nitric oxide synthase 2, inducible (NOS2) - coding DNA reference sequence

(used for variant description)

(last modified May 3, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_000625.4 in the NOS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011470.1, covering NOS2 transcript NM_000625.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5024
                                     ataactttgtagcgagtcgaaaac       c.-241

 .         .         .         .         .         .                g.5084
 tgaggctccggccgcagagaactcagcctcattcctgctttaaaatctctcggccacctt       c.-181

 .         .         .         .         .         .                g.5144
 tgatgaggggactgggcagttctagacagtcccgaagttctcaaggcacaggtctcttcc       c.-121

 .         .         .         .         .       | 02 .             g.6660
 tggtttgactgtccttaccccggggaggcagtgcagccagctgcaag | ccccacagtgaag    c.-61

 .         .         .         .         .         .                g.6720
 aacatctgagctcaaatccagataagtgacataagtgacctgctttgtaaagccatagag       c.-1

          .         .         .         .         .         .       g.6780
 ATGGCCTGTCCTTGGAAATTTCTGTTCAAGACCAAATTCCACCAGTATGCAATGAATGGG       c.60
 M  A  C  P  W  K  F  L  F  K  T  K  F  H  Q  Y  A  M  N  G         p.20

          .         .         .         .         . | 03       .    g.15851
 GAAAAAGACATCAACAACAATGTGGAGAAAGCCCCCTGTGCCACCTCCAG | TCCAGTGACA    c.120
 E  K  D  I  N  N  N  V  E  K  A  P  C  A  T  S  S  |  P  V  T      p.40

          .         .         .         .         .         .       g.15911
 CAGGATGACCTTCAGTATCACAACCTCAGCAAGCAGCAGAATGAGTCCCCGCAGCCCCTC       c.180
 Q  D  D  L  Q  Y  H  N  L  S  K  Q  Q  N  E  S  P  Q  P  L         p.60

          .      | 04  .         .         .         .         .    g.16643
 GTGGAGACGGGAAAG | AAGTCTCCAGAATCTCTGGTCAAGCTGGATGCAACCCCATTGTCC    c.240
 V  E  T  G  K   | K  S  P  E  S  L  V  K  L  D  A  T  P  L  S      p.80

          .         .         .         .         .         .       g.16703
 TCCCCACGGCATGTGAGGATCAAAAACTGGGGCAGCGGGATGACTTTCCAAGACACACTT       c.300
 S  P  R  H  V  R  I  K  N  W  G  S  G  M  T  F  Q  D  T  L         p.100

          .         | 05         .         .         .         .    g.17745
 CACCATAAGGCCAAAGGG | ATTTTAACTTGCAGGTCCAAATCTTGCCTGGGGTCCATTATG    c.360
 H  H  K  A  K  G   | I  L  T  C  R  S  K  S  C  L  G  S  I  M      p.120

          .         .         .         .         .         .       g.17805
 ACTCCCAAAAGTTTGACCAGAGGACCCAGGGACAAGCCTACCCCTCCAGATGAGCTTCTA       c.420
 T  P  K  S  L  T  R  G  P  R  D  K  P  T  P  P  D  E  L  L         p.140

          .         .         .         .        | 06.         .    g.22436
 CCTCAAGCTATCGAATTTGTCAACCAATATTACGGCTCCTTCAAAGA | GGCAAAAATAGAG    c.480
 P  Q  A  I  E  F  V  N  Q  Y  Y  G  S  F  K  E  |  A  K  I  E      p.160

          .         .         .         .         .         .       g.22496
 GAACATCTGGCCAGGGTGGAAGCGGTAACAAAGGAGATAGAAACAACAGGAACCTACCAA       c.540
 E  H  L  A  R  V  E  A  V  T  K  E  I  E  T  T  G  T  Y  Q         p.180

          .         .         .         .         .         .       g.22556
 CTGACGGGAGATGAGCTCATCTTCGCCACCAAGCAGGCCTGGCGCAATGCCCCACGCTGC       c.600
 L  T  G  D  E  L  I  F  A  T  K  Q  A  W  R  N  A  P  R  C         p.200

