neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) - coding DNA reference sequence

(used for variant description)

(last modified March 21, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_006180.3 in the NTRK2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering NTRK2 transcript NM_006180.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       aagacggattctcagacaaggcttgcaaatgccccgca       c.-901

 .         .         .         .         .         .                g.5098
 gccatcatttaactgcacccgcagaatagttacggtttgtcacccgaccctcccggatcg       c.-841

 .         .         .         .         .         .                g.5158
 cctaatttgtccctagtgagaccccgaggctctgcccgcgcctggcttcttcgtagctgg       c.-781

 .         .         .         .         .         .                g.5218
 atgcatatcgtgctccgggcagcgcgggcgcagggcacgcgttcgcgcacaccctagcac       c.-721

 .         .       | 02 .         .         .         .             g.5794
 acatgaacacgcgcaag | agctgaaccaagcacggtttccatttcaaaaagggagacagcc    c.-661

 .         .         .         .         .         .                g.5854
 tctaccgcgattgtagaagagactgtggtgtgaattagggaccgggaggcgtcgaacgga       c.-601

 .         .         | 03         .         .         .             g.6170
 ggaacggttcatcttagag | actaattttctggagtttctgcccctgctctgcgtcagccc    c.-541

 .         .         .         .         .         .                g.6230
 tcacgtcacttcgccagcagtagcagaggcggcggcggcggctcccggaattgggttgga       c.-481

 .         .         .         .         .         .                g.6290
 gcaggagcctcgctggctgcttcgctcgcgctctacgcgctcagtccccggcggtagcag       c.-421

 .         .         .         .         .        | 04.             g.6838
 gagcctggacccaggcgccgccggcgggcgtgaggcgccggagcccgg | cctcgaggtgca    c.-361

 .         .         .         .         .         .                g.6898
 taccggacccccattcgcatctaacaaggaatctgcgccccagagagtcccgggagcgcc       c.-301

 .         .         .         .         .         .                g.6958
 gccggtcggtgcccggcgcgccgggccatgcagcgacggccgccgcggagctccgagcag       c.-241

 .         .         .         .         .         .                g.7018
 cggtagcgcccccctgtaaagcggttcgctatgccggggccactgtgaaccctgccgcct       c.-181

 .         .         .         .         .         .                g.7078
 gccggaacactcttcgctccggaccagctcagcctctgataagctggactcggcacgccc       c.-121

 .         .         .         .         .         .                g.7138
 gcaacaagcaccgaggagttaagagagccgcaagcgcagggaaggcctccccgcacgggt       c.-61

 .         .         .         .         .         .                g.7198
 gggggaaagcggccggtgcagcgcggggacaggcactcgggctggcactggctgctaggg       c.-1

          .         .         .         .         .         .       g.7258
 ATGTCGTCCTGGATAAGGTGGCATGGACCCGCCATGGCGCGGCTCTGGGGCTTCTGCTGG       c.60
 M  S  S  W  I  R  W  H  G  P  A  M  A  R  L  W  G  F  C  W         p.20

          .         .         .         .         .         .       g.7318
 CTGGTTGTGGGCTTCTGGAGGGCCGCTTTCGCCTGTCCCACGTCCTGCAAATGCAGTGCC       c.120
 L  V  V  G  F  W  R  A  A  F  A  C  P  T  S  C  K  C  S  A         p.40

          .         .         .         .         .         .       g.7378
 TCTCGGATCTGGTGCAGCGACCCTTCTCCTGGCATCGTGGCATTTCCGAGATTGGAGCCT       c.180
 S  R  I  W  C  S  D  P  S  P  G  I  V  A  F  P  R  L  E  P         p.60

          .         .         .   | 05     .         .         .    g.38636
 AACAGTGTAGATCCTGAGAACATCACCGAAAT | TTTCATCGCAAACCAGAAAAGGTTAGAA    c.240
 N  S  V  D  P  E  N  I  T  E  I  |  F  I  A  N  Q  K  R  L  E      p.80

