notch 3 (NOTCH3) - coding DNA reference sequence

(used for variant description)

(last modified September 14, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_000435.2 in the NOTCH3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009819.1, covering NOTCH3 transcript NM_000435.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             gcggcgcggaggctgg       c.-61

 .         .         .         .         .         .                g.5076
 cccgggacgcgcccggagcccagggaaggagggaggaggggagggtcgcggccggccgcc       c.-1

          .         .         .         .         .         .       g.5136
 ATGGGGCCGGGGGCCCGTGGCCGCCGCCGCCGCCGTCGCCCGATGTCGCCGCCACCGCCA       c.60
 M  G  P  G  A  R  G  R  R  R  R  R  R  P  M  S  P  P  P  P         p.20

          .         .         .         .         .         | 02    g.8405
 CCGCCACCCGTGCGGGCGCTGCCCCTGCTGCTGCTGCTAGCGGGGCCGGGGGCTGCAG | CC    c.120
 P  P  P  V  R  A  L  P  L  L  L  L  L  A  G  P  G  A  A  A |       p.40

          .         .         .         .         .         .       g.8465
 CCCCCTTGCCTGGACGGAAGCCCGTGTGCAAATGGAGGTCGTTGCACCCAGCTGCCCTCC       c.180
 P  P  C  L  D  G  S  P  C  A  N  G  G  R  C  T  Q  L  P  S         p.60

          .        | 03.         .         .         .         .    g.13505
 CGGGAGGCTGCCTGCCT | GTGCCCGCCTGGCTGGGTGGGTGAGCGGTGTCAGCTGGAGGAC    c.240
 R  E  A  A  C  L  |  C  P  P  G  W  V  G  E  R  C  Q  L  E  D      p.80

          .         .         .         .         .         .       g.13565
 CCCTGTCACTCAGGCCCCTGTGCTGGCCGTGGTGTCTGCCAGAGTTCAGTGGTGGCTGGC       c.300
 P  C  H  S  G  P  C  A  G  R  G  V  C  Q  S  S  V  V  A  G         p.100

          .         .         .         . | 04       .         .    g.13703
 ACCGCCCGATTCTCATGCCGGTGCCCCCGTGGCTTCCGAG | GCCCTGACTGCTCCCTGCCA    c.360
 T  A  R  F  S  C  R  C  P  R  G  F  R  G |   P  D  C  S  L  P      p.120

          .         .         .         .         .         .       g.13763
 GATCCCTGCCTCAGCAGCCCTTGTGCCCACGGTGCCCGCTGCTCAGTGGGGCCCGATGGA       c.420
 D  P  C  L  S  S  P  C  A  H  G  A  R  C  S  V  G  P  D  G         p.140

          .         .         .         .         .         .       g.13823
 CGCTTCCTCTGCTCCTGCCCACCTGGCTACCAGGGCCGCAGCTGCCGAAGCGACGTGGAT       c.480
 R  F  L  C  S  C  P  P  G  Y  Q  G  R  S  C  R  S  D  V  D         p.160

          .         .         .         .         .         .       g.13883
 GAGTGCCGGGTGGGTGAGCCCTGCCGCCATGGTGGCACCTGCCTCAACACACCTGGCTCC       c.540
 E  C  R  V  G  E  P  C  R  H  G  G  T  C  L  N  T  P  G  S         p.180

          .         .         .         .         .         .       g.13943
 TTCCGCTGCCAGTGTCCAGCTGGCTACACAGGGCCACTATGTGAGAACCCCGCGGTGCCC       c.600
 F  R  C  Q  C  P  A  G  Y  T  G  P  L  C  E  N  P  A  V  P         p.200

          .         .         .         .         .         .       g.14003
 TGTGCACCCTCACCATGCCGTAACGGGGGCACCTGCAGGCAGAGTGGCGACCTCACTTAC       c.660
 C  A  P  S  P  C  R  N  G  G  T  C  R  Q  S  G  D  L  T  Y         p.220

          .          | 05        .         .         .         .    g.14155
 GACTGTGCCTGTCTTCCTG | GGTTTGAGGGTCAGAATTGTGAAGTGAACGTGGACGACTGT    c.720
 D  C  A  C  L  P  G |   F  E  G  Q  N  C  E  V  N  V  D  D  C      p.240

          .         .         .         .         .         .       g.14215
 CCAGGACACCGATGTCTCAATGGGGGGACATGCGTGGATGGCGTCAACACCTATAACTGC       c.780
 P  G  H  R  C  L  N  G  G  T  C  V  D  G  V  N  T  Y  N  C         p.260

          .         .   | 06     .         .         .         .    g.14362
 CAGTGCCCTCCTGAGTGGACAG | GCCAGTTCTGCACGGAGGACGTGGATGAGTGTCAGCTG    c.840
 Q  C  P  P  E  W  T  G |   Q  F  C  T  E  D  V  D  E  C  Q  L      p.280

          .         .         .         .         .         .       g.14422
 CAGCCCAACGCCTGCCACAATGGGGGTACCTGCTTCAACACGCTGGGTGGCCACAGCTGC       c.900
 Q  P  N  A  C  H  N  G  G  T  C  F  N  T  L  G  G  H  S  C         p.300