          .         .         . | 07       .         .         .    g.23453
 ATTGGGAGGATCCAGTGGTCCAACCTGCAG | GTCTTCGATGCCCGCAGCTGTTCCACTGCC    c.660
 I  G  R  I  Q  W  S  N  L  Q   | V  F  D  A  R  S  C  S  T  A      p.220

          .         .         .         .         .         .       g.23513
 CGGGAAATGTTTGAACACATCTGCAGACACGTGCGTTACTCCACCAACAATGGCAACATC       c.720
 R  E  M  F  E  H  I  C  R  H  V  R  Y  S  T  N  N  G  N  I         p.240

    | 08     .         .         .         .         .         .    g.24410
 AG | GTCGGCCATCACCGTGTTCCCCCAGCGGAGTGATGGCAAGCACGACTTCCGGGTGTGG    c.780
 R  |  S  A  I  T  V  F  P  Q  R  S  D  G  K  H  D  F  R  V  W      p.260

          .         .         .         .         .         .       g.24470
 AATGCTCAGCTCATCCGCTATGCTGGCTACCAGATGCCAGATGGCAGCATCAGAGGGGAC       c.840
 N  A  Q  L  I  R  Y  A  G  Y  Q  M  P  D  G  S  I  R  G  D         p.280

          .         .     | 09   .         .         .         .    g.24659
 CCTGCCAACGTGGAATTCACTCAG | CTGTGCATCGACCTGGGCTGGAAGCCCAAGTACGGC    c.900
 P  A  N  V  E  F  T  Q   | L  C  I  D  L  G  W  K  P  K  Y  G      p.300

          .         .         .         .         .         .       g.24719
 CGCTTCGATGTGGTCCCCCTGGTCCTGCAGGCCAATGGCCGTGACCCTGAGCTCTTCGAA       c.960
 R  F  D  V  V  P  L  V  L  Q  A  N  G  R  D  P  E  L  F  E         p.320

          .         .         .         .     | 10   .         .    g.26489
 ATCCCACCTGACCTTGTGCTTGAGGTGGCCATGGAACATCCCAA | ATACGAGTGGTTTCGG    c.1020
 I  P  P  D  L  V  L  E  V  A  M  E  H  P  K  |  Y  E  W  F  R      p.340

          .         .         .         .         .         .       g.26549
 GAACTGGAGCTAAAGTGGTACGCCCTGCCTGCAGTGGCCAACATGCTGCTTGAGGTGGGC       c.1080
 E  L  E  L  K  W  Y  A  L  P  A  V  A  N  M  L  L  E  V  G         p.360

          .         .         .         .         .         .       g.26609
 GGCCTGGAGTTCCCAGGGTGCCCCTTCAATGGCTGGTACATGGGCACAGAGATCGGAGTC       c.1140
 G  L  E  F  P  G  C  P  F  N  G  W  Y  M  G  T  E  I  G  V         p.380

          .         .         .          | 11        .         .    g.26759
 CGGGACTTCTGTGACGTCCAGCGCTACAACATCCTGGAG | GAAGTGGGCAGGAGAATGGGC    c.1200
 R  D  F  C  D  V  Q  R  Y  N  I  L  E   | E  V  G  R  R  M  G      p.400

          .         .         .         .         .         .       g.26819
 CTGGAAACGCACAAGCTGGCCTCGCTCTGGAAAGACCAGGCTGTCGTTGAGATCAACATT       c.1260
 L  E  T  H  K  L  A  S  L  W  K  D  Q  A  V  V  E  I  N  I         p.420

          .         .  | 12      .         .         .         .    g.31117
 GCTGTGCTCCATAGTTTCCAG | AAGCAGAATGTGACCATCATGGACCACCACTCGGCTGCA    c.1320
 A  V  L  H  S  F  Q   | K  Q  N  V  T  I  M  D  H  H  S  A  A      p.440

          .         .         .         .         .         .       g.31177
 GAATCCTTCATGAAGTACATGCAGAATGAATACCGGTCCCGTGGGGGCTGCCCGGCAGAC       c.1380
 E  S  F  M  K  Y  M  Q  N  E  Y  R  S  R  G  G  C  P  A  D         p.460

