         .         .       g.22915
 CGTCTGTTCCTGGACGGAGACATCCTCCGCCAGGACAGAGTCTCCAAAGGCTGCTACTCC       c.1500
 R  L  F  L  D  G  D  I  L  R  Q  D  R  V  S  K  G  C  Y  S         p.500

          .         .         .         .         .         .       g.22975
 TTCATCCACCTCAGCTTCCAGCAGTTTCTCACTGCCCTGTTCTACACCCTGGAGAAGGAG       c.1560
 F  I  H  L  S  F  Q  Q  F  L  T  A  L  F  Y  T  L  E  K  E         p.520

          .         .         .         .         .         .       g.23035
 GAGGAAGAGGATAGGGACGGCCACACCTGGGACATTGGGGACGTACAGAAGCTGCTTTCC       c.1620
 E  E  E  D  R  D  G  H  T  W  D  I  G  D  V  Q  K  L  L  S         p.540

          .         .         .         .         .         .       g.23095
 GGAGTAGAAAGACTCAGGAACCCCGACCTGATCCAAGCAGGCTACTACTCCTTTGGCCTC       c.1680
 G  V  E  R  L  R  N  P  D  L  I  Q  A  G  Y  Y  S  F  G  L         p.560

          .         .         .         .         .         .       g.23155
 GCTAACGAGAAGAGAGCCAAGGAGTTGGAGGCCACTTTTGGCTGCCGGATGTCACCGGAC       c.1740
 A  N  E  K  R  A  K  E  L  E  A  T  F  G  C  R  M  S  P  D         p.580

          .         .         .         .         .         .       g.23215
 ATCAAACAGGAATTGCTGCGATGCGACATAAGTTGTAAGGGTGGACATTCAACGGTGACA       c.1800
 I  K  Q  E  L  L  R  C  D  I  S  C  K  G  G  H  S  T  V  T         p.600

          .         .         .         .         .         .       g.23275
 GACCTGCAGGAGCTCCTCGGCTGTCTGTACGAGTCTCAGGAGGAGGAGCTGGTGAAGGAG       c.1860
 D  L  Q  E  L  L  G  C  L  Y  E  S  Q  E  E  E  L  V  K  E         p.620

          .         .         .         .         .         .       g.23335
 GTGATGGCTCAGTTCAAAGAAATATCCCTGCACTTAAATGCAGTAGACGTTGTGCCATCT       c.1920
 V  M  A  Q  F  K  E  I  S  L  H  L  N  A  V  D  V  V  P  S         p.640

          .         .         .         .         .         .       g.23395
 TCATTCTGCGTCAAGCACTGTCGAAACCTGCAGAAAATGTCACTGCAGGTAATAAAGGAG       c.1980
 S  F  C  V  K  H  C  R  N  L  Q  K  M  S  L  Q  V  I  K  E         p.660

          .         .         .         .         . | 07       .    g.24773
 AATCTCCCGGAGAATGTCACTGCGTCTGAATCAGACGCCGAGGTTGAGAG | ATCCCAGGAT    c.2040
 N  L  P  E  N  V  T  A  S  E  S  D  A  E  V  E  R  |  S  Q  D      p.680

          .         .         .         .         .         .       g.24833
 GATCAGCACATGCTTCCTTTCTGGACGGACCTTTGTTCCATATTTGGATCAAATAAGGAT       c.2100
 D  Q  H  M  L  P  F  W  T  D  L  C  S  I  F  G  S  N  K  D         p.700

          .         .         .         .         .         .       g.24893
 CTGATGGGTCTAGCAATCAATGATAGCTTTCTCAGTGCCTCCCTAGTAAGGATCCTGTGT       c.2160
 L  M  G  L  A  I  N  D  S  F  L  S  A  S  L  V  R  I  L  C         p.720

          .         .         .         .  | 08      .         .    g.25886
 GAACAAATAGCCTCTGACACCTGTCATCTCCAGAGAGTGGT | GTTCAAAAACATTTCCCCA    c.2220
 E  Q  I  A  S  D  T  C  H  L  Q  R  V  V  |  F  K  N  I  S  P      p.740

          .         .         .         .         .         .       g.25946
 GCTGATGCTCATCGGAACCTCTGCCTAGCTCTTCGAGGTCACAAGACTGTAACGTATCTG       c.2280
 A  D  A  H  R  N  L  C  L  A  L  R  G  H  K  T  V  T  Y  L         p.760

          .         .         .         .         .         .       g.26006
 ACCCTTCAAGGCAATGACCAGGATGATATGTTTCCCGCATTGTGTGAGGTCTTGAGACAT       c.2340
 T  L  Q  G  N  D  Q  D  D  M  F  P  A  L  C  E  V  L  R  H         p.780

          .         .       | 09 .         .         .         .    g.29772
 CCAGAATGTAACCTGCGATATCTCGG | GTTGGTGTCTTGTTCCGCTACCACTCAGCAGTGG    c.2400
 P  E  C  N  L  R  Y  L  G  |  L  V  S  C  S  A  T  T  Q  Q  W      p.800