          .         .         .         .         .         .       g.14482
 GTGTGTGTCAATGGCTGGACAGGCGAGAGCTGCAGTCAGAATATCGATGACTGTGCCACA       c.960
 V  C  V  N  G  W  T  G  E  S  C  S  Q  N  I  D  D  C  A  T         p.320

          .         .         .         .         .         .       g.14542
 GCCGTGTGCTTCCATGGGGCCACCTGCCATGACCGCGTGGCTTCTTTCTACTGTGCCTGC       c.1020
 A  V  C  F  H  G  A  T  C  H  D  R  V  A  S  F  Y  C  A  C         p.340

          .       | 07 .         .         .         .         .    g.16597
 CCCATGGGCAAGACTG | GCCTCCTGTGTCACCTGGATGACGCCTGTGTCAGCAACCCCTGC    c.1080
 P  M  G  K  T  G |   L  L  C  H  L  D  D  A  C  V  S  N  P  C      p.360

          .         .         .         .         .         .       g.16657
 CACGAGGATGCTATCTGTGACACAAATCCGGTGAACGGCCGGGCCATTTGCACCTGTCCT       c.1140
 H  E  D  A  I  C  D  T  N  P  V  N  G  R  A  I  C  T  C  P         p.380

          .         .         .         .         .   | 08     .    g.16815
 CCCGGCTTCACGGGTGGGGCATGTGACCAGGATGTGGACGAGTGCTCTATCG | GCGCCAAC    c.1200
 P  G  F  T  G  G  A  C  D  Q  D  V  D  E  C  S  I  G |   A  N      p.400

          .         .         .         .         .         .       g.16875
 CCCTGCGAGCACTTGGGCAGGTGCGTGAACACGCAGGGCTCCTTCCTGTGCCAGTGCGGT       c.1260
 P  C  E  H  L  G  R  C  V  N  T  Q  G  S  F  L  C  Q  C  G         p.420

          .         .         .         .         .         .       g.16935
 CGTGGCTACACTGGACCTCGCTGTGAGACCGATGTCAACGAGTGTCTGTCGGGGCCCTGC       c.1320
 R  G  Y  T  G  P  R  C  E  T  D  V  N  E  C  L  S  G  P  C         p.440

          .         .         .         .         .         | 09    g.17635
 CGAAACCAGGCCACGTGCCTCGACCGCATAGGCCAGTTCACCTGTATCTGTATGGCAG | GC    c.1380
 R  N  Q  A  T  C  L  D  R  I  G  Q  F  T  C  I  C  M  A  G |       p.460

          .         .         .         .         .         .       g.17695
 TTCACAGGAACCTATTGCGAGGTGGACATTGACGAGTGTCAGAGTAGCCCCTGTGTCAAC       c.1440
 F  T  G  T  Y  C  E  V  D  I  D  E  C  Q  S  S  P  C  V  N         p.480

          .         .         .         .         .   | 10     .    g.17995
 GGTGGGGTCTGCAAGGACCGAGTCAATGGCTTCAGCTGCACCTGCCCCTCGG | GCTTCAGC    c.1500
 G  G  V  C  K  D  R  V  N  G  F  S  C  T  C  P  S  G |   F  S      p.500

          .         .         .         .         .         .       g.18055
 GGCTCCACGTGTCAGCTGGACGTGGACGAATGCGCCAGCACGCCCTGCAGGAATGGCGCC       c.1560
 G  S  T  C  Q  L  D  V  D  E  C  A  S  T  P  C  R  N  G  A         p.520

          .         .         .         .       | 11 .         .    g.18657
 AAATGCGTGGACCAGCCCGATGGCTACGAGTGCCGCTGTGCCGAGG | GCTTTGAGGGCACG    c.1620
 K  C  V  D  Q  P  D  G  Y  E  C  R  C  A  E  G |   F  E  G  T      p.540

          .         .         .         .         .         .       g.18717
 CTGTGTGATCGCAACGTGGACGACTGCTCCCCTGACCCATGCCACCATGGTCGCTGCGTG       c.1680
 L  C  D  R  N  V  D  D  C  S  P  D  P  C  H  H  G  R  C  V         p.560

          .         .         .         .         .         .       g.18777
 GATGGCATCGCCAGCTTCTCATGTGCCTGTGCTCCTGGCTACACGGGCACACGCTGCGAG       c.1740
 D  G  I  A  S  F  S  C  A  C  A  P  G  Y  T  G  T  R  C  E         p.580

          .         .         .         .         .         .       g.18837
 AGCCAGGTGGACGAATGCCGCAGCCAGCCCTGCCGCCATGGCGGCAAATGCCTAGACCTG       c.1800
 S  Q  V  D  E  C  R  S  Q  P  C  R  H  G  G  K  C  L  D  L         p.600

          .         .         .         . | 12       .         .    g.19013
 GTGGACAAGTACCTCTGCCGCTGCCCTTCTGGGACCACAG | GTGTGAACTGCGAAGTGAAC    c.1860
 V  D  K  Y  L  C  R  C  P  S  G  T  T  G |   V  N  C  E  V  N      p.620

