nuclear receptor subfamily 4, group A, member 2 (NR4A2) - coding DNA reference sequence

(used for variant description)

(last modified December 21, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_006186.3 in the NR4A2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering NR4A2 transcript NM_006186.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5002
                                                           gc       c.-421

 .         .         .         .         .         .                g.5062
 tgacgcgcgctgacgcgcggagactttaggtgcatgttggcagcggcagcgcaagccaca       c.-361

 .         .         .         .         .         .                g.5122
 taaacaaaggcacattggcggccagggccagtccgcccggcggctcgcgcacggctccgc       c.-301

 .         .         .         .         .         .                g.5182
 ggtcccttttgcctgtccagccggccgcctgtccctgctccctccctccgtgaggtgtcc       c.-241

 .         .         .         .         .         .                g.5242
 gggttcccttcgcccagctctcccacccctacccgaccccggcgcccgggctcccagagg       c.-181

 .         .         .         .         .         .    | 02        g.6990
 gaactgcacttcggcagagttgaatgaatgaagacagacgcggagaactcctaa | ggagga    c.-121

 .         .         .         .         .         .                g.7050
 gattggacaggctggactccccattgcttttctaaaaatcttggaaactttgtccttcat       c.-61

 .         .         .         .         .         .        | 03    g.7589
 tgaattacgacactgtccacctttaatttcctcgaaaacgcctgtaactcggctgaag | cc    c.-1

          .         .         .         .         .         .       g.7649
 ATGCCTTGTGTTCAGGCGCAGTATGGGTCCTCGCCTCAAGGAGCCAGCCCCGCTTCTCAG       c.60
 M  P  C  V  Q  A  Q  Y  G  S  S  P  Q  G  A  S  P  A  S  Q         p.20

          .         .         .         .         .         .       g.7709
 AGCTACAGTTACCACTCTTCGGGAGAATACAGCTCCGATTTCTTAACTCCAGAGTTTGTC       c.120
 S  Y  S  Y  H  S  S  G  E  Y  S  S  D  F  L  T  P  E  F  V         p.40

          .         .         .         .         .         .       g.7769
 AAGTTTAGCATGGACCTCACCAACACTGAAATCACTGCCACCACTTCTCTCCCCAGCTTC       c.180
 K  F  S  M  D  L  T  N  T  E  I  T  A  T  T  S  L  P  S  F         p.60

          .         .         .         .         .         .       g.7829
 AGTACCTTTATGGACAACTACAGCACAGGCTACGACGTCAAGCCACCTTGCTTGTACCAA       c.240
 S  T  F  M  D  N  Y  S  T  G  Y  D  V  K  P  P  C  L  Y  Q         p.80

          .         .         .         .         .         .       g.7889
 ATGCCCCTGTCCGGACAGCAGTCCTCCATTAAGGTAGAAGACATTCAGATGCACAACTAC       c.300
 M  P  L  S  G  Q  Q  S  S  I  K  V  E  D  I  Q  M  H  N  Y         p.100

          .         .         .         .         .         .       g.7949
 CAGCAACACAGCCACCTGCCCCCCCAGTCTGAGGAGATGATGCCGCACTCCGGGTCGGTT       c.360
 Q  Q  H  S  H  L  P  P  Q  S  E  E  M  M  P  H  S  G  S  V         p.120

          .         .         .         .         .         .       g.8009
 TACTACAAGCCCTCCTCGCCCCCGACGCCCACCACCCCGGGCTTCCAGGTGCAGCACAGC       c.420
 Y  Y  K  P  S  S  P  P  T  P  T  T  P  G  F  Q  V  Q  H  S         p.140

          .         .         .         .         .         .       g.8069
 CCCATGTGGGACGACCCGGGATCTCTCCACAACTTCCACCAGAACTACGTGGCCACTACG       c.480
 P  M  W  D  D  P  G  S  L  H  N  F  H  Q  N  Y  V  A  T  T         p.160

          .         .         .         .         .         .       g.8129
 CACATGATCGAGCAGAGGAAAACGCCAGTCTCCCGCCTCTCCCTCTTCTCCTTTAAGCAA       c.540
 H  M  I  E  Q  R  K  T  P  V  S  R  L  S  L  F  S  F  K  Q         p.180

          .         .         .         .         .         .       g.8189
 TCGCCCCCTGGCACCCCGGTGTCTAGTTGCCAGATGCGCTTCGACGGGCCCCTGCACGTC       c.600
 S  P  P  G  T  P  V  S  S  C  Q  M  R  F  D  G  P  L  H  V         p.200

          .         .         .         .         .         .       g.8249
 CCCATGAACCCGGAGCCCGCCGGCAGCCACCACGTGGTGGACGGGCAGACCTTCGCTGTG       c.660
 P  M  N  P  E  P  A  G  S  H  H  V  V  D  G  Q  T  F  A  V         p.220