          .         .         .         .        | 06.         .    g.38810
 ATCATCAACGAAGATGATGTTGAAGCTTATGTGGGACTGAGAAATCT | GACAATTGTGGAT    c.300
 I  I  N  E  D  D  V  E  A  Y  V  G  L  R  N  L  |  T  I  V  D      p.100

          .         .         .         .         .          | 07    g.44294
 TCTGGATTAAAATTTGTGGCTCATAAAGCATTTCTGAAAAACAGCAACCTGCAGCACAT | C    c.360
 S  G  L  K  F  V  A  H  K  A  F  L  K  N  S  N  L  Q  H  I  |      p.120

          .         .         .         .         .         .       g.44354
 AATTTTACCCGAAACAAACTGACGAGTTTGTCTAGGAAACATTTCCGTCACCTTGACTTG       c.420
 N  F  T  R  N  K  L  T  S  L  S  R  K  H  F  R  H  L  D  L         p.140

          | 08         .         .         .         .         .    g.47138
 TCTGAACT | GATCCTGGTGGGCAATCCATTTACATGCTCCTGTGACATTATGTGGATCAAG    c.480
 S  E  L  |  I  L  V  G  N  P  F  T  C  S  C  D  I  M  W  I  K      p.160

          .         .         .         .         .         .       g.47198
 ACTCTCCAAGAGGCTAAATCCAGTCCAGACACTCAGGATTTGTACTGCCTGAATGAAAGC       c.540
 T  L  Q  E  A  K  S  S  P  D  T  Q  D  L  Y  C  L  N  E  S         p.180

          .         .         .         .    | 09    .         .    g.60039
 AGCAAGAATATTCCCCTGGCAAACCTGCAGATACCCAATTGTG | GTTTGCCATCTGCAAAT    c.600
 S  K  N  I  P  L  A  N  L  Q  I  P  N  C  G |   L  P  S  A  N      p.200

          .         .         .         .         .         .       g.60099
 CTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTG       c.660
 L  A  A  P  N  L  T  V  E  E  G  K  S  I  T  L  S  C  S  V         p.220

          .         .         .         .         .         .       g.60159
 GCAGGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATG       c.720
 A  G  D  P  V  P  N  M  Y  W  D  V  G  N  L  V  S  K  H  M         p.240

  | 10       .         .         .         .         .         .    g.60733
  | AATGAAACAAGCCACACACAGGGCTCCTTAAGGATAACTAACATTTCATCCGATGACAGT    c.780
  | N  E  T  S  H  T  Q  G  S  L  R  I  T  N  I  S  S  D  D  S      p.260

          .         .         .         .         .         .       g.60793
 GGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAAC       c.840
 G  K  Q  I  S  C  V  A  E  N  L  V  G  E  D  Q  D  S  V  N         p.280

          .    | 11    .         .         .         .         .    g.64150
 CTCACTGTGCATT | TTGCACCAACTATCACATTTCTCGAATCTCCAACCTCAGACCACCAC    c.900
 L  T  V  H  F |   A  P  T  I  T  F  L  E  S  P  T  S  D  H  H      p.300

          .         .         .         .         .         .       g.64210
 TGGTGCATTCCATTCACTGTGAAAGGCAACCCCAAACCAGCGCTTCAGTGGTTCTATAAC       c.960
 W  C  I  P  F  T  V  K  G  N  P  K  P  A  L  Q  W  F  Y  N         p.320

          .         .         .         .         .         .       g.64270
 GGGGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACG       c.1020
 G  A  I  L  N  E  S  K  Y  I  C  T  K  I  H  V  T  N  H  T         p.340

          .         .         .         .         .         .       g.64330
 GAGTACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATGAACAATGGGGACTACACT       c.1080
 E  Y  H  G  C  L  Q  L  D  N  P  T  H  M  N  N  G  D  Y  T         p.360

