5'-nucleotidase, cytosolic II (NT5C2) - coding DNA reference sequence

(used for variant description)

(last modified January 6, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_012229.4 in the NT5C2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_042272.1, covering NT5C2 transcript NM_012229.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                gggcggggagggc       c.-181

 .         .         .         .         .         .        | 02    g.16980
 gcgcgttgaggcggctgcggcagttgcgcgctgggattgttgcggtgcgctggagccg | ag    c.-121

 .         .         .         .         .         .                g.17040
 tttcgctctgctgcccaggctggagtacagtgatgtgatctcctgacgtcaagtgatcca       c.-61

 .         .         .         .      | 03  .         .             g.23348
 ttcgcctcggcctcccaaagttctgggattacaagt | aatacaaaatacagttaaaataaa    c.-1

          .         .         .         .         .         .       g.23408
 ATGTCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT       c.60
 M  S  T  S  W  S  D  R  L  Q  N  A  A  D  M  P  A  N  M  D         p.20

          .         .         .         .  | 04      .         .    g.58846
 AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCG | GGTGTTTGTGAACCGAAGT    c.120
 K  H  A  L  K  K  Y  R  R  E  A  Y  H  R  |  V  F  V  N  R  S      p.40

          .         .         .         .         .      | 05  .    g.91605
 TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTG | TGTAC    c.180
 L  A  M  E  K  I  K  C  F  G  F  D  M  D  Y  T  L  A  V |   Y      p.60

          .         .         .         .         .         .       g.91665
 AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT       c.240
 K  S  P  E  Y  E  S  L  G  F  E  L  T  V  E  R  L  V  S  I         p.80

          .         .         .         .         .    | 06    .    g.92512
 GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAG | GGGACTT    c.300
 G  Y  P  Q  E  L  L  S  F  A  Y  D  S  T  F  P  T  R  |  G  L      p.100

          .         .         .         .         .         .       g.92572
 GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC       c.360
 V  F  D  T  L  Y  G  N  L  L  K  V  D  A  Y  G  N  L  L  V         p.120

          .         .          | 07        .         .         .    g.97011
 TGTGCACATGGATTTAACTTTATAAGGGG | ACCAGAAACTAGAGAACAGTATCCAAATAAA    c.420
 C  A  H  G  F  N  F  I  R  G  |  P  E  T  R  E  Q  Y  P  N  K      p.140

          .         .         .         .         .         .       g.97071
 TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA       c.480
 F  I  Q  R  D  D  T  E  R  F  Y  I  L  N  T  L  F  N  L  P         p.160

   | 08      .         .         .         .         .          | 09 g.98288
 G | AGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAG | T c.540
 E |   T  Y  L  L  A  C  L  V  D  F  F  T  N  C  P  R  Y  T  S  |   p.180

          .         .         .         .         .         .       g.98348
 TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT       c.600
 C  E  T  G  F  K  D  G  D  L  F  M  S  Y  R  S  M  F  Q  D         p.200

          .         .         .    | 10    .         .         .    g.99349
 GTAAGAGATGCTGTTGACTGGGTTCATTACAAG | GGCTCCCTTAAGGAAAAGACAGTTGAA    c.660
 V  R  D  A  V  D  W  V  H  Y  K   | G  S  L  K  E  K  T  V  E      p.220

          .         .        | 11.         .         .         .    g.100965
 AATCTTGAGAAGTATGTAGTCAAAGAT | GGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG    c.720
 N  L  E  K  Y  V  V  K  D   | G  K  L  P  L  L  L  S  R  M  K      p.240

          .         .         .         .         .  | 12      .    g.102335
 GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGAT | AAAATTATG    c.780
 E  V  G  K  V  F  L  A  T  N  S  D  Y  K  Y  T  D   | K  I  M      p.260

