nucleotide binding protein-like (NUBPL) - coding DNA reference sequence

(used for variant description)

(last modified May 19, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_025152.2 in the NUBPL gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000014.8, covering NUBPL transcript NM_025152.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5055
      actccgcgccacccgcgacagtttcccagcagggctcacagcagcgttccgcgtc       c.-1

          .         .         .         .         .         .       g.5115
 ATGGGGATTTGGCAGCGTCTGCTGCTTTTTGGTGGGGTGTCGCTCCGGGCTGGTGGCGGG       c.60
 M  G  I  W  Q  R  L  L  L  F  G  G  V  S  L  R  A  G  G  G         p.20

          .         .         .         .         | 02         .    g.5695
 GCCACTGCCCCGCTTGGGGGAAGCCGAGCGATGGTTTGTGGGCGCCAG | TTGTCTGGCGCC    c.120
 A  T  A  P  L  G  G  S  R  A  M  V  C  G  R  Q   | L  S  G  A      p.40

          .         .         .         .         .         .       g.5755
 GGGAGTGAGACCCTAAAACAAAGAAGAACACAAATCATGTCCCGAGGACTTCCAAAGCAG       c.180
 G  S  E  T  L  K  Q  R  R  T  Q  I  M  S  R  G  L  P  K  Q         p.60

          .         .         .         .         .         .       g.5815
 AAACCGATAGAAGGTGTTAAACAAGTTATAGTTGTGGCTTCTGGAAAGGGTGGAGTCGGA       c.240
 K  P  I  E  G  V  K  Q  V  I  V  V  A  S  G  K  G  G  V  G         p.80

          .       | 03 .         .         .         .  | 04      . g.42913
 AAATCTACTACAGCAG | TGAATCTTGCACTTGCACTAGCAGCGAACGATTCG | TCCAAGGCC c.300
 K  S  T  T  A  V |   N  L  A  L  A  L  A  A  N  D  S   | S  K  A   p.100

          .         .         .         .         .         .       g.42973
 ATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAA       c.360
 I  G  L  L  D  V  D  V  Y  G  P  S  V  P  K  M  M  N  L  K         p.120

          .         .   | 05     .         .         .         .    g.117008
 GGAAATCCGGAATTATCACAGA | GCAACCTAATGAGGCCTCTCTTGAATTATGGTATTGCT    c.420
 G  N  P  E  L  S  Q  S |   N  L  M  R  P  L  L  N  Y  G  I  A      p.140

    | 06     .         .         .         .         .         .    g.117157
 TG | TATGTCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGTAGTTTGGAGAGGCCTTATG    c.480
 C  |  M  S  M  G  F  L  V  E  E  S  E  P  V  V  W  R  G  L  M      p.160

          .         .         .    | 07    .         .         .    g.231422
 GTAATGTCGGCCATTGAGAAATTGTTGAGGCAG | GTAGATTGGGGTCAACTGGACTACTTA    c.540
 V  M  S  A  I  E  K  L  L  R  Q   | V  D  W  G  Q  L  D  Y  L      p.180

          .         .         .         .         .         .       g.231482
 GTTGTAGACATGCCACCAGGAACTGGAGATGTGCAGTTATCAGTCTCACAGAATATTCCT       c.600
 V  V  D  M  P  P  G  T  G  D  V  Q  L  S  V  S  Q  N  I  P         p.200

         | 08.         .         .         .         .         .    g.270297
 ATAACAG | GTGCTGTGATTGTCTCCACGCCCCAGGACATCGCATTGATGGATGCACACAAG    c.660
 I  T  G |   A  V  I  V  S  T  P  Q  D  I  A  L  M  D  A  H  K      p.220

          .         .         .    | 09    .         .         .    g.290113
 GGTGCTGAGATGTTTCGCAGAGTCCACGTGCCC | GTCCTTGGCCTTGTCCAAAACATGAGT    c.720
 G  A  E  M  F  R  R  V  H  V  P   | V  L  G  L  V  Q  N  M  S      p.240

          .         .         .         .         .         .       g.290173
 GTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGG       c.780
 V  F  Q  C  P  K  C  K  H  K  T  H  I  F  G  A  D  G  A  R         p.260

          .         .         .     | 10   .         .         .    g.293760
 AAACTAGCACAGACCCTTGGTCTTGAAGTTCTAG | GAGACATTCCCTTACACCTTAATATA    c.840
 K  L  A  Q  T  L  G  L  E  V  L  G |   D  I  P  L  H  L  N  I      p.280

          .         .         .         .         .        | 11.    g.302736
 AGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGATGAG | GCC    c.900
 R  E  A  S  D  T  G  Q  P  I  V  F  S  Q  P  E  S  D  E   | A      p.300

          .         .         .         .         .         .       g.302796
 AAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGAATGA       c.960
 K  A  Y  L  R  I  A  V  E  V  V  R  R  L  P  S  P  S  E  X         p.319

          .         .         .         .         .         .       g.302856
 ttccccaagtgtcctggaaatttgcctggtactgacattaagaggacctttggaaatcag       c.*60

          .         .         .         .         .         .       g.302916
 caatgtggtgatggaacctacagaaataatagaaatcataactgttttatttctaaggaa       c.*120

