nitrogen permease regulator-like 2 (S. cerevisiae) (NPRL2) - coding DNA reference sequence

(used for variant description)

(last modified November 8, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_006545.4 in the NPRL2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering NPRL2 transcript NM_006545.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  agcgtgaatcccttagcgcaccgcctccccaagtgctgccagc       c.-361

 .         .         .         .         .         .                g.5103
 atgctgcccctccacgctagggacttgcctgcctctgccgcagcgcagatctgatgcggt       c.-301

 .         .         .         .         .         .                g.5163
 ggtttcctccaaagaaagcgggatactccgggccctgccgcgcgcaccgccgctccgtca       c.-241

 .         .         .         .         .         .                g.5223
 cggagccgctttacttccgggtgcgacgtctacccacccaggacttcctgggacgagccg       c.-181

 .         .         .         .         .         .                g.5283
 tcccccgccccagccacgcctctgagtcgcgctgcgcaggcgccattgggcagagggatt       c.-121

 .         .         .         .         .         .                g.5343
 ggcaagcttgcgtgccccagcgacacaggcctcgaggctgtctctgacaagtgttcacag       c.-61

 .         .         .         .         .         .                g.5403
 gaggtggggacgcctctgcgcgaggaacgaggagctacgggcctgggcccggttattgcc       c.-1

          .         .         .         .         .         .       g.5463
 ATGGGCAGCGGCTGCCGCATCGAATGCATATTCTTCAGCGAGTTCCACCCCACGCTGGGA       c.60
 M  G  S  G  C  R  I  E  C  I  F  F  S  E  F  H  P  T  L  G         p.20

          .         | 02         .         .         .         .    g.6075
 CCCAAGATCACCTATCAG | GTCCCTGAAGACTTCATCTCCCGAGAGCTGTTTGACACAGTC    c.120
 P  K  I  T  Y  Q   | V  P  E  D  F  I  S  R  E  L  F  D  T  V      p.40

          .         .         .         .         . | 03       .    g.6232
 CAAGTGTACATCATCACCAAGCCAGAGCTGCAGAACAAGCTTATCACTGT | CACAGCTATG    c.180
 Q  V  Y  I  I  T  K  P  E  L  Q  N  K  L  I  T  V  |  T  A  M      p.60

          .         .         .         .         .         .       g.6292
 GAAAAGAAGCTGATCGGCTGTCCTGTGTGCATCGAACACAAGAAGTACAGCCGCAATGCT       c.240
 E  K  K  L  I  G  C  P  V  C  I  E  H  K  K  Y  S  R  N  A         p.80

          .         .         .         .         .         .       g.6352
 CTCCTCTTCAACCTGGGCTTCGTGTGTGATGCCCAGGCCAAGACCTGCGCCCTCGAGCCC       c.300
 L  L  F  N  L  G  F  V  C  D  A  Q  A  K  T  C  A  L  E  P         p.100

          .         .         .          | 04        .         .    g.6582
 ATTGTTAAAAAGCTGGCTGGCTATCTGACCACACTAGAG | CTAGAGAGCAGCTTCGTGTCC    c.360
 I  V  K  K  L  A  G  Y  L  T  T  L  E   | L  E  S  S  F  V  S      p.120

          .         .         .         .         .         .       g.6642
 ATGGAGGAGAGCAAGCAGAAGTTGGTGCCCATCATGACCATCTTGCTGGAGGAGCTAAAT       c.420
 M  E  E  S  K  Q  K  L  V  P  I  M  T  I  L  L  E  E  L  N         p.140

          .         .         | 05         .         .         .    g.7077
 GCCTCAGGCCGGTGCACTCTGCCCATTG | ATGAGTCCAACACCATCCACTTGAAGGTGATT    c.480
 A  S  G  R  C  T  L  P  I  D |   E  S  N  T  I  H  L  K  V  I      p.160

