nucleoporin 43kDa (NUP43) - coding DNA reference sequence

(used for variant description)

(last modified April 11, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_198887.1 in the NUP43 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering NUP43 transcript NM_198887.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    gctgagaggcgcgtactgtgcttgctttttgcagtacctgctgcggccgctttcggc       c.-1

          .         .         .         .         .         .       g.5117
 ATGGAGGAAATTTATGCGAAGTTTGTGTCCCAGAAAATCAGCAAAACCCGCTGGCGACCG       c.60
 M  E  E  I  Y  A  K  F  V  S  Q  K  I  S  K  T  R  W  R  P         p.20

          .         .         .         .         .         .       g.5177
 CTGCCTCCGGGAAGTTTACAGACCGCGGAGACGTTCGCTACAGGATCTTGGGACAATGAG       c.120
 L  P  P  G  S  L  Q  T  A  E  T  F  A  T  G  S  W  D  N  E         p.40

  | 02       .         .         .         .         .         .    g.5550
  | GAAAATTATATTTCACTGTGGTCTATTGGAGATTTTGGAAACTTGGACTCTGATGGAGGG    c.180
  | E  N  Y  I  S  L  W  S  I  G  D  F  G  N  L  D  S  D  G  G      p.60

          .         .         .         .         .         .       g.5610
 TTTGAAGGAGACCATCAGTTATTGTGTGATATCAGACACCATGGTGATGTAATGGATTTA       c.240
 F  E  G  D  H  Q  L  L  C  D  I  R  H  H  G  D  V  M  D  L         p.80

     | 03    .         .         .         .         .         .    g.7894
 CAG | TTTTTTGACCAGGAAAGAATTGTCGCTGCTTCATCAACAGGATGTGTAACAGTTTTC    c.300
 Q   | F  F  D  Q  E  R  I  V  A  A  S  S  T  G  C  V  T  V  F      p.100

          .         .  | 04      .         .         .         .    g.9021
 CTTCACCATCCAAATAACCAG | ACTCTGTCAGTCAACCAGCAGTGGACTACAGCTCACTAC    c.360
 L  H  H  P  N  N  Q   | T  L  S  V  N  Q  Q  W  T  T  A  H  Y      p.120

          .         .         .         .         .         .       g.9081
 CACACAGGCCCTGGCAGTCCTTCCTATAGCAGTGCACCATGTACAGGTGTTGTGTGCAAC       c.420
 H  T  G  P  G  S  P  S  Y  S  S  A  P  C  T  G  V  V  C  N         p.140

          .         .         .         .         .         .       g.9141
 AACCCAGAAATCGTTACAGTTGGAGAGGATGGTCGAATAAATCTCTTCAGAGCTGATCAC       c.480
 N  P  E  I  V  T  V  G  E  D  G  R  I  N  L  F  R  A  D  H         p.160

          .         .   | 05     .         .         .         .    g.12812
 AAGGAAGCTGTAAGAACCATAG | ACAATGCAGATAGTAGTACACTCCATGCTGTAACCTTT    c.540
 K  E  A  V  R  T  I  D |   N  A  D  S  S  T  L  H  A  V  T  F      p.180

          .         .         .         .         .         .       g.12872
 CTTCGAACTCCTGAGATTCTTACTGTAAATTCAATTGGACAGTTGAAAATATGGGATTTC       c.600
 L  R  T  P  E  I  L  T  V  N  S  I  G  Q  L  K  I  W  D  F         p.200

          .         .         .         | 06         .         .    g.14952
 AGACAACAAGGAAATGAGCCTTCTCAGATATTGTCACT | GACTGGTGACCGAGTGCCACTC    c.660
 R  Q  Q  G  N  E  P  S  Q  I  L  S  L  |  T  G  D  R  V  P  L      p.220

          .         .         .         .         .         .       g.15012
 CACTGTGTTGATAGACATCCCAACCAACAGCATGTTGTAGCTACTGGTGGCCAAGATGGA       c.720
 H  C  V  D  R  H  P  N  Q  Q  H  V  V  A  T  G  G  Q  D  G         p.240

          .         .         .         .         .         .       g.15072
 ATGTTGAGTATTTGGGATGTTAGACAAGGTACTATGCCTGTATCTCTGCTGAAGGCTCAT       c.780
 M  L  S  I  W  D  V  R  Q  G  T  M  P  V  S  L  L  K  A  H         p.260