          .         .         .    | 13    .         .         .    g.103878
 ACTTACCTGTTTGACTTCCCACATGGCCCCAAG | CCTGGGAGCTCCCATCGACCATGGCAG    c.840
 T  Y  L  F  D  F  P  H  G  P  K   | P  G  S  S  H  R  P  W  Q      p.280

          .         .         .         .         .         .       g.103938
 TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA       c.900
 S  Y  F  D  L  I  L  V  D  A  R  K  P  L  F  F  G  E  G  T         p.300

          .         .  | 14      .         .         .         .    g.104307
 GTACTGCGTCAGGTGGATACT | AAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC    c.960
 V  L  R  Q  V  D  T   | K  T  G  K  L  K  I  G  T  Y  T  G  P      p.320

          .         .         | 15         .         .         .    g.105029
 CTACAGCATGGTATCGTCTACTCAGGAG | GTTCTTCTGATACGATCTGTGACCTGTTGGGA    c.1020
 L  Q  H  G  I  V  Y  S  G  G |   S  S  D  T  I  C  D  L  L  G      p.340

          .         .         .         .         .         .       g.105089
 GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA       c.1080
 A  K  G  K  D  I  L  Y  I  G  D  H  I  F  G  D  I  L  K  S         p.360

          .         .         .         .         .         .       g.105149
 AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT       c.1140
 K  K  R  Q  G  W  R  T  F  L  V  I  P  E  L  A  Q  E  L  H         p.380

          .          | 16        .         .         .         .    g.106732
 GTCTGGACTGACAAGAGTT | CACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT    c.1200
 V  W  T  D  K  S  S |   L  F  E  E  L  Q  S  L  D  I  F  L  A      p.400

          .  | 17      .         .         .         .         .    g.107359
 GAACTCTACAA | GCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG    c.1260
 E  L  Y  K  |  H  L  D  S  S  S  N  E  R  P  D  I  S  S  I  Q      p.420

          .   | 18     .         .         .         .         .    g.107567
 AGACGTATTAAG | AAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG    c.1320
 R  R  I  K   | K  V  T  H  D  M  D  M  C  Y  G  M  M  G  S  L      p.440

          .         .         .         .         .         .       g.107627
 TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC       c.1380
 F  R  S  G  S  R  Q  T  L  F  A  S  Q  V  M  R  Y  A  D  L         p.460

          .         .         .         .         .         .       g.107687
 TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC       c.1440
 Y  A  A  S  F  I  N  L  L  Y  Y  P  F  S  Y  L  F  R  A  A         p.480

           | 19        .         .         .         .         .    g.108449
 CATGTCTTG | ATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG    c.1500
 H  V  L   | M  P  H  E  S  T  V  E  H  T  H  V  D  I  N  E  M      p.500

          .         .         .         .         .         .       g.108509
 GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG       c.1560
 E  S  P  L  A  T  R  N  R  T  S  V  D  F  K  D  T  D  Y  K         p.520

          .         .         .         .         .         .       g.108569
 CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC       c.1620
 R  H  Q  L  T  R  S  I  S  E  I  K  P  P  N  L  F  P  L  A         p.540

          .         .         .         .         .         .       g.108629
 CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA       c.1680
 P  Q  E  I  T  H  C  H  D  E  D  D  D  E  E  E  E  E  E  E         p.560

                                                                    g.108635
 GAATAA                                                             c.1686
 E  X                                                               p.561

          .         .         .         .         .         .       g.108695
 ggaggaaaaccaaaaccccaagcacccattaaacaagtcctggcaggactcacaggaaca       c.*60

          .         .         .         .         .         .       g.108755
 aacgaggtccctgttagggttctactcgggggagggagggggctccatgaaaggtacgtc       c.*120

          .         .         .         .         .         .       g.108815
 tgaaaagtttctgaagattttattatcatagatacttgttttggttttgtgtatctgtac       c.*180

          .         .         .         .         .         .       g.108875
 tctctgcagatggtccaaaattgtaatggagtctgtattagaagaaaataagggtaaaat       c.*240