          .         .         .         .         .         .       g.19073
 ATTGACGACTGTGCCAGCAACCCCTGCACCTTTGGAGTCTGCCGTGATGGCATCAACCGC       c.1920
 I  D  D  C  A  S  N  P  C  T  F  G  V  C  R  D  G  I  N  R         p.640

          .         .         .  | 13      .         .         .    g.20331
 TACGACTGTGTCTGCCAACCTGGCTTCACAG | GGCCCCTTTGTAACGTGGAGATCAATGAG    c.1980
 Y  D  C  V  C  Q  P  G  F  T  G |   P  L  C  N  V  E  I  N  E      p.660

          .         .         .         .         .         .       g.20391
 TGTGCTTCCAGCCCATGCGGCGAGGGAGGTTCCTGTGTGGATGGGGAAAATGGCTTCCGC       c.2040
 C  A  S  S  P  C  G  E  G  G  S  C  V  D  G  E  N  G  F  R         p.680

          .         .         .         .         .         .       g.20451
 TGCCTCTGCCCGCCTGGCTCCTTGCCCCCACTCTGCCTCCCCCCGAGCCATCCCTGTGCC       c.2100
 C  L  C  P  P  G  S  L  P  P  L  C  L  P  P  S  H  P  C  A         p.700

          .         .         .         .     | 14   .         .    g.20589
 CATGAGCCCTGCAGTCACGGCATCTGCTATGATGCACCTGGCGG | GTTCCGCTGTGTGTGT    c.2160
 H  E  P  C  S  H  G  I  C  Y  D  A  P  G  G  |  F  R  C  V  C      p.720

          .         .         .         .         .         .       g.20649
 GAGCCTGGCTGGAGTGGCCCCCGCTGCAGCCAGAGCCTGGCCCGAGACGCCTGTGAGTCC       c.2220
 E  P  G  W  S  G  P  R  C  S  Q  S  L  A  R  D  A  C  E  S         p.740

          .         .         .         .         .         .       g.20709
 CAGCCGTGCAGGGCCGGTGGGACATGCAGCAGCGATGGAATGGGTTTCCACTGCACCTGC       c.2280
 Q  P  C  R  A  G  G  T  C  S  S  D  G  M  G  F  H  C  T  C         p.760

          .       | 15 .         .         .         .         .    g.21006
 CCGCCTGGTGTCCAGG | GACGTCAGTGTGAACTCCTCTCCCCCTGCACCCCGAACCCCTGT    c.2340
 P  P  G  V  Q  G |   R  Q  C  E  L  L  S  P  C  T  P  N  P  C      p.780

          .         .         .         .         .         .       g.21066
 GAGCATGGGGGCCGCTGCGAGTCTGCCCCTGGCCAGCTGCCTGTCTGCTCCTGCCCCCAG       c.2400
 E  H  G  G  R  C  E  S  A  P  G  Q  L  P  V  C  S  C  P  Q         p.800

          . | 16       .         .         .         .         .    g.21581
 GGCTGGCAAG | GCCCACGATGCCAGCAGGATGTGGACGAGTGTGCTGGCCCCGCACCCTGT    c.2460
 G  W  Q  G |   P  R  C  Q  Q  D  V  D  E  C  A  G  P  A  P  C      p.820

          .         .         .         .         .         .       g.21641
 GGCCCTCATGGTATCTGCACCAACCTGGCAGGGAGTTTCAGCTGCACCTGCCATGGAGGG       c.2520
 G  P  H  G  I  C  T  N  L  A  G  S  F  S  C  T  C  H  G  G         p.840

          .         .         .         .       | 17 .         .    g.24194
 TACACTGGCCCTTCCTGCGATCAGGACATCAATGACTGTGACCCCA | ACCCATGCCTGAAC    c.2580
 Y  T  G  P  S  C  D  Q  D  I  N  D  C  D  P  N |   P  C  L  N      p.860

          .         .         .         .         .         .       g.24254
 GGTGGCTCGTGCCAAGACGGCGTGGGCTCCTTTTCCTGCTCCTGCCTCCCTGGTTTCGCC       c.2640
 G  G  S  C  Q  D  G  V  G  S  F  S  C  S  C  L  P  G  F  A         p.880

          .         .         .         .         .         .       g.24314
 GGCCCACGATGCGCCCGCGATGTGGATGAGTGCCTGAGCAACCCCTGCGGCCCGGGCACC       c.2700
 G  P  R  C  A  R  D  V  D  E  C  L  S  N  P  C  G  P  G  T         p.900

          .         .         .         .         .         .       g.24374
 TGTACCGACCACGTGGCCTCCTTCACCTGCACCTGCCCGCCAGGCTACGGAGGCTTCCAC       c.2760
 C  T  D  H  V  A  S  F  T  C  T  C  P  P  G  Y  G  G  F  H         p.920

