neuregulin 1 (NRG1) - coding DNA reference sequence

(used for variant description)

(last modified November 24, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_013956.3 in the NRG1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012005.1, covering NRG1 transcript NM_013956.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.913945
                        gaggccaggggagggtgcgaaggaggcgcctgcctcc       c.-481

 .         .         .         .         .         .                g.914005
 aacctgcgggcgggaggtgggtggctgcggggcaattgaaaaagagccggcgaggagttc       c.-421

 .         .         .         .         .         .                g.914065
 cccgaaacttgttggaactccgggctcgcgcggaggccaggagctgagcggcggcggctg       c.-361

 .         .         .         .         .         .                g.914125
 ccggacgatgggagcgtgagcaggacggtgataacctctccccgatcgggttgcgagggc       c.-301

 .         .         .         .         .         .                g.914185
 gccgggcagaggccaggacgcgagccgccagcggtgggacccatcgacgacttcccgggg       c.-241

 .         .         .         .         .         .                g.914245
 cgacaggagcagccccgagagccagggcgagcgcccgttccaggtggccggaccgcccgc       c.-181

 .         .         .         .         .         .                g.914305
 cgcgtccgcgccgcgctccctgcaggcaacgggagacgcccccgcgcagcgcgagcgcct       c.-121

 .         .         .         .         .         .                g.914365
 cagcgcggccgctcgctctccccctcgagggacaaacttttcccaaacccgatccgagcc       c.-61

 .         .         .         .         .         .                g.914425
 cttggaccaaactcgcctgcgccgagagccgtccgcgtagagcgctccgtctccggcgag       c.-1

          .         .         .         .         .         .       g.914485
 ATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCC       c.60
 M  S  E  R  K  E  G  R  G  K  G  K  G  K  K  K  E  R  G  S         p.20

          .         .         .         . | 02       .         .    g.961546
 GGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAG | CCTTGCCTCCCCGATTGAAA    c.120
 G  K  K  P  E  S  A  A  G  S  Q  S  P  A |   L  P  P  R  L  K      p.40

          .         .         .         .         .         .       g.961606
 GAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGT       c.180
 E  M  K  S  Q  E  S  A  A  G  S  K  L  V  L  R  C  E  T  S         p.60

          .         .         .         .         .         .       g.961666
 TCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAA       c.240
 S  E  Y  S  S  L  R  F  K  W  F  K  N  G  N  E  L  N  R  K         p.80

          .         .         .         | 03         .         .    g.971282
 AACAAACCACAAAATATCAAGATACAAAAAAAGCCAGG | GAAGTCAGAACTTCGCATTAAC    c.300
 N  K  P  Q  N  I  K  I  Q  K  K  P  G  |  K  S  E  L  R  I  N      p.100

          .         .         .         .         .         .       g.971342
 AAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAAT       c.360
 K  A  S  L  A  D  S  G  E  Y  M  C  K  V  I  S  K  L  G  N         p.120

          .         .         .         . | 04       .         .    g.980232
 GACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACG | AGATCATCACTGGTATGCCA    c.420
 D  S  A  S  A  N  I  T  I  V  E  S  N  E |   I  I  T  G  M  P      p.140

          .         .         .  | 05      .         .         .    g.982562
 GCCTCAACTGAAGGAGCATATGTGTCTTCAG | AGTCTCCCATTAGAATATCAGTATCCACA    c.480
 A  S  T  E  G  A  Y  V  S  S  E |   S  P  I  R  I  S  V  S  T      p.160

          .         .   | 06     .         .         .         .    g.1093685
 GAAGGAGCAAATACTTCTTCAT | CTACATCTACATCCACCACTGGGACAAGCCATCTTGTA    c.540
 E  G  A  N  T  S  S  S |   T  S  T  S  T  T  G  T  S  H  L  V      p.180

          .         .         .         .         .         .       g.1093745
 AAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATGGTGAAA       c.600
 K  C  A  E  K  E  K  T  F  C  V  N  G  G  E  C  F  M  V  K         p.200

          .         .         .   | 07     .         .         .    g.1108401
 GACCTTTCAAACCCCTCGAGATACTTGTGCAA | GTGCCCAAATGAGTTTACTGGTGATCGC    c.660
 D  L  S  N  P  S  R  Y  L  C  K  |  C  P  N  E  F  T  G  D  R      p.220

