neuropeptide S receptor 1 (NPSR1) - coding DNA reference sequence

(used for variant description)

(last modified November 4, 2019)

This file was created to facilitate the description of sequence variants on transcript NM_207173.1 in the NPSR1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012185.2, covering NPSR1 transcript NM_207173.1.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.5008
                                                     gggctcag       c.-121

 .         .         .         .         .         .                g.5068
 ggagggctctgtgcctccgttcagcagagctgcagctgctgcccagctctcaggaggcaa       c.-61

 .         .         .         .         .         .                g.5128
 gctggactccctcactcagctgcaggagcaaggacagtgaggctcaaccccgcctgagcc       c.-1

          .         .         .         .         .         .       g.5188
 ATGCCAGCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGACGCTGGAT       c.60
 M  P  A  N  F  T  E  G  S  F  D  S  S  G  T  G  Q  T  L  D         p.20

          .         .         .         .         .         .       g.5248
 TCTTCCCCAGTGGCTTGCACTGAAACAGTGACTTTTACTGAAGTGGTGGAAGGAAAGGAA       c.120
 S  S  P  V  A  C  T  E  T  V  T  F  T  E  V  V  E  G  K  E         p.40

          .         .        | 02.         .         .         .    g.31300
 TGGGGTTCCTTCTACTACTCCTTTAAG | ACTGAGCAATTGATAACTCTGTGGGTCCTCTTT    c.180
 W  G  S  F  Y  Y  S  F  K   | T  E  Q  L  I  T  L  W  V  L  F      p.60

          .         .         .         .         .         .       g.31360
 GTTTTTACCATTGTTGGAAACTCCGTTGTGCTTTTTTCCACATGGAGGAGAAAGAAGAAG       c.240
 V  F  T  I  V  G  N  S  V  V  L  F  S  T  W  R  R  K  K  K         p.80

          .         .         .         . | 03       .         .    g.125197
 TCAAGAATGACCTTCTTTGTGACTCAGCTGGCCATCACAG | ATTCTTTCACAGGACTGGTC    c.300
 S  R  M  T  F  F  V  T  Q  L  A  I  T  D |   S  F  T  G  L  V      p.100

          .         .         .         .         .         .       g.125257
 AACATCTTGACAGATATTAATTGGCGATTCACTGGAGACTTCACGGCACCTGACCTGGTT       c.360
 N  I  L  T  D  I  N  W  R  F  T  G  D  F  T  A  P  D  L  V         p.120

          .         .     | 04   .         .         .         .    g.158521
 TGCCGAGTGGTCCGCTATTTGCAG | GTTGTGCTGCTCTACGCCTCTACCTACGTCCTGGTG    c.420
 C  R  V  V  R  Y  L  Q   | V  V  L  L  Y  A  S  T  Y  V  L  V      p.140

          .         .         .         .         .         | 05    g.174118
 TCCCTCAGCATAGACAGATACCATGCCATCGTCTACCCCATGAAGTTCCTTCAAGGAG | AA    c.480
 S  L  S  I  D  R  Y  H  A  I  V  Y  P  M  K  F  L  Q  G  E |       p.160

          .         .         .         .         .         .       g.174178
 AAGCAAGCCAGGGTCCTCATTGTGATCGCCTGGAGCCTGTCTTTTCTGTTCTCCATTCCC       c.540
 K  Q  A  R  V  L  I  V  I  A  W  S  L  S  F  L  F  S  I  P         p.180

          .         .         .         .         .         .       g.174238
 ACCCTGATCATATTTGGGAAGAGGACACTGTCCAACGGTGAAGTGCAGTGCTGGGCCCTG       c.600
 T  L  I  I  F  G  K  R  T  L  S  N  G  E  V  Q  C  W  A  L         p.200

          .         .         .         .         .         .       g.174298
 TGGCCTGACGACTCCTACTGGACCCCATACATGACCATCGTGGCCTTCCTGGTGTACTTC       c.660
 W  P  D  D  S  Y  W  T  P  Y  M  T  I  V  A  F  L  V  Y  F         p.220

          .         . | 06       .         .         .         .    g.181139
 ATCCCTCTGACAATCATCAG | CATCATGTATGGCATTGTGATCCGAACTATTTGGATTAAA    c.720
 I  P  L  T  I  I  S  |  I  M  Y  G  I  V  I  R  T  I  W  I  K      p.240

          .         .         .        | 07.         .         .    g.191634
 AGCAAAACCTACGAAACAGTGATTTCCAACTGCTCAG | ATGGGAAACTGTGCAGCAGCTAT    c.780
 S  K  T  Y  E  T  V  I  S  N  C  S  D |   G  K  L  C  S  S  Y      p.260

          .         .         .         .         .         .       g.191694
 AACCGAGGACTCATCTCAAAGGCAAAAATCAAGGCTATCAAGTATAGCATCATCATCATT       c.840
 N  R  G  L  I  S  K  A  K  I  K  A  I  K  Y  S  I  I  I  I         p.280

      | 08   .         .         .         .         .         .    g.195254
 CTTG | CCTTCATCTGCTGTTGGAGTCCATACTTCCTGTTTGACATTTTGGACAATTTCAAC    c.900
 L  A |   F  I  C  C  W  S  P  Y  F  L  F  D  I  L  D  N  F  N      p.300

          .         .         .         .         .         .       g.195314
 CTCCTTCCAGACACCCAGGAGCGTTTCTATGCCTCTGTGATCATTCAGAACCTGCCAGCA       c.960
 L  L  P  D  T  Q  E  R  F  Y  A  S  V  I  I  Q  N  L  P  A         p.320

          .         .         .         .         .         .       g.195374
 TTGAATAGTGCCATCAACCCCCTCATCTACTGTGTCTTCAGCAGCTCCATCTCTTTCCCC       c.1020
 L  N  S  A  I  N  P  L  I  Y  C  V  F  S  S  S  I  S  F  P         p.340

       | 09  .         .         .         .         .         .    g.224846
 TGCAG | GGTCATCCGTCTCCGTCAGCTCCAGGAGGCTGCGCTAATGCTCTGCCCTCAACGA    c.1080
 C  R  |  V  I  R  L  R  Q  L  Q  E  A  A  L  M  L  C  P  Q  R      p.360

          .         .         .         .         .                 g.224900
 GAGAACTGGAAGGGTACTTGGCCAGGTGTACCTTCCTGGGCTCTTCCAAGGTGA             c.1134
 E  N  W  K  G  T  W  P  G  V  P  S  W  A  L  P  R  X               p.377

          .         .         .         .         .         .       g.224960
 cagctctcaccctgtgctgcaggtggccctgtgcctggtgccacttctcactgcttacca       c.*60

          .         .         .         .         .         .       g.225020
 gggcacaaggacaccagtggttcccaaaatgggtcacagcaggatggcctgcatcagatt       c.*120

          .         .                                               g.225048
 caccagggagggctataagaaggcagac                                       c.*148

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Neuropeptide S receptor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.