          .         .         .   | 18     .         .         .    g.24847
 TGCGAACAGGACCTGCCCGACTGCAGCCCCAG | CTCCTGCTTCAATGGCGGGACCTGTGTG    c.2820
 C  E  Q  D  L  P  D  C  S  P  S  |  S  C  F  N  G  G  T  C  V      p.940

          .         .         .         .         .         .       g.24907
 GACGGCGTGAACTCGTTCAGCTGCCTGTGCCGTCCCGGCTACACAGGAGCCCACTGCCAA       c.2880
 D  G  V  N  S  F  S  C  L  C  R  P  G  Y  T  G  A  H  C  Q         p.960

          .         .         .         .         .         .       g.24967
 CATGAGGCAGACCCCTGCCTCTCGCGGCCCTGCCTACACGGGGGCGTCTGCAGCGCCGCC       c.2940
 H  E  A  D  P  C  L  S  R  P  C  L  H  G  G  V  C  S  A  A         p.980

          .         .         .         .         .     | 19   .    g.25159
 CACCCTGGCTTCCGCTGCACCTGCCTCGAGAGCTTCACGGGCCCGCAGTGCCAG | ACGCTG    c.3000
 H  P  G  F  R  C  T  C  L  E  S  F  T  G  P  Q  C  Q   | T  L      p.1000

          .         .         .         .         .         .       g.25219
 GTGGATTGGTGCAGCCGCCAGCCTTGTCAAAACGGGGGTCGCTGCGTCCAGACTGGGGCC       c.3060
 V  D  W  C  S  R  Q  P  C  Q  N  G  G  R  C  V  Q  T  G  A         p.1020

          .         .         .         .         .         .       g.25279
 TATTGCCTTTGTCCCCCTGGATGGAGCGGACGCCTCTGTGACATCCGAAGCTTGCCCTGC       c.3120
 Y  C  L  C  P  P  G  W  S  G  R  L  C  D  I  R  S  L  P  C         p.1040

          .         .   | 20     .         .         .         .    g.25763
 AGGGAGGCCGCAGCCCAGATCG | GGGTGCGGCTGGAGCAGCTGTGTCAGGCGGGTGGGCAG    c.3180
 R  E  A  A  A  Q  I  G |   V  R  L  E  Q  L  C  Q  A  G  G  Q      p.1060

          .         .         .         .         .         .       g.25823
 TGTGTGGATGAAGACAGCTCCCACTACTGCGTGTGCCCAGAGGGCCGTACTGGTAGCCAC       c.3240
 C  V  D  E  D  S  S  H  Y  C  V  C  P  E  G  R  T  G  S  H         p.1080

          .         .         .         .         .         .       g.25883
 TGTGAGCAGGAGGTGGACCCCTGCTTGGCCCAGCCCTGCCAGCATGGGGGGACCTGCCGT       c.3300
 C  E  Q  E  V  D  P  C  L  A  Q  P  C  Q  H  G  G  T  C  R         p.1100

          .         .        | 21.         .         .         .    g.26518
 GGCTATATGGGGGGCTACATGTGTGAG | TGTCTTCCTGGCTACAATGGTGATAACTGTGAG    c.3360
 G  Y  M  G  G  Y  M  C  E   | C  L  P  G  Y  N  G  D  N  C  E      p.1120

          .         .         .         .         .         .       g.26578
 GACGACGTGGACGAGTGTGCCTCCCAGCCCTGCCAGCACGGGGGTTCATGCATTGACCTC       c.3420
 D  D  V  D  E  C  A  S  Q  P  C  Q  H  G  G  S  C  I  D  L         p.1140

          .         .         .         . | 22       .         .    g.26719
 GTGGCCCGCTATCTCTGCTCCTGTCCCCCAGGAACGCTGG | GGGTGCTCTGCGAGATTAAT    c.3480
 V  A  R  Y  L  C  S  C  P  P  G  T  L  G |   V  L  C  E  I  N      p.1160

          .         .         .         .         .         .       g.26779
 GAGGATGACTGCGGCCCAGGCCCACCGCTGGACTCAGGGCCCCGGTGCCTACACAATGGC       c.3540
 E  D  D  C  G  P  G  P  P  L  D  S  G  P  R  C  L  H  N  G         p.1180

          .         .         .         .         .         .       g.26839
 ACCTGCGTGGACCTGGTGGGTGGTTTCCGCTGCACCTGTCCCCCAGGATACACTGGTTTG       c.3600
 T  C  V  D  L  V  G  G  F  R  C  T  C  P  P  G  Y  T  G  L         p.1200

          .         .         .         .         .         .       g.26899
 CGCTGCGAGGCAGACATCAATGAGTGTCGCTCAGGTGCCTGCCACGCGGCACACACCCGG       c.3660
 R  C  E  A  D  I  N  E  C  R  S  G  A  C  H  A  A  H  T  R         p.1220

          .         .         .         .         .         | 23    g.27042
 GACTGCCTGCAGGACCCAGGCGGAGGTTTCCGTTGCCTTTGTCATGCTGGCTTCTCAG | GT    c.3720
 D  C  L  Q  D  P  G  G  G  F  R  C  L  C  H  A  G  F  S  G |       p.1240