          .         .         .         .         .         .       g.302976
 agaatgtcttcatatttgacttgctaagctaaggttcacaaaactttgatgtatcaatgt       c.*180

          .         .         .         .         .         .       g.303036
 taactgctatatttaggaattttttgaaagctggtgtgtaccacctgcaaagaactgcat       c.*240

          .         .         .         .         .         .       g.303096
 tttattttattgaattacccctttagaaatcacgagtttatgatgttacaagtccatttt       c.*300

          .         .         .         .         .         .       g.303156
 gggagagaactgtacactttttgcaggaccacagaattagtaatttaaatgatatactaa       c.*360

          .         .         .         .         .         .       g.303216
 atttgtgtatgggcataagtattacgccttcccaccaggcaatttggactgtctttgaat       c.*420

          .         .         .         .         .         .       g.303276
 cctgtctttggtactgtcttggacatgttcttaatatgaacctctgcttcttcatctgga       c.*480

          .         .         .         .         .         .       g.303336
 tcacactataccccagacttaatgaatttcagtctccaggagtggagcctgaacatatgt       c.*540

          .         .         .         .         .         .       g.303396
 atttttagtaagaccatgatgatgttgatgatgattctggtaatcatggcagtaagaata       c.*600

          .         .         .         .         .         .       g.303456
 atagctaacatttaacaagttaattataattgttcttccatttgtgtgagtgggtactat       c.*660

          .         .         .         .         .         .       g.303516
 tatctccattttacagataagtaatttgagatataatttgaaggcactcaaccttgagtg       c.*720

          .         .         .         .         .         .       g.303576
 tcttgctgagggttactgtatctagcaggtgatggagcttggatttgaacttgagtaatt       c.*780

          .         .         .         .         .         .       g.303636
 cgatattagattcatctttttgtacaccaatgtgcttttgttaattaaaaaaagtcggtg       c.*840

          .         .         .         .         .         .       g.303696
 gtggctaggcgtggtggctcacgcctgtaatcccagcactttgggaggttgaggtgggtg       c.*900

          .         .         .         .         .         .       g.303756
 gatcatgaggtcaggagttcaagaccagcctgaccaacatggtgaaaccccgtctctact       c.*960

          .         .         .         .         .         .       g.303816
 aaaaatacaaaaattagctgggtgtggtggcatatgcctgtaatcccagctactcgggag       c.*1020

          .         .         .         .         .         .       g.303876
 gctgaggcaggagaatcatttcaacccgggaggctgaggttgcagtgagtggagattgta       c.*1080

          .         .         .         .         .         .       g.303936
 ccactgcactccagcctggtcaatggagtgcgactccatctcaaaaaaaaaaaaaaaaaa       c.*1140

          .         .         .         .         .         .       g.303996
 aaaaaaagtcgggggagatgcaatatttagcatttcctcaaactttttttggccatgaaa       c.*1200

          .         .         .         .         .         .       g.304056
 tccaccacccccctcctttttcagagcatttcatgaagttcacatttcaaataatacatt       c.*1260

          .         .         .         .         .         .       g.304116
 ttgaaaaacatttatcttgtctaattgaagctcaaagagatagagtcaatgacttttcaa       c.*1320

          .         .         .         .         .         .       g.304176
 agtcaggtagcagatagttttaaagctgcaagtactgataagtgtgagccattagttaat       c.*1380

          .         .         .         .         .         .       g.304236
 tcgcatttataaagaagtggtctgtcacttttggcaaatgtcttgacatctgttgctcta       c.*1440

          .         .         .         .         .         .       g.304296
 cagttgtcaactagaaaattaggcatagagtttcacattattataagcatgttttcacac       c.*1500

          .         .         .         .         .         .       g.304356
 aaaaacatgtacattgatgtttattgcaattttatgtgtaataaccaaaaacaacccaga       c.*1560

          .         .         .         .         .         .       g.304416
 ttttcttcattgggtaaatgattaaacaaaccatagtacattcataccgtgagtgctact       c.*1620

          .         .         .         .         .         .       g.304476
 cagcaataaaaaagaacaaactatgggtacaggcagcaacttataattccagagaattat       c.*1680

          .         .         .         .         .         .       g.304536
 gctgaatgaaaaaggccaatttaaaaaggttttgtaccaaaagattccatttatataacg       c.*1740

          .         .         .         .         .         .       g.304596
 ttcttgaagtgacataattatagaaatggagaacagattagtggtggctgtgttaaggag       c.*1800

          .         .         .         .         .         .       g.304656
 ggggtgaggatgggagagaattgggcgtggctgtgagaaacatgagggatccttgtgatg       c.*1860

          .         .         .         .         .         .       g.304716
 atggaaatgttctatatcacagctatcgatgtcagtatcccagttgtgatattgtgctat       c.*1920

          .         .         .         .         .         .       g.304776
 agttttgcaagatgttaccactgggggaaattgggtgaagggcacatggaatctctgtat       c.*1980

          .         .         .         .         .         .       g.304836
 tatttcaactgcatgtaaatctacaattatctcaaaataaaaataaaagttaaaaaaaca       c.*2040

                                                                    g.304840
 caaa                                                               c.*2044

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nucleotide binding protein-like protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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