nuclear receptor subfamily 1, group H, member 4 (NR1H4) - coding DNA reference sequence

(used for variant description)

(last modified May 30, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_001206977.1 in the NR1H4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029843.1, covering NR1H4 transcript NM_001206977.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  tctatgtttatatcatttagcagggaaggattgttaatgacta       c.-601

 .         .         .         .         .         .                g.5103
 atctgtgtccatgaggcacagagccaaggaagagatgctgctgctagcccagaaggccgc       c.-541

 .         .         .         .         .         .                g.5163
 ctgtgatcatgcacagtacactggaactctctcctcctcctcacctcattgtctccccga       c.-481

 .         .         .         .         .         .                g.5223
 cttatcctaatgcgaaattggattctgagcatttgtagcaaaatcgctgggatctggaga       c.-421

 .         .         .         .         .         .                g.5283
 ggaagactcagtccagaatcctcccagggccttgaaagtccatctctgacccaaaacaat       c.-361

 .    | 02    .         .         .         .         .             g.22099
 ccaa | actttagctctgtcgtccaggctggaatgcagtggcatgatcagagttcactgcag    c.-301

 .         .         .         .         .         .                g.22159
 cctcgacctcccaggctcaagtgatcctcctgcttcaacttcccaagtagcttggctggg       c.-241

 .         .         .         .         .         . | 03           g.23739
 actacaggtgtgcatcaccatgcccagctaatttttaaatttttattagag | ggaggtaga    c.-181

 .         .         .         .         .         .                g.23799
 agacatcgtagaaggagtgaaagaagaaaagaagacttagaaacatagctcaaagtgaac       c.-121

 .         .         .         .         .         .                g.23859
 actgcttctcttagtttcctggatttcttctggacatttcctcaagatgaaacttcagac       c.-61

 .      | 04  .         .         .         .         .             g.24551
 actttg | gagttttttttgaagaccaccataaagaaagtgcatttcaattgaaaaatttgg    c.-1

          .         .         .         .         .         .       g.24611
 ATGGGATCAAAAATGAATCTCATTGAACATTCCCATTTACCTACCACAGATGAATTTTCT       c.60
 M  G  S  K  M  N  L  I  E  H  S  H  L  P  T  T  D  E  F  S         p.20

          .          | 05        .         .         .         .    g.42046
 TTTTCTGAAAATTTATTTG | GTGTTTTAACAGAACAAGTGGCAGGTCCTCTGGGACAGAAC    c.120
 F  S  E  N  L  F  G |   V  L  T  E  Q  V  A  G  P  L  G  Q  N      p.40

          .         .         .         .         .         .       g.42106
 CTGGAAGTGGAACCATACTCGCAATACAGCAATGTTCAGTTTCCCCAAGTTCAACCACAG       c.180
 L  E  V  E  P  Y  S  Q  Y  S  N  V  Q  F  P  Q  V  Q  P  Q         p.60

          .         .         .         .         .         .       g.42166
 ATTTCCTCGTCATCCTATTATTCCAACCTGGGTTTCTACCCCCAGCAGCCTGAAGAGTGG       c.240
 I  S  S  S  S  Y  Y  S  N  L  G  F  Y  P  Q  Q  P  E  E  W         p.80

          .         .         .         .         .         .       g.42226
 TACTCTCCTGGAATATATGAACTCAGGCGTATGCCAGCTGAGACTCTCTACCAGGGAGAA       c.300
 Y  S  P  G  I  Y  E  L  R  R  M  P  A  E  T  L  Y  Q  G  E         p.100

          .         .         .         .         .         .       g.42286
 ACTGAGGTAGCAGAGATGCCTGTAACAAAGAAGCCCCGCATGGGCGCGTCAGCAGGGAGG       c.360
 T  E  V  A  E  M  P  V  T  K  K  P  R  M  G  A  S  A  G  R         p.120

          .         .         .         .         .         .       g.42346
 ATCAAAGGGGATGAGCTGTGTGTTGTTTGTGGAGACAGAGCCTCTGGATACCACTATAAT       c.420
 I  K  G  D  E  L  C  V  V  C  G  D  R  A  S  G  Y  H  Y  N         p.140

          .         .      | 06  .         .         .         .    g.63720
 GCACTGACCTGTGAGGGGTGTAAAG | GTTTCTTCAGGAGAAGCATTACCAAAAACGCTGTG    c.480
 A  L  T  C  E  G  C  K  G |   F  F  R  R  S  I  T  K  N  A  V      p.160

          .         .         .         .         .         .       g.63780
 TACAAGTGTAAAAACGGGGGCAACTGTGTGATGGATATGTACATGCGAAGAAAGTGTCAA       c.540
 Y  K  C  K  N  G  G  N  C  V  M  D  M  Y  M  R  R  K  C  Q         p.180

          .         .         .         .         .         | 07    g.66119
 GAGTGTCGACTAAGGAAATGCAAAGAGATGGGAATGTTGGCTGAATGTATGTATACAG | GC    c.600
 E  C  R  L  R  K  C  K  E  M  G  M  L  A  E  C  M  Y  T  G |       p.200

          .         .         .         .         .         .       g.66179
 TTGTTAACTGAAATTCAGTGTAAATCTAAGCGACTGAGAAAAAATGTGAAGCAGCATGCA       c.660
 L  L  T  E  I  Q  C  K  S  K  R  L  R  K  N  V  K  Q  H  A         p.220