          .         .         .         .         .         .       g.64390
 CTAATAGCCAAGAATGAGTATGGGAAGGATGAGAAACAGATTTCTGCTCACTTCATGGGC       c.1140
 L  I  A  K  N  E  Y  G  K  D  E  K  Q  I  S  A  H  F  M  G         p.380

          .          | 12        .         .         .      | 13  . g.81427
 TGGCCTGGAATTGACGATG | GTGCAAACCCAAATTATCCTGATGTAATTTATGAAG | ATTAT c.1200
 W  P  G  I  D  D  G |   A  N  P  N  Y  P  D  V  I  Y  E  D |   Y   p.400

          .         .         .         .         .         .       g.81487
 GGAACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACA       c.1260
 G  T  A  A  N  D  I  G  D  T  T  N  R  S  N  E  I  P  S  T         p.420

          .         .         .       | 14 .         .         .    g.88459
 GACGTCACTGATAAAACCGGTCGGGAACATCTCTCG | GTCTATGCTGTGGTGGTGATTGCG    c.1320
 D  V  T  D  K  T  G  R  E  H  L  S   | V  Y  A  V  V  V  I  A      p.440

          .         .         .         .         .         .       g.88519
 TCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTTAAGTTGGCAAGACACTCC       c.1380
 S  V  V  G  F  C  L  L  V  M  L  F  L  L  K  L  A  R  H  S         p.460

          .       | 15 .         .         .         .         .    g.197533
 AAGTTTGGCATGAAAG | ATTTCTCATGGTTTGGATTTGGGAAAGTAAAATCAAGACAAGGT    c.1440
 K  F  G  M  K  D |   F  S  W  F  G  F  G  K  V  K  S  R  Q  G      p.480

      | 16   .         .         .         .         .         .    g.203748
 GTTG | GCCCAGCCTCCGTTATCAGCAATGATGATGACTCTGCCAGCCCACTCCATCACATC    c.1500
 V  G |   P  A  S  V  I  S  N  D  D  D  S  A  S  P  L  H  H  I      p.500

          .         .         .         .         .         .       g.203808
 TCCAATGGGAGTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGA       c.1560
 S  N  G  S  N  T  P  S  S  S  E  G  G  P  D  A  V  I  I  G         p.520

          .         .         .         .         .         .       g.203868
 ATGACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAACAGTCAGCTC       c.1620
 M  T  K  I  P  V  I  E  N  P  Q  Y  F  G  I  T  N  S  Q  L         p.540

          .    | 17    .         .         .         .         .    g.270658
 AAGCCAGACACAT | TTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTA    c.1680
 K  P  D  T  F |   V  Q  H  I  K  R  H  N  I  V  L  K  R  E  L      p.560

          .         .         .         .         .         .       g.270718
 GGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAG       c.1740
 G  E  G  A  F  G  K  V  F  L  A  E  C  Y  N  L  C  P  E  Q         p.580

          .         .     | 18   .         .         .         .    g.284947
 GACAAGATCTTGGTGGCAGTGAAG | ACCCTGAAGGATGCCAGTGACAATGCACGCAAGGAC    c.1800
 D  K  I  L  V  A  V  K   | T  L  K  D  A  S  D  N  A  R  K  D      p.600

          .         .         .         .         .         .       g.285007
 TTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTAT       c.1860
 F  H  R  E  A  E  L  L  T  N  L  Q  H  E  H  I  V  K  F  Y         p.620

          .         .         .         .         .         .       g.285067
 GGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGAC       c.1920
 G  V  C  V  E  G  D  P  L  I  M  V  F  E  Y  M  K  H  G  D         p.640

          .        | 19.         .         .         .         .    g.291775
 CTCAACAAGTTCCTCAG | GGCACACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCG    c.1980
 L  N  K  F  L  R  |  A  H  G  P  D  A  V  L  M  A  E  G  N  P      p.660

