NOP58 ribonucleoprotein (NOP58) - coding DNA reference sequence

(used for variant description)

(last modified June 23, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_015934.3 in the NOP58 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering NOP58 transcript NM_015934.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5030
                               gcagcgtgttctgattctttgcgggacggc       c.-121

 .         .         .         .         .         .                g.5090
 gagcgcatttgtgctttgcccgccgcggcctaggaggccttttgaggccgcgtagtcggt       c.-61

 .         .         .         .         .         .                g.5150
 gtttttgaactgactctacagcttctggcaggccgtgcggcgccctgacccggcctcacc       c.-1

          .         .         .         .      | 02  .         .    g.14336
 ATGTTGGTGCTGTTTGAAACGTCTGTGGGTTACGCCATCTTTAAG | GTTCTAAATGAGAAG    c.60
 M  L  V  L  F  E  T  S  V  G  Y  A  I  F  K   | V  L  N  E  K      p.20

          .         .         .         .         .         .       g.14396
 AAACTTCAAGAGGTTGATAGTTTATGGAAAGAATTTGAAACTCCAGAGAAAGCAAACAAA       c.120
 K  L  Q  E  V  D  S  L  W  K  E  F  E  T  P  E  K  A  N  K         p.40

    | 03     .         .         .         .         .      | 04  . g.21564
 AT | AGTAAAGCTAAAACATTTTGAGAAATTTCAGGATACAGCAGAAGCATTAGCAG | CATTC c.180
 I  |  V  K  L  K  H  F  E  K  F  Q  D  T  A  E  A  L  A  A |   F   p.60

          .         .         .         .         .         .       g.21624
 ACAGCTCTGATGGAGGGCAAAATCAATAAGCAGCTGAAAAAAGTTCTGAAGAAAATAGTA       c.240
 T  A  L  M  E  G  K  I  N  K  Q  L  K  K  V  L  K  K  I  V         p.80

          .         .         .         .         .        | 05.    g.23556
 AAAGAAGCCCATGAACCGCTGGCAGTAGCTGATGCTAAACTAGGAGGGGTCATAAAG | GAA    c.300
 K  E  A  H  E  P  L  A  V  A  D  A  K  L  G  G  V  I  K   | E      p.100

          .         .         .         .         .         .       g.23616
 AAGCTGAATCTCAGTTGTATCCATAGTCCTGTTGTTAATGAACTTATGAGAGGAATTCGT       c.360
 K  L  N  L  S  C  I  H  S  P  V  V  N  E  L  M  R  G  I  R         p.120

          .         .         .         .         .         .       g.23676
 TCACAAATGGATGGATTAATCCCTGGGGTAGAACCACGTGAAATGGCAGCTATGTGTCTT       c.420
 S  Q  M  D  G  L  I  P  G  V  E  P  R  E  M  A  A  M  C  L         p.140

          .     | 06   .         .         .         .         .    g.26914
 GGATTGGCTCACAG | CCTGTCTCGATATAGATTGAAGTTTAGCGCTGATAAAGTAGACACA    c.480
 G  L  A  H  S  |  L  S  R  Y  R  L  K  F  S  A  D  K  V  D  T      p.160

          .          | 07        .         .         .         .    g.29572
 ATGATTGTTCAGGCAATTT | CCTTGTTAGATGACTTGGATAAAGAACTAAACAACTACATT    c.540
 M  I  V  Q  A  I  S |   L  L  D  D  L  D  K  E  L  N  N  Y  I      p.180

          .         .         .         .         .         .       g.29632
 ATGCGATGTAGAGAATGGTATGGCTGGCATTTCCCTGAATTAGGAAAAATTATTTCAGAT       c.600
 M  R  C  R  E  W  Y  G  W  H  F  P  E  L  G  K  I  I  S  D         p.200

          .         .         .     | 08   .         .         .    g.30359
 AATTTAACATACTGCAAGTGTTTACAGAAAGTTG | GCGATAGGAAGAACTATGCCTCTGCC    c.660
 N  L  T  Y  C  K  C  L  Q  K  V  G |   D  R  K  N  Y  A  S  A      p.220

          .         .         .         .         .         .       g.30419
 AAGCTTTCTGAGTTGCTGCCAGAAGAAGTTGAAGCAGAAGTGAAAGCAGCTGCAGAGATA       c.720
 K  L  S  E  L  L  P  E  E  V  E  A  E  V  K  A  A  A  E  I         p.240

          .         .         .         .         .         .       g.30479
 TCAATGGGAACAGAGGTTTCAGAAGAAGATATTTGCAATATTCTGCATCTTTGCACCCAG       c.780
 S  M  G  T  E  V  S  E  E  D  I  C  N  I  L  H  L  C  T  Q         p.260

  | 09       .         .         .         .         .         .    g.32045
  | GTGATTGAAATCTCTGAATATCGAACCCAGCTCTATGAATATCTACAAAATCGAATGATG    c.840
  | V  I  E  I  S  E  Y  R  T  Q  L  Y  E  Y  L  Q  N  R  M  M      p.280