          .         .         .         .         .         .       g.27102
 CCTCGCTGTCAGACTGTCCTGTCTCCCTGCGAGTCCCAGCCATGCCAGCATGGAGGCCAG       c.3780
 P  R  C  Q  T  V  L  S  P  C  E  S  Q  P  C  Q  H  G  G  Q         p.1260

          .         .         .         .         .        | 24.    g.27894
 TGCCGTCCTAGCCCGGGTCCTGGGGGTGGGCTGACCTTCACCTGTCACTGTGCCCAG | CCG    c.3840
 C  R  P  S  P  G  P  G  G  G  L  T  F  T  C  H  C  A  Q   | P      p.1280

          .         .         .         .         .         .       g.27954
 TTCTGGGGTCCGCGTTGCGAGCGGGTGGCGCGCTCCTGCCGGGAGCTGCAGTGCCCGGTG       c.3900
 F  W  G  P  R  C  E  R  V  A  R  S  C  R  E  L  Q  C  P  V         p.1300

          .         .         .         .         .         .       g.28014
 GGCGTCCCATGCCAGCAGACGCCCCGCGGGCCGCGCTGCGCCTGCCCCCCAGGGTTGTCG       c.3960
 G  V  P  C  Q  Q  T  P  R  G  P  R  C  A  C  P  P  G  L  S         p.1320

          .         .         .         .         .         .       g.28074
 GGACCCTCCTGCCGCAGCTTCCCGGGGTCGCCGCCGGGGGCCAGCAACGCCAGCTGCGCG       c.4020
 G  P  S  C  R  S  F  P  G  S  P  P  G  A  S  N  A  S  C  A         p.1340

          .         .         .         .         .         .       g.28134
 GCCGCCCCCTGTCTCCACGGGGGCTCCTGCCGCCCCGCGCCGCTCGCGCCCTTCTTCCGC       c.4080
 A  A  P  C  L  H  G  G  S  C  R  P  A  P  L  A  P  F  F  R         p.1360

          .         .         .         .         .         .       g.28194
 TGCGCTTGCGCGCAGGGCTGGACCGGGCCGCGCTGCGAGGCGCCCGCCGCGGCACCCGAG       c.4140
 C  A  C  A  Q  G  W  T  G  P  R  C  E  A  P  A  A  A  P  E         p.1380

          .         .         .         .         .         .       g.28254
 GTCTCGGAGGAGCCGCGGTGCCCGCGCGCCGCCTGCCAGGCCAAGCGCGGGGACCAGCGC       c.4200
 V  S  E  E  P  R  C  P  R  A  A  C  Q  A  K  R  G  D  Q  R         p.1400

          .         .         .         .         .         .       g.28314
 TGCGACCGCGAGTGCAACAGCCCAGGCTGCGGCTGGGACGGCGGCGACTGCTCGCTGAGC       c.4260
 C  D  R  E  C  N  S  P  G  C  G  W  D  G  G  D  C  S  L  S         p.1420

          .         .         .         .         .         .       g.28374
 GTGGGCGACCCCTGGCGGCAATGCGAGGCGCTGCAGTGCTGGCGCCTCTTCAACAACAGC       c.4320
 V  G  D  P  W  R  Q  C  E  A  L  Q  C  W  R  L  F  N  N  S         p.1440

          .         .         .         .         .         .       g.28434
 CGCTGCGACCCCGCCTGCAGCTCGCCCGCCTGCCTCTACGACAACTTCGACTGCCACGCC       c.4380
 R  C  D  P  A  C  S  S  P  A  C  L  Y  D  N  F  D  C  H  A         p.1460

          .         .    | 25    .         .         .         .    g.31618
 GGTGGCCGCGAGCGCACTTGCAA | CCCGGTGTACGAGAAGTACTGCGCCGACCACTTTGCC    c.4440
 G  G  R  E  R  T  C  N  |  P  V  Y  E  K  Y  C  A  D  H  F  A      p.1480

          .         .         .         .         .         .       g.31678
 GACGGCCGCTGCGACCAGGGCTGCAACACGGAGGAGTGCGGCTGGGATGGGCTGGATTGT       c.4500
 D  G  R  C  D  Q  G  C  N  T  E  E  C  G  W  D  G  L  D  C         p.1500

          .         .         .         .         .         .       g.31738
 GCCAGCGAGGTGCCGGCCCTGCTGGCCCGCGGCGTGCTGGTGCTCACAGTGCTGCTGCCG       c.4560
 A  S  E  V  P  A  L  L  A  R  G  V  L  V  L  T  V  L  L  P         p.1520

          .         .         .         .         .         .       g.31798
 CCAGAGGAGCTACTGCGTTCCAGCGCCGACTTTCTGCAGCGGCTCAGCGCCATCCTGCGC       c.4620
 P  E  E  L  L  R  S  S  A  D  F  L  Q  R  L  S  A  I  L  R         p.1540