          .         .         .         .         .         .       g.291835
 CCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATG       c.2040
 P  T  E  L  T  Q  S  Q  M  L  H  I  A  Q  Q  I  A  A  G  M         p.680

          .         .         .         .         .         .       g.291895
 GTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTC       c.2100
 V  Y  L  A  S  Q  H  F  V  H  R  D  L  A  T  R  N  C  L  V         p.700

          .         .         .         .         .         .       g.291955
 GGGGAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACT       c.2160
 G  E  N  L  L  V  K  I  G  D  F  G  M  S  R  D  V  Y  S  T         p.720

          .   | 20     .         .         .         .         .    g.356703
 GACTACTACAGG | GTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGC    c.2220
 D  Y  Y  R   | V  G  G  H  T  M  L  P  I  R  W  M  P  P  E  S      p.740

          .         .         .         .         .         .       g.356763
 ATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGG       c.2280
 I  M  Y  R  K  F  T  T  E  S  D  V  W  S  L  G  V  V  L  W         p.760

          .         .         .         .         .  | 21      .    g.357710
 GAGATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTCAAACAATGAG | GTGATAGAG    c.2340
 E  I  F  T  Y  G  K  Q  P  W  Y  Q  L  S  N  N  E   | V  I  E      p.780

          .         .         .         .         .         .       g.357770
 TGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAG       c.2400
 C  I  T  Q  G  R  V  L  Q  R  P  R  T  C  P  Q  E  V  Y  E         p.800

          .         .         .         .         .         .       g.357830
 CTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCAT       c.2460
 L  M  L  G  C  W  Q  R  E  P  H  M  R  K  N  I  K  G  I  H         p.820

          .         .         .         .         .                 g.357887
 ACCCTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAG          c.2517
 T  L  L  Q  N  L  A  K  A  S  P  V  Y  L  D  I  L  G  X            p.838

          .         .         .         .         .         .       g.357947
 ggcccttttccccagaccgatccttcccaacgtactcctcagacgggctgagaggatgaa       c.*60

          .         .         .         .         .         .       g.358007
 catcttttaactgccgctggaggccaccaagctgctctccttcactctgacagtattaac       c.*120

          .         .         .         .         .         .       g.358067
 atcaaagactccgagaagctctcgagggaagcagtgtgtacttcttcatccatagacaca       c.*180

          .         .         .         .         .         .       g.358127
 gtattgacttctttttggcattatctctttctctctttccatctcccttggttgttcctt       c.*240

          .         .         .         .         .         .       g.358187
 tttctttttttaaattttctttttcttttttttttcgtcttccctgcttcacgattctta       c.*300

          .         .         .         .         .         .       g.358247
 ccctttcttttgaatcaatctggcttctgcattactattaactctgcatagacaaaggcc       c.*360

          .         .         .         .         .         .       g.358307
 ttaacaaacgtaatttgttatatcagcagacactccagtttgcccaccacaactaacaat       c.*420

          .         .         .         .         .         .       g.358367
 gccttgttgtattcctgcctttgatgtggatgaaaaaaagggaaaacaaatatttcactt       c.*480

          .         .         .         .         .         .       g.358427
 aaactttgtcacttctgctgtacagatatcgagagtttctatggattcacttctatttat       c.*540

          .         .         .         .         .         .       g.358487
 ttattattattactgttcttattgtttttggatggcttaagcctgtgtataaaaaagaaa       c.*600

          .         .         .         .         .         .       g.358547
 acttgtgttcaatctgtgaagcctttatctatgggagattaaaaccagagagaaagaaga       c.*660

          .         .         .         .         .         .       g.358607
 tttattatgaaccgcaatatgggaggaacaaagacaaccactgggatcagctggtgtcag       c.*720