          .         .         .         .         .         .       g.32105
 GCCATTGCACCCAATGTTACAGTCATGGTTGGGGAATTAGTTGGAGCACGGCTTATTGCT       c.900
 A  I  A  P  N  V  T  V  M  V  G  E  L  V  G  A  R  L  I  A         p.300

         | 10.         .         .         .         .         .    g.34935
 CATGCAG | GTTCTCTTTTAAATTTGGCCAAGCATGCAGCTTCTACCGTTCAGATTCTTGGA    c.960
 H  A  G |   S  L  L  N  L  A  K  H  A  A  S  T  V  Q  I  L  G      p.320

          .         .         .         .         .         .       g.34995
 GCTGAAAAGGCACTTTTCAGAGCCCTCAAATCTAGACGGGATACCCCTAAGTATGGTCTC       c.1020
 A  E  K  A  L  F  R  A  L  K  S  R  R  D  T  P  K  Y  G  L         p.340

          .         .         .         .         .  | 11      .    g.36596
 ATTTATCATGCTTCACTCGTGGGCCAGACAAGTCCCAAACACAAAGGAAAG | ATTTCTCGA    c.1080
 I  Y  H  A  S  L  V  G  Q  T  S  P  K  H  K  G  K   | I  S  R      p.360

          .         .         .         .         .         .       g.36656
 ATGCTGGCAGCCAAAACCGTTTTGGCTATCCGTTATGATGCTTTTGGTGAGGATTCAAGT       c.1140
 M  L  A  A  K  T  V  L  A  I  R  Y  D  A  F  G  E  D  S  S         p.380

          .         .         .         .         .         .       g.36716
 TCTGCAATGGGAGTTGAGAACAGAGCCAAATTAGAGGCCAGGTTGAGAACTTTGGAAGAC       c.1200
 S  A  M  G  V  E  N  R  A  K  L  E  A  R  L  R  T  L  E  D         p.400

        | 12 .         .         .         .         .         .    g.37107
 AGAGGG | ATAAGAAAAATAAGTGGAACAGGAAAAGCATTAGCAAAAACAGAAAAATATGAA    c.1260
 R  G   | I  R  K  I  S  G  T  G  K  A  L  A  K  T  E  K  Y  E      p.420

          | 13         .         .         .         .         .    g.39494
 CACAAAAG | TGAAGTGAAGACTTACGATCCTTCTGGTGACTCCACACTTCCAACCTGTTCT    c.1320
 H  K  S  |  E  V  K  T  Y  D  P  S  G  D  S  T  L  P  T  C  S      p.440

          .         .         .         .         .         .       g.39554
 AAAAAACGCAAAATAGAACAGGTAGATAAAGAGGATGAAATTACTGAAAAGAAAGCCAAA       c.1380
 K  K  R  K  I  E  Q  V  D  K  E  D  E  I  T  E  K  K  A  K         p.460

          .         .   | 14     .         .         .         .    g.42167
 AAAGCCAAGATTAAAGTTAAAG | TTGAAGAAGAGGAAGAAGAAAAAGTGGCAGAAGAAGAA    c.1440
 K  A  K  I  K  V  K  V |   E  E  E  E  E  E  K  V  A  E  E  E      p.480

          .         .         .         .         .         .       g.42227
 GAAACATCTGTGAAGAAGAAGAAGAAAAGGGGTAAAAAGAAACACATTAAGGAAGAACCA       c.1500
 E  T  S  V  K  K  K  K  K  R  G  K  K  K  H  I  K  E  E  P         p.500

          .         .         .          | 15        .         .    g.42615
 CTTTCTGAGGAAGAACCATGTACCAGCACAGCAATTGCT | AGTCCAGAGAAAAAGAAGAAA    c.1560
 L  S  E  E  E  P  C  T  S  T  A  I  A   | S  P  E  K  K  K  K      p.520

          .         .         .                                     g.42645
 AAGAAAAAAAAGAGAGAGAACGAGGATTAA                                     c.1590
 K  K  K  K  R  E  N  E  D  X                                       p.529

          .         .         .         .         .         .       g.42705
 cagaaaggaattacgattatatcacccggacacacatcatgcttaagattcaactgggag       c.*60

          .         .         .         .         .         .       g.42765
 cataccagggatgctctctaacgtaatcaagggaaggttcagtaagacaaagtgatttat       c.*120

          .         .         .         .         .         .       g.42825
 catctataacttcaaacctatttgtcttgacatcaactctgttaaccttatgtcatcatt       c.*180

          .         .         .         .                           g.42870
 tcttagagtctttgatatacaaataaaattttctttgtattttaa                      c.*225

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The NOP58 ribonucleoprotein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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