          .         .         .         .         .         .       g.31237
 TGGATTTGGCTGGTCCCTCCCATGTCTGGGAGCATCACCCCCGTGTTTCACCAGGAGATG       c.1440
 W  I  W  L  V  P  P  M  S  G  S  I  T  P  V  F  H  Q  E  M         p.480

          .         .         .       | 13 .         .         .    g.32310
 CTGAACTACGTCCTGTCCCCTTTCTACTACTATCAG | GTAGAGGCCTGGAAAACCCATGTC    c.1500
 L  N  Y  V  L  S  P  F  Y  Y  Y  Q   | V  E  A  W  K  T  H  V      p.500

          .         .         .         .         .          | 14    g.33078
 TGGCAGGACGAGAAGCGGAGACCCAAGAGAAGAGAGATTCCATTGAAAGTCTTGGTCAA | A    c.1560
 W  Q  D  E  K  R  R  P  K  R  R  E  I  P  L  K  V  L  V  K  |      p.520

          .         .         .         .         .         .       g.33138
 GCTGTGCTCTTTGCCTGTATGCTGATGCGCAAGACAATGGCGTCCCGAGTCAGAGTCACC       c.1620
 A  V  L  F  A  C  M  L  M  R  K  T  M  A  S  R  V  R  V  T         p.540

          .         .         .         .         .         .       g.33198
 ATCCTCTTTGCGACAGAGACAGGAAAATCAGAGGCGCTGGCCTGGGACCTGGGGGCCTTA       c.1680
 I  L  F  A  T  E  T  G  K  S  E  A  L  A  W  D  L  G  A  L         p.560

          .         .     | 15   .         .         .         .    g.34548
 TTCAGCTGTGCCTTCAACCCCAAG | GTTGTCTGCATGGATAAGTACAGGCTGAGCTGCCTG    c.1740
 F  S  C  A  F  N  P  K   | V  V  C  M  D  K  Y  R  L  S  C  L      p.580

          .         .         .         .         .         .       g.34608
 GAGGAGGAACGGCTGCTGTTGGTGGTGACCAGTACGTTTGGCAATGGAGACTGCCCTGGC       c.1800
 E  E  E  R  L  L  L  V  V  T  S  T  F  G  N  G  D  C  P  G         p.600

           | 16        .         .         .         .          | 17 g.36379
 AATGGAGAG | AAACTGAAGAAATCGCTCTTCATGCTGAAAGAGCTCAACAACAAATTCAG | G c.1860
 N  G  E   | K  L  K  K  S  L  F  M  L  K  E  L  N  N  K  F  R  |   p.620

          .         .         .         .         .         .       g.36439
 TACGCTGTGTTTGGCCTCGGCTCCAGCATGTACCCTCGGTTCTGCGCCTTTGCTCATGAC       c.1920
 Y  A  V  F  G  L  G  S  S  M  Y  P  R  F  C  A  F  A  H  D         p.640

          .         .         .         .         .         .       g.36499
 ATTGATCAGAAGCTGTCCCACCTGGGGGCCTCTCAGCTCACCCCGATGGGAGAAGGGGAT       c.1980
 I  D  Q  K  L  S  H  L  G  A  S  Q  L  T  P  M  G  E  G  D         p.660

          .         .         .         .         .     | 18   .    g.37698
 GAGCTCAGTGGGCAGGAGGACGCCTTCCGCAGCTGGGCCGTGCAAACCTTCAAG | GCAGCC    c.2040
 E  L  S  G  Q  E  D  A  F  R  S  W  A  V  Q  T  F  K   | A  A      p.680

          .         .         .         .         .         .       g.37758
 TGTGAGACGTTTGATGTCCGAGGCAAACAGCACATTCAGATCCCCAAGCTCTACACCTCC       c.2100
 C  E  T  F  D  V  R  G  K  Q  H  I  Q  I  P  K  L  Y  T  S         p.700

          .         .         .         .         .         .       g.37818
 AATGTGACCTGGGACCCGCACCACTACAGGCTCGTGCAGGACTCACAGCCTTTGGACCTC       c.2160
 N  V  T  W  D  P  H  H  Y  R  L  V  Q  D  S  Q  P  L  D  L         p.720

         | 19.         .         .         .         .         .    g.38994
 AGCAAAG | CCCTCAGCAGCATGCATGCCAAGAACGTGTTCACCATGAGGCTCAAATCTCGG    c.2220
 S  K  A |   L  S  S  M  H  A  K  N  V  F  T  M  R  L  K  S  R      p.740