          .         .         .         .         .         .       g.358667
 tccctacttaggaaatactcagcaactgttagctgggaagaatgtattcggcaccttccc       c.*780

          .         .         .         .         .         .       g.358727
 ctgaggacctttctgaggagtaaaaagactactggcctctgtgccatggatgattctttt       c.*840

          .         .         .         .         .         .       g.358787
 cccatcaccagaaatgatagcgtgcagtagagagcaaagatggcttccgtgagacacaag       c.*900

          .         .         .         .         .         .       g.358847
 atggcgcatagtgtgctcggacacagttttgtcttcgtaggttgtgatgatagcactggt       c.*960

          .         .         .         .         .         .       g.358907
 ttgtttctcaagcgctatccacagaacctttgtcaacttcagttgaaaagaggtggattc       c.*1020

          .         .         .         .         .         .       g.358967
 atgtccagagctcatttcggggtcaggtgggaaagccaagaacttggaaaagataagaca       c.*1080

          .         .         .         .         .         .       g.359027
 agctataaattcggaggcaagtttcttttacaatgaacttttcagatctcacttccctcc       c.*1140

          .         .         .         .         .         .       g.359087
 gacccctaacttccatgcccacccgtccttttaactgtgcaagcaaaattgtgcatggtc       c.*1200

          .         .         .         .         .         .       g.359147
 ttcgtcgattaataccttgtgtgcagacactactgctccagacgtcgtttccctgatagg       c.*1260

          .         .         .         .         .         .       g.359207
 tagagcagatccataaaaaggtatgacttatacaattaggggaagctaatggagtttatt       c.*1320

          .         .         .         .         .         .       g.359267
 agctgagtatcaatgtctctgcgttgtacggtggtgatgggttttaatgaatatggaccc       c.*1380

          .         .         .         .         .         .       g.359327
 tgaagcctggaaatcctcatccacgtcgaacccacaggactgtgggaagggcagaatcaa       c.*1440

          .         .         .         .         .         .       g.359387
 tccctaagggaaaggaaacctcaccctgagggcatcacatgcactcatgttcagtgtaca       c.*1500

          .         .         .         .         .         .       g.359447
 caggtcaagtcccttgctctgggctctagttgggagagtggtttcattccaagtgtactc       c.*1560

          .         .         .         .         .         .       g.359507
 cattgtcagtatgctgtttttgtttccttcactccattcaaaaagtcaaaatacaaaatt       c.*1620

          .         .         .         .         .         .       g.359567
 tggcacagcatgccaacgggaggctgtgcccagaccaagcactggaagtgtgcttctagg       c.*1680

          .         .         .         .         .         .       g.359627
 catagtcattggttttgcaaaaagagggctcaaatttaaatagaaatttacagctatttg       c.*1740

          .         .         .         .         .         .       g.359687
 aatggtcagatataccaagaaagaaaaatatttctgttcctcaagaaaacttgctaccct       c.*1800

          .         .         .         .         .         .       g.359747
 ctgtgaggggaattttgctaaacttgacatctttataacatgagccagattgaaagggag       c.*1860

          .         .         .         .         .         .       g.359807
 tgattttcattcatcttaggtcatgttatttcatatttgtttctgaaggtgcgatagctc       c.*1920

          .         .         .         .         .         .       g.359867
 tgttttaggttttgcttgcgcctgttaattactggaacaccttatttttcattaaaggct       c.*1980

          .         .         .         .         .         .       g.359927
 ttgaaagccaattctcaaaaattcaaaagtgcaaattaacagaacaaaaggaaatccagt       c.*2040

          .         .         .         .         .         .       g.359987
 agcaactgcagtcaagcgagggagttgacaagataaaccttacgtccattcaagttatat       c.*2100

          .         .         .         .         .                 g.360040
 gctggcctatgagagatgagagttgggtcgtttgttctctttgttgatgattt              c.*2153

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Neurotrophic tyrosine kinase, receptor, type 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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