          . | 07       .         .         .         .         .    g.19867
 GAAGCTGAAA | TGTGGGAAGTTCACTTTCACCCATCCAACCCAGAACATCTTTTTACCTGC    c.840
 E  A  E  M |   W  E  V  H  F  H  P  S  N  P  E  H  L  F  T  C      p.280

          .         .         .         .         .         .       g.19927
 TCTGAAGATGGATCCCTCTGGCACTGGGATGCTTCCACAGATGTACCTGAAAAGTCGTCA       c.900
 S  E  D  G  S  L  W  H  W  D  A  S  T  D  V  P  E  K  S  S         p.300

          .    | 08    .         .         .         .         .    g.24401
 CTCTTTCACCAAG | GAGGAAGAAGCAGTACTTTTTTGTCTCATAGCATTAGTAACCAAGCT    c.960
 L  F  H  Q  G |   G  R  S  S  T  F  L  S  H  S  I  S  N  Q  A      p.320

          .         .         .         .         .         .       g.24461
 AATGTTCACCAGTCTGTCATTAGCTCCTGGCTCAGCACTGATCCTGCAAAAGACCGAATT       c.1020
 N  V  H  Q  S  V  I  S  S  W  L  S  T  D  P  A  K  D  R  I         p.340

          .         .         .         .         .         .       g.24521
 GAAATCACAAGCTTACTTCCCAGTAGGTCTCTGTCTGTGAACACTTTGGATGTTTTAGGT       c.1080
 E  I  T  S  L  L  P  S  R  S  L  S  V  N  T  L  D  V  L  G         p.360

          .         .         .         .         .         .       g.24581
 CCTTGTCTTGTTTGTGGAACCGATGCAGAAGCAATTTATGTTACTAGACATCTTTTTTCG       c.1140
 P  C  L  V  C  G  T  D  A  E  A  I  Y  V  T  R  H  L  F  S         p.380

                                                                    g.24584
 TAG                                                                c.1143
 X                                                                  p.380

          .         .         .         .         .         .       g.24644
 aagtactataattataagatttcagatagaacatgcaattagccttttgaaatccaactt       c.*60

          .         .         .         .         .         .       g.24704
 ctgtgcaaaattttagtatcagaaaatacgagatttgcaggggaaacatcagtaaactac       c.*120

          .         .         .         .         .         .       g.24764
 cattaatgtcaatgcccagttttgacttttgttagcctgacactcccaaacagttgtaga       c.*180

          .         .         .         .         .         .       g.24824
 atccgatagatgactgatggcaaaagattgtgaacatgtggaagaaaatcagtgggattc       c.*240

          .         .         .         .         .         .       g.24884
 tggtgctgatgaataggttgccttcagagtattattgacagacagcttgtggaactaatt       c.*300

          .         .         .         .         .         .       g.24944
 ctttatttttgatgttgtgggaattaacacatcaatggtggttatgggaactaccaatgg       c.*360

          .         .         .         .         .         .       g.25004
 gttcctacaatttttatcagtagtatgtggcatatacaccttcctagtggcagttgccaa       c.*420

          .         .         .         .         .         .       g.25064
 tgttaatgattattctttttattgcaagtatttcctatgatccttccacactttatttcc       c.*480

          .         .         .         .         .         .       g.25124
 ttaataataataaactttttcagaaagaattgagtagagcaaaaatgacaaagatgtgta       c.*540

          .         .         .         .         .         .       g.25184
 gctgtgttcaatttttttttttttttttttttgaggcagagtcttgctctgctggagtgc       c.*600

          .         .         .         .         .         .       g.25244
 ggtggtgcaatctcggctcactgcaacctccacctcccaggttcaagcaattctcctgcc       c.*660

          .         .         .         .         .         .       g.25304
 tcagtctcctgagtagctggaactacaggtgtgcgccaccacgcccagctaatttttgta       c.*720

          .         .         .         .         .         .       g.25364
 attttagtagagacagagtttcaccatgttggccaggatggtctcgatctcttgacctca       c.*780

          .         .         .         .         .         .       g.25424
 tgatccacccgcctcgacctcccaaagtgctgtgattacaggtgtgagccactgcacccg       c.*840

          .         .         .         .         .         .       g.25484
 gcctgaaatttttttaaggtgaaaatgttttgacaagttcctttttcagaataggttttt       c.*900

          .         .         .         .         .         .       g.25544
 gagcagaactctttcagcttgttagacccaactttgcttttgtttagcttcacagcatag       c.*960

          .         .         .         .         .         .       g.25604
 ctgaaagttgccaaactggacattgtgcaataaagtagaattctatattgataagcaaac       c.*1020