          .         .         .         .         .         .       g.31858
 ACCTCGCTGCGCTTCCGCCTGGACGCGCACGGCCAGGCCATGGTCTTCCCTTACCACCGG       c.4680
 T  S  L  R  F  R  L  D  A  H  G  Q  A  M  V  F  P  Y  H  R         p.1560

          .         .         .         .         .       | 26 .    g.35160
 CCTAGTCCTGGCTCCGAACCCCGGGCCCGTCGGGAGCTGGCCCCCGAGGTGATCGG | CTCG    c.4740
 P  S  P  G  S  E  P  R  A  R  R  E  L  A  P  E  V  I  G  |  S      p.1580

          .         .         .         .         .         .       g.35220
 GTAGTAATGCTGGAGATTGACAACCGGCTCTGCCTGCAGTCGCCTGAGAATGATCACTGC       c.4800
 V  V  M  L  E  I  D  N  R  L  C  L  Q  S  P  E  N  D  H  C         p.1600

          .         .         .         .         .         .       g.35280
 TTCCCCGATGCCCAGAGCGCCGCTGACTACCTGGGAGCGTTGTCAGCGGTGGAGCGCCTG       c.4860
 F  P  D  A  Q  S  A  A  D  Y  L  G  A  L  S  A  V  E  R  L         p.1620

          .         .         .  | 27      .         .         .    g.35457
 GACTTCCCGTACCCACTGCGGGACGTGCGGG | GGGAGCCGCTGGAGCCTCCAGAACCCAGC    c.4920
 D  F  P  Y  P  L  R  D  V  R  G |   E  P  L  E  P  P  E  P  S      p.1640

          .         .         .         .         .         .       g.35517
 GTCCCGCTGCTGCCACTGCTAGTGGCGGGCGCTGTCTTGCTGCTGGTCATTCTCGTCCTG       c.4980
 V  P  L  L  P  L  L  V  A  G  A  V  L  L  L  V  I  L  V  L         p.1660

          .         .         .         .         .         .       g.35577
 GGTGTCATGGTGGCCCGGCGCAAGCGCGAGCACAGCACCCTCTGGTTCCCTGAGGGCTTC       c.5040
 G  V  M  V  A  R  R  K  R  E  H  S  T  L  W  F  P  E  G  F         p.1680

          .         .         .         .         .         .       g.35637
 TCACTGCACAAGGACGTGGCCTCTGGTCACAAGGGCCGGCGGGAACCCGTGGGCCAGGAC       c.5100
 S  L  H  K  D  V  A  S  G  H  K  G  R  R  E  P  V  G  Q  D         p.1700

          .     | 28   .         .         .         .         .    g.35857
 GCGCTGGGCATGAA | GAACATGGCCAAGGGTGAGAGCCTGATGGGGGAGGTGGCCACAGAC    c.5160
 A  L  G  M  K  |  N  M  A  K  G  E  S  L  M  G  E  V  A  T  D      p.1720

          .         .         .          | 29        .         .    g.38591
 TGGATGGACACAGAGTGCCCAGAGGCCAAGCGGCTAAAG | GTAGAGGAGCCAGGCATGGGG    c.5220
 W  M  D  T  E  C  P  E  A  K  R  L  K   | V  E  E  P  G  M  G      p.1740

          .         .         .         .         .         .       g.38651
 GCTGAGGAGGCTGTGGATTGCCGTCAGTGGACTCAACACCATCTGGTTGCTGCTGACATC       c.5280
 A  E  E  A  V  D  C  R  Q  W  T  Q  H  H  L  V  A  A  D  I         p.1760

          .         .         .         .         .         .       g.38711
 CGCGTGGCACCAGCCATGGCACTGACACCACCACAGGGCGACGCAGATGCTGATGGCATG       c.5340
 R  V  A  P  A  M  A  L  T  P  P  Q  G  D  A  D  A  D  G  M         p.1780

          .         .   | 30     .         .         .         .    g.39928
 GATGTCAATGTGCGTGGCCCAG | ATGGCTTCACCCCGCTAATGCTGGCTTCCTTCTGTGGG    c.5400
 D  V  N  V  R  G  P  D |   G  F  T  P  L  M  L  A  S  F  C  G      p.1800

          .         .         .         .         .         .       g.39988
 GGGGCTCTGGAGCCAATGCCAACTGAAGAGGATGAGGCAGATGACACATCAGCTAGCATC       c.5460
 G  A  L  E  P  M  P  T  E  E  D  E  A  D  D  T  S  A  S  I         p.1820

          .         .         .         .         .         .       g.40048
 ATCTCCGACCTGATCTGCCAGGGGGCTCAGCTTGGGGCACGGACTGACCGTACTGGCGAG       c.5520
 I  S  D  L  I  C  Q  G  A  Q  L  G  A  R  T  D  R  T  G  E         p.1840

          .         .         .         .         .         .       g.40108
 ACTGCTTTGCACCTGGCTGCCCGTTATGCCCGTGCTGATGCAGCCAAGCGGCTGCTGGAT       c.5580
 T  A  L  H  L  A  A  R  Y  A  R  A  D  A  A  K  R  L  L  D         p.1860