          .         .         .         .         .         .       g.108935
 caggctgaactgcatgtatatggctccactgtggcttgtgacacttttaaaatcatccgt       c.*300

          .         .         .         .         .         .       g.108995
 atgtcagtgtatctggatacacgaggaaaaggaaagagtctcagagtggaacaaagagtg       c.*360

          .         .         .         .         .         .       g.109055
 ggaagaggtgatctgtaatgttacaaattgtgctattactccaaggtccaacttttccag       c.*420

          .         .         .         .         .         .       g.109115
 tgcattacatggtattgtatatcagtggagaaatgtattatttccatgatcaaatgtagt       c.*480

          .         .         .         .         .         .       g.109175
 ctctgttaaggtcaagttttcttttataagcctttaattcatcctcagtgactctggcaa       c.*540

          .         .         .         .         .         .       g.109235
 ggctgcttctctatcactggctttgcacagaagtatgctctacttgcgttgctttagggc       c.*600

          .         .         .         .         .         .       g.109295
 aggattctattttgagggaaaagacagtatccttattaccttttgtttgtttaatagcac       c.*660

          .         .         .         .         .         .       g.109355
 aaatgcttatttgttatccaaaaacaacctccttcttatctgtgataaatctatagaaag       c.*720

          .         .         .         .         .         .       g.109415
 aatttagctgcaagtggacaaaggaacaagcccccagaaaagaaagggaagaactgcctt       c.*780

          .         .         .         .         .         .       g.109475
 cttatactacagaacatgcattagtgtgggctatatagctgtggctcatgctacccaatt       c.*840

          .         .         .         .         .         .       g.109535
 ccagatttctttgtcctctaagagttgattgctgtatattaaaattgaacatcagaggat       c.*900

          .         .         .         .         .         .       g.109595
 gggaagagggctctgtaagccagaaccttactaaagtagagggcacaatcagtgtgaata       c.*960

          .         .         .         .         .         .       g.109655
 aattcacttcagaatctcaagtcaaggccaggcacggcggctcacgcctgtaatcccagc       c.*1020

          .         .         .         .         .         .       g.109715
 actttgggaggccgagacaggcggatcacctgaggtcgggagttcgagaccagccttacc       c.*1080

          .         .         .         .         .         .       g.109775
 aacatggagaaaccccatctctactaaaaatacaaaattacctgggcgtggtggtgcatg       c.*1140

          .         .         .         .         .         .       g.109835
 cctgtaatcccatcatctactcaggaggctgaggcaggagaattgcttgaacccaggagg       c.*1200

          .         .         .         .         .         .       g.109895
 cggaggttgcagtgagccaggattgtgccattgcactccagcctgggcaacaagaacaaa       c.*1260

          .         .         .         .         .         .       g.109955
 actccatctcaaaaaataaaaatcccaatcccaagtcgaaatcacctcttgttttaaaca       c.*1320

          .         .         .         .         .         .       g.110015
 agaatgaatcattactgtgtatgttagggtattaaaactgtttcaccagtacagtgaaag       c.*1380

          .         .         .         .         .         .       g.110075
 ttgtttcaacattttaaacaaacagtggttatagactctttctttaaccattgtatattt       c.*1440

          .         .         .         .         .         .       g.110135
 tcttccattcttgtcattggtcaataggggagggtagattagctgctccagaattcaata       c.*1500

          .         .         .         .         .         .       g.110195
 aagtgtaatatttctaacggtgactttgacctattctgtagtacaactgtaatagctatt       c.*1560

          .         .         .         .         .         .       g.110255
 ggtcttcaagtgggtttagatttggtgacatcagtttgatattctcttaaaggaaataaa       c.*1620

          .         .         .                                     g.110290
 tattcaagaactgattatgttctaacatgattata                                c.*1655

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The 5'-nucleotidase, cytosolic II protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 18
©2004-2017 Leiden University Medical Center