          .         .         .         .         .         .       g.8309
 CCCAACCCCATTCGCAAGCCCGCGTCCATGGGCTTCCCGGGCCTGCAGATCGGCCACGCG       c.720
 P  N  P  I  R  K  P  A  S  M  G  F  P  G  L  Q  I  G  H  A         p.240

          .         .         .         .         .         .       g.8369
 TCTCAGCTGCTCGACACGCAGGTGCCCTCACCGCCGTCGCGGGGCTCCCCCTCCAACGAG       c.780
 S  Q  L  L  D  T  Q  V  P  S  P  P  S  R  G  S  P  S  N  E         p.260

          .         .         .         .         .         .       g.8429
 GGGCTGTGCGCTGTGTGTGGGGACAACGCGGCCTGCCAACACTACGGCGTGCGCACCTGT       c.840
 G  L  C  A  V  C  G  D  N  A  A  C  Q  H  Y  G  V  R  T  C         p.280

          .         .     | 04   .         .         .         .    g.9278
 GAGGGCTGCAAAGGCTTCTTTAAG | CGCACAGTGCAAAAAAATGCAAAATACGTGTGTTTA    c.900
 E  G  C  K  G  F  F  K   | R  T  V  Q  K  N  A  K  Y  V  C  L      p.300

          .         .         .         .         .         .       g.9338
 GCAAATAAAAACTGCCCAGTGGACAAGCGTCGCCGGAATCGCTGTCAGTACTGCCGATTT       c.960
 A  N  K  N  C  P  V  D  K  R  R  R  N  R  C  Q  Y  C  R  F         p.320

          .         .         .     | 05   .         .         .    g.9787
 CAGAAGTGCCTGGCTGTTGGGATGGTCAAAGAAG | TGGTTCGCACAGACAGTTTAAAAGGC    c.1020
 Q  K  C  L  A  V  G  M  V  K  E  V |   V  R  T  D  S  L  K  G      p.340

          .         .         .         .         .         .       g.9847
 CGGAGAGGTCGTTTGCCCTCGAAACCGAAGAGCCCACAGGAGCCCTCTCCCCCTTCGCCC       c.1080
 R  R  G  R  L  P  S  K  P  K  S  P  Q  E  P  S  P  P  S  P         p.360

          .         .         .         .         .         .       g.9907
 CCGGTGAGTCTGATCAGTGCCCTCGTCAGGGCCCATGTCGACTCCAACCCGGCTATGACC       c.1140
 P  V  S  L  I  S  A  L  V  R  A  H  V  D  S  N  P  A  M  T         p.380

          .         | 06         .         .         .         .    g.10897
 AGCCTGGACTATTCCAGG | TTCCAGGCGAACCCTGACTATCAAATGAGTGGAGATGACACC    c.1200
 S  L  D  Y  S  R   | F  Q  A  N  P  D  Y  Q  M  S  G  D  D  T      p.400

          .         .         .         .         .         .       g.10957
 CAGCATATCCAGCAATTCTATGATCTCCTGACTGGCTCCATGGAGATCATCCGGGGCTGG       c.1260
 Q  H  I  Q  Q  F  Y  D  L  L  T  G  S  M  E  I  I  R  G  W         p.420

          .         .         .         .         .         .       g.11017
 GCAGAGAAGATCCCTGGCTTCGCAGACCTGCCCAAAGCCGACCAAGACCTGCTTTTTGAA       c.1320
 A  E  K  I  P  G  F  A  D  L  P  K  A  D  Q  D  L  L  F  E         p.440

          .         .         .         .  | 07      .         .    g.11466
 TCAGCTTTCTTAGAACTGTTTGTCCTTCGATTAGCATACAG | GTCCAACCCAGTGGAGGGT    c.1380
 S  A  F  L  E  L  F  V  L  R  L  A  Y  R  |  S  N  P  V  E  G      p.460

          .         .         .         .         .         .       g.11526
 AAACTCATCTTTTGCAATGGGGTGGTCTTGCACAGGTTGCAATGCGTTCGTGGCTTTGGG       c.1440
 K  L  I  F  C  N  G  V  V  L  H  R  L  Q  C  V  R  G  F  G         p.480

          .         .         .         .         .         .       g.11586
 GAATGGATTGATTCCATTGTTGAATTCTCCTCCAACTTGCAGAATATGAACATCGACATT       c.1500
 E  W  I  D  S  I  V  E  F  S  S  N  L  Q  N  M  N  I  D  I         p.500

          .         .         .         . | 08       .         .    g.11795
 TCTGCCTTCTCCTGCATTGCTGCCCTGGCTATGGTCACAG | AGAGACACGGGCTCAAGGAA    c.1560
 S  A  F  S  C  I  A  A  L  A  M  V  T  E |   R  H  G  L  K  E      p.520