          .         .         .         .         .         .       g.40168
 GCTGGGGCAGACACCAATGCCCAGGACCACTCAGGCCGCACTCCCCTGCACACAGCTGTC       c.5640
 A  G  A  D  T  N  A  Q  D  H  S  G  R  T  P  L  H  T  A  V         p.1880

          .         .        | 31.         .         .         .    g.40499
 ACAGCCGATGCCCAGGGTGTCTTCCAG | ATTCTCATCCGAAACCGCTCTACAGACTTGGAT    c.5700
 T  A  D  A  Q  G  V  F  Q   | I  L  I  R  N  R  S  T  D  L  D      p.1900

          .         .         .         .         .         .       g.40559
 GCCCGCATGGCAGATGGCTCAACGGCACTGATCCTGGCGGCCCGCCTGGCAGTAGAGGGC       c.5760
 A  R  M  A  D  G  S  T  A  L  I  L  A  A  R  L  A  V  E  G         p.1920

          .         .         .         .         .      | 32  .    g.43424
 ATGGTGGAAGAGCTCATCGCCAGCCATGCTGATGTCAATGCTGTGGATGAGCTTG | GGAAA    c.5820
 M  V  E  E  L  I  A  S  H  A  D  V  N  A  V  D  E  L  G |   K      p.1940

          .         .         .         .         .         .       g.43484
 TCAGCCTTACACTGGGCTGCGGCTGTGAACAACGTGGAAGCCACTTTGGCCCTGCTCAAA       c.5880
 S  A  L  H  W  A  A  A  V  N  N  V  E  A  T  L  A  L  L  K         p.1960

          .         .         .    | 33    .         .         .    g.44294
 AATGGAGCCAATAAGGACATGCAGGATAGCAAG | GAGGAGACCCCCCTATTCCTGGCCGCC    c.5940
 N  G  A  N  K  D  M  Q  D  S  K   | E  E  T  P  L  F  L  A  A      p.1980

          .         .         .         .         .         .       g.44354
 CGCGAGGGCAGCTATGAGGCTGCCAAGCTGCTGTTGGACCACTTTGCCAACCGTGAGATC       c.6000
 R  E  G  S  Y  E  A  A  K  L  L  L  D  H  F  A  N  R  E  I         p.2000

          .         .         .         .         .         .       g.44414
 ACCGACCACCTGGACAGGCTGCCGCGGGACGTAGCCCAGGAGAGACTGCACCAGGACATC       c.6060
 T  D  H  L  D  R  L  P  R  D  V  A  Q  E  R  L  H  Q  D  I         p.2020

          .         .         .         .         .         .       g.44474
 GTGCGCTTGCTGGATCAACCCAGTGGGCCCCGCAGCCCCCCCGGTCCCCACGGCCTGGGG       c.6120
 V  R  L  L  D  Q  P  S  G  P  R  S  P  P  G  P  H  G  L  G         p.2040

          .         .         .         .         .         .       g.44534
 CCTCTGCTCTGTCCTCCAGGGGCCTTCCTCCCTGGCCTCAAAGCGGCACAGTCGGGGTCC       c.6180
 P  L  L  C  P  P  G  A  F  L  P  G  L  K  A  A  Q  S  G  S         p.2060

          .         .         .         .         .         .       g.44594
 AAGAAGAGCAGGAGGCCCCCCGGGAAGGCGGGGCTGGGGCCGCAGGGGCCCCGGGGGCGG       c.6240
 K  K  S  R  R  P  P  G  K  A  G  L  G  P  Q  G  P  R  G  R         p.2080

          .         .         .         .         .         .       g.44654
 GGCAAGAAGCTGACGCTGGCCTGCCCGGGCCCCCTGGCTGACAGCTCGGTCACGCTGTCG       c.6300
 G  K  K  L  T  L  A  C  P  G  P  L  A  D  S  S  V  T  L  S         p.2100

          .         .         .         .         .         .       g.44714
 CCCGTGGACTCGCTGGACTCCCCGCGGCCTTTCGGTGGGCCCCCTGCTTCCCCTGGTGGC       c.6360
 P  V  D  S  L  D  S  P  R  P  F  G  G  P  P  A  S  P  G  G         p.2120

          .         .         .         .         .         .       g.44774
 TTCCCCCTTGAGGGGCCCTATGCAGCTGCCACTGCCACTGCAGTGTCTCTGGCACAGCTT       c.6420
 F  P  L  E  G  P  Y  A  A  A  T  A  T  A  V  S  L  A  Q  L         p.2140

          .         .         .         .         .         .       g.44834
 GGTGGCCCAGGCCGGGCGGGTCTAGGGCGCCAGCCCCCTGGAGGATGTGTACTCAGCCTG       c.6480
 G  G  P  G  R  A  G  L  G  R  Q  P  P  G  G  C  V  L  S  L         p.2160

          .         .         .         .         .         .       g.44894
 GGCCTGCTGAACCCTGTGGCTGTGCCCCTCGATTGGGCCCGGCTGCCCCCACCTGCCCCT       c.6540
 G  L  L  N  P  V  A  V  P  L  D  W  A  R  L  P  P  P  A  P         p.2180