          .         .         .         .         .         .       g.25664
 tatttccaaactaaaaatgtgatagataaaagtgtgattaatcaaatgatatgatcagag       c.*1080

          .         .         .         .         .         .       g.25724
 taaagaattttgccattttgatccttttactttgttttagccacctatagtgttaccaac       c.*1140

          .         .         .         .         .         .       g.25784
 catctttatccttgtctgcagggataataatgaactaatgtagtgttttaagataattta       c.*1200

          .         .         .         .         .         .       g.25844
 atgatactatctttccaaactttgttagattttaaatgtattattgacctgagaccttaa       c.*1260

          .         .         .         .         .         .       g.25904
 tgacaaatcactgctattagacaattgaagtgttcatttactttgtaattccaataatca       c.*1320

          .         .         .         .         .         .       g.25964
 tagttatggaattatggtaaggttttgcttttctgtcctaataaatatatatattttttg       c.*1380

          .         .         .         .         .         .       g.26024
 agatggagttttgctcttgttgctgaggctggagtgaaatggcatgatctcagctcactg       c.*1440

          .         .         .         .         .         .       g.26084
 caacctccgtctcttaggttcaagcaattctcctgcctcagcctcccgagtagctgggat       c.*1500

          .         .         .         .         .         .       g.26144
 tacaggtgctcaccaccacacccagctaatttttgtatttttagtagagatggggtttca       c.*1560

          .         .         .         .         .         .       g.26204
 ctgtgttggccaggctggtcttgaactgacctcatgatccacctgcctcagcctcccaaa       c.*1620

          .         .         .         .         .         .       g.26264
 atgctgggattacaggcttgagccactgctcccggctgatttttgtattagtagagacga       c.*1680

          .         .         .         .         .         .       g.26324
 cagggtttcaccatgttggccagggctggtctcgaactcctgaccacaggtaatcagccc       c.*1740

          .         .         .         .         .         .       g.26384
 gcctcggcctcccaaagtgctgggattacaggcgtgagccacttagtatttgtaaccata       c.*1800

          .         .         .         .         .         .       g.26444
 agagaaagtatattttaacagcattacatttcatgccaattgacaagttttgccaatttt       c.*1860

          .         .         .         .         .         .       g.26504
 aataagaaactaagctttatgtaatgtaacaccgtaatttatgaatttgttcattgtcac       c.*1920

          .         .         .         .         .         .       g.26564
 tgcctttattcatgaaactgtcaaatagagtgtctttcaagggttgcaggatcttagaga       c.*1980

          .         .         .         .         .         .       g.26624
 tagaaagtaccttggtgatcatctccagcctaaatttcatcatcccttctatggtattcc       c.*2040

          .         .         .         .         .         .       g.26684
 caacaaattatcatccaacctatacttaaaaacatatggtggccaggcatggtggctcac       c.*2100

          .         .         .         .         .         .       g.26744
 gcctgtaatgctagcactttgggaggccgaggtgggtgaagcacctgaggtcaagagttc       c.*2160

          .         .         .         .         .         .       g.26804
 gagatcagcctggccaacatggcgaaaccccgtctccactaaaaatgcaaaaaaaaaatt       c.*2220

          .         .         .         .         .         .       g.26864
 aaccgggcgtggtggcaggcatctataatcccagctacttgggaggctgaggcaggagaa       c.*2280

          .         .         .         .         .         .       g.26924
 ttgctcaaacccgggaggcagaggttgcagtgacccaagatcgtgccacttcactccagc       c.*2340

          .         .         .         .         .         .       g.26984
 ctgggcaaaagagcaaaacgccatctcaaaaaatatacatatataaggagataaagtttc       c.*2400

          .         .         .         .         .         .       g.27044
 ccattttccaatacagtttcacatttgaacagccctaattgatacaactttatggcaggg       c.*2460

          .         .         .         .         .         .       g.27104
 ttttagtgtgtgagtgggatccaaaacactcaatcctgtaaaagggtacagtcctattgt       c.*2520

          .         .         .         .         .         .       g.27164
 atgttaacacactgatgatgtgagcctgtgagatgagccaatcaccagttgttatgttcg       c.*2580

          .         .         .         .         .         .       g.27224
 aatctgctttgtgttgggacgctttaatgtcagggtttcactaaataaatgaattttcat       c.*2640

                                                                    g.27232
 atactgaa                                                           c.*2648

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nucleoporin 43kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 23
©2004-2020 Leiden University Medical Center