          .         .       | 20 .         .         .         .    g.39847
 CAGAATCTACAAAGTCCGACATCCAG | CCGTGCCACCATCCTGGTGGAACTCTCCTGTGAG    c.2280
 Q  N  L  Q  S  P  T  S  S  |  R  A  T  I  L  V  E  L  S  C  E      p.760

          .         .         .         .         .         .       g.39907
 GATGGCCAAGGCCTGAACTACCTGCCGGGGGAGCACCTTGGGGTTTGCCCAGGCAACCAG       c.2340
 D  G  Q  G  L  N  Y  L  P  G  E  H  L  G  V  C  P  G  N  Q         p.780

          .         .         .         .         .         .       g.39967
 CCGGCCCTGGTCCAAGGTATCCTGGAGCGAGTGGTGGATGGCCCCACACCCCACCAGACA       c.2400
 P  A  L  V  Q  G  I  L  E  R  V  V  D  G  P  T  P  H  Q  T         p.800

          .         .         | 21         .         .         .    g.41417
 GTGCGCCTGGAGGCCCTGGATGAGAGTG | GCAGCTACTGGGTCAGTGACAAGAGGCTGCCC    c.2460
 V  R  L  E  A  L  D  E  S  G |   S  Y  W  V  S  D  K  R  L  P      p.820

          .         .         .         .         .         .       g.41477
 CCCTGCTCACTCAGCCAGGCCCTCACCTACTTCCTGGACATCACCACACCCCCAACCCAG       c.2520
 P  C  S  L  S  Q  A  L  T  Y  F  L  D  I  T  T  P  P  T  Q         p.840

          .         .         .         .         .         .       g.41537
 CTGCTGCTCCAAAAGCTGGCCCAGGTGGCCACAGAAGAGCCTGAGAGACAGAGGCTGGAG       c.2580
 L  L  L  Q  K  L  A  Q  V  A  T  E  E  P  E  R  Q  R  L  E         p.860

          .   | 22     .         .         .         .         .    g.42572
 GCCCTGTGCCAG | CCCTCAGAGTACAGCAAGTGGAAGTTCACCAACAGCCCCACATTCCTG    c.2640
 A  L  C  Q   | P  S  E  Y  S  K  W  K  F  T  N  S  P  T  F  L      p.880

          .         .         .         .         .         .       g.42632
 GAGGTGCTAGAGGAGTTCCCGTCCCTGCGGGTGTCTGCTGGCTTCCTGCTTTCCCAGCTC       c.2700
 E  V  L  E  E  F  P  S  L  R  V  S  A  G  F  L  L  S  Q  L         p.900

          .         .         .         .         .         .       g.42692
 CCCATTCTGAAGCCCAGGTTCTACTCCATCAGCTCCTCCCGGGATCACACGCCCACAGAG       c.2760
 P  I  L  K  P  R  F  Y  S  I  S  S  S  R  D  H  T  P  T  E         p.920

          .         .         .         . | 23       .         .    g.44318
 ATCCACCTGACTGTGGCCGTGGTCACCTACCACACCCGAG | ATGGCCAGGGTCCCCTGCAC    c.2820
 I  H  L  T  V  A  V  V  T  Y  H  T  R  D |   G  Q  G  P  L  H      p.940

          .         .         .         .         .         .       g.44378
 CACGGCGTCTGCAGCACATGGCTCAACAGCCTGAAGCCCCAAGACCCAGTGCCCTGCTTT       c.2880
 H  G  V  C  S  T  W  L  N  S  L  K  P  Q  D  P  V  P  C  F         p.960

          | 24         .         .         .         .         .    g.44837
 GTGCGGAA | TGCCAGCGGCTTCCACCTCCCCGAGGATCCCTCCCATCCTTGCATCCTCATC    c.2940
 V  R  N  |  A  S  G  F  H  L  P  E  D  P  S  H  P  C  I  L  I      p.980