          .         .         .  | 08      .         .      | 09  . g.1120075
 TGCCAAAACTACGTAATGGCCAGCTTCTACA | AGCATCTTGGGATTGAATTTATGG | AGGCG c.720
 C  Q  N  Y  V  M  A  S  F  Y  K |   H  L  G  I  E  F  M  E |   A   p.240

          .         .         .         .         .         .       g.1120135
 GAGGAGCTGTACCAGAAGAGAGTGCTGACCATAACCGGCATCTGCATCGCCCTCCTTGTG       c.780
 E  E  L  Y  Q  K  R  V  L  T  I  T  G  I  C  I  A  L  L  V         p.260

          .         .         .         | 10         .         .    g.1122123
 GTCGGCATCATGTGTGTGGTGGCCTACTGCAAAACCAA | GAAACAGCGGAAAAAGCTGCAT    c.840
 V  G  I  M  C  V  V  A  Y  C  K  T  K  |  K  Q  R  K  K  L  H      p.280

          .         .         .         .         .         .       g.1122183
 GACCGTCTTCGGCAGAGCCTTCGGTCTGAACGAAACAATATGATGAACATTGCCAATGGG       c.900
 D  R  L  R  Q  S  L  R  S  E  R  N  N  M  M  N  I  A  N  G         p.300

          .         .         .         .      | 11  .         .    g.1125019
 CCTCACCATCCTAACCCACCCCCCGAGAATGTCCAGCTGGTGAAT | CAATACGTATCTAAA    c.960
 P  H  H  P  N  P  P  P  E  N  V  Q  L  V  N   | Q  Y  V  S  K      p.320

          .         .         .         .         .         .       g.1125079
 AACGTCATCTCCAGTGAGCATATTGTTGAGAGAGAAGCAGAGACATCCTTTTCCACCAGT       c.1020
 N  V  I  S  S  E  H  I  V  E  R  E  A  E  T  S  F  S  T  S         p.340

          .         .         .         .         .       | 12 .    g.1125902
 CACTATACTTCCACAGCCCATCACTCCACTACTGTCACCCAGACTCCTAGCCACAG | CTGG    c.1080
 H  Y  T  S  T  A  H  H  S  T  T  V  T  Q  T  P  S  H  S  |  W      p.360

          .         .         .         .         .         .       g.1125962
 AGCAACGGACACACTGAAAGCATCCTTTCCGAAAGCCACTCTGTAATCGTGATGTCATCC       c.1140
 S  N  G  H  T  E  S  I  L  S  E  S  H  S  V  I  V  M  S  S         p.380

          .         .         .         .         .         .       g.1126022
 GTAGAAAACAGTAGGCACAGCAGCCCAACTGGGGGCCCAAGAGGACGTCTTAATGGCACA       c.1200
 V  E  N  S  R  H  S  S  P  T  G  G  P  R  G  R  L  N  G  T         p.400

          .         .         .         .         .         .       g.1126082
 GGAGGCCCTCGTGAATGTAACAGCTTCCTCAGGCATGCCAGAGAAACCCCTGATTCCTAC       c.1260
 G  G  P  R  E  C  N  S  F  L  R  H  A  R  E  T  P  D  S  Y         p.420

          .         .    | 13    .         .         .         .    g.1129483
 CGAGACTCTCCTCATAGTGAAAG | GTATGTGTCAGCCATGACCACCCCGGCTCGTATGTCA    c.1320
 R  D  S  P  H  S  E  R  |  Y  V  S  A  M  T  T  P  A  R  M  S      p.440

          .         .         .         .         .         .       g.1129543
 CCTGTAGATTTCCACACGCCAAGCTCCCCCAAATCGCCCCCTTCGGAAATGTCTCCACCC       c.1380
 P  V  D  F  H  T  P  S  S  P  K  S  P  P  S  E  M  S  P  P         p.460

          .         .         .         .         .         .       g.1129603
 GTGTCCAGCATGACGGTGTCCATGCCTTCCATGGCGGTCAGCCCCTTCATGGAAGAAGAG       c.1440
 V  S  S  M  T  V  S  M  P  S  M  A  V  S  P  F  M  E  E  E         p.480

          .         .         .         .         .         .       g.1129663
 AGACCTCTACTTCTCGTGACACCACCAAGGCTGCGGGAGAAGAAGTTTGACCATCACCCT       c.1500
 R  P  L  L  L  V  T  P  P  R  L  R  E  K  K  F  D  H  H  P         p.500