          .         .         .         .         .         .       g.66239
 GATCAGACCGTGAATGAAGACAGTGAAGGTCGTGACTTGCGACAAGTGACCTCGACAACA       c.720
 D  Q  T  V  N  E  D  S  E  G  R  D  L  R  Q  V  T  S  T  T         p.240

          .   | 08     .         .         .         .         .    g.67787
 AAGTCATGCAGG | GAGAAAACTGAACTCACCCCAGATCAACAGACTCTTCTACATTTTATT    c.780
 K  S  C  R   | E  K  T  E  L  T  P  D  Q  Q  T  L  L  H  F  I      p.260

          .         .         .         .         .  | 09      .    g.68184
 ATGGATTCATATAACAAACAGAGGATGCCTCAGGAAATAACAAATAAAATT | TTAAAAGAA    c.840
 M  D  S  Y  N  K  Q  R  M  P  Q  E  I  T  N  K  I   | L  K  E      p.280

          .         .         .         .         .         .       g.68244
 GAATTCAGTGCAGAAGAAAATTTTCTCATTTTGACGGAAATGGCAACCAATCATGTACAG       c.900
 E  F  S  A  E  E  N  F  L  I  L  T  E  M  A  T  N  H  V  Q         p.300

          .         .         .  | 10      .         .         .    g.71928
 GTTCTTGTAGAATTCACAAAAAAGCTACCAG | GATTTCAGACTTTGGACCATGAAGACCAG    c.960
 V  L  V  E  F  T  K  K  L  P  G |   F  Q  T  L  D  H  E  D  Q      p.320

          .         .         .         .         .         .       g.71988
 ATTGCTTTGCTGAAAGGGTCTGCGGTTGAAGCTATGTTCCTTCGTTCAGCTGAGATTTTC       c.1020
 I  A  L  L  K  G  S  A  V  E  A  M  F  L  R  S  A  E  I  F         p.340

          .         .         .         .         .         | 11    g.93114
 AATAAGAAACTTCCGTCTGGGCATTCTGACCTATTGGAAGAAAGAATTCGAAATAGTG | GT    c.1080
 N  K  K  L  P  S  G  H  S  D  L  L  E  E  R  I  R  N  S  G |       p.360

          .         .         .         .         .         .       g.93174
 ATCTCTGATGAATATATAACACCTATGTTTAGTTTTTATAAAAGTATTGGGGAACTGAAA       c.1140
 I  S  D  E  Y  I  T  P  M  F  S  F  Y  K  S  I  G  E  L  K         p.380

          .         .         .         .         .   | 12     .    g.94486
 ATGACTCAAGAGGAGTATGCTCTGCTTACAGCAATTGTTATCCTGTCTCCAG | ATAGACAA    c.1200
 M  T  Q  E  E  Y  A  L  L  T  A  I  V  I  L  S  P  D |   R  Q      p.400

          .         .         .         .         .         .       g.94546
 TACATAAAGGATAGAGAGGCAGTAGAGAAGCTTCAGGAGCCACTTCTTGATGTGCTACAA       c.1260
 Y  I  K  D  R  E  A  V  E  K  L  Q  E  P  L  L  D  V  L  Q         p.420

          .         .         .         .         .         .       g.94606
 AAGTTGTGTAAGATTCACCAGCCTGAAAATCCTCAACACTTTGCCTGTCTCCTGGGTCGC       c.1320
 K  L  C  K  I  H  Q  P  E  N  P  Q  H  F  A  C  L  L  G  R         p.440

          .         .         .         .         .         .       g.94666
 CTGACTGAATTACGGACATTCAATCATCACCACGCTGAGATGCTGATGTCATGGAGAGTA       c.1380
 L  T  E  L  R  T  F  N  H  H  H  A  E  M  L  M  S  W  R  V         p.460

          .         .         .         .         .                 g.94717
 AACGACCACAAGTTTACCCCACTTCTCTGTGAAATCTGGGACGTGCAGTGA                c.1431
 N  D  H  K  F  T  P  L  L  C  E  I  W  D  V  Q  X                  p.476

          .         .         .         .         .         .       g.94777
 tggggattacaggggaggggtctagctcctttttctctctcatattaatctgatgtataa       c.*60

          .         .         .         .         .         .       g.94837
 ctttcctttatttcacttgtacccagtttcactcaagaaatcttgatgaatatttatgtt       c.*120

          .         .         .         .         .         .       g.94897
 gtaattacatgtgtaacttccacaactgtaaatattgggctagatagaacaactttctct       c.*180

          .         .         .         .         .         .       g.94957
 acattgtgttttaaaaggctccagggaatcctgcattctaattggcaagccctgtttgcc       c.*240

          .         .         .         .         .         .       g.95017
 taattaaattgattgttacttcaattctatctgttgaactagggaaaatctcattttgct       c.*300

          .         .         .         .         .         .       g.95077
 catcttaccatattgcatatattttattaaagagttgtattcaatcttggcaataaagca       c.*360

          .                                                         g.95095
 aacataatggcaacagga                                                 c.*378

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nuclear receptor subfamily 1, group H, member 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 21
©2004-2018 Leiden University Medical Center