negative regulator of reactive oxygen species (NRROS) - coding DNA reference sequence

(used for variant description)

(last modified December 11, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_198565.1 in the NRROS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering NRROS transcript NM_198565.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5044
                 ggtagcccagccccgcgttcggctgctctcgaggaggccggagc       c.-61

 .         .         .         .         .       | 02 .             g.19755
 ccccggagacgatgcgccccgcgcagccgcctgcgcctgcgggagcc | ggctgcccttgag    c.-1

          .         .         .         .         .         .       g.19815
 ATGGAGTTGCTGCCTCTTTGGCTCTGCCTGGGTTTTCACTTCCTGACCGTGGGCTGGAGG       c.60
 M  E  L  L  P  L  W  L  C  L  G  F  H  F  L  T  V  G  W  R         p.20

          .         .         .         .         | 03         .    g.24979
 AACAGAAGCGGAACAGCCACAGCAGCCTCCCAAGGAGTCTGCAAGTTG | GTGGGTGGAGCC    c.120
 N  R  S  G  T  A  T  A  A  S  Q  G  V  C  K  L   | V  G  G  A      p.40

          .         .         .         .         .         .       g.25039
 GCTGACTGCCGAGGGCAGAGCCTCGCTTCGGTGCCCAGCAGCCTCCCGCCCCACGCCCGG       c.180
 A  D  C  R  G  Q  S  L  A  S  V  P  S  S  L  P  P  H  A  R         p.60

          .         .         .         .         .         .       g.25099
 ATGCTCACCCTGGATGCCAACCCTCTCAAGACCCTGTGGAATCACTCCCTCCAGCCTTAC       c.240
 M  L  T  L  D  A  N  P  L  K  T  L  W  N  H  S  L  Q  P  Y         p.80

          .         .         .         .         .         .       g.25159
 CCTCTCCTGGAGAGCCTCAGCCTGCACAGCTGCCACCTGGAGCGCATCAGCCGCGGCGCC       c.300
 P  L  L  E  S  L  S  L  H  S  C  H  L  E  R  I  S  R  G  A         p.100

          .         .         .         .         .         .       g.25219
 TTCCAGGAGCAAGGTCACCTGCGCAGCCTGGTCCTGGGGGACAACTGCCTCTCAGAGAAC       c.360
 F  Q  E  Q  G  H  L  R  S  L  V  L  G  D  N  C  L  S  E  N         p.120

          .         .         .         .         .         .       g.25279
 TACGAAGAGACGGCAGCCGCCCTCCACGCCCTGCCGGGCCTGCGGAGGCTGGACTTGTCA       c.420
 Y  E  E  T  A  A  A  L  H  A  L  P  G  L  R  R  L  D  L  S         p.140

          .         .         .         .         .         .       g.25339
 GGAAACGCCCTGACGGAGGACATGGCAGCCCTCATGCTCCAGAACCTCTCCTCGCTGCGG       c.480
 G  N  A  L  T  E  D  M  A  A  L  M  L  Q  N  L  S  S  L  R         p.160

          .         .         .         .         .         .       g.25399
 TCCGTGTCCCTGGCGGGGAACACCATCATGCGGCTGGACGACTCCGTCTTCGAGGGCCTG       c.540
 S  V  S  L  A  G  N  T  I  M  R  L  D  D  S  V  F  E  G  L         p.180

          .         .         .         .         .         .       g.25459
 GAGCGTCTCCGGGAGCTGGATCTGCAGAGGAACTACATCTTCGAGATCGAGGGCGGCGCT       c.600
 E  R  L  R  E  L  D  L  Q  R  N  Y  I  F  E  I  E  G  G  A         p.200

          .         .         .         .         .         .       g.25519
 TTCGACGGCCTGGCTGAGCTGAGGCACCTCAACCTGGCCTTCAACAACCTCCCCTGCATC       c.660
 F  D  G  L  A  E  L  R  H  L  N  L  A  F  N  N  L  P  C  I         p.220