          .         .         .         .         .         .       g.44897
 GGGCCTGGCACAGGCATCGCGCCCTTCCGCAGTTTCTGGCAGCAACGGCTCCATGACTCC       c.3000
 G  P  G  T  G  I  A  P  F  R  S  F  W  Q  Q  R  L  H  D  S         p.1000

          . | 25       .         .         .         .         .    g.45401
 CAGCACAAGG | GAGTGCGGGGAGGCCGCATGACCTTGGTGTTTGGGTGCCGCCGCCCAGAT    c.3060
 Q  H  K  G |   V  R  G  G  R  M  T  L  V  F  G  C  R  R  P  D      p.1020

          .         .         .         .         .         .       g.45461
 GAGGACCACATCTACCAGGAGGAGATGCTGGAGATGGCCCAGAAGGGGGTGCTGCATGCG       c.3120
 E  D  H  I  Y  Q  E  E  M  L  E  M  A  Q  K  G  V  L  H  A         p.1040

          .         .         .          | 26        .         .    g.46475
 GTGCACACAGCCTATTCCCGCCTGCCTGGCAAGCCCAAG | GTCTATGTTCAGGACATCCTG    c.3180
 V  H  T  A  Y  S  R  L  P  G  K  P  K   | V  Y  V  Q  D  I  L      p.1060

          .         .         .         .         .         .       g.46535
 CGGCAGCAGCTGGCCAGCGAGGTGCTCCGTGTGCTCCACAAGGAGCCAGGCCACCTCTAT       c.3240
 R  Q  Q  L  A  S  E  V  L  R  V  L  H  K  E  P  G  H  L  Y         p.1080

          .         .         .         .         .         .       g.46595
 GTTTGCGGGGATGTGCGCATGGCCCGGGACGTGGCCCACACCCTGAAGCAGCTGGTGGCT       c.3300
 V  C  G  D  V  R  M  A  R  D  V  A  H  T  L  K  Q  L  V  A         p.1100

          .         .         .         .         .     | 27   .    g.48182
 GCCAAGCTGAAATTGAATGAGGAGCAGGTCGAGGACTATTTCTTTCAGCTCAAG | AGCCAG    c.3360
 A  K  L  K  L  N  E  E  Q  V  E  D  Y  F  F  Q  L  K   | S  Q      p.1120

          .         .         .         .         .         .       g.48242
 AAGCGCTATCACGAAGATATCTTTGGTGCTGTATTTCCTTACGAGGCGAAGAAGGACAGG       c.3420
 K  R  Y  H  E  D  I  F  G  A  V  F  P  Y  E  A  K  K  D  R         p.1140

          .         .         .         .                           g.48284
 GTGGCGGTGCAGCCCAGCAGCCTGGAGATGTCAGCGCTCTGA                         c.3462
 V  A  V  Q  P  S  S  L  E  M  S  A  L  X                           p.1153

          .         .         .         .         .         .       g.48344
 gggcctacaggaggggttaaagctgccggcacagaacttaaggatggagccagctctgca       c.*60

          .         .         .         .         .         .       g.48404
 ttatctgaggtcacagggcctggggagatggaggaaagtgatatcccccagcctcaagtc       c.*120

          .         .         .         .         .         .       g.48464
 ttatttcctcaacgttgctccccatcaagccctttacttgacctcctaacaagtagcacc       c.*180

          .         .         .         .         .         .       g.48524
 ctggattgatcggagcctcctctctcaaactggggcctccctggtcccttggagacaaaa       c.*240

          .         .         .         .         .         .       g.48584
 tcttaaatgccaggcctggcaagtgggtgaaagatggaacttgctgctgagtgcaccact       c.*300

          .         .         .         .         .         .       g.48644
 tcaagtgaccaccaggaggtgctatcgcaccactgtgtatttaactgccttgtgtacagt       c.*360

          .         .         .         .         .         .       g.48704
 tatttatgcctctgtatttaaaaaactaacacccagtctgttccccatggccacttgggt       c.*420

          .         .         .         .         .         .       g.48764
 cttccctgtatgattccttgatggagatatttacatgaattgcattttactttaatcaca       c.*480

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nitric oxide synthase 2, inducible protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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