          .         .         .         .         .         .       g.29832
 GCTGATCTCTCCTTGGCCCTTGAAGTCAACCAGTCCCTGACGTGCGTAAACCTCTCCGAC       c.2460
 A  D  L  S  L  A  L  E  V  N  Q  S  L  T  C  V  N  L  S  D         p.820

          .         .         .         .         .         .       g.29892
 AATGAGCTTCTGGATGAGGGTGCTAAGTTGCTGTACACAACTTTGAGACACCCCAAGTGC       c.2520
 N  E  L  L  D  E  G  A  K  L  L  Y  T  T  L  R  H  P  K  C         p.840

          .        | 10.         .         .         .         .    g.30261
 TTTCTGCAGAGGTTGTC | GTTGGAAAACTGTCACCTTACAGAAGCCAATTGCAAGGACCTT    c.2580
 F  L  Q  R  L  S  |  L  E  N  C  H  L  T  E  A  N  C  K  D  L      p.860

          .         .         .         .         .         .       g.30321
 GCTGCTGTGTTGGTTGTCAGCCGGGAGCTGACACACCTGTGCTTGGCCAAGAACCCCATT       c.2640
 A  A  V  L  V  V  S  R  E  L  T  H  L  C  L  A  K  N  P  I         p.880

          .         .         .         .         .         .       g.30381
 GGGAATACAGGGGTGAAGTTTCTGTGTGAGGGCTTGAGGTACCCCGAGTGTAAACTGCAG       c.2700
 G  N  T  G  V  K  F  L  C  E  G  L  R  Y  P  E  C  K  L  Q         p.900

          | 11         .         .         .         .         .    g.34037
 ACCTTGGT | GCTTTGGAACTGCGACATAACTAGCGATGGCTGCTGCGATCTCACAAAGCTT    c.2760
 T  L  V  |  L  W  N  C  D  I  T  S  D  G  C  C  D  L  T  K  L      p.920

          .         .         .         .         .         .       g.34097
 CTCCAAGAAAAATCAAGCCTGTTGTGTTTGGATCTGGGGCTGAATCACATAGGAGTTAAG       c.2820
 L  Q  E  K  S  S  L  L  C  L  D  L  G  L  N  H  I  G  V  K         p.940

          .         .         .         .         .          | 12    g.37034
 GGAATGAAGTTCCTGTGTGAGGCTTTGAGGAAACCACTGTGCAACTTGAGATGTCTGTG | G    c.2880
 G  M  K  F  L  C  E  A  L  R  K  P  L  C  N  L  R  C  L  W  |      p.960

          .         .         .         .         .         .       g.37094
 TTGTGGGGATGTTCCATCCCTCCGTTCAGTTGTGAAGACCTCTGCTCTGCCCTCAGCTGC       c.2940
 L  W  G  C  S  I  P  P  F  S  C  E  D  L  C  S  A  L  S  C         p.980

          .         .         .         .         .         .       g.37154
 AACCAGAGCCTCGTCACTCTGGACCTGGGTCAGAATCCCTTGGGGTCTAGTGGAGTGAAG       c.3000
 N  Q  S  L  V  T  L  D  L  G  Q  N  P  L  G  S  S  G  V  K         p.1000

          .         .         .         .         . | 13       .    g.40486
 ATGCTGTTTGAAACCTTGACATGTTCCAGTGGCACCCTCCGGACACTCAG | GTTGAAAATC    c.3060
 M  L  F  E  T  L  T  C  S  S  G  T  L  R  T  L  R  |  L  K  I      p.1020

          .         .         .         .         .         .       g.40546
 GATGACTTTAATGATGAACTCAATAAGCTGCTGGAAGAAATAGAAGAAAAAAACCCACAA       c.3120
 D  D  F  N  D  E  L  N  K  L  L  E  E  I  E  E  K  N  P  Q         p.1040

          .         .         .         .         .         .       g.40606
 CTGATTATTGATACTGAGAAACATCATCCCTGGGCAGAAAGGCCTTCTTCTCATGACTTC       c.3180
 L  I  I  D  T  E  K  H  H  P  W  A  E  R  P  S  S  H  D  F         p.1060

                                                                    g.40615
 ATGATCTGA                                                          c.3189
 M  I  X                                                            p.1062

          .         .         .         .         .         .       g.40675
 atccccccgagtcattcattctccatgaagtcatcgattttccaggtgttggtgaactgc       c.*60

          .         .         .         .         .         .       g.40735
 ctgtgactcctctcctccccggcccctacccctcagggataatgagttcattgctgggct       c.*120

          .         .         .         .         .         .       g.40795
 agatgttttagccatgattctgcctctgttttatacctgcacacatccttatctttgtta       c.*180

          .         .         .         .         .         .       g.40855
 catatgaaatatctgtatcacgggtatattgagagaaataaaggtgagagcattcacaaa       c.*240

                                                                    g.40859
 tgaa                                                               c.*244

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The NLR family, pyrin domain containing 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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