          .         .         .         .         .         .       g.25579
 GTGGACTTCGGGCTCACGCGGCTGCGGGTCCTCAACGTCAGCTACAACGTCCTGGAGTGG       c.720
 V  D  F  G  L  T  R  L  R  V  L  N  V  S  Y  N  V  L  E  W         p.240

          .         .         .         .         .         .       g.25639
 TTCCTCGCGACCGGGGGAGAGGCTGCCTTCGAGCTGGAGACGCTGGACCTGTCTCACAAC       c.780
 F  L  A  T  G  G  E  A  A  F  E  L  E  T  L  D  L  S  H  N         p.260

          .         .         .         .         .         .       g.25699
 CAGCTGCTGTTCTTCCCGCTGCTGCCCCAGTACAGCAAGTTGCGGACCCTCCTGCTGCGC       c.840
 Q  L  L  F  F  P  L  L  P  Q  Y  S  K  L  R  T  L  L  L  R         p.280

          .         .         .         .         .         .       g.25759
 GACAACAACATGGGCTTCTACCGGGACCTGTACAACACCTCGTCGCCGAGGGAGATGGTG       c.900
 D  N  N  M  G  F  Y  R  D  L  Y  N  T  S  S  P  R  E  M  V         p.300

          .         .         .         .         .         .       g.25819
 GCCCAGTTCCTCCTCGTGGACGGCAACGTGACCAACATCACCACCGTCAGCCTCTGGGAA       c.960
 A  Q  F  L  L  V  D  G  N  V  T  N  I  T  T  V  S  L  W  E         p.320

          .         .         .         .         .         .       g.25879
 GAATTCTCCTCCAGCGACCTCGCAGATCTCCGCTTCCTGGACATGAGCCAGAACCAGTTC       c.1020
 E  F  S  S  S  D  L  A  D  L  R  F  L  D  M  S  Q  N  Q  F         p.340

          .         .         .         .         .         .       g.25939
 CAGTACCTGCCAGACGGCTTCCTGAGGAAAATGCCTTCCCTCTCCCACCTGAACCTCCAC       c.1080
 Q  Y  L  P  D  G  F  L  R  K  M  P  S  L  S  H  L  N  L  H         p.360

          .         .         .         .         .         .       g.25999
 CAGAATTGCCTGATGACGCTTCACATTCGGGAGCACGAGCCCCCCGGAGCGCTCACCGAG       c.1140
 Q  N  C  L  M  T  L  H  I  R  E  H  E  P  P  G  A  L  T  E         p.380

          .         .         .         .         .         .       g.26059
 CTGGACCTGAGCCACAACCAGCTGTCGGAGCTGCACCTGGCTCCGGGGCTGGCCAGCTGC       c.1200
 L  D  L  S  H  N  Q  L  S  E  L  H  L  A  P  G  L  A  S  C         p.400

          .         .         .         .         .         .       g.26119
 CTGGGCAGCCTGCGCTTGTTCAACCTGAGCTCCAACCAGCTCCTGGGCGTCCCCCCTGGC       c.1260
 L  G  S  L  R  L  F  N  L  S  S  N  Q  L  L  G  V  P  P  G         p.420

          .         .         .         .         .         .       g.26179
 CTCTTCGCCAATGCTAGGAACATCACTACACTTGACATGAGCCACAATCAGATCTCACTT       c.1320
 L  F  A  N  A  R  N  I  T  T  L  D  M  S  H  N  Q  I  S  L         p.440

          .         .         .         .         .         .       g.26239
 TGTCCCCTGCCAGCTGCCTCGGACCGGGTGGGCCCCCCTAGCTGTGTGGATTTCAGGAAT       c.1380
 C  P  L  P  A  A  S  D  R  V  G  P  P  S  C  V  D  F  R  N         p.460

          .         .         .         .         .         .       g.26299
 ATGGCATCTTTAAGGAGCCTGTCTCTGGAGGGCTGTGGCCTGGGGGCATTGCCAGACTGC       c.1440
 M  A  S  L  R  S  L  S  L  E  G  C  G  L  G  A  L  P  D  C         p.480