          .         .         .         .         .         .       g.1129723
 CAGCAGTTCAGCTCCTTCCACCACAACCCCGCGCATGACAGTAACAGCCTCCCTGCTAGC       c.1560
 Q  Q  F  S  S  F  H  H  N  P  A  H  D  S  N  S  L  P  A  S         p.520

          .         .         .         .         .         .       g.1129783
 CCCTTGAGGATAGTGGAGGATGAGGAGTATGAAACGACCCAAGAGTACGAGCCAGCCCAA       c.1620
 P  L  R  I  V  E  D  E  E  Y  E  T  T  Q  E  Y  E  P  A  Q         p.540

          .         .         .         .         .         .       g.1129843
 GAGCCTGTTAAGAAACTCGCCAATAGCCGGCGGGCCAAAAGAACCAAGCCCAATGGCCAC       c.1680
 E  P  V  K  K  L  A  N  S  R  R  A  K  R  T  K  P  N  G  H         p.560

          .         .         .         .         .         .       g.1129903
 ATTGCTAACAGATTGGAAGTGGACAGCAACACAAGCTCCCAGAGCAGTAACTCAGAGAGT       c.1740
 I  A  N  R  L  E  V  D  S  N  T  S  S  Q  S  S  N  S  E  S         p.580

          .         .         .         .         .         .       g.1129963
 GAAACAGAAGATGAAAGAGTAGGTGAAGATACGCCTTTCCTGGGCATACAGAACCCCCTG       c.1800
 E  T  E  D  E  R  V  G  E  D  T  P  F  L  G  I  Q  N  P  L         p.600

          .         .         .         .         .         .       g.1130023
 GCAGCCAGTCTTGAGGCAACACCTGCCTTCCGCCTGGCTGACAGCAGGACTAACCCAGCA       c.1860
 A  A  S  L  E  A  T  P  A  F  R  L  A  D  S  R  T  N  P  A         p.620

          .         .         .         .         .         .       g.1130083
 GGCCGCTTCTCGACACAGGAAGAAATCCAGGCCAGGCTGTCTAGTGTAATTGCTAACCAA       c.1920
 G  R  F  S  T  Q  E  E  I  Q  A  R  L  S  S  V  I  A  N  Q         p.640

          .                                                         g.1130101
 GACCCTATTGCTGTATAA                                                 c.1938
 D  P  I  A  V  X                                                   p.645

          .         .         .         .         .         .       g.1130161
 aacctaaataaacacatagattcacctgtaaaactttattttatataataaagtattcca       c.*60

          .         .         .         .         .         .       g.1130221
 ccttaaattaaacaatttattttattttagcagttctgcaaatagaaaacaggaaaaaaa       c.*120

          .         .         .         .         .         .       g.1130281
 cttttataaattaaatatatgtatgtaaaaatgtgttatgtgccatatgtagcaattttt       c.*180

          .         .         .         .         .         .       g.1130341
 tacagtatttcaaaacgagaaagatatcaatggtgcctttatgttatgttatgtcgagag       c.*240

          .         .         .         .         .         .       g.1130401
 caagttttgtacagttacagtgattgcttttccacagtatttctgcaaaacctctcatag       c.*300

          .         .         .         .         .         .       g.1130461
 attcagtttttgctggcttcttgtgcattgcattatgatgttgactggatgtatgatttg       c.*360

          .         .         .         .         .         .       g.1130521
 caagacttgcaactgtccctctgtttgcttgtagtagcacccgatcagtatgtcttgtaa       c.*420

          .         .         .         .         .         .       g.1130581
 tggcacatccatccagatatgcctctcttgtgtatgaagttttctttgctttcagaatat       c.*480

          .         .         .         .         .         .       g.1130641
 gaaatgagttgtgtctactctgccagccaaaggtttgcctcattgggctctgagataata       c.*540

          .         .         .         .         .         .       g.1130701
 gtagatccaacagcatgctactattaaatacagcaagaaactgcattaagtaatgttaaa       c.*600

          .         .         .                                     g.1130739
 tattaggaagaaagtaatactgtgatttaaaaaaaact                             c.*638

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Neuregulin 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 20b
©2004-2017 Leiden University Medical Center