          .         .         .         .         .         .       g.11855
 CCCAAGAGAGTGGAAGAACTGCAAAACAAGATTGTAAATTGTCTCAAAGACCACGTGACT       c.1620
 P  K  R  V  E  E  L  Q  N  K  I  V  N  C  L  K  D  H  V  T         p.540

          .         .         .         .         .         .       g.11915
 TTCAACAATGGGGGGTTGAACCGCCCCAATTATTTGTCCAAACTGTTGGGGAAGCTCCCA       c.1680
 F  N  N  G  G  L  N  R  P  N  Y  L  S  K  L  L  G  K  L  P         p.560

          .         .         .         .         .         .       g.11975
 GAACTTCGTACCCTTTGCACACAGGGGCTACAGCGCATTTTCTACCTGAAATTGGAAGAC       c.1740
 E  L  R  T  L  C  T  Q  G  L  Q  R  I  F  Y  L  K  L  E  D         p.580

          .         .         .         .         .                 g.12032
 TTGGTGCCACCGCCAGCAATAATTGACAAACTTTTCCTGGACACTTTACCTTTCTAA          c.1797
 L  V  P  P  P  A  I  I  D  K  L  F  L  D  T  L  P  F  X            p.598

          .         .         .         .         .         .       g.12092
 gacctcctcccaagcacttcaaaggaactggaatgataatggaaactgtcaagagggggc       c.*60

          .         .         .         .         .         .       g.12152
 aagtcacatgggcagagatagccgtgtgagcagtctcagctcaagctgccccccatttct       c.*120

          .         .         .         .         .         .       g.12212
 gtaaccctcctagcccccttgatccctaaagaaaacaaacaaacaaacaaaaactgttgc       c.*180

          .         .         .         .         .         .       g.12272
 tatttcctaacctgcaggcagaacctgaaagggcattttggctccggggcatcctggatt       c.*240

          .         .         .         .         .         .       g.12332
 tagaacatggactacacacaatacagtggtataaactttttattctcagtttaaaaatca       c.*300

          .         .         .         .         .         .       g.12392
 gtttgttgttcagaagaaagattgctataatgtataatgggaaatgtttggccatgcttg       c.*360

          .         .         .         .         .         .       g.12452
 gttgttgcagttcagacaaatgtaacacacacacacatacacacacacacacacacacag       c.*420

          .         .         .         .         .         .       g.12512
 agacacatcttaaggggacccacaagtattgccctttaacaagacttcaaagttttctgc       c.*480

          .         .         .         .         .         .       g.12572
 tgtaaagaaagctgtaatatatagtaaaactaaatgttgcgtgggtggcatgagttgaag       c.*540

          .         .         .         .         .         .       g.12632
 aaggcaaaggcttgtaaatttacccaatgcagtttggctttttaaattattttgtgccta       c.*600

          .         .         .         .         .         .       g.12692
 tttatgaataaatattacaaattctaaaagataagtgtgtttgcaaaaaaaaagaaaata       c.*660

          .         .         .         .         .         .       g.12752
 aatacataaaaaagggacaagcatgttgattctaggttgaaaatgttataggcacttgct       c.*720

          .         .         .         .         .         .       g.12812
 acttcagtaatgtctatattatataaatagtatttcagacactatgtagtctgttagatt       c.*780

          .         .         .         .         .         .       g.12872
 ttataaagattggtagttatctgagcttaaacattttctcaattgtaaaataggtgggca       c.*840

          .         .         .         .         .         .       g.12932
 caagtattacacatcagaaaatcctgacaaaagggacacatagtgtttgtaacaccgtcc       c.*900

          .         .         .         .         .         .       g.12992
 aacattccttgtttgtaagtgttgtatgtaccgttgatgttgataaaaagaaagtttata       c.*960

          .         .         .         .         .         .       g.13052
 tcttgattattttgttgtctaaagctaaacaaaacttgcatgcagcagcttttgactgtt       c.*1020

          .         .         .         .         .         .       g.13112
 tccagagtgcttataatatacataactccctggaaataactgagcactttgaattttttt       c.*1080

          .         .         .         .         .         .       g.13172
 tatgtctaaaattgtcagttaatttattattttgtttgagtaagaattttaatattgcca       c.*1140

          .         .         .         .         .         .       g.13232
 tattctgtagtatttttctttgtatatttctagtatggcacatgatatgagtcactgcct       c.*1200

          .         .         .         .         .         .       g.13292
 ttttttctatggtgtatgacagttagagatgctgattttttttctgataaattctttctt       c.*1260

          .         .         .         .         .                 g.13344
 tgagaaagacaattttaatgtttacaacaataaaccatgtaaatgaacagaa               c.*1312

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nuclear receptor subfamily 4, group A, member 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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