          .         .         .         .         .         .       g.44954
 CCAGGCCCCTCGTTCCTGCTGCCACTGGCGCCGGGACCCCAGCTGCTCAACCCAGGGACC       c.6600
 P  G  P  S  F  L  L  P  L  A  P  G  P  Q  L  L  N  P  G  T         p.2200

          .         .         .         .         .         .       g.45014
 CCCGTCTCCCCGCAGGAGCGGCCCCCGCCTTACCTGGCAGTCCCAGGACATGGCGAGGAG       c.6660
 P  V  S  P  Q  E  R  P  P  P  Y  L  A  V  P  G  H  G  E  E         p.2220

          .         .         .         .         .         .       g.45074
 TACCCGGCGGCTGGGGCACACAGCAGCCCCCCAAAGGCCCGCTTCCTGCGGGTTCCCAGT       c.6720
 Y  P  A  A  G  A  H  S  S  P  P  K  A  R  F  L  R  V  P  S         p.2240

          .         .         .         .         .         .       g.45134
 GAGCACCCTTACCTGACCCCATCCCCCGAATCCCCTGAGCACTGGGCCAGCCCCTCACCT       c.6780
 E  H  P  Y  L  T  P  S  P  E  S  P  E  H  W  A  S  P  S  P         p.2260

          .         .         .         .         .         .       g.45194
 CCCTCCCTCTCAGACTGGTCCGAATCCACGCCTAGCCCAGCCACTGCCACTGGGGCCATG       c.6840
 P  S  L  S  D  W  S  E  S  T  P  S  P  A  T  A  T  G  A  M         p.2280

          .         .         .         .         .         .       g.45254
 GCCACCACCACTGGGGCACTGCCTGCCCAGCCACTTCCCTTGTCTGTTCCCAGCTCCCTT       c.6900
 A  T  T  T  G  A  L  P  A  Q  P  L  P  L  S  V  P  S  S  L         p.2300

          .         .         .         .         .         .       g.45314
 GCTCAGGCCCAGACCCAGCTGGGGCCCCAGCCGGAAGTTACCCCCAAGAGGCAAGTGTTG       c.6960
 A  Q  A  Q  T  Q  L  G  P  Q  P  E  V  T  P  K  R  Q  V  L         p.2320

                                                                    g.45320
 GCCTGA                                                             c.6966
 A  X                                                               p.2321

          .         .         .         .         .         .       g.45380
 gacgctcgtcagttcttagatcttgggggcctaaagagacccccgtcctgcctcctttct       c.*60

          .         .         .         .         .         .       g.45440
 ttctctgtctcttccttccttttagtctttttcatcctcttctctttccaccaaccctcc       c.*120

          .         .         .         .         .         .       g.45500
 tgcatccttgccttgcagcgtgaccgagataggtcatcagcccagggcttcagtcttcct       c.*180

          .         .         .         .         .         .       g.45560
 ttatttataatgggtgggggctaccacccaccctctcagtcttgtgaagagtctgggacc       c.*240

          .         .         .         .         .         .       g.45620
 tccttcttccccacttctctcttccctcattcctttctctctccttctggcctctcattt       c.*300

          .         .         .         .         .         .       g.45680
 ccttacactctgacatgaatgaattattattatttttatttttctttttttttttacatt       c.*360

          .         .         .         .         .         .       g.45740
 ttgtatagaaacaaattcatttaaacaaacttattattattattttttacaaaatatata       c.*420

          .         .         .         .         .         .       g.45800
 tatggagatgctccctccccctgtgaaccccccagtgcccccgtggggctgagtctgtgg       c.*480

          .         .         .         .         .         .       g.45860
 gcccattcggccaagctggattctgtgtacctagtacacaggcatgactgggatcccgtg       c.*540

          .         .         .         .         .         .       g.45920
 taccgagtacacgacccaggtatgtaccaagtaggcacccttgggcgcacccactggggc       c.*600

          .         .         .         .         .         .       g.45980
 caggggtcgggggagtgttgggagcctcctccccaccccacctccctcacttcactgcat       c.*660

          .         .         .         .         .         .       g.46040
 tccagatgggacatgttccatagccttgctggggaagggcccactgccaactccctctgc       c.*720

          .         .         .         .         .         .       g.46100
 cccagccccacccttggccatctccctttgggaactagggggctgctggtgggaaatggg       c.*780

          .         .         .         .         .         .       g.46160
 agccagggcagatgtatgcattcctttgtgtccctgtaaatgtgggactacaagaagagg       c.*840

          .         .         .         .         .         .       g.46220
 agctgcctgagtggtactttctcttcctggtaatcctctggcccagcctcatggcagaat       c.*900

          .         .         .         .         .         .       g.46280
 agaggtatttttaggctatttttgtaatatggcttctggtcaaaatccctgtgtagctga       c.*960

          .         .         .         .         .         .       g.46340
 attcccaagccctgcattgtacagccccccactcccctcaccacctaataaaggaatagt       c.*1020

                                                                    g.46349
 taacactca                                                          c.*1029

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Notch 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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