          .         .         .         .         .         .       g.7137
 GAGCAGCGGCCAGACCCTCCGGTGGCCCAGGAGTATGATGTACCTGTCTTTACCAAAGAC       c.540
 E  Q  R  P  D  P  P  V  A  Q  E  Y  D  V  P  V  F  T  K  D         p.180

          .         .         .         .      | 06  .         .    g.7288
 AAGGAGGATTTCTTCAACTCACAGTGGGACCTCACTACACAACAA | ATCCTGCCCTACATT    c.600
 K  E  D  F  F  N  S  Q  W  D  L  T  T  Q  Q   | I  L  P  Y  I      p.200

          .         .         .         .         .         .       g.7348
 GATGGGTTCCGCCACATCCAGAAGATTTCAGCAGAGGCAGATGTGGAGCTCAACCTGGTG       c.660
 D  G  F  R  H  I  Q  K  I  S  A  E  A  D  V  E  L  N  L  V         p.220

          .         .    | 07    .         .         .         .    g.7529
 CGCATTGCTATCCAGAACCTGCT | GTACTACGGCGTTGTGACACTGGTGTCCATCCTCCAG    c.720
 R  I  A  I  Q  N  L  L  |  Y  Y  G  V  V  T  L  V  S  I  L  Q      p.240

  | 08       .         .         .         .         .         .    g.7705
  | TACTCCAATGTATACTGCCCAACGCCCAAGGTCCAGGACCTGGTAGATGACAAGTCCCTG    c.780
  | Y  S  N  V  Y  C  P  T  P  K  V  Q  D  L  V  D  D  K  S  L      p.260

          .         .         .     | 09   .         .         .    g.7840
 CAAGAGGCATGTCTATCCTACGTGACCAAGCAAG | GGCACAAGAGGGCCAGTCTCCGGGAT    c.840
 Q  E  A  C  L  S  Y  V  T  K  Q  G |   H  K  R  A  S  L  R  D      p.280

          .         .         .         .         .         .       g.7900
 GTGTTCCAGCTATACTGCAGCCTGAGCCCTGGCACTACCGTGCGAGACCTCATTGGCCGC       c.900
 V  F  Q  L  Y  C  S  L  S  P  G  T  T  V  R  D  L  I  G  R         p.300

          .         .         .   | 10     .         .         .    g.8182
 CACCCCCAGCAGCTGCAGCATGTTGATGAACG | GAAGCTGATCCAGTTCGGGCTTATGAAG    c.960
 H  P  Q  Q  L  Q  H  V  D  E  R  |  K  L  I  Q  F  G  L  M  K      p.320

          .         .         .         .         .         .       g.8242
 AACCTCATCAGGCGACTACAGAAGTATCCTGTGCGGGTGACTCGGGAAGAGCAGAGCCAC       c.1020
 N  L  I  R  R  L  Q  K  Y  P  V  R  V  T  R  E  E  Q  S  H         p.340

          .         .         .         .         .      | 11  .    g.8387
 CCTGCCCGGCTTTATACAGGCTGCCACAGCTATGACGAGATCTGCTGCAAGACAG | GCATG    c.1080
 P  A  R  L  Y  T  G  C  H  S  Y  D  E  I  C  C  K  T  G |   M      p.360

          .         .         .         .         .         .       g.8447
 AGCTACCATGAGCTGGATGAGCGGCTTGAAAATGACCCCAACATCATCATCTGCTGGAAG       c.1140
 S  Y  H  E  L  D  E  R  L  E  N  D  P  N  I  I  I  C  W  K         p.380

                                                                    g.8450
 TGA                                                                c.1143
 X                                                                  p.380

          .         .         .         .         .         .       g.8510
 ggctggtagtgactggatggacacattgctgtgggtagtccctcctactaggaggcttgt       c.*60

          .         .         .         .         .                 g.8568
 catactgtctagaggttgactcttagttctgtaaataaagacatccatttcaaacagc         c.*118

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nitrogen permease regulator-like 2 (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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