          .         .         .         .         .         .       g.26359
 CCATTCCAAGGGACCTCCCTGACCTACTTAGACCTCTCAAGCAACTGGGGGGTTCTGAAT       c.1500
 P  F  Q  G  T  S  L  T  Y  L  D  L  S  S  N  W  G  V  L  N         p.500

          .         .         .         .         .         .       g.26419
 GGGAGCCTCGCCCCACTCCAGGATGTTGCCCCCATGTTACAGGTCCTGTCTCTCAGGAAC       c.1560
 G  S  L  A  P  L  Q  D  V  A  P  M  L  Q  V  L  S  L  R  N         p.520

          .         .         .         .         .         .       g.26479
 ATGGGCCTCCACTCCAGCTTTATGGCGTTGGACTTCTCTGGGTTTGGGAATCTCAGGGAC       c.1620
 M  G  L  H  S  S  F  M  A  L  D  F  S  G  F  G  N  L  R  D         p.540

          .         .         .         .         .         .       g.26539
 TTAGATCTGTCGGGGAATTGCTTGACCACCTTCCCAAGGTTTGGGGGCAGCCTGGCCCTG       c.1680
 L  D  L  S  G  N  C  L  T  T  F  P  R  F  G  G  S  L  A  L         p.560

          .         .         .         .         .         .       g.26599
 GAGACCCTGGATCTCCGTAGAAACTCGCTCACAGCCCTTCCCCAGAAGGCTGTGTCTGAG       c.1740
 E  T  L  D  L  R  R  N  S  L  T  A  L  P  Q  K  A  V  S  E         p.580

          .         .         .         .         .         .       g.26659
 CAGCTCTCGAGAGGTCTGCGGACCATCTACCTCAGTCAGAATCCATATGACTGCTGTGGG       c.1800
 Q  L  S  R  G  L  R  T  I  Y  L  S  Q  N  P  Y  D  C  C  G         p.600

          .         .         .         .         .         .       g.26719
 GTGGATGGCTGGGGGGCCCTGCAGCATGGGCAGACGGTGGCCGACTGGGCCATGGTCACC       c.1860
 V  D  G  W  G  A  L  Q  H  G  Q  T  V  A  D  W  A  M  V  T         p.620

          .         .         .         .         .         .       g.26779
 TGCAACCTCTCCTCCAAGATCATCCGCGTGACGGAGCTGCCCGGAGGTGTGCCTCGGGAC       c.1920
 C  N  L  S  S  K  I  I  R  V  T  E  L  P  G  G  V  P  R  D         p.640

          .         .         .         .         .         .       g.26839
 TGCAAGTGGGAGCGGCTGGACCTGGGCCTGCTCTACCTCGTGCTCATCCTCCCCAGCTGC       c.1980
 C  K  W  E  R  L  D  L  G  L  L  Y  L  V  L  I  L  P  S  C         p.660

          .         .         .         .         .         .       g.26899
 CTCACCCTGCTGGTGGCCTGCACTGTCATCGTCCTCACTTTTAAGAAGCCTCTGCTTCAG       c.2040
 L  T  L  L  V  A  C  T  V  I  V  L  T  F  K  K  P  L  L  Q         p.680

          .         .         .                                     g.26938
 GTCATCAAGAGCCGCTGCCACTGGTCCTCCGTTTACTGA                            c.2079
 V  I  K  S  R  C  H  W  S  S  V  Y  X                              p.692

          .         .         .         .         .         .       g.26998
 cctggctgtgtgccaagactcgaaattcggtccgcacacaacaggacactttctctgcca       c.*60

          .         .         .         .         .         .       g.27058
 gctttcaagatgtgatgcagaggccaagtctgacgaattgaagtttcaattaaaatttaa       c.*120

          .         .         .         .         .         .       g.27118
 tatgtttccattcctcatcgcccaccccacccccgcccccaccaccgcccaagttctttt       c.*180

          .         .         .         .         .         .       g.27178
 tccatcattataattcatcctcattatcttggtaaaatatttattaagtgactttttcag       c.*240

          .         .         .         .                           g.27220
 aaataaaaggcaacgtgtctcataaatattttttaaattaaa                         c.*282

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Negative regulator of reactive oxygen species protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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